KEGG   ORTHOLOGY: K00107
Entry
K00107                      KO                                     
Symbol
ALO
Name
D-arabinono-1,4-lactone oxidase [EC:1.1.3.37]
Pathway
map00053  Ascorbate and aldarate metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00053 Ascorbate and aldarate metabolism
    K00107  ALO; D-arabinono-1,4-lactone oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.3  With oxygen as acceptor
    1.1.3.37  D-arabinono-1,4-lactone oxidase
     K00107  ALO; D-arabinono-1,4-lactone oxidase
Other DBs
RN: R02715
COG: COG0277
GO: 0003885
Genes
BBEL: 109465946
BGT: 106075236
HRF: 124141685
HRJ: 124278047
QSU: 111984454 111994983
SCE: YML086C(ALO1)
SEUB: DI49_4004
SPAO: SPAR_M00450
AGO: AGOS_AFR440C
ERC: Ecym_1386
KMX: KLMA_70261(ALO1)
NCS: NCAS_0C00130(NCAS0C00130)
NDI: NDAI_0K00250(NDAI0K00250)
TPF: TPHA_0I00160(TPHA0I00160)
TBL: TBLA_0B02960(TBLA0B02960)
TDL: TDEL_0B00300(TDEL0B00300)
KAF: KAFR_0L02030(KAFR0L02030)
KNG: KNAG_0J00130(KNAG0J00130)
PIC: PICST_88335(ALO1)
CAL: CAALFM_CR09790WA(ALO1)
SLB: AWJ20_4935(ALO1)
NCR: NCU03188
NTE: NEUTE1DRAFT150135(NEUTE1DRAFT_150135)
MGR: MGG_02689
SSCK: SPSK_03251
MAW: MAC_04878
MAJ: MAA_09098
CMT: CCM_03419
BFU: BCIN_09g06500(Bcalo1)
MBE: MBM_09631
ANI: AN0836.2
ANG: ANI_1_1278034(An03g03460)
ALUC: AKAW2_50743A(ALO1)
ACHE: ACHE_30591S(ALO1)
APUU: APUU_50980S(ALO1)
ABE: ARB_01878
TVE: TRV_07142
PTE: PTT_10151
SPO: SPAPB1A10.12c(alo1)
 » show all
Reference
  Authors
Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Baek YW, Hwang CS, Lee JS, Kang SO
  Title
D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 30:895-903 (1998)
DOI:10.1046/j.1365-2958.1998.01133.x
  Sequence
[sce:YML086C]

KEGG   ENZYME: 1.1.3.37
Entry
EC 1.1.3.37                 Enzyme                                 
Name
D-arabinono-1,4-lactone oxidase;
D-arabinono-gamma-lactone oxidase;
ALO
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
Sysname
D-arabinono-1,4-lactone:oxygen oxidoreductase
Reaction(IUBMB)
D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2 [RN:R02715]
Reaction(KEGG)
R02715
Substrate
D-arabinono-1,4-lactone [CPD:C00652];
O2 [CPD:C00007]
Product
dehydro-D-arabinono-1,4-lactone [CPD:C06316];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD). L-Galactono-1,4-lactone, L-gulono-1,4-lactone and L-xylono-1,4-lactone can also act as substrates but D-glucono-1,5-lactone, L-arabinono-1,4-lactone, D-galactono-1,4-lactone and D-gulono-1,4-lactone cannot [1]. With L-galactono-1,4-lactone as substrate, the product is L-ascorbate [3]. The product dehydro-D-arabinono-1,4-lactone had previously been referred to erroneously as D-erythroascorbate (CAS no.: 5776-48-7; formula: C6H8O6), although it was referred to as a five-carbon compound [1].
History
EC 1.1.3.37 created 1999
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K00107  D-arabinono-1,4-lactone oxidase
Genes
BBEL109465946
BGT106075236
HRF124141685
HRJ124278047
QSU111984454 111994983
SCEYML086C(ALO1)
SEUBDI49_4004
SPAOSPAR_M00450
AGOAGOS_AFR440C
ERCEcym_1386
KLAKLLA0_C16896g
KMXKLMA_70261(ALO1)
LTHKLTH0F06820g
VPOKpol_309p4
ZROZYRO0A00836g
CGRCAGL0H04125g
NCSNCAS_0C00130(NCAS0C00130)
NDINDAI_0K00250(NDAI0K00250)
TPFTPHA_0I00160(TPHA0I00160)
TBLTBLA_0B02960(TBLA0B02960)
TDLTDEL_0B00300(TDEL0B00300)
TGBHG536_0H00300
KAFKAFR_0L02030(KAFR0L02030)
KNGKNAG_0J00130(KNAG0J00130)
ZMKHG535_0C05800
PPAPAS_chr2-1_0197
DHADEHA2A02904g
PICPICST_88335(ALO1)
PGUPGUG_01601
SPAASPAPADRAFT_59163
LELLELG_05374
CALCAALFM_CR09790WA(ALO1)
CTPCTRG_05879
COTCORT_0G01540
CDUCD36_34940
CTENCANTEDRAFT_112822
YLIYALI0A21263g
CLUCLUG_02182
CLUSA9F13_02g01177
CAURCJI97_004951
SLBAWJ20_4935(ALO1)
PKZC5L36_0E05670
BNNFOA43_001988
BBRXBRETT_004030
OPAHPODL_00171
SLUDSCDLUD_001293
NCRNCU03188
NTENEUTE1DRAFT150135(NEUTE1DRAFT_150135)
SMPSMAC_02909
PANPODANSg4195
TTTTHITE_119824
MTMMYCTH_2297573
CTHRCTHT_0014270
MGRMGG_02689
PPEIPpBr36_09745
TMNUCRPA7_1407
SSCKSPSK_03251
FGRFGSG_08694
FPUFPSE_11718
FVRFVEG_01967
FOXFOXG_03104
NHENECHADRAFT_59191
TRETRIREDRAFT_5135
TRRM419DRAFT_87210
MAWMAC_04878
MAJMAA_09098
CMTCCM_03419
PLJVFPFJ_05964
VALVDBG_01837
VDAVDAG_01715
CFJCFIO01_11235
CHIGCH63R_07224 CH63R_08599
ELAUCREL1_10706
PFYPFICI_03003
SSLSS1G_14188
BFUBCIN_09g06500(Bcalo1)
MBEMBM_09631
PSCOLY89DRAFT_187667
GLZGLAREA_02371
ANIAN0836.2
AFMAFUA_1G14950
ACTACLA_020400
NFINFIA_010460
AORAO090005001234
ANGANI_1_1278034(An03g03460)
AFVAFLA_004052
ALUCAKAW2_50743A(ALO1)
ACHEACHE_30591S(ALO1)
APUUAPUU_50980S(ALO1)
PCSPc16g13180
PDPPDIP_65760
TMFPMAA_074210
TRGTRUGW13939_09041
CIMCIMG_03293
CPWCPC735_009020
UREUREG_07129
PBLPAAG_05474
PBNPADG_06827
ABEARB_01878
TVETRV_07142
AJEHCAG_02422
BGHBDBG_08395
PNOSNOG_01863
PTEPTT_10151
BZECOCCADRAFT_84782
BSCCOCSADRAFT_41756
BORCOCMIDRAFT_94913
AALTCC77DRAFT_1022132
ZTRMYCGRDRAFT_68116
PFJMYCFIDRAFT_150619
FFUCLAFUR5_03068
BCOMBAUCODRAFT_282374
NPAUCRNP2_2775
TMLGSTUM_00000898001
SPOSPAPB1A10.12c(alo1)
 » show all
Reference
1  [PMID:7957197]
  Authors
Huh WK, Kim ST, Yang KS, Seok YJ, Hah YC, Kang SO.
  Title
Characterisation of D-arabinono-1,4-lactone oxidase from Candida albicans ATCC 10231.
  Journal
Eur J Biochem 225:1073-9 (1994)
DOI:10.1111/j.1432-1033.1994.1073b.x
Reference
2  [PMID:10094636]
  Authors
Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Baek YW, Hwang CS, Lee JS, Kang SO
  Title
D-Erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 30:895-903 (1998)
DOI:10.1046/j.1365-2958.1998.01133.x
  Sequence
[sce:YML086C]
Reference
3  [PMID:10508108]
  Authors
Lee BH, Huh WK, Kim ST, Lee JS, Kang SO.
  Title
Bacterial production of D-erythroascorbic acid and L-ascorbic acid through functional expression of Saccharomyces cerevisiae D-arabinono-1,4-lactone oxidase in Escherichia coli.
  Journal
Appl Environ Microbiol 65:4685-7 (1999)
DOI:10.1128/AEM.65.10.4685-4687.1999
Other DBs
ExplorEnz - The Enzyme Database: 1.1.3.37
IUBMB Enzyme Nomenclature: 1.1.3.37
ExPASy - ENZYME nomenclature database: 1.1.3.37
BRENDA, the Enzyme Database: 1.1.3.37
CAS: 182372-12-9

KEGG   REACTION: R02715
Entry
R02715                      Reaction                               
Name
D-arabinono-1,4-lactone:oxygen oxidoreductase
Definition
D-Arabinono-1,4-lactone + Oxygen <=> Dehydro-D-arabinono-1,4-lactone + Hydrogen peroxide
Equation
Reaction class
RC00195  C00652_C06316
RC02755  C00007_C00027
Enzyme
Pathway
rn00053  Ascorbate and aldarate metabolism
rn01100  Metabolic pathways
Orthology
K00107  D-arabinono-1,4-lactone oxidase [EC:1.1.3.37]
Reference
1  [PMID:8841374]
  Authors
Kim ST, Huh WK, Kim JY, Hwang SW, Kang SO.
  Title
D-arabinose dehydrogenase and biosynthesis of erythroascorbic acid in Candida albicans.
  Journal
Biochim Biophys Acta 1297:1-8 (1996)
Other DBs
RHEA: 23759

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