KEGG   ORTHOLOGY: K00049
Entry
K00049                      KO                                     

Symbol
GRHPR
Name
glyoxylate/hydroxypyruvate reductase [EC:1.1.1.79 1.1.1.81]
Pathway
map00260  Glycine, serine and threonine metabolism
map00620  Pyruvate metabolism
map00630  Glyoxylate and dicarboxylate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
Disease
H00117  Primary hyperoxaluria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
   00630 Glyoxylate and dicarboxylate metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.79  glyoxylate reductase (NADP+)
     K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
    1.1.1.81  hydroxypyruvate reductase
     K00049  GRHPR; glyoxylate/hydroxypyruvate reductase
Other DBs
RN: R00465 R01388 R01392 R02527
GO: 0030267 0016618
Genes
HSA: 9380(GRHPR)
PTR: 465099(GRHPR)
PPS: 100986688(GRHPR)
GGO: 101130665(GRHPR)
PON: 100171680(GRHPR)
NLE: 100583603(GRHPR)
MCC: 694185(GRHPR)
MCF: 102144581(GRHPR)
CSAB: 103219183(GRHPR)
CATY: 105593083(GRHPR)
PANU: 101002778(GRHPR)
RRO: 104667514(GRHPR)
RBB: 108516211(GRHPR)
TFN: 117098976(GRHPR)
PTEH: 111536738(GRHPR)
CJC: 100391044(GRHPR)
SBQ: 101048292(GRHPR)
MMUR: 105873817(GRHPR)
MMU: 76238(Grhpr)
MCAL: 110292456(Grhpr)
MPAH: 110338833(Grhpr)
RNO: 680021(Grhpr)
MCOC: 116095934(Grhpr)
MUN: 110558830(Grhpr)
CGE: 100752744(Grhpr)
PLEU: 114710576(Grhpr)
NGI: 103745721(Grhpr)
HGL: 101701531(Grhpr)
CCAN: 109682753(Grhpr)
OCU: 100347792(GRHPR)
OPI: 101526714(GRHPR)
TUP: 102477381(GRHPR)
CFA: 612041(GRHPR)
VVP: 112930803(GRHPR)
VLG: 121495355(GRHPR)
AML: 100475145(GRHPR)
UMR: 103678479(GRHPR)
UAH: 113260446(GRHPR)
ORO: 101369961(GRHPR)
ELK: 111145704
MPUF: 101674108(GRHPR)
EJU: 114213561(GRHPR)
MLX: 118017942(GRHPR)
FCA: 100302391(GRHPR)
PYU: 121034684(GRHPR)
PBG: 122474637(GRHPR)
PTG: 102967428(GRHPR)
PPAD: 109270134(GRHPR)
AJU: 106981283(GRHPR)
HHV: 120233538(GRHPR)
BTA: 504764(GRHPR)
BOM: 102267118(GRHPR)
BIU: 109563042(GRHPR)
BBUB: 102416142(GRHPR)
CHX: 102183324(GRHPR)
OAS: 101108191(GRHPR)
ODA: 120851414(GRHPR)
CCAD: 122452886(GRHPR)
SSC: 100154014(GRHPR)
CFR: 102524449(GRHPR)
CBAI: 105067357(GRHPR)
CDK: 105102265(GRHPR)
BACU: 103010948(GRHPR)
LVE: 103071384(GRHPR)
OOR: 101280139(GRHPR)
DLE: 111187951(GRHPR)
ECB: 100066566(GRHPR)
EPZ: 103560692(GRHPR)
EAI: 106843901(GRHPR)
MYB: 102254963(GRHPR)
MYD: 102768028(GRHPR)
MMYO: 118667307(GRHPR)
MNA: 107544991(GRHPR)
HAI: 109386378(GRHPR)
DRO: 112304422(GRHPR)
SHON: 118979617(GRHPR)
AJM: 119048765(GRHPR)
MMF: 118629573(GRHPR)
PALE: 102888080(GRHPR)
PGIG: 120597871(GRHPR)
RAY: 107511665(GRHPR)
MJV: 108397497(GRHPR)
TOD: 119232907(GRHPR)
LAV: 100653729(GRHPR)
TMU: 101344280
MDO: 100018478(GRHPR)
SHR: 100928696(GRHPR)
PCW: 110220544(GRHPR)
OAA: 100078890 107546808(GRHPR)
GGA: 426806(GRHPR)
PCOC: 116239461(GRHPR)
MGP: 100549242(GRHPR)
CJO: 107306744(GRHPR)
NMEL: 110389952(GRHPR)
APLA: 101789544(GRHPR)
ACYG: 106048866
TGU: 100229871(GRHPR)
LSR: 110482528(GRHPR)
PMOA: 120501765(GRHPR)
OTC: 121337716(GRHPR)
PRUF: 121351313(GRHPR)
FAB: 101813929(GRHPR)
PHI: 102114621(GRHPR)
PMAJ: 107215710(GRHPR)
CCAE: 111942935
CCW: 104695842(GRHPR)
ETL: 114055219(GRHPR)
CLV: 102096371(GRHPR)
EGZ: 104129511(GRHPR)
NNI: 104012536(GRHPR)
ACUN: 113490425(GRHPR)
PADL: 103914609(GRHPR)
NPD: 112946269 112946279(GRHPR)
AMJ: 102561417 102562816(GRHPR)
CPOO: 109323560 109323583(GRHPR)
GGN: 109297176 109297177(GRHPR)
CPIC: 101939051(GRHPR) 101940973
TST: 117879067 117879164(GRHPR)
ACS: 100558748(grhpr)
PVT: 110077846(GRHPR)
PBI: 103059051(GRHPR)
PMUR: 107291253(GRHPR)
TSR: 106537446(GRHPR)
PGUT: 117661686(GRHPR)
PMUA: 114587374(GRHPR)
ZVI: 118097959(GRHPR)
GJA: 107107231(GRHPR)
XLA: 398508(grhpr.2.L) 398631 414606(grhpr.1.L)
XTR: 493279(grhpr.2) 594879 780243(grhpr.1)
DRE: 402985(grhprb) 497183(grhpra)
CCAR: 109086669(grhpr)
IPU: 100528185(grhpr) 108260755
PHYP: 113544290 113547165(grhpr)
AMEX: 103027682 103046658(grhpr)
EEE: 113582659(grhpr) 113586468
TRU: 101071406(grhpr) 101076742
LCO: 104924345 104933258(grhpr)
NCC: 104945892 104947241(grhpr)
ELY: 117255551(grhprb) 117260472(grhpra)
PLEP: 121942446(grhprb) 121948408(grhpra)
SLUC: 116040490(grhprb) 116064385(grhpra)
ECRA: 117936114(grhprb) 117951855(grhpra)
GAT: 120816868(grhpra) 120825620(grhprb)
PPUG: 119210918(grhpra) 119217431(grhprb)
MSAM: 119888793(grhpra) 119899103(grhprb)
CUD: 121508636(grhprb) 121516399(grhpra)
ONL: 100699147(grhpr) 100707614
OAU: 116324117(grhpra) 116325992(grhprb)
OML: 112153810(grhpra) 112157059(grhprb)
PRET: 103466594 103471304(grhpr)
CTUL: 119790824(grhpra) 119794207(grhprb)
KMR: 108231960(grhprb) 108242403(grhpra)
CSEM: 103383717(grhpr) 103390973
XGL: 120784904(grhpra) 120799850(grhprb)
HCQ: 109518759 109519752(grhpr)
ELS: 105009649(grhpr) 105026161
PKI: 111833437(grhpr) 111844225
AANG: 118227192(grhprb) 118227193(grhpra) 118231364
CMK: 103182154
RTP: 109917484(grhpr)
BFO: 118412687
BBEL: 109478149
CIN: 100178763
SCLV: 120332454
APLC: 110984951
SKO: 100375265
DME: Dmel_CG1236(CG1236)
DSE: 6614018
DSI: Dsimw501_GD19816(Dsim_GD19816) Dsimw501_GD24283(Dsim_GD24283) Dsimw501_GD24284(Dsim_GD24284) Dsimw501_GD24286(Dsim_GD24286)
DAN: 6499141
DGR: 6563671
CCAT: 101452515
BOD: 106627752
SCAC: 106089219
AME: 410042
BVK: 117231482
BVAN: 117156714
CSOL: 105366286
TPRE: 106657316
DAM: 107040952
CCIN: 107268840
AGB: 108912547
LDC: 111507042
APLN: 108736029
PPYR: 116178626
OTU: 111413587
MSEX: 115443874
BANY: 112057596
CLEC: 106660939
FOC: 113204171
ZNE: 110831039
CSEC: 111861517
FCD: 110862584
DMK: 116920035
PVM: 113806196
HAME: 121862379
EAF: 111707198
VDE: 111253783
VJA: 111260391
DPTE: 113789079
EGL: EGR_05219
AMIL: 114955132
PDAM: 113665004
SPIS: 111329423
PTE: PTT_17661
CNE: CNC02760
CNB: CNBC4460
ABV: AGABI2DRAFT120752(AGABI2DRAFT_120752)
MGL: MGL_3541
MRT: MRET_0894
 » show all
Reference
  Authors
Booth MP, Conners R, Rumsby G, Brady RL
  Title
Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase.
  Journal
J Mol Biol 360:178-89 (2006)
DOI:10.1016/j.jmb.2006.05.018
  Sequence
[hsa:9380]

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