KEGG   DISEASE: Cytomegalovirus infection
Entry
H00368                      Disease                                
Name
Cytomegalovirus infection;
CMV infection
Description
Cytomegalovirus (CMV) is a double-stranded DNA virus of the Herpesviridae family acquired by late childhood in the majority of individuals. Primary infection is nonspecific but after that the virus becomes latent in multiple organs and can later be reactivated. CMV is an important and common cause of mortality and morbidity in immunocompromised patients such as those with HIV/AIDS or transplant recipients on immunosuppressive therapy.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00368  Cytomegalovirus infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Certain other viral diseases
   1D82  Cytomegaloviral disease
    H00368  Cytomegalovirus infection
Pathway
hsa05163  Human cytomegalovirus infection
Network
nt06110  MAPK signaling (viruses and bacteria)
nt06114  PI3K signaling (viruses)
nt06119  JAK-STAT signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06124  Chemokine signaling (viruses)
nt06129  MHC presentation (viruses)
nt06130  Cell cycle (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06135  Cytoskeletal regulation (viruses and bacteria)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06167  Human cytomegalovirus (HCMV)
Pathogen
Human herpesvirus 5 (Human cytomegalovirus) [GN:T40080]
Drug
Ganciclovir [DR:D00333]
Ganciclovir sodium [DR:D04301]
Cidofovir [DR:D00273]
Valganciclovir hydrochloride [DR:D03256]
Foscarnet sodium [DR:D00579]
Maribavir [DR:D04859]
Letermovir [DR:D10801]
Other DBs
ICD-11: 1D82
ICD-10: B20.2 B25 B27.1 P35.1
MeSH: D003586
Reference
PMID:21970493 (env_factor, marker)
  Authors
Chisholm C, Lopez L
  Title
Cutaneous infections caused by Herpesviridae: a review.
  Journal
Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS
Reference
  Authors
Fishman JA
  Title
Infections in immunocompromised hosts and organ transplant recipients: essentials.
  Journal
Liver Transpl 17 Suppl 3:S34-7 (2011)
DOI:10.1002/lt.22378
Reference
  Authors
Jackson SE, Mason GM, Wills MR
  Title
Human cytomegalovirus immunity and immune evasion.
  Journal
Virus Res 157:151-60 (2011)
DOI:10.1016/j.virusres.2010.10.031
Reference
PMID:21841300 (drug)
  Authors
Jain M, Duggal S, Chugh TD
  Title
Cytomegalovirus infection in non-immunosuppressed critically ill patients.
  Journal
J Infect Dev Ctries 5:571-9 (2011)
DOI:10.3855/jidc.1487
Reference
PMID:21827433 (marker)
  Authors
Ross SA, Novak Z, Pati S, Boppana SB
  Title
Overview of the diagnosis of cytomegalovirus infection.
  Journal
Infect Disord Drug Targets 11:466-74 (2011)
DOI:10.2174/187152611797636703

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