KEGG   DISEASE: Nasopharyngeal cancer
H00054                      Disease                                

Nasopharyngeal cancer
Nasopharyngeal carcinoma (NPC) is a rare disease in most parts of the world, with an age-standardised annual incidence of less than 1 per 100000. However, in Southern China, parts of Southeast Asia and the Mediterranean basin, NPC is an endemic disease with an incidence of 10-30 per 100000. Genome-wide studies have unravelled multiple chromosomal abnormalities with involvement of specific oncogenes and tumor suppressor genes. Alterations of genes such as Ras association domain family 1A (RASSF1A), p16/INK4A, p14/ARF suggest that multiple cellular pathways were dysregulated in the NPC cells. Studies on the precancerous lesions revealed early genetic changes and a critical role of Epstein- Barr virus (EBV) latent infection in the development of this cancer.
Human diseases [BR:br08402]
  Head and neck cancers
   H00054  Nasopharyngeal cancer
Human diseases in ICD-11 classification [BR:br08403]
 02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of lip, oral cavity or pharynx
     2B6B  Malignant neoplasms of nasopharynx
      H00054  Nasopharyngeal cancer
hsa05200  Pathways in cancer
hsa05169  Epstein-Barr virus infection
N00223  EBV EBNA1 to p53-mediated transcription
N00224  EBV EBNALP RBP-Jk-mediated transcription
N00225  EBV EBNA2 to RBP-Jk-mediated transcription
N00226  EBV EBNA3A/3B/3C to RBP-Jk-mediated transcription
N00262  EBV EBNA3C to intrinsic apoptotic pathway
N00263  EBV EBNA3C to p53-mediated transcription
N00264  EBV EBNA3C to p27-Cell cycle G1/S
N00265  EBV LMP1 to NFKB signaling pathway
N00266  EBV LMP2A to PI3K signaling pathway
N00466  EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00467  EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00468  EBV BPLF1 to TLR2/4-NFKB signaling pathway
N00470  EBV BGLF4 to RIG-I-like receptor signaling pathway
N00471  EBV LMP2A/2B to IFN signaling pathway
N00472  EBV LMP1 to IFN signaling pathway
N00473  EBV BGLF4 to IFN signaling pathway
N00474  EBV BHRF1 to intrinsic apoptotic pathway
N00475  EBV BHRF1 to intrinsic apoptotic pathway
N00476  EBV BHRF1 to intrinsic apoptotic pathway
N00477  EBV BHRF1 to crosstalk between extrinsic and intrinsic apoptotic pathways
N00478  EBV BARF1 to intrinsic apoptotic pathway
N00479  EBV BNLF2a to antigen processing and presentation by MHC class I molecules
N00480  EBV BILF1 to antigen processing and presentation by MHC class I molecules
N00481  EBV BZLF1 to p53-mediated transcription
N00482  EBV EBNA3C to p27-Cell cycle G1/S
N00483  EBV EBNA3C to cell cycle G1/S
N00484  EBV EBNA3C to cell cycle G1/S
N00485  EBV LMP1 to PI3K signaling pathway
N00486  EBV LMP1 to Jak-STAT signaling pathway
N00488  EBV LMP2A to BCR signaling pathway
N01265  EBV vIL10 to IL10R signaling
N01281  EBV BARF1 to CSF1R sigaling
N01407  Metals to JNK signaling pathway
N01408  Metals to RAS-ERK signaling pathway
N01409  Metals to PI3K signaling pathway
N01410  Metals to NFKB signaling pathway
N01411  Metals to NFKB signaling pathway
N01412  Metals to HTF-1 signaling pathway
N01413  Metals to KEAP1-NRF2 signalig pathway
RASSF1 (promoter hypermethylation) [HSA:11186] [KO:K09850]
p16/INK4A (promoter hypermethylation) [HSA:1029] [KO:K06621]
Bcl-2 (overexpression) [HSA:596] [KO:K02161]
EDNRB (promoter hypermethylation) [HSA:1910] [KO:K04198]
TSLC1 (promoter hypermethylation) [HSA:23705] [KO:K06781]
E-cadherin (decreased expression) [HSA:999] [KO:K05689]
Formaldehyde [CPD:C00067]
Salted fish (Chinese-style)
Tobacco smoking and tobacco smoke
Wood dust
Human herpesvirus 4 (Epstein-Barr virus) [GN:T40079]
ICD-O: 8072/3, Tumor type: Non-keratinizing carcinoma
ICD-O: 8071/3, Tumor type: Keratinizing squamous cell carcinoma
ICD-O: 8083/3, Tumor type: Basaloid squamous cell carcinoma
Other DBs
ICD-11: 2B6B
ICD-10: C11
MeSH: D009303
PMID:15958470 (description, carcinogen)
Chan AT
Head and neck cancer: treatment of nasopharyngeal cancer.
Ann Oncol 16 Suppl 2:ii265-8 (2005)
PMID:12450731 (description, gene, carcinogen)
Lo KW, Huang DP.
Genetic and epigenetic changes in nasopharyngeal carcinoma.
Semin Cancer Biol 12:451-62 (2002)
PMID:15510157 (gene, tumor type)
Young LS, Rickinson AB.
Epstein-Barr virus: 40 years on.
Nat Rev Cancer 4:757-68 (2004)
PMID:15760280 (carcinogen)
Schottenfeld D, Beebe-Dimmer JL.
Advances in cancer epidemiology: understanding causal mechanisms and the evidence for implementing interventions.
Annu Rev Public Health 26:37-60 (2005)
PMID:17033133 (carcinogen)
Binetti R, Costamagna FM, Marcello I.
Development of carcinogenicity classifications and evaluations: the case of formaldehyde.
Ann Ist Super Sanita 42:132-43 (2006)
PMID:16140628 (carcinogen)
Cogliano VJ, Grosse Y, Baan RA, Straif K, Secretan MB, El Ghissassi F.
Meeting report: summary of IARC monographs on formaldehyde, 2-butoxyethanol, and 1-tert-butoxy-2-propanol.
Environ Health Perspect 113:1205-8 (2005)
PMID:17530489 (carcinogen)
Abnet CC.
Carcinogenic food contaminants.
Cancer Invest 25:189-96 (2007)
PMID:15552776 (carcinogen)
Sasco AJ, Secretan MB, Straif K.
Tobacco smoking and cancer: a brief review of recent epidemiological evidence.
Lung Cancer 45 Suppl 2:S3-9 (2004)
PMID:12176778 (marker)
Chan AT, Teo PM, Johnson PJ.
Nasopharyngeal carcinoma.
Ann Oncol 13:1007-15 (2002)
PMID:12450734 (marker)
Chan KC, Lo YM.
Circulating EBV DNA as a tumor marker for nasopharyngeal carcinoma.
Semin Cancer Biol 12:489-96 (2002)

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