KEGG   DISEASE: Polycystic ovary syndrome
Entry
H01739                      Disease                                
Name
Polycystic ovary syndrome
Description
Polycystic ovary syndrome (PCOS) is a common heterogeneous endocrine disorder characterized by elevated androgen levels, menstrual irregularities, and/or small cysts on one or both ovaries. Clinical manifestations include oligomenorrhea or amenorrhea, hirsutism, and frequently infertility. Clinical signs of PCOS include elevated luteinizing hormone (LH) and gonadotropin-releasing hormone (GnRH) levels, whereas follicle-stimulating hormone (FSH) levels are muted or unchanged. As a result of the increase in GnRH, stimulation of the ovarian theca cells, in turn, produces more androgens. Risk factors for PCOS in adults includes insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. PCOS can be described as an oligogenic disorder in which the interaction of a number of genetic and environmental factors determine the heterogeneous, clinical, and biochemical phenotype. Management of clinical manifestations of PCOS includes oral contraceptives for menstrual irregularities and hirsutism. Treatment options for infertility include clomiphene, laparoscopic ovarian drilling, gonadotropins, and assisted reproductive technology.
Category
Endocrine system disease; Reproductive system disease
Brite
Human diseases [BR:br08402]
 Reproductive system diseases
  Reproductive system diseases
   H01739  Polycystic ovary syndrome
Human diseases in ICD-11 classification [BR:br08403]
 05 Endocrine, nutritional or metabolic diseases
  Endocrine diseases
   Disorders of the gonadal hormone system
    5A80  Ovarian dysfunction
     H01739  Polycystic ovary syndrome
Other DBs
ICD-11: 5A80.1
ICD-10: E28.2
MeSH: D011085
Reference
  Authors
Sirmans SM, Pate KA
  Title
Epidemiology, diagnosis, and management of polycystic ovary syndrome.
  Journal
Clin Epidemiol 6:1-13 (2013)
DOI:10.2147/CLEP.S37559
Reference
PMID:23946629 (description, drug)
  Authors
Ndefo UA, Eaton A, Green MR
  Title
Polycystic ovary syndrome: a review of treatment options with a focus on pharmacological approaches.
  Journal
P T 38:336-55 (2013)
Reference
  Authors
Barthelmess EK, Naz RK
  Title
Polycystic ovary syndrome: current status and future perspective.
  Journal
Front Biosci (Elite Ed) 6:104-19 (2014)
DOI:10.2741/e695

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