KEGG   ORTHOLOGY: K00089
Entry
K00089                      KO                                     
Symbol
AKR1C2
Name
3alpha-hydroxysteroid 3-dehydrogenase [EC:1.1.1.213 1.1.1.357]
Pathway
map00140  Steroid hormone biosynthesis
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Disease
H00607  46,XY gonadal dysgenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
   05208 Chemical carcinogenesis - reactive oxygen species
    K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.213  3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00089  AKR1C2; 3alpha-hydroxysteroid 3-dehydrogenase
Other DBs
RN: R08955 R08957 R08960
GO: 0047026
Genes
HSA: 1646(AKR1C2)
PTR: 100612191(AKR1C2)
PPS: 103783188
NLE: 100603603
DNM: 101429786
Reference
PMID:7998972
  Authors
Del Bello B, Maellaro E, Sugherini L, Santucci A, Comporti M, Casini AF
  Title
Purification of NADPH-dependent dehydroascorbate reductase from rat liver and its identification with 3 alpha-hydroxysteroid dehydrogenase.
  Journal
Biochem J 304 ( Pt 2):385-90 (1994)
DOI:10.1042/bj3040385
Reference
PMID:8274401
  Authors
Qin KN, New MI, Cheng KC
  Title
Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.
  Journal
J Steroid Biochem Mol Biol 46:673-9 (1993)
DOI:10.1016/0960-0760(93)90308-j
  Sequence
[hsa:1646]

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (6)   
   KEGG ENZYME (2)   
   KEGG REACTION (3)   
   KEGG RCLASS (1)   
Gene (7)   
   KEGG GENES (5)   
   OC (2)   
Literature (2)   
   PubMed (2)   
All databases (25)   

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