KEGG   DISEASE: Acne vulgaris
Entry
H01445                      Disease                                

Name
Acne vulgaris
  Supergrp
Anaerobic infection [DS:H01410]
Description
Acne is a chronic inflammatory disease of the pilosebaceous unit resulting from androgen-induced increased sebum production, altered keratinization, inflammation, and bacterial colonization of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. P. acnes is a Gram-positive bacterium that forms part of the normal flora of the skin, oral cavity, large intestine, the conjunctiva and the external ear canal. Although P. acnes is primarily recognized for its role in acne, it's also famous as an opportunistic pathogen causing a range of postoperative and device-related infections.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Bacterial infections
  Infections caused by actinobacteria
   H01445  Acne vulgaris
Human diseases in ICD-11 classification [BR:br08403]
 14 Diseases of the skin
  Skin disorders involving specific cutaneous structures
   Disorders of the epidermis and epidermal appendages
    Disorders of the hair follicle
     Acne and related disorders
      ED80  Acne
       H01445  Acne vulgaris
Pathogen
Propionibacterium acnes [GN:pac pach]
Drug
Tetracycline hydrochloride [DR:D02122]
Doxycycline [DR:D00307]
Doxycycline calcium [DR:D03903]
Minocycline hydrochloride [DR:D00850]
Tazarotene [DR:D01132]
Tretinoin [DR:D00094]
Adapalene [DR:D01112]
Trifarotene [DR:D11225]
Clindamycin phosphate and tretinoin [DR:D11084]
Adapalene and benzoyl peroxide [DR:D10792]
Benzoyl peroxide [DR:D03093]
Clindamycin phosphate and benzoyl peroxide [DR:D10602]
Benzoyl peroxide and erythromycin [DR:D11646]
Clindamycin phosphate [DR:D01073]
Erythromycin [DR:D00140]
Sulfacetamide sodium [DR:D00871]
Dapsone [DR:D00592]
Norgestimate and ethinyl estradiol [DR:D10590]
Sarecycline hydrochloride [DR:D10667]
Clascoterone [DR:D11451]
Other DBs
ICD-11: ED80
ICD-10: L70.0
MeSH: D000152
MedlinePlus: 000873
Reference
  Authors
Williams HC, Dellavalle RP, Garner S
  Title
Acne vulgaris.
  Journal
Lancet 379:361-72 (2012)
DOI:10.1016/S0140-6736(11)60321-8
Reference
  Authors
Perry A, Lambert P
  Title
Propionibacterium acnes: infection beyond the skin.
  Journal
Expert Rev Anti Infect Ther 9:1149-56 (2011)
DOI:10.1586/eri.11.137

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