KEGG   ORTHOLOGY: K00157
Entry
K00157                      KO                                     
Symbol
AOX
Name
aldehyde oxidase [EC:1.2.3.1]
Pathway
map00280  Valine, leucine and isoleucine degradation
map00350  Tyrosine metabolism
map00380  Tryptophan metabolism
map00750  Vitamin B6 metabolism
map00760  Nicotinate and nicotinamide metabolism
map00830  Retinol metabolism
map00982  Drug metabolism - cytochrome P450
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map04630  JAK-STAT signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K00157  AOX; aldehyde oxidase
   00350 Tyrosine metabolism
    K00157  AOX; aldehyde oxidase
   00380 Tryptophan metabolism
    K00157  AOX; aldehyde oxidase
  09108 Metabolism of cofactors and vitamins
   00750 Vitamin B6 metabolism
    K00157  AOX; aldehyde oxidase
   00760 Nicotinate and nicotinamide metabolism
    K00157  AOX; aldehyde oxidase
   00830 Retinol metabolism
    K00157  AOX; aldehyde oxidase
  09111 Xenobiotics biodegradation and metabolism
   00982 Drug metabolism - cytochrome P450
    K00157  AOX; aldehyde oxidase
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K00157  AOX; aldehyde oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.3  With oxygen as acceptor
    1.2.3.1  aldehyde oxidase
     K00157  AOX; aldehyde oxidase
Other DBs
RN: R01709 R02125 R02657 R03871 R04085 R04904 R08349 R08384 R08408
GO: 0004031
Genes
HSA: 316(AOX1)
PTR: 459863(AOX1) 747025
PPS: 100968717(AOX1) 117979316
GGO: 101125522(AOX1) 115933782
PON: 100451794(AOX4) 100939468(AOX1)
NLE: 100583419 100583754(AOX1)
MCC: 701024(AOX1) 701502(AOX4) 701613(AOX2)
MCF: 102131116(AOX1) 102134468(AOX2) 102134825(AOX4)
MTHB: 126932103 126932129 126932306
CSAB: 103217611 103217617 103217619
PANU: 101001006(AOX1) 101002286(AOX4) 101002632(AOX2)
CJC: 100393665(AOX1) 100394388(AOX2)
OGA: 100941419(AOX2) 100951638(AOX4) 100952155(AOX1)
MMU: 11761(Aox1) 213043(Aox2) 71724(Aox3) 71872(Aox4)
RNO: 316421(Aox2) 316424(Aox4) 493909(Aox3) 54349(Aox1)
HGL: 101710340 101722324(Aox4) 101722898(Aox1)
CPOC: 100714172(Aox4) 100719938(Aox2) 100720210(Aox1)
OCU: 100008601(AOX1) 100345417(AOX2) 100345675(AOX3) 100354428(AOX4)
CFA: 488467(AOX4) 608849(AOX2)
AML: 100470835(AOX4) 100471086(AOX2) 100474367(AOX1)
FCA: 101085487(AOX1)
PYU: 121030893
PBG: 122481631
LRUF: 124514163
PTG: 102949513(AOX1) 102967431
PPAD: 109254456
AJU: 106979979(AOX1)
HHV: 120220681(AOX1)
BTA: 338074(AOX1) 518393(AOX4) 531699(AOX2)
SSC: 100523701(AOX1) 100525616(AOX2) 100623394(AOX4)
OOR: 101285123(AOX1)
DLE: 111171714
PCAD: 102987494 102992680(AOX1)
PSIU: 116757111
EPZ: 103541147(AOX1) 103543311
MYB: 102249846 102257951(AOX1)
MYD: 102755298(AOX1) 102771691
MMYO: 118661030(AOX1) 118661465
DRO: 112307752
SHON: 118985255 118985256(AOX1)
PHAS: 123824455(AOX1) 123824456
MDO: 100016433(AOX2) 100029977(AOX1) 100030014(AOX4) 107648868
OAA: 100092481(AOX1)
GGA: 424071(AOX1) 424072(AOX2)
MGP: 100548803(AOX1) 100549268
CJO: 107316537(AOX1)
NMEL: 110400687(AOX1)
APLA: 101795737(AOX1)
ACYG: 106039970(AOX1)
AFUL: 116490590(AOX1)
TGU: 100217503(AOX1)
LSR: 110484579(AOX1)
SCAN: 103814515(AOX1)
PMOA: 120496991(AOX1)
OTC: 121335283(AOX1)
PRUF: 121356479(AOX1)
GFR: 102031924(AOX1)
FAB: 101818190(AOX1)
PHI: 102105114(AOX1)
PMAJ: 107207425(AOX1)
CCAE: 111931979(AOX1)
CCW: 104693769(AOX1)
CBRC: 103612225(AOX1)
ETL: 114055687 114055700(AOX1)
ZAB: 102060431(AOX1)
ACHL: 103809102(AOX1)
FPG: 101915658(AOX1)
FCH: 102057814(AOX1)
CLV: 102097486(AOX1)
EGZ: 104130522
NNI: 104010254(AOX1)
PLET: 104617618(AOX1)
PCRI: 104029512(AOX1)
ACUN: 113480959
TALA: 104368060
PADL: 103923316(AOX1)
AFOR: 103903466
ACHC: 115342961(AOX1)
HALD: 104314966(AOX1)
CCRI: 104168783(AOX1)
CSTI: 104551760
EHS: 104505946(AOX1)
MUI: 104533676(AOX1)
FGA: 104069670(AOX1)
LDI: 104349693(AOX1)
MNB: 103779598(AOX1)
OHA: 104332303(AOX1)
NNT: 104399881
DPUB: 104309286(AOX1)
PGUU: 104458228 104461397(AOX1)
AVIT: 104275859
CVF: 104291037(AOX1) 104291038
TGT: 104565871 104570847(AOX1)
DNE: 112985928(AOX1) 112986459
SCAM: 104150179(AOX1) 104150187
PSS: 102452808(AOX1) 102453236
CPIC: 101949109 101949373(AOX1)
TST: 117885114
PVT: 110089018 110089019(AOX1)
SUND: 121919022(AOX1)
PBI: 103048615(AOX1)
PMUR: 107291766(AOX1)
CTIG: 120312632(AOX1)
PGUT: 117673209(AOX1)
VKO: 123024314(AOX1) 123024423
PMUA: 114607773 114607791(AOX1)
XLA: 108701447 108701448 108701449(aox1.L) 444490(aox1.S)
XTR: 100379890(aox1) 100493336 100495429(aox1)
DRE: 570457(aox6) 64265(aox5)
CCAR: 109060027
CAUA: 113040179 113064802(aox1)
PPRM: 120486809(aox6) 120486811(aox5)
MAMB: 125254213(aox5) 125254220(aox6)
IPU: 108259545(aox6)
PHYP: 113524277
SMEO: 124379761(aox6)
TFD: 113649223(aox6)
EEE: 113585478
TRU: 101069055(aox1)
LCO: 104937222(aox1)
ELY: 117249798(aox6)
EFO: 125884896(aox6)
SLUC: 116048613(aox6)
ECRA: 117939455(aox6)
ESP: 116674009(aox1)
PFLV: 114550961
GAT: 120825730(aox6)
PPUG: 119219585(aox6)
MSAM: 119905158(aox6)
CUD: 121506461(aox6)
ALAT: 119015200(aox6)
MZE: 101479847(aox1)
ONL: 100708434(aox6)
OAU: 116317008(aox6)
OLA: 101168436(aox1)
OML: 112156643(aox6)
XMA: 102223145(aox1)
XCO: 114140277(aox1)
XHE: 116716236(aox1)
PRET: 103457351(aox1)
PFOR: 103149483(aox1)
PLAI: 106951183(aox1)
PMEI: 106906675(aox1)
GAF: 122827269(aox6)
CVG: 107082806(aox1)
CTUL: 119791441(aox6)
GMU: 124861890(aox6)
NFU: 107384677(aox1)
AOCE: 111570749(aox1)
POV: 109639006 109639051(aox1)
HHIP: 117778377(aox6) 117778544(aox5)
HSP: 118103339(aox6) 118103344(aox5)
LCF: 108873170(aox6)
SLAL: 111670357(aox1)
XGL: 120798313(aox6)
HCQ: 109520227(aox1)
BPEC: 110175588(aox1) 110175628
MALB: 109955752(aox1)
BSPL: 114845600(aox6)
OTW: 112253972(aox6) 112266560(aox5)
OMY: 110495922(aox5) 110527537(aox6)
OGO: 124008373 124010596(aox5)
SNH: 120033102(aox6) 120050454(aox5)
CCLU: 121556372(aox5) 121556373(aox6)
ELS: 105022540(aox1)
PKI: 111856671(aox1)
AANG: 118223618(aox6) 118223619(aox5)
PSPA: 121322943(aox5)
ARUT: 117402944(aox5)
LCM: 102354789(AOX1) 102358967
RTP: 109935677(aox1)
BBEL: 109484006
CEL: CELE_B0222.9(gad-3)
 » show all
Reference
  Authors
Huang DY, Furukawa A, Ichikawa Y
  Title
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.
  Journal
Arch Biochem Biophys 364:264-72 (1999)
DOI:10.1006/abbi.1999.1129
  Sequence
[mmu:11761] [ocu:100008601]
Reference
  Authors
Garattini E, Fratelli M, Terao M
  Title
The mammalian aldehyde oxidase gene family.
  Journal
Hum Genomics 4:119-30 (2009)
DOI:10.1186/1479-7364-4-2-119
Reference
  Authors
Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M
  Title
Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.
  Journal
Nat Chem Biol 9:693-700 (2013)
DOI:10.1038/nchembio.1352
  Sequence

KEGG   ORTHOLOGY: K07249
Entry
K07249                      KO                                     
Symbol
ALDH1A
Name
retinal dehydrogenase [EC:1.2.1.36]
Pathway
map00830  Retinol metabolism
map01100  Metabolic pathways
Disease
H01027  Microphthalmia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07249  ALDH1A; retinal dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.36  retinal dehydrogenase
     K07249  ALDH1A; retinal dehydrogenase
Other DBs
RN: R02123 R08385
GO: 0001758
Genes
HSA: 216(ALDH1A1) 220(ALDH1A3) 8854(ALDH1A2)
PTR: 453686(ALDH1A3) 464529(ALDH1A1) 746847(ALDH1A2)
PPS: 100967518(ALDH1A3) 100976079(ALDH1A2) 100994654(ALDH1A1)
GGO: 101135029(ALDH1A3) 101135810(ALDH1A1) 101139899(ALDH1A2)
PON: 100174688(ALDH1A1) 100452276(ALDH1A3)
NLE: 100584839(ALDH1A1) 100586116(ALDH1A3) 100604565(ALDH1A2)
MCC: 694231(ALDH1A3) 702235(ALDH1A2) 702598(ALDH1A1)
MCF: 101865761(ALDH1A1) 102115665(ALDH1A3) 102120533(ALDH1A2)
MTHB: 126937461 126958472 126959950
CSAB: 103219585(ALDH1A1) 103231285(ALDH1A3) 103245564(ALDH1A2)
CATY: 105584180(ALDH1A1) 105593981(ALDH1A3) 105601098(ALDH1A2)
TGE: 112607893(ALDH1A1) 112627744(ALDH1A2) 112628514(ALDH1A3)
RRO: 104670902(ALDH1A2) 104672127(ALDH1A1) 104676802(ALDH1A3)
RBB: 108517690(ALDH1A1) 108522929(ALDH1A3) 108545023(ALDH1A2)
TFN: 117070124(ALDH1A3) 117070593(ALDH1A2) 117098468(ALDH1A1)
PTEH: 111527337(ALDH1A3) 111543351(ALDH1A1) 111553680(ALDH1A2)
CJC: 100397394(ALDH1A3) 100407242(ALDH1A1) 100413342(ALDH1A2)
SBQ: 101036566(ALDH1A1) 101040576(ALDH1A2) 101054138(ALDH1A3)
CSYR: 103260701(ALDH1A2) 103271053(ALDH1A3) 103272419(ALDH1A1)
OGA: 100940500(ALDH1A3) 100941310(ALDH1A1) 100961174(ALDH1A2) 100966723 100967039
MMU: 11668(Aldh1a1) 19378(Aldh1a2) 26358(Aldh1a7) 56847(Aldh1a3)
MCAL: 110285566 110286084 110297746(Aldh1a3) 110301178(Aldh1a2)
MPAH: 110316784(Aldh1a3) 110318664 110321962 110327235(Aldh1a2)
RNO: 116676(Aldh1a2) 24188(Aldh1a1) 266603(Aldh1a3) 29651(Aldh1a7)
MCOC: 116072970(Aldh1a2) 116102356(Aldh1a3) 116103646 116103650
MUN: 110539716(Aldh1a1) 110539717 110546444(Aldh1a3) 110563079(Aldh1a2)
PLEU: 114690728(Aldh1a2) 114695478(Aldh1a3) 114709799(Aldh1a1) 114709824 114709833
NGI: 103737699 103737700(Aldh1a1) 103745514(Aldh1a2) 103747192(Aldh1a3)
HGL: 101696832 101697212 101699741(Aldh1a2) 101700669(Aldh1a3) 101705109 101706446(Aldh1a1)
DORD: 105981188(Aldh1a2) 105982529(Aldh1a3) 105987255(Aldh1a1)
DSP: 122114480(Aldh1a2) 122124008(Aldh1a3) 122124649(Aldh1a1)
OCU: 100008636(ALDH1A1) 100339014(ALDH1A2) 100356011(ALDH1A3)
OPI: 101530793(ALDH1A1) 101531551(ALDH1A2) 101532963(ALDH1A3)
TUP: 102471053(ALDH1A2) 102479319(ALDH1A1) 102491549(ALDH1A3)
CFA: 100856346(ALDH1A3) 476323(ALDH1A1) 478319(ALDH1A2)
CLUD: 112644716(ALDH1A1) 112653444(ALDH1A3) 112675863(ALDH1A2)
VVP: 112920507(ALDH1A2) 112922104(ALDH1A1) 112922339(ALDH1A3)
VLG: 121485029(ALDH1A1) 121485596(ALDH1A2) 121489866(ALDH1A3)
AML: 100467752(ALDH1A3) 100468591(ALDH1A2)
UMR: 103660039(ALDH1A3) 103663346(ALDH1A1) 103663347 103676790(ALDH1A2)
UAH: 113263632(ALDH1A3) 113269676(ALDH1A2) 113269854(ALDH1A1)
MPUF: 101674037(ALDH1A2) 101679832(ALDH1A1) 101690008(ALDH1A3)
ORO: 101376607(ALDH1A1) 101379244(ALDH1A2) 101381188(ALDH1A3)
EJU: 114197898(ALDH1A1) 114206505(ALDH1A2) 114223808(ALDH1A3)
ZCA: 113908854(ALDH1A2) 113909117(ALDH1A3) 113934932(ALDH1A1)
MLX: 118003320(ALDH1A2) 118022990(ALDH1A3) 118026291(ALDH1A1)
NSU: 110572260(ALDH1A3) 110583844(ALDH1A2) 110584415(ALDH1A1)
FCA: 101081050(ALDH1A3) 101082916(ALDH1A2) 101090397(ALDH1A1)
PYU: 121013631(ALDH1A1) 121041766(ALDH1A2) 121042494(ALDH1A3)
PBG: 122468306(ALDH1A3) 122468589(ALDH1A2) 122475460(ALDH1A1)
PTG: 102949007(ALDH1A2) 102949855(ALDH1A1) 102952022(ALDH1A3)
PPAD: 109262922(ALDH1A2) 109273343(ALDH1A3) 109275394(ALDH1A1)
AJU: 106967069(ALDH1A1) 106972083(ALDH1A3) 106973786(ALDH1A2)
HHV: 120230876(ALDH1A2) 120233703(ALDH1A3) 120238019(ALDH1A1)
BTA: 281615(ALDH1A1) 507093(ALDH1A3) 535075(ALDH1A2)
BOM: 102271327(ALDH1A2) 102280344(ALDH1A1) 102284286(ALDH1A3)
BIU: 109562959(ALDH1A1) 109575619(ALDH1A3)
BBUB: 102394840(ALDH1A3) 102397240(ALDH1A1) 102410138(ALDH1A2)
CHX: 102171605(ALDH1A1) 102179885(ALDH1A3) 102181689(ALDH1A2)
OAS: 101109831(ALDH1A3) 101117509(ALDH1A2) 443343(ALDH1A1)
ODA: 120853039(ALDH1A2) 120873445(ALDH1A1) 120875269(ALDH1A3)
CCAD: 122443555(ALDH1A2) 122453367(ALDH1A1) 122455277(ALDH1A3)
SSC: 100517137(ALDH1A1) 100737077(ALDH1A2) 102162530(ALDH1A3)
CFR: 102504927(ALDH1A3) 102516021(ALDH1A2) 102517350(ALDH1A1) 102521572
CBAI: 105067277(ALDH1A1) 105075150(ALDH1A3) 105080463(ALDH1A2) 105083513
CDK: 105088595 105088658(ALDH1A2) 105093453(ALDH1A3) 105106124(ALDH1A1)
VPC: 102527938(ALDH1A1) 102538438(ALDH1A3) 102539813 102543319(ALDH1A2)
BACU: 103001749(ALDH1A1) 103008947(ALDH1A2) 103013550(ALDH1A3)
LVE: 103073135(ALDH1A2) 103082981(ALDH1A3) 103085237(ALDH1A1)
OOR: 101271446(ALDH1A1) 101274847(ALDH1A2) 101279390(ALDH1A3)
DLE: 111174597(ALDH1A1) 111177659(ALDH1A2) 111187345(ALDH1A3)
PCAD: 102978495(ALDH1A2) 102987484(ALDH1A1) 102991584(ALDH1A3)
PSIU: 116749742(ALDH1A2) 116749998(ALDH1A3) 116755990(ALDH1A1)
ECB: 100054550(ALDH1A2) 100054931(ALDH1A1) 100057072(ALDH1A3)
EPZ: 103552036(ALDH1A2) 103557113(ALDH1A3) 103565224(ALDH1A1)
EAI: 106830048(ALDH1A2) 106836116(ALDH1A1) 106839471(ALDH1A3)
MYB: 102241863(ALDH1A3) 102245019(ALDH1A2) 102252022(ALDH1A1)
MYD: 102755098(ALDH1A2) 102758582(ALDH1A3) 102769215(ALDH1A1)
MMYO: 118652741(ALDH1A2) 118667457(ALDH1A1) 118679269(ALDH1A3)
MLF: 102419279(ALDH1A1) 102427395(ALDH1A3) 102431439(ALDH1A2)
MNA: 107527999(ALDH1A3) 107532323(ALDH1A1) 107533749(ALDH1A2)
PKL: 118716486(ALDH1A1) 118720602(ALDH1A2)
HAI: 109380344(ALDH1A3) 109387016(ALDH1A1) 109390699(ALDH1A2)
DRO: 112300261(ALDH1A1) 112305956(ALDH1A3) 112311378(ALDH1A2)
SHON: 118992025(ALDH1A3) 118992256(ALDH1A2) 118997813(ALDH1A1)
AJM: 119045588(ALDH1A1) 119049791(ALDH1A3) 119053478(ALDH1A2)
PDIC: 114488577(ALDH1A3) 114492876(ALDH1A2) 114503846(ALDH1A1)
PHAS: 123808628(ALDH1A2) 123809774(ALDH1A3) 123820156(ALDH1A1)
MMF: 118629448(ALDH1A2) 118629787(ALDH1A1) 118640852(ALDH1A3)
RFQ: 117018946(ALDH1A3) 117023969(ALDH1A2) 117032327(ALDH1A1)
PALE: 102889864(ALDH1A3) 102895099(ALDH1A1) 102896470(ALDH1A2)
PGIG: 120585460(ALDH1A1) 120587354(ALDH1A3) 120604591(ALDH1A2)
PVP: 105290278(ALDH1A3) 105294325(ALDH1A2) 105299482(ALDH1A1)
RAY: 107511645(ALDH1A1) 107515787(ALDH1A3) 107518612(ALDH1A2)
MJV: 108391415(ALDH1A2) 108405240(ALDH1A1)
TOD: 119231244(ALDH1A1) 119238668(ALDH1A2) 119244337(ALDH1A3)
SARA: 101537617(ALDH1A2) 101550624(ALDH1A3) 101555562(ALDH1A1)
DNM: 101411196(ALDH1A1) 101417301(ALDH1A3) 101421471(ALDH1A2)
MDO: 100019941(ALDH1A2) 100020742(ALDH1A1) 100020791(ALDH1A4) 100020853(ALDH1A5) 100020879(ALDH1A6) 100616732(ALDH1A3)
OAA: 100074461(ALDH1A1) 100083368(ALDH1A3) 100093567(ALDH1A2)
GGA: 395264(ALDH1A1) 395389(ALDH1A3) 395844(ALDH1A2)
PCOC: 116225439(ALDH1A3) 116238858(ALDH1A1) 116244655(ALDH1A2)
MGP: 100545801(ALDH1A2) 100546607(ALDH1A3) 104915075
CJO: 107306209(ALDH1A1) 107318519(ALDH1A2) 107318982(ALDH1A3)
NMEL: 110390028(ALDH1A1) 110403577(ALDH1A3) 110403626(ALDH1A2)
APLA: 101793139(ALDH1A3) 101801759(ALDH1A2) 101802481(ALDH1A1)
ACYG: 106033699(ALDH1A2) 106036495(ALDH1A3) 106044484(ALDH1A1)
AFUL: 116493340(ALDH1A2) 116493579(ALDH1A3) 116500900(ALDH1A1)
TGU: 100223406(ALDH1A1) 100231202(ALDH1A3) 751771(ALDH1A2)
LSR: 110471422(ALDH1A2) 110476505(ALDH1A1) 110482959(ALDH1A3)
SCAN: 103815983(ALDH1A2) 103816096(ALDH1A3) 103822878
PMOA: 120507136(ALDH1A1) 120508986(ALDH1A2) 120509067(ALDH1A3)
OTC: 121343425(ALDH1A2) 121343543(ALDH1A3) 121345373(ALDH1A1)
PRUF: 121348658(ALDH1A1) 121354455(ALDH1A2) 121354475(ALDH1A3)
GFR: 102037159(ALDH1A3) 102043395(ALDH1A2) 102043637(ALDH1A1)
FAB: 101812539(ALDH1A1) 101813835(ALDH1A2) 101816772(ALDH1A3)
PHI: 102103267(ALDH1A1) 102105549(ALDH1A3) 102111147(ALDH1A2)
PMAJ: 107209234(ALDH1A2) 107209559(ALDH1A3) 107215910(ALDH1A1)
CCAE: 111933997(ALDH1A3) 111934165(ALDH1A2) 111941552(ALDH1A1)
CCW: 104683830(ALDH1A2) 104683903(ALDH1A3) 104685243(ALDH1A1)
CBRC: 103616402(ALDH1A1) 103618683(ALDH1A2) 103619202(ALDH1A3)
ETL: 114055250(ALDH1A3) 114056360(ALDH1A2) 114056667(ALDH1A1)
ZAB: 102062950(ALDH1A2) 102071162(ALDH1A3) 102073126(ALDH1A1)
ACHL: 103797339 103799205(ALDH1A3) 103801309
FPG: 101914714(ALDH1A1) 101915870(ALDH1A3) 101919921(ALDH1A2)
FCH: 102048413(ALDH1A1) 102050613(ALDH1A3) 102051355(ALDH1A2)
CLV: 102086687(ALDH1A2) 102089147(ALDH1A3) 102091373(ALDH1A1)
EGZ: 104122868(ALDH1A3) 104123840(ALDH1A1) 104130885(ALDH1A2)
NNI: 104016850 104017064(ALDH1A3) 104017279 104020883(ALDH1A1)
PLET: 104616708(ALDH1A1) 104618005(ALDH1A3) 104621882(ALDH1A2)
PCRI: 104036080 104037140(ALDH1A2) 104037423(ALDH1A3)
ACUN: 113483899(ALDH1A3) 113484203(ALDH1A2) 113489966(ALDH1A1)
TALA: 104360351(ALDH1A3) 104366322(ALDH1A2) 104367722(ALDH1A1)
PADL: 103914768(ALDH1A3) 103914861(ALDH1A2) 103920375(ALDH1A1)
AFOR: 103899812(ALDH1A2) 103903959(ALDH1A1) 103907320(ALDH1A3)
ACHC: 115337352(ALDH1A1) 115341215(ALDH1A2) 115341862(ALDH1A3)
HALD: 104317640(ALDH1A1) 104320298(ALDH1A3) 104321548(ALDH1A2)
CCRI: 104158760(ALDH1A1) 104164330(ALDH1A3) 104169077(ALDH1A2)
CSTI: 104554760(ALDH1A3) 104561841
CMAC: 104476288(ALDH1A3) 104477985(ALDH1A2) 104487392(ALDH1A1)
MUI: 104538991(ALDH1A2) 104546486
FGA: 104070104 104080241(ALDH1A3) 104080934(ALDH1A1)
GSTE: 104257225(ALDH1A3) 104257602(ALDH1A2) 104259718(ALDH1A1)
OHA: 104330459(ALDH1A2) 104333376(ALDH1A1) 104339286(ALDH1A3)
NNT: 104402951(ALDH1A1) 104405213(ALDH1A2) 104413303(ALDH1A3)
DPUB: 104299709(ALDH1A3) 104304846(ALDH1A1) 104309867(ALDH1A2)
PGUU: 104458831(ALDH1A3) 104464908(ALDH1A2) 104468635(ALDH1A1)
AVIT: 104268147(ALDH1A3) 104276034 104278500(ALDH1A1) 104278661
CVF: 104287080(ALDH1A2) 104287675(ALDH1A1) 104288207(ALDH1A3)
AAM: 106490505 106495827(ALDH1A3) 106496536(ALDH1A2)
AROW: 112963646(ALDH1A2) 112965236(ALDH1A1) 112970104(ALDH1A3)
NPD: 112944392(ALDH1A1) 112948314(ALDH1A3) 112952787(ALDH1A2)
TGT: 104567495(ALDH1A2) 104568849(ALDH1A3) 104572980(ALDH1A1)
DNE: 112981888(ALDH1A1) 112991112(ALDH1A2) 112996312(ALDH1A3)
SCAM: 104148164(ALDH1A3) 104148306(ALDH1A2) 104149542(ALDH1A1) 104150505
ASN: 102368111(ALDH1A3) 102376803(ALDH1A2) 102378695(ALDH1A1)
AMJ: 102558250(ALDH1A2) 102571914(ALDH1A1) 102573093(ALDH1A3)
CPOO: 109308980(ALDH1A2) 109309164(ALDH1A3) 109323434(ALDH1A1)
GGN: 109288461(ALDH1A3) 109288644(ALDH1A2) 109297589(ALDH1A1)
PSS: 102446643(ALDH1A2) 102450892(ALDH1A3) 102453636(ALDH1A1)
CMY: 102939103(ALDH1A3) 102943259(ALDH1A2) 102943361(ALDH1A1)
CPIC: 101933340(ALDH1A1) 101943620(ALDH1A2) 101946404(ALDH1A3)
TST: 117875210 117878955(ALDH1A1) 117883790(ALDH1A2)
CABI: 116816661(ALDH1A3) 116821166(ALDH1A2) 116835367(ALDH1A1)
MRV: 120373845(ALDH1A3) 120374049(ALDH1A2) 120407796(ALDH1A1)
ACS: 100555228(aldh1a3) 100556217(aldh1a2) 100566345(aldh1a1)
PVT: 110072975(ALDH1A3) 110074545(ALDH1A2) 110081706 110081707
SUND: 121922062(ALDH1A1) 121932608(ALDH1A2) 121935429(ALDH1A3)
PBI: 103055946(ALDH1A2) 103056376(ALDH1A3) 103057171(ALDH1A1)
PMUR: 107283177(ALDH1A2) 107283882(ALDH1A3) 107288134(ALDH1A1)
CTIG: 120306552(ALDH1A2) 120315206(ALDH1A3) 120316237(ALDH1A1)
TSR: 106542885(ALDH1A2) 106545343(ALDH1A1)
PGUT: 117660953(ALDH1A2) 117661441(ALDH1A1) 117669868(ALDH1A3)
VKO: 123027728(ALDH1A2) 123030809(ALDH1A3) 123031379(ALDH1A1)
PMUA: 114584290(ALDH1A2) 114584458(ALDH1A3) 114606374(ALDH1A1)
ZVI: 118076796(ALDH1A1) 118093058(ALDH1A2) 118093098(ALDH1A3)
GJA: 107108680(ALDH1A2) 107111752(ALDH1A1) 107116104(ALDH1A3)
STOW: 125424467(ALDH1A2) 125424633(ALDH1A3) 125436716(ALDH1A1)
XLA: 108712817(aldh1a3.S) 108712938(aldh1a2.S) 394296(aldh1a1.S) 397728(aldh1a1.L) 399389(aldh1a2.L) 733178(aldh1a3.L)
XTR: 100485844(aldh1a3) 613078(aldh1a1) 734052(aldh1a2)
NPR: 108789830(ALDH1A2) 108790072(ALDH1A3) 108791719(ALDH1A1)
RTEM: 120931145(ALDH1A3) 120931377(ALDH1A2) 120943199(ALDH1A1)
BBUF: 120985765(ALDH1A2) 120985989(ALDH1A3) 120989155(ALDH1A1)
BGAR: 122922381(ALDH1A1) 122927514(ALDH1A3) 122929655(ALDH1A2)
DRE: 116713(aldh1a2) 751785(aldh1a3)
PPRM: 120479728(aldh1a3) 120491443 120491654
MAMB: 125264466(aldh1a3) 125264713(aldh1a2)
IPU: 108259626(aldh1a2) 108271441(aldh1a3)
PHYP: 113536398(aldh1a3) 113540928(aldh1a2)
SMEO: 124379900(aldh1a2) 124391474(aldh1a3)
TFD: 113636797(aldh1a2) 113654168(aldh1a3)
AMEX: 103032207(aldh1a3) 103042804(aldh1a2)
EEE: 113573937(aldh1a3) 113575738(aldh1a2)
TRU: 100294697(raldh3) 115246414(aldh1a3) 613232(aldh1a2)
LCO: 104924302(aldh1a2) 104929720(aldh1a3)
NCC: 104960054(aldh1a2) 104961728
CGOB: 115004864(aldh1a3) 115013264(aldh1a1) 115025071(aldh1a2)
ELY: 117252033 117255575(aldh1a2) 117266244(aldh1a3)
EFO: 125879741(aldh1a3) 125889979 125899920(aldh1a2)
PLEP: 121942467(aldh1a3) 121944054 121947788(aldh1a2)
SLUC: 116045174(aldh1a3) 116060588(aldh1a2)
ECRA: 117945336(aldh1a2) 117947487(aldh1a3)
ESP: 116686793(aldh1a3) 116689324(aldh1a2)
PFLV: 114558146(aldh1a3) 114564945(aldh1a2)
GAT: 120810508(aldh1a2) 120811078(aldh1a3)
PPUG: 119197102(aldh1a2) 119198453(aldh1a3)
MSAM: 119883181(aldh1a3) 119890022(aldh1a2) 119892392
CUD: 121509741 121510222(aldh1a2) 121510572(aldh1a3)
ALAT: 119018328(aldh1a2) 119018811(aldh1a3) 119019782
MZE: 101467043(aldh1a2) 101472510(aldh1a1)
ONL: 100709766(aldh1a2) 100710237(aldh1a1)
OAU: 116323019 116334580(aldh1a2)
OLA: 100049450(aldh1a2)
OML: 112139085(aldh1a3) 112161158(aldh1a2)
XMA: 102225737(aldh1a2) 102232034(aldh1a3)
XCO: 114142943(aldh1a2) 114143203(aldh1a3)
XHE: 116718396(aldh1a3) 116718605(aldh1a2)
PRET: 103462270(aldh1a3) 103462518(aldh1a2)
PFOR: 103149193(aldh1a3) 103153816(aldh1a2)
PLAI: 106958538(aldh1a2) 106960771
PMEI: 106914006(aldh1a2) 106927605(aldh1a3)
GAF: 122843682(aldh1a2) 122846329(aldh1a3)
CVG: 107087020(aldh1a3) 107095651(aldh1a2)
CTUL: 119778643(aldh1a2) 119797668(aldh1a3)
GMU: 124866653(aldh1a3) 124867346(aldh1a2)
NFU: 107381378(aldh1a2)
KMR: 108229802(aldh1a2)
ALIM: 106531687(aldh1a2)
NWH: 119425501 119428292(aldh1a2)
MCEP: 125005601(aldh1a2) 125005764(aldh1a3)
CSEM: 103379028 103398364(aldh1a2)
POV: 109624736(aldh1a3) 109633667(aldh1a1) 109636896(aldh1a2)
SSEN: 122760924(aldh1a2) 122762621
HHIP: 117758972(aldh1a2) 117759508(aldh1a3) 117767453
HSP: 118111159(aldh1a2) 118113998(aldh1a3) 118115656
SDU: 111218496(aldh1a2) 111220437(aldh1a3) 111226670(aldh1a1)
SLAL: 111644902 111655138(aldh1a2) 111656552(aldh1a3)
XGL: 120791475(aldh1a2) 120791604(aldh1a3) 120805334
HCQ: 109525955(aldh1a2)
BPEC: 110175209(aldh1a2)
MALB: 109965394(aldh1a2) 109973808(aldh1a3)
BSPL: 114852240(aldh1a2) 114852553(aldh1a3) 114862681
OTW: 112249186 112263245 112263719(aldh1a2) 112264247(aldh1a3)
ONE: 115113656(aldh1a2) 115139809
ELS: 105014397(aldh1a3) 105014483(aldh1a1) 105016492(aldh1a2)
AANG: 118207144 118215636 118226706(aldh1a3) 118226798(aldh1a2)
LOC: 102685231(aldh1a1) 102689169(aldh1a2) 102694141(aldh1a3)
LCM: 102347553(ALDH1A1) 102352592(ALDH1A2) 102366661(ALDH1A3)
CMK: 103182367(aldh1a1) 103187113 103187716(aldh1a3)
SCLV: 120345907
APLC: 110984698
CNS: 116338689
LHT: 122498066
CCIN: 107270205
MSEX: 115449569
BANY: 112053045
NIQ: 126769274
PPOT: 106103486
PXU: 106116038
PRAP: 110999476
SDM: 118190454
PCAN: 112555783
ADF: 107345189
SPIS: 111334097
DDI: DDB_G0290479(hydA)
 » show all
Reference
PMID:2591967
  Authors
Hsu LC, Chang WC, Yoshida A
  Title
Genomic structure of the human cytosolic aldehyde dehydrogenase gene.
  Journal
Genomics 5:857-65 (1989)
DOI:10.1016/0888-7543(89)90127-4
  Sequence
[hsa:216]
Reference
  Authors
Molotkov A, Duester G
  Title
Genetic evidence that retinaldehyde dehydrogenase Raldh1 (Aldh1a1) functions downstream of alcohol dehydrogenase Adh1 in metabolism of retinol to retinoic acid.
  Journal
J Biol Chem 278:36085-90 (2003)
DOI:10.1074/jbc.M303709200

KEGG   ENZYME: 1.2.3.1
Entry
EC 1.2.3.1                  Enzyme                                 
Name
aldehyde oxidase;
quinoline oxidase;
retinal oxidase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With oxygen as acceptor
Sysname
aldehyde:oxygen oxidoreductase
Reaction(IUBMB)
an aldehyde + H2O + O2 = a carboxylate + H2O2 [RN:R00635]
Reaction(KEGG)
Substrate
aldehyde [CPD:C00071];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
carboxylate [CPD:C00060];
H2O2 [CPD:C00027]
Comment
Contains molybdenum, [2Fe-2S] centres and FAD. The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides [4,6].
The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11, retinal oxidase) [5,7].
History
EC 1.2.3.1 created 1961, modified 2002, modified 2004, modified 2012
Pathway
ec00280  Valine, leucine and isoleucine degradation
ec00350  Tyrosine metabolism
ec00380  Tryptophan metabolism
ec00750  Vitamin B6 metabolism
ec00760  Nicotinate and nicotinamide metabolism
ec00830  Retinol metabolism
ec00982  Drug metabolism - cytochrome P450
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00157  aldehyde oxidase
Genes
HSA316(AOX1)
PTR459863(AOX1) 747025
PPS100968717(AOX1) 117979316
GGO101125522(AOX1) 115933782
PON100451794(AOX4) 100939468(AOX1)
NLE100583419 100583754(AOX1)
MCC701024(AOX1) 701502(AOX4) 701613(AOX2)
MCF102131116(AOX1) 102134468(AOX2) 102134825(AOX4)
MTHB126932103 126932129 126932306
CSAB103217611 103217617 103217619
CATY105580017 105580021 105580200
PANU101001006(AOX1) 101002286(AOX4) 101002632(AOX2)
TGE112635867 112636354(AOX1) 112636356
RRO104670351 104670357 104670457
RBB108531964 108532268 108532294
TFN117095234 117095238 117095242
PTEH111546911 111546926
CJC100393665(AOX1) 100394388(AOX2)
SBQ101032494 101033246 101042764
CSYR103271035 103271036 103272311(AOX1)
MMUR105856978 105856979 105856981
LCAT123643320 123643621 123643919
OGA100941419(AOX2) 100951638(AOX4) 100952155(AOX1)
MMU11761(Aox1) 213043(Aox2) 71724(Aox3) 71872(Aox4)
MCAL110290283 110290296(Aox1) 110291452 110301976
MPAH110321275 110321290(Aox1) 110321921
RNO316421(Aox2) 316424(Aox4) 493909(Aox3) 54349(Aox1)
MCOC116088453 116088454 116088456 116089178
MUN110559600(Aox1) 110559602 110559604 110559605
CGE100759157 100760212 100760504 100765484 113830655
MAUA101823275 101823544 101823809 101842897
PLEU114704265 114704588 114704606 114704613
MORG121444847 121444853 121444857 121458912 121458936 121458975
MFOT126511776 126511844 126511892
AAMP119803860 119803866 119803907 119803936
NGI103734373 103734384 103734392(Aox1) 103734495
HGL101710340 101722324(Aox4) 101722898(Aox1)
CPOC100714172(Aox4) 100719938(Aox2) 100720210(Aox1)
CCAN109680764 109688486 109692416(Aox1)
DORD105981417(Aox1) 105983958 105984047 105997286
DSP122096444 122096445(Aox1) 122096446 122096447
NCAR124979845 124980255 124980836
OCU100008601(AOX1) 100345417(AOX2) 100345675(AOX3) 100354428(AOX4)
OPI101522091 101522599 101522842 101522997(AOX1)
TUP102482260 102484619(AOX1) 102490052
CFA488467(AOX4) 608849(AOX2)
CLUD112656511 112656802 112656803
VVP112922800 112922804 112922830
VLG121480502 121480828
AML100470835(AOX4) 100471086(AOX2) 100474367(AOX1)
UMR103659730 103659731 103659946
UAH113250605 113250606 113250607
UAR123798185(AOX1) 123798186 123798188
ELK111141059 111142784 111153602
LLV125094988 125095839 125095960
MPUF101693479 101694323
ORO101369776 101370075 101382582
EJU114222997 114225005 114225222
ZCA113919830(AOX1) 113919964 113920864
MLX118012164 118012656 118012657
NSU110591947 110592050 110592052
FCA101085487(AOX1)
PYU121030893
PBG122481631
LRUF124514163
PTG102949513(AOX1) 102967431
PPAD109254456
AJU106979979(AOX1)
HHV120220681(AOX1)
BTA338074(AOX1) 518393(AOX4) 531699(AOX2)
BOM102272565(AOX1) 102281032 102283927
BIU109569300(AOX1) 109569310 109569328
BBUB102390255(AOX1) 102391150 102391488
CHX102171556 102187632 102188176
OAS101102548 101104557(AOX1) 101104808
ODA120854638 120854640(AOX1) 120854641
CCAD122426455 122426514 122426516
SSC100523701(AOX1) 100525616(AOX2) 100623394(AOX4)
CFR102510869 102511253 102511500
CBAI105082310 105082311 105082336
CDK105099168 105099169 105099170
VPC102539001 102539248 102539743(AOX1)
BACU102998479 103003536
LVE103073473 103073747
OOR101285123(AOX1)
DLE111171714
PCAD102987494 102992680(AOX1)
PSIU116757111
ECB100067782(AOX4) 100070976(AOX1) 100146423 100146833 111767394
EPZ103541147(AOX1) 103543311
EAI106823492 106823501 106825581 106829471 123285083
MYB102249846 102257951(AOX1)
MYD102755298(AOX1) 102771691
MMYO118661030(AOX1) 118661465
MLF102432042 102432361 102434556(AOX1)
MNA107524097 107524106 107544193(AOX1)
PKL118709128 118709266
HAI109379197 109379198 109379243(AOX1)
DRO112307752
SHON118985255 118985256(AOX1)
AJM119065501 119065518
PDIC114494690 114495389
PHAS123824455(AOX1) 123824456
MMF118624997 118624998 118625352
RFQ117025797(AOX1) 117025942 117026362
PALE102879869 102895358
PGIG120587516 120587727(AOX1) 120587729
PVP105298171 105298172
RAY107503175 107503179
MJV108391579(AOX1) 108391580 108391581
TOD119254820 119254822 119256085(AOX1)
SARA101540525(AOX1) 101540787 101541048
LAV100662726 100665003 100665288 100665571(AOX1)
TMU101340907 101341581
DNM101442318 101443649 101444097
MDO100016433(AOX2) 100029977(AOX1) 100030014(AOX4) 107648868
GAS123241402 123241403 123241891 123242136
SHR100921509 100923855(AOX1) 100924119 100929481
PCW110197327 110207269 110207271(AOX1)
OAA100092481(AOX1)
GGA424071(AOX1) 424072(AOX2)
PCOC116233962 116233971
MGP100548803(AOX1) 100549268
CJO107316537(AOX1)
NMEL110400687(AOX1)
APLA101795737(AOX1)
ACYG106039970(AOX1)
AFUL116490590(AOX1)
TGU100217503(AOX1)
LSR110484579(AOX1)
SCAN103814515(AOX1)
PMOA120496991(AOX1)
OTC121335283(AOX1)
PRUF121356479(AOX1)
GFR102031924(AOX1)
FAB101818190(AOX1)
PHI102105114(AOX1)
PMAJ107207425(AOX1)
CCAE111931979(AOX1)
CCW104693769(AOX1)
CBRC103612225(AOX1)
ETL114055687 114055700(AOX1)
ZAB102060431(AOX1)
ACHL103809102(AOX1)
FPG101915658(AOX1)
FCH102057814(AOX1)
CLV102097486(AOX1)
EGZ104130522
NNI104010254(AOX1)
PLET104617618(AOX1)
PCRI104029512(AOX1)
ACUN113480959
TALA104368060
PADL103923316(AOX1)
AFOR103903466
ACHC115342961(AOX1)
HALD104314966(AOX1)
CCRI104168783(AOX1)
CSTI104551760
EHS104505946(AOX1)
CMAC104483252 104483254
MUI104533676(AOX1)
FGA104069670(AOX1)
GSTE104251026 104251139
LDI104349693(AOX1)
MNB103779598(AOX1)
OHA104332303(AOX1)
NNT104399881
DPUB104309286(AOX1)
PGUU104458228 104461397(AOX1)
ACAR104526462 104526463
AVIT104275859
CVF104291037(AOX1) 104291038
AAM106492369 106492373
AROW112969295 112969296
NPD112955066 112955438
TGT104565871 104570847(AOX1)
DNE112985928(AOX1) 112986459
SCAM104150179(AOX1) 104150187
ASN102376558 102377274 102377506 102383614
AMJ102557817 102558050 102558282 102558513(AOX1)
CPOO109322697 109322746 109322941
GGN109301888 109301889 109301892
PSS102452808(AOX1) 102453236
CMY102932261 102932848
CPIC101949109 101949373(AOX1)
TST117885114
CABI116836083 116836084
MRV120374990 120375097
ACS100565091 100565481 100565681 100565879
PVT110089018 110089019(AOX1)
SUND121919022(AOX1)
PBI103048615(AOX1)
PMUR107291766(AOX1)
CTIG120312632(AOX1)
PGUT117673209(AOX1)
VKO123024314(AOX1) 123024423
PMUA114607773 114607791(AOX1)
ZVI118095602 118095633
GJA107108261(AOX1) 107113599 107113600 107117016
STOW125426207 125427118 125427247
XLA108701447 108701448 108701449(aox1.L) 444490(aox1.S)
XTR100379890(aox1) 100493336 100495429(aox1)
NPR108797592 108799582 108799583 108799585
RTEM120943718 120943719 120943720 120943721
BBUF121007369 121007452 121008091 121008794
BGAR122944374 122945394 122945807 122945874
DRE570457(aox6) 64265(aox5)
SRX107739315 107739343
SANH107653532 107687882
SGH107600982 107600984
CCAR109060027
CAUA113040179 113064802(aox1)
PPRM120486809(aox6) 120486811(aox5)
MAMB125254213(aox5) 125254220(aox6)
IPU108259545(aox6)
PHYP113524277
SMEO124379761(aox6)
TFD113649223(aox6)
AMEX103034951 103035279
EEE113585478
TRU101069055(aox1)
TNGGSTEN00031889G001
LCO104937222(aox1)
CGOB115018359 115021409
ELY117249798(aox6)
EFO125884896(aox6)
SLUC116048613(aox6)
ECRA117939455(aox6)
ESP116674009(aox1)
PFLV114550961
GAT120825730(aox6)
PPUG119219585(aox6)
MSAM119905158(aox6)
CUD121506461(aox6)
ALAT119015200(aox6)
MZE101479847(aox1)
ONL100708434(aox6)
OAU116317008(aox6)
OLA101168436(aox1)
OML112156643(aox6)
XMA102223145(aox1)
XCO114140277(aox1)
XHE116716236(aox1)
PRET103457351(aox1)
PFOR103149483(aox1)
PLAI106951183(aox1)
PMEI106906675(aox1)
GAF122827269(aox6)
CVG107082806(aox1)
CTUL119791441(aox6)
GMU124861890(aox6)
NFU107384677(aox1)
NWH119428820 119428855
AOCE111570749(aox1)
MCEP125001147 125001148
POV109639006 109639051(aox1)
SSEN122758201 122758208
HHIP117778377(aox6) 117778544(aox5)
HSP118103339(aox6) 118103344(aox5)
LCF108873170(aox6)
SDU111232312 111232447
SLAL111670357(aox1)
XGL120798313(aox6)
HCQ109520227(aox1)
BPEC110175588(aox1) 110175628
MALB109955752(aox1)
BSPL114845600(aox6)
SASA106574294 106575224
STRU115179813 115195969
OTW112253972(aox6) 112266560(aox5)
OMY110495922(aox5) 110527537(aox6)
OGO124008373 124010596(aox5)
ONE115129646 115129647
SALP111953152 111970984
SNH120033102(aox6) 120050454(aox5)
CCLU121556372(aox5) 121556373(aox6)
ELS105022540(aox1)
SFM108930665 108930901
PKI111856671(aox1)
AANG118223618(aox6) 118223619(aox5)
LOC102691296 102691496
PSPA121322943(aox5)
ARUT117402944(aox5)
LCM102354789(AOX1) 102358967
RTP109935677(aox1)
BBEL109484006
CELCELE_B0222.9(gad-3)
CBRCBG_19218 CBG_19219
 » show all
Reference
1  [PMID:16747217]
  Authors
Gordon AH, Green DE, Subrahmanyan V
  Title
Liver aldehyde oxidase.
  Journal
Biochem J 34:764-74 (1940)
DOI:10.1042/bj0340764
Reference
2  [PMID:20985642]
  Authors
KNOX WE
  Title
The quinine-oxidizing enzyme and liver aldehyde oxidase.
  Journal
J Biol Chem 163:699-711 (1946)
Reference
3  [PMID:13201608]
  Authors
MAHLER HR, MACKLER B, GREEN DE.
  Title
Studies on metalloflavoproteins. III. Aldehyde oxidase: a molybdoflavoprotein.
  Journal
J Biol Chem 210:465-80 (1954)
Reference
4  [PMID:5044040]
  Authors
Krenitsky TA, Neil SM, Elion GB, Hitchings GH
  Title
A comparison of the specificities of xanthine oxidase and aldehyde oxidase.
  Journal
Arch Biochem Biophys 150:585-99 (1972)
DOI:10.1016/0003-9861(72)90078-1
Reference
5  [PMID:8262244]
  Authors
Tomita S, Tsujita M, Ichikawa Y
  Title
Retinal oxidase is identical to aldehyde oxidase.
  Journal
FEBS Lett 336:272-4 (1993)
DOI:10.1016/0014-5793(93)80818-F
Reference
6  [PMID:9015384]
  Authors
Yoshihara S, Tatsumi K
  Title
Purification and characterization of hepatic aldehyde oxidase in male and female  mice.
  Journal
Arch Biochem Biophys 338:29-34 (1997)
DOI:10.1006/abbi.1996.9774
Reference
7  [PMID:10190983]
  Authors
Huang DY, Furukawa A, Ichikawa Y
  Title
Molecular cloning of retinal oxidase/aldehyde oxidase cDNAs from rabbit and mouse livers and functional expression of recombinant mouse retinal oxidase cDNA in Escherichia coli.
  Journal
Arch Biochem Biophys 364:264-72 (1999)
DOI:10.1006/abbi.1999.1129
  Sequence
[mmu:11761] [ocu:100008601]
Reference
8  [PMID:14659539]
  Authors
Uchida H, Kondo D, Yamashita A, Nagaosa Y, Sakurai T, Fujii Y, Fujishiro K, Aisaka K, Uwajima T.
  Title
Purification and characterization of an aldehyde oxidase from Pseudomonas sp. KY 4690.
  Journal
FEMS Microbiol Lett 229:31-6 (2003)
DOI:10.1016/S0378-1097(03)00781-X
Other DBs
ExplorEnz - The Enzyme Database: 1.2.3.1
IUBMB Enzyme Nomenclature: 1.2.3.1
ExPASy - ENZYME nomenclature database: 1.2.3.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.2.3.1
BRENDA, the Enzyme Database: 1.2.3.1
CAS: 9029-07-6

KEGG   ENZYME: 1.2.1.36
Entry
EC 1.2.1.36                 Enzyme                                 
Name
retinal dehydrogenase;
cytosolic retinal dehydrogenase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
retinal:NAD+ oxidoreductase
Reaction(IUBMB)
retinal + NAD+ + H2O = retinoate + NADH + 2 H+ [RN:R02123]
Reaction(KEGG)
R02123;
(other) R08385
Substrate
retinal [CPD:C00376];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
retinoate [CPD:C00777];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
A metalloflavoprotein (FAD). Acts on both the 11-trans- and 13-cis-forms of retinal.
History
EC 1.2.1.36 created 1972
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K07249  retinal dehydrogenase
Genes
HSA216(ALDH1A1) 220(ALDH1A3) 8854(ALDH1A2)
PTR453686(ALDH1A3) 464529(ALDH1A1) 746847(ALDH1A2)
PPS100967518(ALDH1A3) 100976079(ALDH1A2) 100994654(ALDH1A1)
GGO101135029(ALDH1A3) 101135810(ALDH1A1) 101139899(ALDH1A2)
PON100174688(ALDH1A1) 100452276(ALDH1A3)
NLE100584839(ALDH1A1) 100586116(ALDH1A3) 100604565(ALDH1A2)
MCC694231(ALDH1A3) 702235(ALDH1A2) 702598(ALDH1A1)
MCF101865761(ALDH1A1) 102115665(ALDH1A3) 102120533(ALDH1A2)
MTHB126937461 126958472 126959950
CSAB103219585(ALDH1A1) 103231285(ALDH1A3) 103245564(ALDH1A2)
CATY105584180(ALDH1A1) 105593981(ALDH1A3) 105601098(ALDH1A2)
PANU101010190(ALDH1A1) 101011792(ALDH1A3) 101022100 116273020 116275817
TGE112607893(ALDH1A1) 112627744(ALDH1A2) 112628514(ALDH1A3)
RRO104670902(ALDH1A2) 104672127(ALDH1A1) 104676802(ALDH1A3)
RBB108517690(ALDH1A1) 108522929(ALDH1A3) 108545023(ALDH1A2)
TFN117070124(ALDH1A3) 117070593(ALDH1A2) 117098468(ALDH1A1)
PTEH111527337(ALDH1A3) 111543351(ALDH1A1) 111553680(ALDH1A2)
CJC100397394(ALDH1A3) 100407242(ALDH1A1) 100413342(ALDH1A2)
SBQ101036566(ALDH1A1) 101040576(ALDH1A2) 101054138(ALDH1A3)
CSYR103260701(ALDH1A2) 103271053(ALDH1A3) 103272419(ALDH1A1)
MMUR105871281(ALDH1A3) 105874767 105874769 105874770 105881397(ALDH1A2)
LCAT123623225(ALDH1A2) 123644546(ALDH1A3) 123645639 123645640 123646038 123646040
OGA100940500(ALDH1A3) 100941310(ALDH1A1) 100961174(ALDH1A2) 100966723 100967039
MMU11668(Aldh1a1) 19378(Aldh1a2) 26358(Aldh1a7) 56847(Aldh1a3)
MCAL110285566 110286084 110297746(Aldh1a3) 110301178(Aldh1a2)
MPAH110316784(Aldh1a3) 110318664 110321962 110327235(Aldh1a2)
RNO116676(Aldh1a2) 24188(Aldh1a1) 266603(Aldh1a3) 29651(Aldh1a7)
MCOC116072970(Aldh1a2) 116102356(Aldh1a3) 116103646 116103650
MUN110539716(Aldh1a1) 110539717 110546444(Aldh1a3) 110563079(Aldh1a2)
CGE100761706 100768227(Aldh1a3) 100768367 100768654 100772304(Aldh1a2)
MAUA101822890 101827627(Aldh1a3) 101830606(Aldh1a2) 101832671 101835395
PLEU114690728(Aldh1a2) 114695478(Aldh1a3) 114709799(Aldh1a1) 114709824 114709833
MORG121446641(Aldh1a3) 121454016 121454017 121454075 121454409 121466091(Aldh1a2)
MFOT126491277 126505902 126510746 126510749 126510753 126510763 126510784
AAMP119802822(Aldh1a3) 119808373 119809649(Aldh1a2) 119812513 119814113 119823686
NGI103737699 103737700(Aldh1a1) 103745514(Aldh1a2) 103747192(Aldh1a3)
HGL101696832 101697212 101699741(Aldh1a2) 101700669(Aldh1a3) 101705109 101706446(Aldh1a1)
CPOC100716195(Aldh1a3) 100718164(Aldh1a2) 100728538 100732581 100732853 100733140 100733423
CCAN109675085 109677403 109680288 109685045(Aldh1a3) 109700567 109700678 109700680 109702502(Aldh1a2)
DORD105981188(Aldh1a2) 105982529(Aldh1a3) 105987255(Aldh1a1)
DSP122114480(Aldh1a2) 122124008(Aldh1a3) 122124649(Aldh1a1)
NCAR124964681 124972029 124977853
OCU100008636(ALDH1A1) 100339014(ALDH1A2) 100356011(ALDH1A3)
OPI101530793(ALDH1A1) 101531551(ALDH1A2) 101532963(ALDH1A3)
TUP102471053(ALDH1A2) 102479319(ALDH1A1) 102491549(ALDH1A3)
CFA100856346(ALDH1A3) 476323(ALDH1A1) 478319(ALDH1A2)
CLUD112644716(ALDH1A1) 112653444(ALDH1A3) 112675863(ALDH1A2)
VVP112920507(ALDH1A2) 112922104(ALDH1A1) 112922339(ALDH1A3)
VLG121485029(ALDH1A1) 121485596(ALDH1A2) 121489866(ALDH1A3)
AML100467752(ALDH1A3) 100468591(ALDH1A2)
UMR103660039(ALDH1A3) 103663346(ALDH1A1) 103663347 103676790(ALDH1A2)
UAH113263632(ALDH1A3) 113269676(ALDH1A2) 113269854(ALDH1A1)
UAR123781490 123785669(ALDH1A2) 123790783(ALDH1A3) 123793442 123793443
ELK111152582 111153257 111153535
LLV125083351 125105049 125105133
MPUF101674037(ALDH1A2) 101679832(ALDH1A1) 101690008(ALDH1A3)
ORO101376607(ALDH1A1) 101379244(ALDH1A2) 101381188(ALDH1A3)
EJU114197898(ALDH1A1) 114206505(ALDH1A2) 114223808(ALDH1A3)
ZCA113908854(ALDH1A2) 113909117(ALDH1A3) 113934932(ALDH1A1)
MLX118003320(ALDH1A2) 118022990(ALDH1A3) 118026291(ALDH1A1)
NSU110572260(ALDH1A3) 110583844(ALDH1A2) 110584415(ALDH1A1)
FCA101081050(ALDH1A3) 101082916(ALDH1A2) 101090397(ALDH1A1)
PYU121013631(ALDH1A1) 121041766(ALDH1A2) 121042494(ALDH1A3)
PBG122468306(ALDH1A3) 122468589(ALDH1A2) 122475460(ALDH1A1)
LRUF124508556 124517352 124525047
PTG102949007(ALDH1A2) 102949855(ALDH1A1) 102952022(ALDH1A3)
PPAD109262922(ALDH1A2) 109273343(ALDH1A3) 109275394(ALDH1A1)
AJU106967069(ALDH1A1) 106972083(ALDH1A3) 106973786(ALDH1A2)
HHV120230876(ALDH1A2) 120233703(ALDH1A3) 120238019(ALDH1A1)
BTA281615(ALDH1A1) 507093(ALDH1A3) 535075(ALDH1A2)
BOM102271327(ALDH1A2) 102280344(ALDH1A1) 102284286(ALDH1A3)
BIU109562959(ALDH1A1) 109575619(ALDH1A3)
BBUB102394840(ALDH1A3) 102397240(ALDH1A1) 102410138(ALDH1A2)
CHX102171605(ALDH1A1) 102179885(ALDH1A3) 102181689(ALDH1A2)
OAS101109831(ALDH1A3) 101117509(ALDH1A2) 443343(ALDH1A1)
ODA120853039(ALDH1A2) 120873445(ALDH1A1) 120875269(ALDH1A3)
CCAD122443555(ALDH1A2) 122453367(ALDH1A1) 122455277(ALDH1A3)
SSC100517137(ALDH1A1) 100737077(ALDH1A2) 102162530(ALDH1A3)
CFR102504927(ALDH1A3) 102516021(ALDH1A2) 102517350(ALDH1A1) 102521572
CBAI105067277(ALDH1A1) 105075150(ALDH1A3) 105080463(ALDH1A2) 105083513
CDK105088595 105088658(ALDH1A2) 105093453(ALDH1A3) 105106124(ALDH1A1)
VPC102527938(ALDH1A1) 102538438(ALDH1A3) 102539813 102543319(ALDH1A2)
BACU103001749(ALDH1A1) 103008947(ALDH1A2) 103013550(ALDH1A3)
LVE103073135(ALDH1A2) 103082981(ALDH1A3) 103085237(ALDH1A1)
OOR101271446(ALDH1A1) 101274847(ALDH1A2) 101279390(ALDH1A3)
DLE111174597(ALDH1A1) 111177659(ALDH1A2) 111187345(ALDH1A3)
PCAD102978495(ALDH1A2) 102987484(ALDH1A1) 102991584(ALDH1A3)
PSIU116749742(ALDH1A2) 116749998(ALDH1A3) 116755990(ALDH1A1)
ECB100054550(ALDH1A2) 100054931(ALDH1A1) 100057072(ALDH1A3)
EPZ103552036(ALDH1A2) 103557113(ALDH1A3) 103565224(ALDH1A1)
EAI106830048(ALDH1A2) 106836116(ALDH1A1) 106839471(ALDH1A3)
MYB102241863(ALDH1A3) 102245019(ALDH1A2) 102252022(ALDH1A1)
MYD102755098(ALDH1A2) 102758582(ALDH1A3) 102769215(ALDH1A1)
MMYO118652741(ALDH1A2) 118667457(ALDH1A1) 118679269(ALDH1A3)
MLF102419279(ALDH1A1) 102427395(ALDH1A3) 102431439(ALDH1A2)
MNA107527999(ALDH1A3) 107532323(ALDH1A1) 107533749(ALDH1A2)
PKL118716486(ALDH1A1) 118720602(ALDH1A2)
HAI109380344(ALDH1A3) 109387016(ALDH1A1) 109390699(ALDH1A2)
DRO112300261(ALDH1A1) 112305956(ALDH1A3) 112311378(ALDH1A2)
SHON118992025(ALDH1A3) 118992256(ALDH1A2) 118997813(ALDH1A1)
AJM119045588(ALDH1A1) 119049791(ALDH1A3) 119053478(ALDH1A2)
PDIC114488577(ALDH1A3) 114492876(ALDH1A2) 114503846(ALDH1A1)
PHAS123808628(ALDH1A2) 123809774(ALDH1A3) 123820156(ALDH1A1)
MMF118629448(ALDH1A2) 118629787(ALDH1A1) 118640852(ALDH1A3)
RFQ117018946(ALDH1A3) 117023969(ALDH1A2) 117032327(ALDH1A1)
PALE102889864(ALDH1A3) 102895099(ALDH1A1) 102896470(ALDH1A2)
PGIG120585460(ALDH1A1) 120587354(ALDH1A3) 120604591(ALDH1A2)
PVP105290278(ALDH1A3) 105294325(ALDH1A2) 105299482(ALDH1A1)
RAY107511645(ALDH1A1) 107515787(ALDH1A3) 107518612(ALDH1A2)
MJV108391415(ALDH1A2) 108405240(ALDH1A1)
TOD119231244(ALDH1A1) 119238668(ALDH1A2) 119244337(ALDH1A3)
SARA101537617(ALDH1A2) 101550624(ALDH1A3) 101555562(ALDH1A1)
LAV100657666(ALDH1A2) 100661242 100661525 100662556 100662829 100671859(ALDH1A3)
TMU101348934 101350663 101352608
DNM101411196(ALDH1A1) 101417301(ALDH1A3) 101421471(ALDH1A2)
MDO100019941(ALDH1A2) 100020742(ALDH1A1) 100020791(ALDH1A4) 100020853(ALDH1A5) 100020879(ALDH1A6) 100616732(ALDH1A3)
GAS123233362 123233386 123236111(ALDH1A2) 123236172(ALDH1A3) 123249478
SHR100918704 100918961 100919222 100920413(ALDH1A3) 100933258(ALDH1A2)
PCW110192524(ALDH1A3) 110205281(ALDH1A2) 110223801 110223822 110223863
OAA100074461(ALDH1A1) 100083368(ALDH1A3) 100093567(ALDH1A2)
GGA395264(ALDH1A1) 395389(ALDH1A3) 395844(ALDH1A2)
PCOC116225439(ALDH1A3) 116238858(ALDH1A1) 116244655(ALDH1A2)
MGP100545801(ALDH1A2) 100546607(ALDH1A3) 104915075
CJO107306209(ALDH1A1) 107318519(ALDH1A2) 107318982(ALDH1A3)
NMEL110390028(ALDH1A1) 110403577(ALDH1A3) 110403626(ALDH1A2)
APLA101793139(ALDH1A3) 101801759(ALDH1A2) 101802481(ALDH1A1)
ACYG106033699(ALDH1A2) 106036495(ALDH1A3) 106044484(ALDH1A1)
AFUL116493340(ALDH1A2) 116493579(ALDH1A3) 116500900(ALDH1A1)
TGU100223406(ALDH1A1) 100231202(ALDH1A3) 751771(ALDH1A2)
LSR110471422(ALDH1A2) 110476505(ALDH1A1) 110482959(ALDH1A3)
SCAN103815983(ALDH1A2) 103816096(ALDH1A3) 103822878
PMOA120507136(ALDH1A1) 120508986(ALDH1A2) 120509067(ALDH1A3)
OTC121343425(ALDH1A2) 121343543(ALDH1A3) 121345373(ALDH1A1)
PRUF121348658(ALDH1A1) 121354455(ALDH1A2) 121354475(ALDH1A3)
GFR102037159(ALDH1A3) 102043395(ALDH1A2) 102043637(ALDH1A1)
FAB101812539(ALDH1A1) 101813835(ALDH1A2) 101816772(ALDH1A3)
PHI102103267(ALDH1A1) 102105549(ALDH1A3) 102111147(ALDH1A2)
PMAJ107209234(ALDH1A2) 107209559(ALDH1A3) 107215910(ALDH1A1)
CCAE111933997(ALDH1A3) 111934165(ALDH1A2) 111941552(ALDH1A1)
CCW104683830(ALDH1A2) 104683903(ALDH1A3) 104685243(ALDH1A1)
CBRC103616402(ALDH1A1) 103618683(ALDH1A2) 103619202(ALDH1A3)
ETL114055250(ALDH1A3) 114056360(ALDH1A2) 114056667(ALDH1A1)
ZAB102062950(ALDH1A2) 102071162(ALDH1A3) 102073126(ALDH1A1)
ACHL103797339 103799205(ALDH1A3) 103801309
FPG101914714(ALDH1A1) 101915870(ALDH1A3) 101919921(ALDH1A2)
FCH102048413(ALDH1A1) 102050613(ALDH1A3) 102051355(ALDH1A2)
CLV102086687(ALDH1A2) 102089147(ALDH1A3) 102091373(ALDH1A1)
EGZ104122868(ALDH1A3) 104123840(ALDH1A1) 104130885(ALDH1A2)
NNI104016850 104017064(ALDH1A3) 104017279 104020883(ALDH1A1)
PLET104616708(ALDH1A1) 104618005(ALDH1A3) 104621882(ALDH1A2)
PCRI104036080 104037140(ALDH1A2) 104037423(ALDH1A3)
ACUN113483899(ALDH1A3) 113484203(ALDH1A2) 113489966(ALDH1A1)
TALA104360351(ALDH1A3) 104366322(ALDH1A2) 104367722(ALDH1A1)
PADL103914768(ALDH1A3) 103914861(ALDH1A2) 103920375(ALDH1A1)
AFOR103899812(ALDH1A2) 103903959(ALDH1A1) 103907320(ALDH1A3)
ACHC115337352(ALDH1A1) 115341215(ALDH1A2) 115341862(ALDH1A3)
HALD104317640(ALDH1A1) 104320298(ALDH1A3) 104321548(ALDH1A2)
CCRI104158760(ALDH1A1) 104164330(ALDH1A3) 104169077(ALDH1A2)
CSTI104554760(ALDH1A3) 104561841
EHS104504311 104516057(ALDH1A3) 104516714
CMAC104476288(ALDH1A3) 104477985(ALDH1A2) 104487392(ALDH1A1)
MUI104538991(ALDH1A2) 104546486
FGA104070104 104080241(ALDH1A3) 104080934(ALDH1A1)
GSTE104257225(ALDH1A3) 104257602(ALDH1A2) 104259718(ALDH1A1)
LDI104344447 104349028(ALDH1A3) 104354018
MNB103768686 103772590(ALDH1A3) 103779898
OHA104330459(ALDH1A2) 104333376(ALDH1A1) 104339286(ALDH1A3)
NNT104402951(ALDH1A1) 104405213(ALDH1A2) 104413303(ALDH1A3)
DPUB104299709(ALDH1A3) 104304846(ALDH1A1) 104309867(ALDH1A2)
PGUU104458831(ALDH1A3) 104464908(ALDH1A2) 104468635(ALDH1A1)
ACAR104521035 104523868 104531085
AVIT104268147(ALDH1A3) 104276034 104278500(ALDH1A1) 104278661
CVF104287080(ALDH1A2) 104287675(ALDH1A1) 104288207(ALDH1A3)
AAM106490505 106495827(ALDH1A3) 106496536(ALDH1A2)
AROW112963646(ALDH1A2) 112965236(ALDH1A1) 112970104(ALDH1A3)
NPD112944392(ALDH1A1) 112948314(ALDH1A3) 112952787(ALDH1A2)
TGT104567495(ALDH1A2) 104568849(ALDH1A3) 104572980(ALDH1A1)
DNE112981888(ALDH1A1) 112991112(ALDH1A2) 112996312(ALDH1A3)
SCAM104148164(ALDH1A3) 104148306(ALDH1A2) 104149542(ALDH1A1) 104150505
ASN102368111(ALDH1A3) 102376803(ALDH1A2) 102378695(ALDH1A1)
AMJ102558250(ALDH1A2) 102571914(ALDH1A1) 102573093(ALDH1A3)
CPOO109308980(ALDH1A2) 109309164(ALDH1A3) 109323434(ALDH1A1)
GGN109288461(ALDH1A3) 109288644(ALDH1A2) 109297589(ALDH1A1)
PSS102446643(ALDH1A2) 102450892(ALDH1A3) 102453636(ALDH1A1)
CMY102939103(ALDH1A3) 102943259(ALDH1A2) 102943361(ALDH1A1)
CPIC101933340(ALDH1A1) 101943620(ALDH1A2) 101946404(ALDH1A3)
TST117875210 117878955(ALDH1A1) 117883790(ALDH1A2)
CABI116816661(ALDH1A3) 116821166(ALDH1A2) 116835367(ALDH1A1)
MRV120373845(ALDH1A3) 120374049(ALDH1A2) 120407796(ALDH1A1)
ACS100555228(aldh1a3) 100556217(aldh1a2) 100566345(aldh1a1)
PVT110072975(ALDH1A3) 110074545(ALDH1A2) 110081706 110081707
SUND121922062(ALDH1A1) 121932608(ALDH1A2) 121935429(ALDH1A3)
PBI103055946(ALDH1A2) 103056376(ALDH1A3) 103057171(ALDH1A1)
PMUR107283177(ALDH1A2) 107283882(ALDH1A3) 107288134(ALDH1A1)
CTIG120306552(ALDH1A2) 120315206(ALDH1A3) 120316237(ALDH1A1)
TSR106542885(ALDH1A2) 106545343(ALDH1A1)
PGUT117660953(ALDH1A2) 117661441(ALDH1A1) 117669868(ALDH1A3)
VKO123027728(ALDH1A2) 123030809(ALDH1A3) 123031379(ALDH1A1)
PMUA114584290(ALDH1A2) 114584458(ALDH1A3) 114606374(ALDH1A1)
ZVI118076796(ALDH1A1) 118093058(ALDH1A2) 118093098(ALDH1A3)
GJA107108680(ALDH1A2) 107111752(ALDH1A1) 107116104(ALDH1A3)
STOW125424467(ALDH1A2) 125424633(ALDH1A3) 125436716(ALDH1A1)
XLA108712817(aldh1a3.S) 108712938(aldh1a2.S) 394296(aldh1a1.S) 397728(aldh1a1.L) 399389(aldh1a2.L) 733178(aldh1a3.L)
XTR100485844(aldh1a3) 613078(aldh1a1) 734052(aldh1a2)
NPR108789830(ALDH1A2) 108790072(ALDH1A3) 108791719(ALDH1A1)
RTEM120931145(ALDH1A3) 120931377(ALDH1A2) 120943199(ALDH1A1)
BBUF120985765(ALDH1A2) 120985989(ALDH1A3) 120989155(ALDH1A1)
BGAR122922381(ALDH1A1) 122927514(ALDH1A3) 122929655(ALDH1A2)
DRE116713(aldh1a2) 751785(aldh1a3)
SRX107741429 107742307 107750602 107755645
SANH107662254 107670770 107692006 107700428
SGH107553814 107563436(aldh1a3) 107585984 107593009
CAUA113051522 113051918 113105750 113105933
PPRM120479728(aldh1a3) 120491443 120491654
MAMB125264466(aldh1a3) 125264713(aldh1a2)
IPU108259626(aldh1a2) 108271441(aldh1a3)
PHYP113536398(aldh1a3) 113540928(aldh1a2)
SMEO124379900(aldh1a2) 124391474(aldh1a3)
TFD113636797(aldh1a2) 113654168(aldh1a3)
AMEX103032207(aldh1a3) 103042804(aldh1a2)
EEE113573937(aldh1a3) 113575738(aldh1a2)
TRU100294697(raldh3) 115246414(aldh1a3) 613232(aldh1a2)
LCO104924302(aldh1a2) 104929720(aldh1a3)
NCC104960054(aldh1a2) 104961728
CGOB115004864(aldh1a3) 115013264(aldh1a1) 115025071(aldh1a2)
ELY117252033 117255575(aldh1a2) 117266244(aldh1a3)
EFO125879741(aldh1a3) 125889979 125899920(aldh1a2)
PLEP121942467(aldh1a3) 121944054 121947788(aldh1a2)
SLUC116045174(aldh1a3) 116060588(aldh1a2)
ECRA117945336(aldh1a2) 117947487(aldh1a3)
ESP116686793(aldh1a3) 116689324(aldh1a2)
PFLV114558146(aldh1a3) 114564945(aldh1a2)
GAT120810508(aldh1a2) 120811078(aldh1a3)
PPUG119197102(aldh1a2) 119198453(aldh1a3)
MSAM119883181(aldh1a3) 119890022(aldh1a2) 119892392
CUD121509741 121510222(aldh1a2) 121510572(aldh1a3)
ALAT119018328(aldh1a2) 119018811(aldh1a3) 119019782
MZE101467043(aldh1a2) 101472510(aldh1a1)
ONL100709766(aldh1a2) 100710237(aldh1a1)
OAU116323019 116334580(aldh1a2)
OLA100049450(aldh1a2)
OML112139085(aldh1a3) 112161158(aldh1a2)
XMA102225737(aldh1a2) 102232034(aldh1a3)
XCO114142943(aldh1a2) 114143203(aldh1a3)
XHE116718396(aldh1a3) 116718605(aldh1a2)
PRET103462270(aldh1a3) 103462518(aldh1a2)
PFOR103149193(aldh1a3) 103153816(aldh1a2)
PLAI106958538(aldh1a2) 106960771
PMEI106914006(aldh1a2) 106927605(aldh1a3)
GAF122843682(aldh1a2) 122846329(aldh1a3)
CVG107087020(aldh1a3) 107095651(aldh1a2)
CTUL119778643(aldh1a2) 119797668(aldh1a3)
GMU124866653(aldh1a3) 124867346(aldh1a2)
NFU107381378(aldh1a2)
KMR108229802(aldh1a2)
ALIM106531687(aldh1a2)
NWH119425501 119428292(aldh1a2)
AOCE111578411 111586204
MCEP125005601(aldh1a2) 125005764(aldh1a3)
CSEM103379028 103398364(aldh1a2)
POV109624736(aldh1a3) 109633667(aldh1a1) 109636896(aldh1a2)
SSEN122760924(aldh1a2) 122762621
HHIP117758972(aldh1a2) 117759508(aldh1a3) 117767453
HSP118111159(aldh1a2) 118113998(aldh1a3) 118115656
LCF108878679 108887709 108894298
SDU111218496(aldh1a2) 111220437(aldh1a3) 111226670(aldh1a1)
SLAL111644902 111655138(aldh1a2) 111656552(aldh1a3)
XGL120791475(aldh1a2) 120791604(aldh1a3) 120805334
HCQ109525955(aldh1a2)
BPEC110175209(aldh1a2)
MALB109965394(aldh1a2) 109973808(aldh1a3)
BSPL114852240(aldh1a2) 114852553(aldh1a3) 114862681
SASA100196764(aldh1a2) 106562207 106562593 106580065 106587345 106596301
STRU115166862 115167238 115199852 115203100 115203462
OTW112249186 112263245 112263719(aldh1a2) 112264247(aldh1a3)
OMY110506179 110506538 110511357 110526416(aldh1a2) 110535799
OGO124023952 124033740 124035503(aldh1a3) 124035724 124036084
ONE115113656(aldh1a2) 115139809
SALP111958080 111969386 111974440
SNH120025014 120056176 120057079(aldh1a3) 120062686
CCLU121548348 121551225 121579446(aldh1a2) 123492575
ELS105014397(aldh1a3) 105014483(aldh1a1) 105016492(aldh1a2)
SFM108926709(aldh1a2) 108931142 108938965(aldh1a1) 108940973 108942070
PKI111839365(aldh1a1) 111844960 111845088(aldh1a2) 111846815 111859929
AANG118207144 118215636 118226706(aldh1a3) 118226798(aldh1a2)
LOC102685231(aldh1a1) 102689169(aldh1a2) 102694141(aldh1a3)
PSPA121295028 121295050 121299028 121299271 121319050
ARUT117421379 117427647 117429112(aldh1a2) 117429182 117962922
LCM102347553(ALDH1A1) 102352592(ALDH1A2) 102366661(ALDH1A3)
CMK103182367(aldh1a1) 103187113 103187716(aldh1a3)
RTP109914376 109927365 109936109
BFO118404482 118404502 118409490 118420468 118420853 118420854
BBEL109466029 109482376 109482378
CIN100176963 100180131 100180469 100183764 100187192
SCLV120345907
APLC110984698
SKO100366585 100373123 100374395 100374643
RZE108354845 108355648 108355907 108356359
CNS116338689
LHT122498066
CCIN107270205
MSEX115449569
BANY112053045
NIQ126769274
PPOT106103486
PXU106116038
PRAP110999476
HZE124631810 124631811 124632026 124632056
SLIU111355504 111355563 111355564 111355716 111355768
OFU114364018 114364019
DMK116932326 116932752
DSV119432812 119445710 119464418 119464423
RSAN119390586 119401255
RMP119163924 119188190
VDE111253631 111255468
VJA111260122 111264459
CSCU111631690 111632445 111639634
PTEP107449834 107449839 107454366
SDM118190454
LGILOTGIDRAFT_192810 LOTGIDRAFT_207312 LOTGIDRAFT_218707
PCAN112555783
BGT106050660 106064232
GAE121370067 121379933 121380841
HRF124147014 124147015 124147016
HRJ124288919 124288920 124289007
CRG105332228 105334905 105334906
MYI110453071 110453099 110453102 110458855
PMAX117318447 117334205 117334228 117334930 117345095
MMER123522904 123522905 123548489 123548490 123554004 123566313 123566425
OBI106870422 106870425 106870426
OSN115217862 115217865 115217972
LAK106156728 106156729 106156733 106166480
NVE5498213 5507624 5517592
EPA110232957 110253458
ATEN116289168 116308659
ADF107345189
AMIL114946847 114960058
PDAM113680780 113680782 113684511
SPIS111334097
FOXFOXG_15201
NHENECHADRAFT_56373
APUUAPUU_70167A
FFUCLAFUR5_06763
NPAUCRNP2_7806
DDIDDB_G0290479(hydA)
 » show all
Reference
1  [PMID:4312676]
  Authors
Moffa DJ, Lotspeich FJ, Krause RF.
  Title
Preparation and properties of retinal-oxidizing enzyme from rat intestinal mucosa.
  Journal
J Biol Chem 245:439-47 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.36
IUBMB Enzyme Nomenclature: 1.2.1.36
ExPASy - ENZYME nomenclature database: 1.2.1.36
BRENDA, the Enzyme Database: 1.2.1.36
CAS: 37250-99-0

KEGG   REACTION: R08384
Entry
R08384                      Reaction                               
Name
retinal:oxygen oxidoreductase
Definition
9-cis-Retinal + Oxygen + H2O <=> 9-cis-Retinoic acid + Hydrogen peroxide
Equation
Reaction class
RC00218  C15493_C16681
RC02755  C00007_C00027
Enzyme
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K00157  aldehyde oxidase [EC:1.2.3.1]

KEGG   REACTION: R08385
Entry
R08385                      Reaction                               
Name
retinal:NAD+ oxidoreductase
Definition
9-cis-Retinal + NAD+ + H2O <=> 9-cis-Retinoic acid + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00218  C15493_C16681
Enzyme
Pathway
rn00830  Retinol metabolism
rn01100  Metabolic pathways
Orthology
K07249  retinal dehydrogenase [EC:1.2.1.36]
Other DBs
RHEA: 42087

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