KEGG   DISEASE: Kaposi sarcoma
Entry
H00041                      Disease                                
Name
Kaposi sarcoma
  Supergrp
Solid tumor [DS:H02421]
Soft tissue sarcomas [DS:H02427]
Description
Kaposi sarcoma (KS) is an angioproliferative disease classified into classic KS, endemic KS, iatrogenic KS, and HIV-associated KS (HIV-KS), however, share the same histological traits and are all associated with infection by the human herpesvirus 8 (HHV8; also known as KSHV). Evidence indicates that KS progression occurs upon the deregulated expression of anti-apoptotic genes (Bcl-2), oncogenes (c-myc, c-int, ras) and oncosuppressor genes (TP53), and is associated with the long-lasting expression of HHV8 latency genes (LANA, v-cyc D, v-FLIP, Kaposin). All these genes are, in fact, expressed or altered in most KS spindle cells in the nodular-late stage of KS. Bcl-2 acts as a major KS progression factor, and TP53 and c-myc may also have a role in disease progression. HHV8 latency gene products may be involved in KS progression due to their capability of promoting cell growth by direct effects or antiapoptotic effects.
Category
Cancer
Brite
Human diseases [BR:br08402]
 Cancers
  Cancers of soft tissues and bone
   H00041  Kaposi sarcoma
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00041  Kaposi sarcoma
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant mesenchymal neoplasms
     2B57  Kaposi sarcoma, primary site
      H00041  Kaposi sarcoma
Pathway
hsa05167  Kaposi sarcoma-associated herpesvirus infection
Related
pathway
hsa05200  Pathways in cancer
hsa05203  Viral carcinogenesis
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06115  WNT signaling (viruses and bacteria)
nt06119  JAK-STAT signaling (viruses)
nt06120  Calcium signaling (viruses and bacteria)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06124  Chemokine signaling (viruses)
nt06128  Autophagy (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06136  Complement activation (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06164  Kaposi sarcoma-associated herpesvirus (KSHV)
nt06513  Complement activation
Gene
BCL2 (overexpression) [HSA:596] [KO:K02161]
MYC (overexpression) [HSA:4609] [KO:K04377]
FGF3 (overexpression, mutation) [HSA:2248] [KO:K04358]
KRAS (overexpression, mutation) [HSA:3845] [KO:K07827]
TP53 [HSA:7157] [KO:K04451]
Carcinogen
Azathioprine [CPD:C06837]
Pathogen
Human herpesvirus 8 (KSHV) [GN:T40081]
Human immunodeficiency virus 1 [GN:T40001]
Drug
Alitretinoin [DR:D02815]
Vinblastine sulfate [DR:D01068]
Paclitaxel [DR:D00491]
Doxorubicin hydrochloride [DR:D01275]
Interferon alfa-2b [DR:D02745]
Other DBs
ICD-11: 2B57
ICD-10: C46
MeSH: D012514
Reference
PMID:11423257 (GENE)
  Authors
Ensoli B, Sgadari C, Barillari G, Sirianni MC, Sturzl M, Monini P
  Title
Biology of Kaposi's sarcoma.
  Journal
Eur J Cancer 37:1251-69 (2001)
DOI:10.1016/S0959-8049(01)00121-6
Reference
  Authors
Schwartz RA.
  Title
Kaposi's sarcoma: an update.
  Journal
J Surg Oncol 87:146-51 (2004)
DOI:10.1002/jso.20090

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