KEGG   ORTHOLOGY: K00288
Entry
K00288                      KO                                     

Symbol
MTHFD
Name
methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase [EC:1.5.1.5 3.5.4.9 6.3.4.3]
Pathway
map00670  One carbon pool by folate
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map01240  Biosynthesis of cofactors
Module
M00141  C1-unit interconversion, eukaryotes
Disease
H00262  Spina bifida
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00670 One carbon pool by folate
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.5  Acting on the CH-NH group of donors
   1.5.1  With NAD+ or NADP+ as acceptor
    1.5.1.5  methylenetetrahydrofolate dehydrogenase (NADP+)
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.4  In cyclic amidines
    3.5.4.9  methenyltetrahydrofolate cyclohydrolase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.4  Other carbon-nitrogen ligases
    6.3.4.3  formate---tetrahydrofolate ligase
     K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K00288  MTHFD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase
Other DBs
RN: R00943 R01220 R01655
GO: 0004488 0004477 0004329
Genes
HSA: 4522(MTHFD1)
PTR: 452965(MTHFD1)
PPS: 100986093(MTHFD1)
GGO: 101145772(MTHFD1)
PON: 100173036(MTHFD1)
NLE: 100592446(MTHFD1)
MCC: 707059(MTHFD1)
MCF: 102146226(MTHFD1)
CSAB: 103229163(MTHFD1)
CATY: 105582920(MTHFD1)
PANU: 101014176 116275895(MTHFD1)
RRO: 104678419(MTHFD1)
RBB: 108542410(MTHFD1)
TFN: 117069476(MTHFD1)
PTEH: 111555804(MTHFD1)
CJC: 100385373(MTHFD1)
SBQ: 101050716(MTHFD1)
MMUR: 105856425 105878372(MTHFD1)
MMU: 108156(Mthfd1)
MCAL: 110306712(Mthfd1)
MPAH: 110324943(Mthfd1)
RNO: 64300(Mthfd1)
MCOC: 116080147(Mthfd1)
MUN: 110547762(Mthfd1)
CGE: 100763862(Mthfd1)
PLEU: 114697741(Mthfd1)
NGI: 103730291 103749265(Mthfd1)
HGL: 101707403(Mthfd1)
CCAN: 109691124(Mthfd1)
OCU: 100347271(MTHFD1)
OPI: 101521869(MTHFD1)
TUP: 102473748(MTHFD1)
CFA: 480352(MTHFD1)
VVP: 112922441 112927162(MTHFD1)
VLG: 121493082(MTHFD1)
AML: 100467466(MTHFD1)
UMR: 103672303(MTHFD1)
ORO: 101381197(MTHFD1)
ELK: 111139993
MPUF: 101675940(MTHFD1)
EJU: 114218032(MTHFD1)
MLX: 118002597(MTHFD1)
FCA: 101086816(MTHFD1)
PYU: 121031892(MTHFD1)
PBG: 122469207(MTHFD1)
PTG: 102971656(MTHFD1)
PPAD: 109268333(MTHFD1)
AJU: 106971326(MTHFD1)
HHV: 120238417(MTHFD1)
BTA: 534382(MTHFD1)
BOM: 102275233(MTHFD1)
BIU: 109565242(MTHFD1)
BBUB: 102414409(MTHFD1)
CHX: 102186214(MTHFD1)
OAS: 101109020(MTHFD1)
ODA: 120852813(MTHFD1)
CCAD: 122443744(MTHFD1)
SSC: 414382(MTHFD1)
CFR: 102504065(MTHFD1)
CBAI: 105074665(MTHFD1)
CDK: 105086194(MTHFD1)
BACU: 103017005(MTHFD1)
LVE: 103090767(MTHFD1)
OOR: 101275041(MTHFD1)
DLE: 111173070(MTHFD1)
PCAD: 102996417(MTHFD1)
ECB: 100062154(MTHFD1)
EPZ: 103559580(MTHFD1)
EAI: 106840123(MTHFD1)
MYB: 102241254(MTHFD1)
MYD: 102757978(MTHFD1)
MMYO: 118656389(MTHFD1)
MNA: 107545676(MTHFD1)
PKL: 118716826(MTHFD1)
HAI: 109382053(MTHFD1)
DRO: 112311419(MTHFD1)
SHON: 118976948(MTHFD1)
AJM: 119034794(MTHFD1)
MMF: 118625248(MTHFD1)
PALE: 102878910(MTHFD1)
PGIG: 120612739(MTHFD1)
RAY: 107509318(MTHFD1)
MJV: 108396567
TOD: 119239179(MTHFD1)
LAV: 100661814(MTHFD1)
TMU: 101351465
MDO: 100027684(MTHFD1)
SHR: 100917465(MTHFD1)
PCW: 110220613(MTHFD1)
OAA: 100079541(MTHFD1)
GGA: 423508(MTHFD1)
PCOC: 116236792(MTHFD1)
MGP: 100542376(MTHFD1)
CJO: 107315290(MTHFD1)
NMEL: 110401467(MTHFD1)
APLA: 101798457(MTHFD1)
ACYG: 106037251(MTHFD1)
TGU: 100218066(MTHFD1)
LSR: 110484120(MTHFD1)
SCAN: 103826371(MTHFD1)
PMOA: 120513525(MTHFD1)
OTC: 121333550(MTHFD1)
PRUF: 121358274(MTHFD1)
GFR: 102040140(MTHFD1)
FAB: 101820743(MTHFD1)
PHI: 102101641(MTHFD1)
PMAJ: 107206040(MTHFD1)
CCW: 104687153(MTHFD1)
ETL: 114063210(MTHFD1)
FPG: 101913340(MTHFD1)
FCH: 102059574(MTHFD1)
CLV: 102091689(MTHFD1)
EGZ: 104131673(MTHFD1)
NNI: 104010143(MTHFD1)
ACUN: 113480420(MTHFD1)
PADL: 103924255(MTHFD1)
AAM: 106483010(MTHFD1)
AROW: 112976925(MTHFD1)
NPD: 112947190(MTHFD1)
DNE: 112991525(MTHFD1)
ASN: 102377792(MTHFD1)
AMJ: 102576903(MTHFD1)
CPOO: 109320648(MTHFD1)
GGN: 109298383(MTHFD1)
PSS: 102452269(MTHFD1)
CMY: 102943369(MTHFD1)
CPIC: 101941983(MTHFD1)
TST: 117876176(MTHFD1)
CABI: 116821306(MTHFD1)
ACS: 100553949(mthfd1)
PVT: 110082847(MTHFD1)
PBI: 103058437(MTHFD1)
PMUR: 107285163(MTHFD1)
TSR: 106542509(MTHFD1)
PGUT: 117675173(MTHFD1)
PMUA: 114603772(MTHFD1)
ZVI: 118079842(MTHFD1)
GJA: 107119326(MTHFD1)
XLA: 380266(mthfd1.L)
XTR: 493369(mthfd1)
NPR: 108787125(MTHFD1)
DRE: 260441(mthfd1b) 567587(mthfd1a)
SANH: 107668238 107675313(mthfd1)
CCAR: 109107607
IPU: 108257577(mthfd1) 108269612(Mthfd1)
PHYP: 113538830(mthfd1) 113547678
AMEX: 103042181(mthfd1) 103044195
TRU: 101079275(mthfd1)
LCO: 104924805(mthfd1)
NCC: 104947195(mthfd1)
CGOB: 115026983
ELY: 117267507(mthfd1b)
PLEP: 121953795(mthfd1b)
SLUC: 116035453(mthfd1b)
ECRA: 117935578(mthfd1b)
PFLV: 114546438(mthfd1)
GAT: 120832525(mthfd1b)
PPUG: 119227835(mthfd1b)
MSAM: 119909874(mthfd1b)
CUD: 121526513(mthfd1b)
MZE: 101477222(mthfd1)
ONL: 100709978(mthfd1)
OAU: 116322325(mthfd1b)
OLA: 101174548
OML: 112144482(mthfd1b)
XMA: 102224500(mthfd1)
XCO: 114133834
XHE: 116708634(mthfd1)
PRET: 103458564(mthfd1)
CVG: 107094373(mthfd1)
CTUL: 119789559(mthfd1b)
NFU: 107392490(mthfd1)
KMR: 108232073(mthfd1b)
ALIM: 106519747
AOCE: 111577893(mthfd1)
CSEM: 103390162(mthfd1)
LCF: 108892567
SDU: 111225814
SLAL: 111652470(mthfd1)
XGL: 120795619(mthfd1b)
HCQ: 109526130(mthfd1)
BPEC: 110155272
MALB: 109968362
SASA: 106581504(mthfd1) 106607641
OTW: 112217304 112261855(mthfd1b)
OMY: 110497985(mthfd1b) 110521990
SALP: 111968792(mthfd1) 111973247
ELS: 105015635(mthfd1) 105021712
SFM: 108919610(mthfd1)
PKI: 111838814(mthfd1)
AANG: 118226224(mthfd1b) 118229883
LOC: 102692950(mthfd1)
PSPA: 121330102(mthfd1b)
ARUT: 117424974
LCM: 102347033(MTHFD1)
CMK: 103189752(mthfd1b)
RTP: 109912330
BFO: 118416985
BBEL: 109483747
CIN: 100185664
SCLV: 120339367
SPU: 589933
APLC: 110975175
SKO: 100366866
DME: Dmel_CG4067(pug)
DER: 6551976
DSE: 6606937
DSI: Dsimw501_GD18702(Dsim_GD18702)
DAN: 6500329
DSR: 110189968
DPE: 6594045
DMN: 108156189
DWI: 6648231
DGR: 6568260
DAZ: 108608669
DNV: 115563676
DHE: 111597189
DVI: 6629959
CCAT: 101455112
BOD: 106622932
MDE: 101891351
SCAC: 106093221
LCQ: 111683240
ACOZ: 120947871
AARA: 120904090
AAG: 5567414
AALB: 109411581
AME: 550749
ACER: 108001354
BIM: 100741383
BBIF: 117211293
BVK: 117234666
BVAN: 117161905
BTER: 100644014
CCAL: 108624805
OBB: 114882865
MGEN: 117218350
NMEA: 116427518
CGIG: 122400645
SOC: 105195662
MPHA: 105831994
AEC: 105144492
ACEP: 105622571
PBAR: 105431753
VEM: 105567713
HST: 105192491
DQU: 106744693
CFO: 105252037
FEX: 115234303
LHU: 105668747
PGC: 109852088
OBO: 105274937
PCF: 106792378
PFUC: 122523670
NVI: 100118909
CSOL: 105362769
TPRE: 106656190
MDL: 103575930
FAS: 105269130
DAM: 107037338
CCIN: 107262872
AGB: 108909972
LDC: 111510065
NVL: 108563026
APLN: 108735487
BMOR: 101743494
BMAN: 114247836
MSEX: 115443407
BANY: 112047455
PMAC: 106721613
PPOT: 106101093
PXU: 106120123
PRAP: 110993574
ZCE: 119828841
HAW: 110379090
TNL: 113498638
PXY: 105382326
API: 100167020
DNX: 107167392
AGS: 114123150
RMD: 113549729
BTAB: 109035160
DCI: 103507868
CLEC: 106671085
HHAL: 106689024
NLU: 111052053
FOC: 113209893
ZNE: 110829788
CSEC: 111863838
FCD: 110845338
DMK: 116922782
HAME: 121865049
HAZT: 108670351
EAF: 111704632
DSV: 119464325
RSAN: 119401378
RMP: 119164035
VDE: 111246231
VJA: 111261073
TUT: 107361733
DPTE: 113795631
CSCU: 111620117
CEL: CELE_K07E3.4(K07E3.4)
TSP: Tsp_00651
PCAN: 112570838
BGT: 106057065
GAE: 121371275
CRG: 105345937
MYI: 110450445
PMAX: 117323000
OBI: 106869903
OSN: 115211121
LAK: 106174568
NVE: 5521643
EPA: 110244187
ATEN: 116289095
ADF: 107335679
AMIL: 114955603
PDAM: 113676803
SPIS: 111342997
DGT: 114531584
AQU: 100634307
SCE: YBR084W(MIS1) YGR204W(ADE3)
KMX: KLMA_60087(ADE3) KLMA_70359(MIS1)
NCS: NCAS_0A07290(NCAS0A07290) NCAS_0I01350(NCAS0I01350)
NDI: NDAI_0A07650(NDAI0A07650) NDAI_0D02270(NDAI0D02270)
TPF: TPHA_0A03820(TPHA0A03820) TPHA_0A04840(TPHA0A04840)
TBL: TBLA_0B07610(TBLA0B07610) TBLA_0I02160(TBLA0I02160)
TDL: TDEL_0E04950(TDEL0E04950) TDEL_0F02070(TDEL0F02070)
KAF: KAFR_0B04020(KAFR0B04020) KAFR_0C00240(KAFR0C00240)
PIC: PICST_80013(MIS1) PICST_88119(ADE3)
SLB: AWJ20_1713(MIS1) AWJ20_943(MIS1)
BNN: FOA43_000962(ADE3) FOA43_002991(MIS1)
BBRX: BRETT_001568(MIS1_1) BRETT_003752(MIS1_2)
NCR: NCU03877
NTE: NEUTE1DRAFT88125(NEUTE1DRAFT_88125)
MGR: MGG_01014
SSCK: SPSK_10843
MAW: MAC_07740
MAJ: MAA_00020
ANI: AN2998.2
ANG: ANI_1_3132024(An02g12420)
ABE: ARB_04625
TVE: TRV_06219
PNO: SNOG_01593(SNOG_01592)
PTE: PTT_13570
CNE: CNG00590
CNB: CNBG4190
TASA: A1Q1_07904
ABP: AGABI1DRAFT118122(AGABI1DRAFT_118122)
ABV: AGABI2DRAFT183212(AGABI2DRAFT_183212)
MGL: MGL_2903
MRT: MRET_3502
TCR: 511741.50
LMA: LMJF_30_2600(FTHS)
LIF: LINJ_30_2590(FTHS)
LBZ: LBRM_30_2550(FTHS)
LPAN: LPMP_302520(FTHS)
DAT: HRM2_16700(fhs)
DTO: TOL2_C11840(fhs)
DOV: DSCO28_69530(fhs)
DLI: dnl_37200(fhs)
DMM: dnm_074850(fhs)
SFU: Sfum_2687
DBR: Deba_2227
PTH: PTH_0200(MIS1)
MANA: MAMMFC1_00478(fhs)
ATM: ANT_16290(fhs)
ABAT: CFX1CAM_0631(fhs)
CAP: CLDAP_24240(fhs)
PBF: CFX0092_A0468(fhs)
TTF: THTE_1797
KST: KSMBR1_3178(ftsH_6)
PBU: L21SP3_00111(fhs)
PBAS: SMSP2_00980(fhs)
VBL: L21SP4_02432(fhs)
TAZ: TREAZ_1389(fhs)
TYE: THEYE_A0513(fhs)
CTHI: THC_1752
BANA: BARAN1_0794(fhs)
 » show all
Reference
PMID:3053686
  Authors
Hum DW, Bell AW, Rozen R, MacKenzie RE
  Title
Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
  Journal
J Biol Chem 263:15946-50 (1988)
  Sequence
[hsa:4522]
Reference
  Authors
Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A, Scott JM, Swanson DA
  Title
A polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: report of the Birth Defects Research Group.
  Journal
Am J Hum Genet 71:1207-15 (2002)
DOI:10.1086/344213

DBGET integrated database retrieval system