KEGG   DISEASE: Group A streptococcal pharyngitis
Entry
H01424                      Disease                                
Name
Group A streptococcal pharyngitis;
Group A streptococcal tonsillitis;
Group A streptococcal pharyngotonsillitis
  Supergrp
Streptococcal infection [DS:H00333]
Description
Group A streptococcal pharyngitis is an acute infection of the oropharynx and/or nasopharynx that is caused by group A streptococcus (Streptococcus pyogenes). Group A streptococcus is responsible for 5-15% of cases of pharyngitis in adults and 20-30% of cases in children, and is the most common cause of bacterial pharyngitis. The disorder is primarily a disease of children between 5 and 15 years of age, and, in temperate climates, it usually occurs in the winter and early spring. The onset of symptoms in patients is often abrupt. In addition to throat pain, symptoms may include fever, chills, malaise, headache, and particularly in younger children abdominal pain, nausea, and vomiting. Cough, coryza, and conjunctivitis are not typical symptoms of streptococcal pharyngitis, and, if present, they suggest an alternative cause such as a viral infection. In most persons, fever resolves within 3-5 days, and throat pain resolves within 1 week, even without specific treatment. Antibiotic treatment reduces the risk of subsequent development of acute rheumatic fever and suppurative complications.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by Gram-positive bacteria
   H01424  Group A streptococcal pharyngitis
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Certain staphylococcal or streptococcal diseases
   1B51  Streptococcal pharyngitis
    H01424  Group A streptococcal pharyngitis
Pathogen
Streptococcus pyogenes [GN:sph spi spj spa spb]
Drug
Ceftibuten hydrate [DR:D02121]
Cefdinir monohydrate [DR:D11571]
Cefditoren pivoxil [DR:D01628]
Clarithromycin [DR:D00276]
Other DBs
ICD-11: 1B51
ICD-10: J02.0
Reference
  Authors
Bisno AL, Gerber MA, Gwaltney JM Jr, Kaplan EL, Schwartz RH
  Title
Practice guidelines for the diagnosis and management of group A streptococcal pharyngitis. Infectious Diseases Society of America.
  Journal
Clin Infect Dis 35:113-25 (2002)
DOI:10.1086/340949
Reference
PMID:21323542 (description, drug)
  Authors
Wessels MR
  Title
Clinical practice. Streptococcal pharyngitis.
  Journal
N Engl J Med 364:648-55 (2011)
DOI:10.1056/NEJMcp1009126

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