KEGG   DISEASE: Histoplasmosis
Entry
H01062                      Disease                                

Name
Histoplasmosis
Description
Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum that occurs in temperate and tropical climates. It is one of the most frequent invasive fungal infections in immunocompromised patients or patients receiving tumor necrosis factor (TNF) blockers. Most affected patients present with pneumonitis, and sometimes the disease may be disseminated from the lungs to other organs.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Mycosis
  Infections caused by ascomycetes
   H01062  Histoplasmosis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Mycoses
   1F2A  Histoplasmosis
    H01062  Histoplasmosis
Pathogen
Histoplasma capsulatum [GN:aje]
Tumor necrosis factor (TNF) blockers [DR:D02598 D02597 D00742]
Drug
Amphotericin B [DR:D00203]
Ketoconazole [DR:D00351]
Itraconazole [DR:D00350]
Other DBs
ICD-11: 1F2A
ICD-10: B39.9
MeSH: D006660
Reference
  Authors
Gupta AO, Singh N
  Title
Immune reconstitution syndrome and fungal infections.
  Journal
Curr Opin Infect Dis 24:527-33 (2011)
DOI:10.1097/QCO.0b013e32834ab20a
Reference
  Authors
Perfect JR
  Title
The impact of the host on fungal infections.
  Journal
Am J Med 125:S39-51 (2012)
DOI:10.1016/j.amjmed.2011.10.010
Reference
PMID:19951231 (env_factor, drug)
  Authors
Hage CA, Bowyer S, Tarvin SE, Helper D, Kleiman MB, Joseph Wheat L
  Title
Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy.
  Journal
Clin Infect Dis 50:85-92 (2010)
DOI:10.1086/648724
Reference
  Authors
Jazwinski A, Naggie S, Perfect J
  Title
Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance.
  Journal
Mycoses 54:270-2 (2011)
DOI:10.1111/j.1439-0507.2009.01796.x
Reference
PMID:17409220 (marker)
  Authors
LeMonte A, Egan L, Connolly P, Durkin M, Wheat LJ
  Title
Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria.
  Journal
Clin Vaccine Immunol 14:802-3 (2007)
DOI:10.1128/CVI.00035-07

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