KEGG   ORTHOLOGY: K00270
Entry
K00270                      KO                                     
Symbol
pdh
Name
phenylalanine dehydrogenase [EC:1.4.1.20]
Pathway
map00350  Tyrosine metabolism
map00360  Phenylalanine metabolism
map00400  Phenylalanine, tyrosine and tryptophan biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00360 Phenylalanine metabolism
    K00270  pdh; phenylalanine dehydrogenase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K00270  pdh; phenylalanine dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.1  With NAD+ or NADP+ as acceptor
    1.4.1.20  phenylalanine dehydrogenase
     K00270  pdh; phenylalanine dehydrogenase
Other DBs
RN: R00688 R09830
GO: 0050175
Genes
BTD: BTI_5242
BUU: WS70_19890
BSAV: WS86_20905
BUL: BW21_4864
BUD: AQ610_28820
BIF: N288_11510
BFD: NCTC4823_03400(pdh_2)
BDA: FSZ17_10715
BSHI: LGQ02_06840
BBAD: K7T73_17795
BACO: OXB_2922
BEO: BEH_00940
BHA: BH0218(pdh)
OIH: OB2878
GKA: GK2031(pdh)
GTN: GTNG_1916
GGH: GHH_c20750(pdh)
PCAL: BV455_03379(pdh)
ANM: GFC28_427(pdh)
AAMY: GFC30_1772(pdh)
ANL: GFC29_1197(pdh)
VPN: A21D_01988(pdh)
PASA: BAOM_4375(pdh)
PSYO: PB01_19085
ESI: Exig_0386
EAN: Eab7_0362(pdh)
JEO: JMA_35970
PABS: JIR001_05320(ldh)
TMR: Tmar_1152
AG: BAA08816(pdh)
 » show all
Reference
PMID:8535000
  Authors
Yamada A, Dairi T, Ohno Y, Huang XL, Asano Y
  Title
Nucleotide sequencing of phenylalanine dehydrogenase gene from Bacillus badius IAM 11059.
  Journal
Biosci Biotechnol Biochem 59:1994-5 (1995)
DOI:10.1271/bbb.59.1994
  Sequence
Reference
PMID:3311741
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x

KEGG   ENZYME: 1.4.1.20
Entry
EC 1.4.1.20                 Enzyme                                 
Name
phenylalanine dehydrogenase;
L-phenylalanine dehydrogenase;
PHD
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With NAD+ or NADP+ as acceptor
Sysname
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Reaction(IUBMB)
L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH + H+ [RN:R00688]
Reaction(KEGG)
R00688;
(other) R00145 R00146 R09830
Substrate
L-phenylalanine [CPD:C00079];
H2O [CPD:C00001];
NAD+ [CPD:C00003]
Product
phenylpyruvate [CPD:C00166];
NH3 [CPD:C00014];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzymes from Bacillus badius and Sporosarcina ureae are highly specific for L-phenylalanine; that from Bacillus sphaericus also acts on L-tyrosine.
History
EC 1.4.1.20 created 1989
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00270  phenylalanine dehydrogenase
Genes
BTDBTI_5242
BUUWS70_19890
BSAVWS86_20905
BULBW21_4864
BUDAQ610_28820
BIFN288_11510
BFDNCTC4823_03400(pdh_2)
BDAFSZ17_10715
BSHILGQ02_06840
BBADK7T73_17795
BACOOXB_2922
BHKB4U37_11725
BCOHBC6307_11155
BEOBEH_00940
PKSIE339_04020
BHABH0218(pdh)
BONA361_12115
BKOCKF48_14850
CSUAIM538_12510
CFIRNAF01_10810
CSOALIS82_12725
OIHOB2878
GKAGK2031(pdh)
GTEGTCCBUS3UF5_23040
GTKGT3570_09480
GTMGT3921_09425
GLIGLN3_03090
BCALCWI35_00265
GTNGTNG_1916
GYCGYMC61_2857
GYAGYMC52_1987
GMCGY4MC1_1502
GGHGHH_c20750(pdh)
GJFM493_10405
GEJA0V43_07810
GZAIC807_06150
GTHGeoth_1594
PTLAOT13_14870
PTBDER53_14730
PCALBV455_03379(pdh)
ANMGFC28_427(pdh)
AAMYGFC30_1772(pdh)
ANLGFC29_1197(pdh)
ANDGRQ40_10590
ACAIISX45_08215
VIGBKP57_13055
VPNA21D_01988(pdh)
VPTKBP50_02890
FPNABE65_003865
FARABE41_003915
PASABAOM_4375(pdh)
PSYHD0S48_01850
PSYOPB01_19085
POFGS400_11785
NMKCHR53_20485
BVQFHE72_02655
RMFD5E69_02585
BVJI5776_15075
BOUI5818_18765
CTHUHUR95_03565
HYIK2M58_06305
ESIExig_0386
EANEab7_0362(pdh)
EXMU719_01985
EXUESP131_04430
EACEKKI46_02245
AFXJZ786_20650
ACURJZ785_24655
TUMCBW65_09705
TABCIG75_18085
JEOJMA_35970
SPSYAZE41_14025
RSTATY39_01260
PANCE2636_08200
LFBC1X05_13650
TVUAB849_007145
KPULGXN76_03225
KEBGXN75_03355
PABSJIR001_05320(ldh)
TMRTmar_1152
THEFE1B22_09430
AACDLWP59_32015
LEDBBK82_09900
 » show all
Reference
1  [PMID:3112142]
  Authors
Asano Y, Nakazawa A, Endo K.
  Title
Novel phenylalanine dehydrogenases from Sporosarcina ureae and Bacillus sphaericus. Purification and characterization.
  Journal
J Biol Chem 262:10346-54 (1987)
Reference
2  [PMID:3311741]
  Authors
Asano Y, Nakazawa A, Endo K, Hibino Y, Ohmori M, Numao N, Kondo K
  Title
Phenylalanine dehydrogenase of Bacillus badius. Purification, characterization and gene cloning.
  Journal
Eur J Biochem 168:153-9 (1987)
DOI:10.1111/j.1432-1033.1987.tb13399.x
Other DBs
ExplorEnz - The Enzyme Database: 1.4.1.20
IUBMB Enzyme Nomenclature: 1.4.1.20
ExPASy - ENZYME nomenclature database: 1.4.1.20
BRENDA, the Enzyme Database: 1.4.1.20
CAS: 69403-12-9

KEGG   REACTION: R00688
Entry
R00688                      Reaction                               
Name
L-phenylalanine:NAD+ oxidoreductase (deaminating)
Definition
L-Phenylalanine + H2O + NAD+ <=> Phenylpyruvate + Ammonia + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00006  C00079_C00166
Enzyme
Pathway
rn00360  Phenylalanine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00270  phenylalanine dehydrogenase [EC:1.4.1.20]
Other DBs
RHEA: 21411

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