KEGG   DISEASE: Ankylosing spondylitis
H01674                      Disease                                
Ankylosing spondylitis;
Bechterew disease
Ankylosing spondylitis (AS), formerly also known as Bechterew's disease, is a rheumatic disease of the axial skeleton that mainly affects the spine and the sacroiliac joint in the pelvis. AS is one of a group of inflammatory diseases, called spondyloarthritides, which share features. This disease is characterized by erosion, sclerosis, and ossification, which may result in complete fusion and rigidity of the spine. Regarding extra-articular manifestations, the most frequent is anterior uveitis. The major functional losses occur during the first 10 years of disease. It usually begins in the second or third decade of life, preferentially in HLA-B27-positive Caucasian males. Its etiology and pathogenesis are not completely understood, but the most prevalent hypothesis involves immune mediation as its major mechanism, including several cytokines. To date, more than 40 genetic variants have been identified that influence the risk of developing AS, including HLA alleles such as HLA-B27.
Immune system disease; Musculoskeletal disease
Human diseases [BR:br08402]
 Immune system diseases
  Allergies and autoimmune diseases
   H01674  Ankylosing spondylitis
 Musculoskeletal diseases
  Skeletal diseases
   H01674  Ankylosing spondylitis
Human diseases in ICD-11 classification [BR:br08403]
 15 Diseases of the musculoskeletal system or connective tissue
  Conditions associated with the spine
   Inflammation of spine
    FA92  Inflammatory spondyloarthritis
     H01674  Ankylosing spondylitis
hsa04612  Antigen processing and presentation
HLA-B [HSA:3106] [KO:K06751]
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Indomethacin [DR:D00141]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Naproxen [DR:D00118]
Naproxen sodium [DR:D00970]
Corticotropin [DR:D00146]
Cortisone acetate [DR:D00973]
Celecoxib [DR:D00567]
Tofacitinib citrate [DR:D09783]
Etanercept [DR:D00742]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Certolizumab pegol [DR:D03441]
Golimumab [DR:D04358]
Secukinumab [DR:D09967]
Naproxen and esomeprazole magnesium [DR:D11576]
Meclofenamate sodium [DR:D00169]
See also H00630 Rheumatoid arthritis and H01656 Psoriasis.
Other DBs
ICD-11: FA92
ICD-10: M45
MeSH: D013167
OMIM: 106300
Gouveia EB, Elmann D, Morales MS
Ankylosing spondylitis and uveitis: overview.
Rev Bras Reumatol 52:742-56 (2012)
PMID:27445458 (drug)
Koenders MI, van den Berg WB
Secukinumab for rheumatology: development and its potential place in therapy.
Drug Des Devel Ther 10:2069-80 (2016)
Brown MA, Kenna T, Wordsworth BP
Genetics of ankylosing spondylitis--insights into pathogenesis.
Nat Rev Rheumatol 12:81-91 (2016)

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