KEGG   DISEASE: Aspergillosis
Entry
H01328                      Disease                                
Name
Aspergillosis
Description
Pulmonary aspergillus infections can be classified based on clinical syndromes into saprophytic infections, allergic disease and invasive disease. Invasive pulmonary aspergillosis, occurring in immunocompromised patients, reflects the most serious disease with a high case-fatality rate. Of the 185 recognized species of Aspergillus, 20 are known to cause infections in humans. Aspergillus fumigatus accounts for about 65 percent of all invasive infections in humans and is the mostly encountered species in pulmonary infections. Aspergillus flavus, Aspergillus niger, Aspergillus terreus and Aspergillus nidulans are less frequently causes of invasive and pulmonary infections.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Mycosis
  Infections caused by ascomycetes
   H01328  Aspergillosis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Mycoses
   1F20  Aspergillosis
    H01328  Aspergillosis
Related
pathway
hsa04625  C-type lectin receptor signaling pathway
Gene
CLEC1A (susceptibility) [HSA:51267] [KO:K10069]
CLEC7A (susceptibility) [HSA:64581] [KO:K10074]
Pathogen
Aspergillus fumigatus [GN:afm]
Aspergillus flavus [GN:afv]
Aspergillus clavatus [GN:act]
Drug
Amphotericin B [DR:D00203]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Itraconazole [DR:D00350]
Voriconazole [DR:D00578]
Posaconazole [DR:D02555]
Caspofungin acetate [DR:D02501]
Isavuconazonium sulfate [DR:D10643]
Other DBs
ICD-11: 1F20
ICD-10: B44
MeSH: D001228
MedlinePlus: 001326
OMIM: 614079
Reference
  Authors
Warris A
  Title
The biology of pulmonary aspergillus infections.
  Journal
J Infect 69 Suppl 1:S36-41 (2014)
DOI:10.1016/j.jinf.2014.07.011
Reference
PMID:29489751 (CLEC1A)
  Authors
Stappers MHT, Clark AE, Aimanianda V, Bidula S, Reid DM, Asamaphan P, Hardison SE, Dambuza IM, Valsecchi I, Kerscher B, Plato A, Wallace CA, Yuecel R, Hebecker B, da Gloria Teixeira Sousa M, Cunha C, Liu Y, Feizi T, Brakhage AA, Kwon-Chung KJ, Gow NAR, Zanda M, Piras M, Zanato C, Jaeger M, Netea MG, van de Veerdonk FL, Lacerda JF, Campos A, Carvalho A, Willment JA, Latge JP, Brown GD
  Title
Recognition of DHN-melanin by a C-type lectin receptor is required for immunity to Aspergillus.
  Journal
Nature 555:382-386 (2018)
DOI:10.1038/nature25974
Reference
PMID:22674328 (CLEC7A)
  Authors
Iliev ID, Funari VA, Taylor KD, Nguyen Q, Reyes CN, Strom SP, Brown J, Becker CA, Fleshner PR, Dubinsky M, Rotter JI, Wang HL, McGovern DP, Brown GD, Underhill DM
  Title
Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.
  Journal
Science 336:1314-7 (2012)
DOI:10.1126/science.1221789

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