KEGG   ORTHOLOGY: K00365
Entry
K00365                      KO                                     
Symbol
uaZ
Name
urate oxidase [EC:1.7.3.3]
Pathway
map00230  Purine metabolism
map00232  Caffeine metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00546  Purine degradation, xanthine => urea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K00365  uaZ; urate oxidase
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K00365  uaZ; urate oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.3  With oxygen as acceptor
    1.7.3.3  factor-independent urate hydroxylase
     K00365  uaZ; urate oxidase
Other DBs
RN: R02106 R07981
GO: 0004846
Genes
GGO: 101139849
NLE: 100597726
MCC: 714004
MCF: 102117077
MTHB: 126963640
CSAB: 103224536
CATY: 105593567
PANU: 100998784
TGE: 112628445
RRO: 104677513
RBB: 108527687
TFN: 117092165
PTEH: 111540355
CANG: 105521857
CJC: 100397154
SBQ: 101040936
MMUR: 105861795
LCAT: 123635474
PCOQ: 105823900
OGA: 100956247
MMU: 22262(Uox)
MCAL: 110291256
MPAH: 110320533
RNO: 114768(Uox)
MCOC: 116094386
MUN: 110555015
CGE: 100768251
MAUA: 101827959
PLEU: 114698269
MORG: 121448318
MFOT: 126512381
AAMP: 119801296
NGI: 103728098
HGL: 101719675
CPOC: 100733081
CCAN: 109688705
DORD: 105987044
DSP: 122103685
NCAR: 124975056
OCU: 100009266
OPI: 101526796
TUP: 102500418
GVR: 103589597
CFA: 490189(UOX)
CLUD: 112640984
VVP: 112924412
VLG: 121487812
AML: 100470134
UMR: 103662970
UAH: 113254484
UAR: 123794967
ELK: 111143395
LLV: 125098225
MPUF: 101691492
ORO: 101366343
EJU: 114208481
ZCA: 113935935
MLX: 118019225
NSU: 110580448
LWW: 102731882
FCA: 101096750
PYU: 121027381
PBG: 122480700
LRUF: 124514465
PTG: 102971100
PPAD: 109246177
AJU: 106973351
HHV: 120241661
BTA: 514113(UOX)
BOM: 102267915
BIU: 109556136
BBUB: 102411007
BBIS: 105003256
CHX: 102168228
OAS: 101109838
ODA: 120856945
CCAD: 122436770
SSC: 397510(UOX)
CFR: 102505313
CBAI: 105075495
CDK: 105095038
VPC: 102527220
BACU: 103009966
LVE: 103070467
OOR: 101275718
DLE: 111178377
PCAD: 102983042
PSIU: 116759011
ECB: 100064919
EPZ: 103557286
EAI: 106824012
MYB: 102244414
MYD: 102751767
MMYO: 118676280
MLF: 102440467
MNA: 107543171
PKL: 118722346
HAI: 109385433
DRO: 112309394
SHON: 118997369
AJM: 119062885
PDIC: 114497513
PHAS: 123816544
MMF: 118626625
RFQ: 117027787
PALE: 102878680
PGIG: 120583274
PVP: 105289066
RAY: 107511587
MJV: 108386581
TOD: 119235842
SARA: 101539405
LAV: 100668450
TMU: 101357598
ETF: 101645372
DNM: 101420609
MDO: 100012925
SHR: 100917431
PCW: 110209927
OAA: 100078972
GGA: 101747367
PCOC: 116233357
MGP: 100551010
CJO: 107317543
NMEL: 110402305
APLA: 101797537
ACYG: 106033995
AFUL: 116491890
TGU: 100189932
LSR: 110468816
SCAN: 103815159
PMOA: 120510834
OTC: 121345123
PRUF: 121362003
GFR: 102040716
FAB: 101806442
PHI: 102109233
PMAJ: 107208239
CCAE: 111932859
CCW: 104695300
CBRC: 103612803
ETL: 114064914
ZAB: 102068609
ACHL: 103804863
FPG: 101917753
CLV: 102096622
EGZ: 104122902
NNI: 104015567
PLET: 104615236
PCRI: 104028066
ACUN: 113482838
PADL: 103925216
AFOR: 103894871
ACHC: 115349367
HALD: 104325205
HLE: 104841219
AGEN: 126041576
GCL: 127019105
CCRI: 104168242
CSTI: 104553163
EHS: 104506561
CMAC: 104487562
MUI: 104545040
FGA: 104083146
GSTE: 104262264
LDI: 104341663
MNB: 103774213
OHA: 104338833
NNT: 104408380
DPUB: 104300110
PGUU: 104459978
ACAR: 104524358
CPEA: 104396832
AVIT: 104281460
CVF: 104286147
CUCA: 104055208
TEO: 104378013
BRHI: 104489179
AAM: 106499688
AROW: 112961906
NPD: 112946255
TGT: 104565328
DNE: 112993126
SCAM: 104143000
ASN: 102373915
AMJ: 102571917(UOX)
CPOO: 109307346
GGN: 109305327
ACS: 100552598
PVT: 110079741
SUND: 121930000
PBI: 103058911
PMUR: 107285242
CTIG: 120297891
PGUT: 117677350
VKO: 123024487
PMUA: 114598436
ZVI: 118089130
GJA: 107117302
STOW: 125432806
XLA: 108714977 399031(uox.L)
XTR: 496896(uox)
NPR: 108791380
RTEM: 120945980
BBUF: 120979288
BGAR: 122943160
DRE: 436604(uox)
SRX: 107742901
SGH: 107560424
CAUA: 113054948
PPRM: 120464182(uox)
MAMB: 125257006(uox)
IPU: 100528126(uox)
PHYP: 113529137
SMEO: 124391089(uox)
TFD: 113651623(uox)
AMEX: 103030682
EEE: 113581895
TRU: 101078943
LCO: 104931943
NCC: 104941345
CGOB: 115006622
ELY: 117253362(uox)
EFO: 125896147(uox)
PLEP: 121966164(uox)
SLUC: 116055423(uox)
ECRA: 117950664(uox)
ESP: 116695973
PFLV: 114561451
GAT: 120823961(uox)
PPUG: 119216288(uox)
MSAM: 119900633(uox)
CUD: 121512608(uox)
ALAT: 119028391(uox)
MZE: 101475077
ONL: 100711225
OAU: 116333045(uox)
OLA: 101159660
OML: 112150775(uox)
XMA: 102230976
XCO: 114150834
PRET: 103464157
GAF: 122838692(uox)
CVG: 107087215
CTUL: 119774617(uox)
GMU: 124873961(uox)
NFU: 107392713
KMR: 108234387(uox)
ALIM: 106511397
NWH: 119430624(uox)
AOCE: 111586381
MCEP: 125008934(uox)
CSEM: 103392251
POV: 109625259
SSEN: 122780818(uox)
HHIP: 117759928(uox)
HSP: 118121341(uox)
LCF: 108881276(uox)
SDU: 111230334
SLAL: 111658501
XGL: 120790336(uox)
HCQ: 109522038
BPEC: 110160092
MALB: 109958355
BSPL: 114854463(uox)
SASA: 100136464
STRU: 115157933
OTW: 112217413(uox)
OMY: 110521955(uox)
OGO: 123994963(uox)
ONE: 115139545
SNH: 120054592(uox)
CCLU: 121533288(uox)
ELS: 105008143
SFM: 108923494
PKI: 111860542
AANG: 118225826(uox)
LOC: 102689735
PSPA: 121331102(uox)
ARUT: 117411523(uox)
PSEX: 120515285(uox)
LCM: 102360643
CMK: 103174706(uox)
RTP: 109916159
BFO: 118421545
BBEL: 109484575
SPU: 588974
SKO: 100368654
DME: Dmel_CG7171(Uro)
DER: 6541683
DSE: 6611569
DSI: Dsimw501_GD23486(Dsim_GD23486)
DAN: 6498135
DSR: 110177005
DPO: 4817128
DMN: 108162944
DNV: 108651295
DHE: 111594568
MDE: 101898809
SCAC: 106083689
LCQ: 111689741
LSQ: 119610979
HIS: 119646430
ACOZ: 120958706
AARA: 120902654
ASTE: 118513006
AAG: 5573896
CPII: 120419666
CNS: 116346306
BCOO: 119077146
SOC: 105195412
MPHA: 105838404
AEC: 105151023
ACEP: 105619788
PBAR: 105424989
VEM: 105566523
CFO: 105250801
FEX: 115237203
NVI: 100123613
CSOL: 105362970
TPRE: 106660479
MDL: 103575239
CGLO: 123264328
FAS: 105267657
DAM: 107040184
AGIF: 122851816
CINS: 118073878
LHT: 122512438
CCIN: 107266172
NVL: 108565014
APLN: 108738723
PPYR: 116171766
BMOR: 692784
BMAN: 114245860
MSEX: 115456267
BANY: 112058287
NIQ: 126781382
PMAC: 106714268
PPOT: 106099909
PXU: 106127743
PRAP: 110994260
PBX: 123708860
PNAP: 125050850
ZCE: 119829197
CCRC: 123706419
HAW: 110371086
HZE: 124646187
TNL: 113501006
SLIU: 111352624
OFU: 114355854
PXY: 105386323
BTAB: 109043127
HHAL: 106687253
NLU: 111055219
TPAL: 117639546
CSEC: 111861757
SGRE: 126272511
FCD: 110846031
DMK: 116916130
DPZ: 124328924
PVM: 113823704
HAME: 121861661
PCLA: 123762554
PTRU: 123507136
EAF: 111718131
LSM: 121119799
CRG: 105344267
MYI: 110442106
PMAX: 117321933
NVE: 5502102
EPA: 110235296
ATEN: 116298613
ADF: 107344624
AMIL: 114976626
PDAM: 113668211
SPIS: 111329290
ATH: AT2G26230
ALY: 9330632
CRB: 17894740
BRP: 103828734
BOE: 106301645
RSZ: 108861971
CPAP: 110814496
CIT: 102631080
TCC: 18586835
GRA: 105779785
GAB: 108460823
DZI: 111296600
EGR: 104421156
GMX: 100037445(UR2) 547453(UR9)
VRA: 106770791
VAR: 108326630
VUN: 114189624
CCAJ: 109815339
APRC: 113871129
MTR: 25483173
CAM: 101500535(nodulin-35)
PSAT: 127091038
LJA: Lj6g3v0143890.1(Lj6g3v0143890.1)
FVE: 101304417
PPER: 18778286
PMUM: 103330981
PAVI: 110758511
PDUL: 117618742
PXB: 103933611
ZJU: 107413131
MNT: 21395798
CSV: 101206975
CMO: 103489372
BHJ: 120081363
MCHA: 111018658
RCU: 8272393
JCU: 105649139
MESC: 110625006
POP: 7491607
PEU: 105125425
PALZ: 118060109
JRE: 109002171
CILL: 122291413
QLO: 115984267
TWL: 119989287
VVI: 100232988
SLY: 100037732
SPEN: 107002894
SOT: 102581180
SSTN: 125851616
CANN: 107851994
NSY: 104211356
NTO: 104091371
NAU: 109212210
INI: 109147930
ITR: 116000078
SIND: 105161011
OEU: 111375160
EGT: 105977732
APAN: 127259913
HAN: 110925667
ECAD: 122603156
LSV: 111916296
CCAV: 112524727
DCR: 108205953
CSIN: 114302288
BVG: 104907803
SOE: 110804304
MING: 122058293
TSS: 122642274
OSA: 4324793
DOSA: Os01t0865100-01(Os01g0865100)
OBR: 102704100
BDI: 100845980
ATS: 109743862
LPER: 127344314
SBI: 110433901
ZMA: 100274529
SITA: 101785812
SVS: 117858963
PHAI: 112895402
PDA: 103721005
MUS: 103979093
PEQ: 110022445
AOF: 109836810
NCOL: 116252767
ATR: 18444423
PPP: 112291670
TDL: TDEL_0F02670(TDEL0F02670)
PIC: PICST_40781(URO1)
CAL: CAALFM_C200180CA(CaO19.2114)
NCR: NCU07853
NTE: NEUTE1DRAFT62263(NEUTE1DRAFT_62263)
MGR: MGG_05283
SSCK: SPSK_07787
MAW: MAC_01658
MAJ: MAA_02492
CMT: CCM_09432
MBE: MBM_07067
ANI: AN9470.2
ANG: ANI_1_1150034(An03g02330) ANI_1_826024(An02g06030)
ABE: ARB_05777
TVE: TRV_04465
PTE: PTT_12595
CNE: CNI02420
CNB: CNBH2300
TASA: A1Q1_03024
ABP: AGABI1DRAFT42333(AGABI1DRAFT_42333)
ABV: AGABI2DRAFT65743(AGABI2DRAFT_65743)
DDI: DDB_G0286427(uox)
DFA: DFA_04065(uox)
SPAR: SPRG_09685
SCL: sce4023
NEN: NCHU2750_43570(uaZ)
BQB: J4P68_0017380(pucL)
RBK: E0H22_18805(pucL)
VGO: GJW-30_1_02473(uox)
TRB: HB776_14910(pucL)
SNO: Snov_3388
STAR: G3545_19125(pucL)
ANC: GBB76_11060(pucL)
APRA: G3A50_10785(pucL)
APOL: K9D25_07670(pucL)
MET: M446_5249
MNO: Mnod_5813
MOR: MOC_0208(pucL)
MEE: DA075_04800(pucL)
METS: DK389_23800(pucL)
METI: DK427_21980(pucL)
MMES: MMSR116_07040(pucL)
MTEA: DK419_18885(pucL)
MIND: mvi_57850
MOG: MMB17_23025(pucL)
MTAD: M6G65_01020(pucL)
LIZ: LGH83_16080(pucL)
MGRO: FZ046_12950(pucL)
MSPG: F6B93_21710(pucL)
MMAG: MMAD_14320
MARZ: MARA_24760
MAUB: MAUB_52830
MMUC: C1S78_010080(pucL)
MBOK: MBOE_38490
MAB: MAB_2929c
MABB: MASS_2864
MCHE: BB28_14755
MSTE: MSTE_02898
MSAL: DSM43276_02713(uox)
ASD: AS9A_4198
MPAK: MIU77_08040(pucL)
CCYC: SCMU_33800
NFA: NFA_52420
NFR: ERS450000_04639(uox)
NTP: CRH09_09400(pucL) CRH09_28995(pucL)
NOZ: DMB37_18055(pucL) DMB37_37640(pucL)
NOD: FOH10_19465(pucL) FOH10_19505(pucL) FOH10_22330(pucL)
NAH: F5544_19135(pucL) F5544_19190(pucL) F5544_41710(pucL)
NAD: NCTC11293_00174(uox)
NIE: KV110_18175(pucL) KV110_38435(pucL)
NTC: KHQ06_14250(pucL) KHQ06_34870(pucL)
NHU: H0264_26720(pucL) H0264_26810(pucL) H0264_33950(pucL)
NYA: LTV02_07860(pucL) LTV02_39005(pucL)
NGP: LTT66_09200(pucL)
RER: RER_21140
REY: O5Y_10090
RQI: C1M55_10755(pucL)
RBY: CEJ39_08885(pucL)
RFA: A3L23_00088(uox)
RHS: A3Q41_03326(uox)
RRT: 4535765_01297(uox)
RCR: NCTC10994_02749(uox)
RTM: G4H71_07535(pucL)
RKO: JWS14_08055(pucL) JWS14_24360(pucL)
RGO: KYT97_07985(pucL)
RPSK: JWS13_20565(pucL) JWS13_38140(pucL)
GAM: GII34_19405(pucL)
SCO: SCO6211(SC2G5.32)
SALB: XNR_0633
SMA: SAVERM_2018(pucL)
SGR: SGR_1309
SGB: WQO_28725
SHY: SHJG_7271
SMAL: SMALA_6025
SSOI: I1A49_33990(pucL)
SFA: Sfla_1052
SBH: SBI_02950
SDV: BN159_2098(uox)
SALS: SLNWT_0615
STRP: F750_5793
SFI: SFUL_6171
STRE: GZL_02614
SLD: T261_1848
SAMB: SAM23877_5951(uox)
SPRI: SPRI_1552
SRW: TUE45_06834(uox)
SLE: sle_14680(sle_14680)
SKY: D0C37_04465(pucL)
SALW: CP975_29065(pucL)
SCAD: DN051_10065(pucL)
SPHW: NFX46_10560(pucL)
SALU: DC74_6400
SALL: SAZ_32150
STRD: NI25_08290
SLAU: SLA_6161
SALJ: SMD11_1431
SLX: SLAV_08750(uox1) SLAV_19850(uox2)
SFK: KY5_6544
SNZ: DC008_27920(pucL)
SGE: DWG14_01832(uox)
SRJ: SRO_1626
SLK: SLUN_31845(pucL)
SDX: C4B68_08275(pucL)
SGD: ELQ87_07305(pucL)
SQZ: FQU76_27825(pucL)
SCYA: EJ357_37535(pucL)
SAST: CD934_05370(pucL)
STIR: DDW44_25770(pucL)
SKA: CP970_08370(pucL)
SGZ: C0216_00835(pucL) C0216_09630(pucL)
SVN: CP980_06850(pucL) CP980_16355(pucL)
SNK: CP967_04940(pucL)
SHAW: CEB94_32780(pucL)
SRK: FGW37_25900(pucL)
SFIC: EIZ62_05855(pucL)
SGAL: CP966_29230(pucL)
SSPO: DDQ41_27250(pucL)
SVR: CP971_05920(pucL)
SPAD: DVK44_29130(pucL)
SFY: GFH48_10320(pucL)
SAQU: EJC51_37370(pucL)
SGF: HEP81_01812(pucL)
SCAV: CVT27_28220(pucL)
SSEO: D0Z67_23530(pucL)
SBY: H7H31_05850(pucL)
SRIM: CP984_07770(pucL)
SSUB: CP968_07340(pucL) CP968_16230(pucL)
SPHV: F9278_39005(pucL)
SCIN: CP977_12085(pucL) CP977_27595(pucL)
SFUG: CNQ36_26555(pucL)
SCHA: CP983_08880(pucL)
SGX: H4W23_14535(pucL) H4W23_31460(pucL)
SCOE: CP976_34700(pucL)
SBAT: G4Z16_05235(pucL)
SSPB: CP982_32520(pucL)
SNF: JYK04_04550(uox_1) JYK04_06648(uox_2)
SPLA: CP981_30710(pucL)
SBRO: GQF42_33475(pucL)
SATA: C5746_33465(pucL)
SCHF: IPT68_29600(pucL)
SHUN: DWB77_01706(uox)
SHAR: HUT13_23620(pucL)
SCYG: S1361_31105(uox)
SFEU: IM697_31620(pucL)
SLIA: HA039_06290(pucL)
SDW: K7C20_29340(pucL)
SVD: CP969_30170(pucL)
SCAL: I6J39_29300(pucL)
SAUH: SU9_028245(pucL)
SMOB: J7W19_25710(pucL)
SPRA: CP972_28745(pucL)
SPEU: CGZ69_29805(pucL)
SROI: IAG44_08030(pucL)
SXN: IAG42_07000(pucL) IAG42_33225(pucL)
SGJ: IAG43_26550(pucL)
SHK: J2N69_30500(pucL)
SANU: K7396_07820(pucL)
STRY: EQG64_29500(pucL)
SDD: D9753_06965(pucL)
SACT: DMT42_30625(pucL)
SGOB: test1122_22950(pucL)
SINE: KI385_35295(pucL)
SLF: JEQ17_11085(pucL)
SDEC: L3078_37050(pucL)
SAOV: G3H79_06600(pucL)
SDUR: M4V62_10215(pucL)
SYAN: NRK68_17710(pucL) NRK68_27690(pucL)
SRUG: F0345_24495(pucL)
SAKB: K1J60_09385(pucL)
STAA: LDH80_08970(pucL)
SCT: SCAT_4779
KSK: KSE_63370
KIS: HUT16_29980(pucL)
STRI: C7M71_005125(pucL)
STRH: GXP74_11090(pucL)
ABRY: NYE86_24550(pucL)
PSIC: J4E96_12620(pucL)
CMC: CMN_00267
CCAF: FGD68_03405(pucL)
MLV: CVS47_02416(uox)
MCHN: HCR76_11440(pucL)
MRN: K8F61_18255(pucL)
RRY: C1O28_06925(pucL)
RIA: C7V51_05370(pucL)
RFS: C1I64_04450(pucL)
RTE: GSU10_08445(pucL)
CUG: C1N91_12385(pucL)
AGM: DCE93_10615(pucL)
AMAU: DSM26151_07360(uox)
ASOI: MTP13_00050(pucL)
CRY: B7495_07110(pucL)
HUM: DVJ78_09150(pucL)
GRY: D7I44_02135(pucL) D7I44_04275(pucL)
HEA: HL652_10655(pucL)
FRN: F1C15_05910(pucL)
GLN: F1C58_03565(pucL)
AGX: AGREI_1041(uox)
SUBT: KPL76_08265(pucL)
SUBA: LQ955_09995(pucL)
ART: Arth_3427
ARR: ARUE_c35390(uox)
ARN: CGK93_19080(pucL)
ARTH: C3B78_16720(pucL)
AJG: KKR91_16125(pucL)
ASUN: KG104_17015(pucL)
ASUF: MNQ99_01645(pucL)
APOA: J0916_01035(pucL)
AAU: AAur_3402
PUE: FV140_18025(pucL)
PNV: JMY29_16285(pucL)
ACH: Achl_3208
PSNI: NIBR502771_08300(pucL)
PSEY: GU243_13025(pucL)
GLU: F0M17_16430(pucL)
GPR: JQN66_17120(pucL)
GMI: NMP99_17010(pucL)
GMY: XH9_08860(pucL)
KRH: KRH_19780
KRS: EQG70_15655(pucL)
KVR: CIB50_0001106(uox)
PAEY: KUF55_18075(pucL)
BRV: CFK39_12195(pucL)
BRZ: CFK38_15305(pucL)
BRR: C1N80_00895(pucL)
LMOI: VV02_25695
YIM: J5M86_13145(pucL)
ALX: LVQ62_04540(pucL)
CPRT: FIC82_008685(pucL)
CFL: Cfla_2783
CDON: KKR89_13785(pucL)
CWAN: KG103_14115(pucL)
CFEN: KG102_05300(pucL)
PSEI: GCE65_05025(pucL)
SERJ: SGUI_2186
ORN: DV701_17990(pucL)
ORZ: FNH13_01510(pucL)
BLIN: BLSMQ_0835
BLUT: EW640_09275(pucL)
BCAU: I6G59_07265(pucL)
GYU: FE374_12735(pucL)
MPH: MLP_22140
NCA: Noca_1142
NOY: EXE57_07460(pucL)
NSN: EXE58_12285(pucL)
NANO: G5V58_13160(pucL)
NARO: CFH99_02280(pucL)
NCQ: K6T13_03965(pucL)
MUZ: H4N58_17085(pucL)
KQI: F1D05_01410(pucL)
NDA: Ndas_0718
NAL: B005_3625(pucL)
NGV: CDO52_20165(pucL)
NEX: NE857_10685(pucL)
SNAH: OUQ99_23580(pucL)
SAIU: J4H86_24115(pucL)
ACTW: F7P10_32560(pucL)
AGRA: AGRA3207_006116(pucL)
SRO: Sros_2773
NOW: GBF35_17930(pucL)
NCX: Nocox_14920(uox)
NGN: LCN96_17925(pucL)
TBI: Tbis_2592
FAL: FRAAL4508
GOB: Gobs_2838
BLAP: MVA48_15790(pucL)
MMAR: MODMU_0113(uox)
KRA: Krad_2071
SEN: SACE_6736
SACG: FDZ84_08590(pucL)
AMD: AMED_1926
AMN: RAM_09770
AMM: AMES_1910
AMZ: B737_1912
AOI: AORI_5946
AJA: AJAP_09695(uox)
AMYC: CU254_07830(pucL) CU254_30640(pucL)
AMYY: YIM_11225(uox1) YIM_19285(uox2)
AORI: SD37_29145
AACD: LWP59_08070(pucL)
APRT: MUY14_26865(pucL)
AROO: NQK81_36965(pucL)
ATHM: L1857_10665(pucL) L1857_22270(pucL)
PDX: Psed_1766
PSEA: WY02_01130
PSEE: FRP1_13340
PSEH: XF36_13125
PBRO: HOP40_08910(pucL) HOP40_22150(pucL)
PPEL: H6H00_24935(pucL)
APRE: CNX65_29160(pucL)
AMI: Amir_5939
SESP: BN6_71160(uox)
SSYI: EKG83_39890(pucL)
KAL: KALB_4480
ALO: CRK55966
SACE: GIY23_11935(pucL)
ACTU: Actkin_01818(uox)
MCAB: HXZ27_12115(pucL)
ACTN: L083_6156
AFS: AFR_31535
PLAB: C6361_23935(pucL)
PLAT: C6W10_32815(pucL)
DVC: Dvina_12145(pucL)
DFU: Dfulv_11265(pucL)
DROS: Drose_11010(pucL) Drose_25530(pucL)
DAUR: Daura_11405(pucL)
DMAT: Dmats_11725(pucL)
CCAZ: COUCH_12645(pucL)
CAI: Caci_4737
SNA: Snas_2538
AEY: CDG81_19595(pucL)
JTL: M6D93_19090(pucL)
RXY: Rxyl_2843
RUB: GBA63_15660(pucL)
RMAR: GBA65_15320(pucL)
ERZ: ER308_09430(pucL)
DRA: DR_1160
DGE: Dgeo_2601
DEIN: DAAJ005_13635(pucL)
DPH: EHF33_16910(pucL)
LUO: HHL09_09775(pucL)
MFF: MFFC18_06180(uox)
AAGG: ETAA8_33800(uox)
PND: Pla175_41560(uox)
AMOB: HG15A2_03670(uox)
SACI: Sinac_4646
GRW: FTO74_13545(pucL)
GRB: GOB94_05375(pucL)
TALB: FTW19_00715(pucL)
ABAS: ACPOL_2451
ADIN: H7849_02395(pucL)
CPI: Cpin_6768
CHIH: GWR21_13205(pucL)
CFIL: MYF79_29545(pucL)
SPIK: EXU85_15930(pucL)
SPIB: G8759_09020(pucL)
HYJ: FHG12_10350(pucL)
HQI: H9L05_03275(pucL)
HTS: HMJ29_15970(pucL)
 » show all
Reference
PMID:9360612
  Authors
Colloc'h N, el Hajji M, Bachet B, L'Hermite G, Schiltz M, Prange T, Castro B, Mornon JP
  Title
Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 A resolution.
  Journal
Nat Struct Biol 4:947-52 (1997)
DOI:10.1038/nsb1197-947
  Sequence

KEGG   ORTHOLOGY: K16838
Entry
K16838                      KO                                     
Symbol
pucL
Name
urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:1.7.3.3 4.1.1.97]
Pathway
map00230  Purine metabolism
map00232  Caffeine metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00546  Purine degradation, xanthine => urea
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K16838  pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K16838  pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.3  With oxygen as acceptor
    1.7.3.3  factor-independent urate hydroxylase
     K16838  pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.97  2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
     K16838  pucL; urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Other DBs
RN: R02106 R06604 R07981
GO: 0004846 0051997
Genes
BSU: BSU32450(pucL)
BSR: I33_3345(pucL)
BSL: A7A1_2459
BSH: BSU6051_32450(pucL)
BSY: I653_15640
BSUT: BSUB_03463(pucL)
BSUL: BSUA_03463(pucL)
BSUS: Q433_17750
BSO: BSNT_09727(pucL)
BSN: BSn5_07115
BSQ: B657_32450(pucL)
BSX: C663_3103(pucL)
BSS: BSUW23_15825(pucL)
BST: GYO_3538(pucL)
BMOJ: HC660_31270(pucL)
BTEQ: G4P54_16535(pucL)
BCAB: EFK13_16635(pucL)
BRY: M0696_16330(pucL)
BJS: MY9_3258
BACY: QF06_14540
BACL: BS34A_35410(pucL)
BALM: BsLM_3241
BEO: BEH_09915
BHA: BH0759
BCL: ABC3735
GGH: GHH_c21820(pucL)
GEA: GARCT_02054(uao)
PCAL: BV455_03585(uao)
PFRI: L8956_22270(pucL)
SCIA: HUG15_17705(pucL)
MEKU: HUW50_12970(pucL)
MLIT: KDJ21_024500(pucL)
BBEV: BBEV_2689(uao)
BSE: Bsel_0582
PMS: KNP414_03236(uao)
PMW: B2K_17880
PSWU: SY83_16740
PPSC: EHS13_20750(pucL)
PALB: EJC50_19205(pucL)
PRZ: GZH47_00525(pucL)
PLYC: GXP70_15750(pucL)
CHEB: HH215_09665(pucL)
BTS: Btus_2019
KPUL: GXN76_09800(pucL)
KEB: GXN75_10260(pucL)
KBS: EPA93_23380(pucL)
TRA: Trad_1503
SUS: Acid_0359
ABAC: LuPra_02263(pucL_1)
HAAD: MW046_18160(pucL)
NMO: Nmlp_3624(pucL1)
HDO: MUK72_06530(pucL)
HWC: Hqrw_2223(pucL1)
HVO: HVO_B0300(pucL1)
HALE: G3A49_07345(pucL)
HAQ: DU484_08165(pucL)
HAJ: DU500_08200(pucL)
NVR: FEJ81_21285(pucL)
 » show all
Reference
  Authors
Kim K, Park J, Rhee S
  Title
Structural and functional basis for (S)-allantoin formation in the ureide pathway.
  Journal
J Biol Chem 282:23457-64 (2007)
DOI:10.1074/jbc.M703211200
  Sequence
[bsu:BSU32450]

KEGG   ENZYME: 1.7.3.3
Entry
EC 1.7.3.3                  Enzyme                                 
Name
factor-independent urate hydroxylase;
uric acid oxidase;
uricase;
uricase II;
urate oxidase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With oxygen as acceptor
Sysname
urate:oxygen oxidoreductase
Reaction(IUBMB)
urate + O2 + H2O = 5-hydroxyisourate + H2O2 [RN:R02106]
Reaction(KEGG)
R02106;
(other) R07981
Substrate
urate [CPD:C00366];
O2 [CPD:C00007];
H2O [CPD:C00001]
Product
5-hydroxyisourate [CPD:C11821];
H2O2 [CPD:C00027]
Comment
This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC 3.5.2.17, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC 1.14.13.113 (FAD-dependent urate hydroxylase).
History
EC 1.7.3.3 created 1961, modified 2002, modified 2005, modified 2010
Pathway
ec00230  Purine metabolism
ec00232  Caffeine metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K00365  urate oxidase
K16838  urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
Genes
GGO101139849
NLE100597726
MCC714004
MCF102117077
MTHB126963640
CSAB103224536
CATY105593567
PANU100998784
TGE112628445
RRO104677513
RBB108527687
TFN117092165
PTEH111540355
CANG105521857
CJC100397154
SBQ101040936
MMUR105861795
LCAT123635474
PCOQ105823900
OGA100956247
MMU22262(Uox)
MCAL110291256
MPAH110320533
RNO114768(Uox)
MCOC116094386
MUN110555015
CGE100768251
MAUA101827959
PLEU114698269
MORG121448318
MFOT126512381
AAMP119801296
NGI103728098
HGL101719675
CPOC100733081
CCAN109688705
DORD105987044
DSP122103685
NCAR124975056
OCU100009266
OPI101526796
TUP102500418
GVR103589597
CFA490189(UOX)
CLUD112640984
VVP112924412
VLG121487812
AML100470134
UMR103662970
UAH113254484
UAR123794967
ELK111143395
LLV125098225
MPUF101691492
ORO101366343
EJU114208481
ZCA113935935
MLX118019225
NSU110580448
LWW102731882
FCA101096750
PYU121027381
PBG122480700
LRUF124514465
PTG102971100
PPAD109246177
AJU106973351
HHV120241661
BTA514113(UOX)
BOM102267915
BIU109556136
BBUB102411007
BBIS105003256
CHX102168228
OAS101109838
ODA120856945
CCAD122436770
SSC397510(UOX)
CFR102505313
CBAI105075495
CDK105095038
VPC102527220
BACU103009966
LVE103070467
OOR101275718
DLE111178377
PCAD102983042
PSIU116759011
ECB100064919
EPZ103557286
EAI106824012
MYB102244414
MYD102751767
MMYO118676280
MLF102440467
MNA107543171
PKL118722346
HAI109385433
DRO112309394
SHON118997369
AJM119062885
PDIC114497513
PHAS123816544
MMF118626625
RFQ117027787
PALE102878680
PGIG120583274
PVP105289066
RAY107511587
MJV108386581
TOD119235842
SARA101539405
LAV100668450
TMU101357598
ETF101645372
DNM101420609
MDO100012925
SHR100917431
PCW110209927
OAA100078972
GGA101747367
PCOC116233357
MGP100551010
CJO107317543
NMEL110402305
APLA101797537
ACYG106033995
AFUL116491890
TGU100189932
LSR110468816
SCAN103815159
PMOA120510834
OTC121345123
PRUF121362003
GFR102040716
FAB101806442
PHI102109233
PMAJ107208239
CCAE111932859
CCW104695300
CBRC103612803
ETL114064914
ZAB102068609
ACHL103804863
FPG101917753
CLV102096622
EGZ104122902
NNI104015567
PLET104615236
PCRI104028066
PCAO104045270 104049055
ACUN113482838
PADL103925216
AFOR103894871
ACHC115349367
HALD104325205
HLE104841219
AGEN126041576
GCL127019105
CCRI104168242
CSTI104553163
EHS104506561
CMAC104487562
MUI104545040
FGA104083146
GSTE104262264
LDI104341663
MNB103774213
OHA104338833
NNT104408380
DPUB104300110
PGUU104459978
ACAR104524358
CPEA104396832
AVIT104281460
CVF104286147
CUCA104055208
TEO104378013
BRHI104489179
AAM106499688
AROW112961906
NPD112946255
TGT104565328
DNE112993126
SCAM104143000
ASN102373915
AMJ102571917(UOX)
CPOO109307346
GGN109305327
PSS102453497 102453977
CMY102932244 102932468
CPIC101936730 101944737
TST117882030 117882031
CABI116835757 116835765
MRV120370462 120370465
ACS100552598
PVT110079741
SUND121930000
PBI103058911
PMUR107285242
CTIG120297891
PGUT117677350
VKO123024487
PMUA114598436
ZVI118089130
GJA107117302
STOW125432806
XLA108714977 399031(uox.L)
XTR496896(uox)
NPR108791380
RTEM120945980
BBUF120979288
BGAR122943160
DRE436604(uox)
SRX107742901
SANH107658581 107669002
SGH107560424
CAUA113054948
PPRM120464182(uox)
MAMB125257006(uox)
IPU100528126(uox)
PHYP113529137
SMEO124391089(uox)
TFD113651623(uox)
AMEX103030682
EEE113581895
TRU101078943
TNGGSTEN00022862G001
LCO104931943
NCC104941345
CGOB115006622
ELY117253362(uox)
EFO125896147(uox)
PLEP121966164(uox)
SLUC116055423(uox)
ECRA117950664(uox)
ESP116695973
PFLV114561451
GAT120823961(uox)
PPUG119216288(uox)
MSAM119900633(uox)
CUD121512608(uox)
ALAT119028391(uox)
MZE101475077
ONL100711225
OAU116333045(uox)
OLA101159660
OML112150775(uox)
XMA102230976
XCO114150834
XHE116725610 116727894
PRET103464157
PFOR103130861 103130884
PLAI106941472 106959866
PMEI106923626 106930008
GAF122838692(uox)
CVG107087215
CTUL119774617(uox)
GMU124873961(uox)
NFU107392713
KMR108234387(uox)
ALIM106511397
NWH119430624(uox)
AOCE111586381
MCEP125008934(uox)
CSEM103392251
POV109625259
SSEN122780818(uox)
HHIP117759928(uox)
HSP118121341(uox)
LCF108881276(uox)
SDU111230334
SLAL111658501
XGL120790336(uox)
HCQ109522038
BPEC110160092
MALB109958355
BSPL114854463(uox)
SASA100136464
STRU115157933
OTW112217413(uox)
OMY110521955(uox)
OGO123994963(uox)
ONE115139545
SALP111976044 112080518
SNH120054592(uox)
CCLU121533288(uox)
ELS105008143
SFM108923494
PKI111860542
AANG118225826(uox)
LOC102689735
PSPA121331102(uox)
ARUT117411523(uox)
PSEX120515285(uox)
LCM102360643
CMK103174706(uox)
RTP109916159
BFO118421545
BBEL109484575
SPU588974
APLC110981412 110981429
SKO100368654
DMEDmel_CG7171(Uro)
DER6541683
DSE6611569
DSIDsimw501_GD23486(Dsim_GD23486)
DYADyak_GE14614
DAN6498135
DSR110177005
DPO4817128
DPE113565904 6589893
DMN108162944
DWI6644051 6644053
DGR6563033 6563721
DMODmoj_GI24222
DNV108651295
DHE111594568
DVI116650345 6632471
CCAT101459269 101459637
BOD106615260 106615274
RZE108375841 108375849 108381710
MDE101898809
SCAC106083689
LCQ111689741
LSQ119610979
HIS119646430
AGAAgaP_AGAP008440
ACOZ120958706
AARA120902654
ASTE118513006
AAG5573896
AALB109421342 109432570
CQUCpipJ_CPIJ003456
CPII120419666
CNS116346306
BCOO119077146
SOC105195412
MPHA105838404
AEC105151023
ACEP105619788
PBAR105424989
VEM105566523
CFO105250801
FEX115237203
NVI100123613
CSOL105362970
TPRE106660479
MDL103575239
CGLO123264328
FAS105267657
DAM107040184
AGIF122851816
CINS118073878
LHT122512438
CCIN107266172
NVL108565014
APLN108738723
PPYR116171766
OTU111422709 111422711
BMOR692784
BMAN114245860
MSEX115456267
DPLKGM_214269
BANY112058287
NIQ126781382
PMAC106714268
PPOT106099909
PXU106127743
PRAP110994260
PBX123708860
PNAP125050850
ZCE119829197
CCRC123706419
HAW110371086
HZE124646187
TNL113501006
SLIU111352624
OFU114355854
PXY105386323
CFEL113372146 113373825
BTAB109043127
HHAL106687253
NLU111055219
FOC113214317 113216932
TPAL117639546
CSEC111861757
SGRE126272511
FCD110846031
DPXDAPPUDRAFT_233847
DMK116916130
DPZ124328924
PVM113823704
PJA122244711 122244712 122260867
PCHN125046135 125046249
HAME121861661
PCLA123762554
PTRU123507136
EAF111718131
LSM121119799
PPOI119107387 119108531
CRG105344267
MYI110442106
PMAX117321933
MMER123550385 123556138
LAK106154707 106179546
NVE5502102
EPA110235296
ATEN116298613
ADF107344624
AMIL114976626
PDAM113668211
SPIS111329290
ATHAT2G26230
ALY9330632
CRB17894740
CSAT104700982 104750279
EUSEUTSA_v10021194mg
BRP103828734
BNA106357878 106452898
BOE106301645
RSZ108861971
THJ104801755 104804947 104823771
CPAP110814496
CIT102631080
CICCICLE_v10016037mg
PVY116105727 116111772
MINC123192500 123227169
TCC18586835
GRA105779785
GHI107927605 107943104
GAB108460823
DZI111296600
EGR104421156
GMX100037445(UR2) 547453(UR9)
GSJ114369476 114403422
PVUPHAVU_007G234300g
VRA106770791
VAR108326630
VUN114189624
CCAJ109815339
APRC113871129
MTR25483173
CAM101500535(nodulin-35)
PSAT127091038
LJALj6g3v0143890.1(Lj6g3v0143890.1)
ADU107474240 107474983 107479189 107488723
AIP107625265 107625653
AHF112727467 112727863 112744064 112749077 112783692 112786132 112790539
LANG109336232 109359424
FVE101304417
RCN112189051 112189060
PPER18778286
PMUM103330981
PAVI110758511
PDUL117618742
MDM103418481 103438828
PXB103933611
ZJU107413131
MNT21395798
CSV101206975
CMO103489372
BHJ120081363
MCHA111018658
CMAX111467578 111482298
CMOS111449433 111458738
CPEP111792556 111801822
RCU8272393
JCU105649139
HBR110664227 110667476
MESC110625006
POP7491607
PEU105125425
PALZ118060109
JRE109002171
CILL122291413
QSU111993769 112017931 112021353
QLO115984267
TWL119989287
VVI100232988
VRI117927573 117929383
SLY100037732
SPEN107002894
SOT102581180
SSTN125851616
CANN107851994
NTA107791874 107813779
NSY104211356
NTO104091371
NAU109212210
INI109147930
ITR116000078
SIND105161011
OEU111375160
EGT105977732
SSPL121749463 121792365
APAN127259913
HAN110925667
ECAD122603156
LSV111916296
CCAV112524727
DCR108205953
CSIN114302288
BVG104907803
SOE110804304
CQI110723244 110737418
NNU104590108 104601391
MING122058293
TSS122642274
PSOM113313717 113323856
OSA4324793
DOSAOs01t0865100-01(Os01g0865100)
OBR102704100
BDI100845980
ATS109743862
TDC119269687 119277699
TAES100037659 123062701 123079860
LPER127344314
SBI110433901
ZMA100274529
SITA101785812
SVS117858963
PVIR120673542 120708771
PHAI112895402
PDA103721005
EGU105032853 105034366
MUS103979093
ZOF122041864 122046387
DCT110092579 110114143
PEQ110022445
AOF109836810
NCOL116252767
ATR18444423
SMOSELMODRAFT_156451 SELMODRAFT_172716
PPP112291670
CRECHLRE_12g504950v5
VCNVOLCADRAFT_73602
CSLCOCSUDRAFT_52384
CVRCHLNCDRAFT_20118
BPGBathy08g04420
MISMICPUN_64532
GSLGasu_65630
CCPCHC_T00000418001
KLAKLLA0_E10935g
KMXKLMA_20057
LTHKLTH0H09262g
ZROZYRO0G09482g
TGBHG536_0D04740
TDLTDEL_0F02670(TDEL0F02670)
ZMKHG535_0B05580
PPAPAS_chr2-2_0279
DHADEHA2A07194g
PICPICST_40781(URO1)
PGUPGUG_02092
SPAASPAPADRAFT_136352
LELLELG_01182
CALCAALFM_C200180CA(CaO19.2114)
CTPCTRG_01093
COTCORT_0A12930
CDUCD36_15160
CTENCANTEDRAFT_116017
YLIYALI0F09251g
CLUCLUG_05509
CLUSA9F13_16g00825
CAURCJI97_005601
SLBAWJ20_2522
PKZC5L36_0B08050
BNNFOA43_000942
BBRXBRETT_003773
OPAHPODL_00339
SLUDSCDLUD_001535
NCRNCU07853
NTENEUTE1DRAFT62263(NEUTE1DRAFT_62263)
SMPSMAC_02127
PANPODANSg5539
TTTTHITE_2171067
MTMMYCTH_2315024
CTHRCTHT_0071370
MGRMGG_05283
PPEIPpBr36_03665
TMNUCRPA7_3858
SSCKSPSK_07787
FGRFGSG_04126
FPUFPSE_00146
FVRFVEG_10312
FOXFOXG_11511
NHENECHADRAFT_81764
TRETRIREDRAFT_76381
TRRM419DRAFT_24207
MAWMAC_01658
MAJMAA_02492
CMTCCM_09432
PLJVFPFJ_02363
VALVDBG_06639
VDAVDAG_05692
CFJCFIO01_08679
CLUPCLUP02_02622
CHIGCH63R_01989
SAPOSAPIO_CDS2119
ELAUCREL1_184
PFYPFICI_05327
SSLSS1G_00106
BFUBCIN_03g06830
MBEMBM_07067
PSCOLY89DRAFT_688903
GLZGLAREA_06901
ANIAN9470.2
AFMAFUA_2G10520
ACTACLA_069530
NFINFIA_085890
AORAO090011000588
ANGANI_1_1150034(An03g02330) ANI_1_826024(An02g06030)
AFVAFLA_007981
ALUCAKAW2_21127A AKAW2_40206S
ACHEACHE_40565A
APUUAPUU_11005A
PCSPc22g20960
PDPPDIP_63940
TMFPMAA_047670
TRGTRUGW13939_07826
CIMCIMG_04344
CPWCPC735_073860
UREUREG_01592
PBLPAAG_01437
PBNPADG_00331
ABEARB_05777
TVETRV_04465
AJEHCAG_08071
BGHBDBG_07100
PNOSNOG_08332
PTEPTT_12595
BZECOCCADRAFT_86661
BSCCOCSADRAFT_124032
BORCOCMIDRAFT_82479
AALTCC77DRAFT_1017270
ZTRMYCGRDRAFT_70045
PFJMYCFIDRAFT_184206
FFUCLAFUR5_09863
BCOMBAUCODRAFT_114390
NPAUCRNP2_5250
TMLGSTUM_00004503001
SPOSPCC1223.09
CNECNI02420
CNBCNBH2300
CNGCNAG_04307
CGICGB_H3440W
TMSTREMEDRAFT_70604
TASAA1Q1_03024
TVSTRAVEDRAFT_156281
DSQDICSQDRAFT_145006 DICSQDRAFT_70560
PCOPHACADRAFT_251616
SHSSTEHIDRAFT_117903
HIRHETIRDRAFT_439423
PSQPUNSTDRAFT_91772
ADLAURDEDRAFT_59877
FMEFOMMEDRAFT_102646
GTRGLOTRDRAFT_62332
LBCLACBIDRAFT_190858
CCICC1G_04058
ABPAGABI1DRAFT42333(AGABI1DRAFT_42333)
ABVAGABI2DRAFT65743(AGABI2DRAFT_65743)
PCUBJR316_0006458
MPRMPER_10554
MRRMoror_16610
MOREE1B28_005762
CPUTCONPUDRAFT_118951
SLASERLADRAFT_356374
WSEWALSEDRAFT_59270
WICJ056_002062
UMAUMAG_00672
PFPPFL1_00057
PGRPGTG_04959
MLRMELLADRAFT_39009
DDIDDB_G0286427(uox)
DPPDICPUDRAFT_49836
DFADFA_04065(uox)
ACANACA1_220120
PTIPHATRDRAFT_29736
PIFPITG_18435 PITG_18437
PSOJPHYSODRAFT_469313 PHYSODRAFT_477479
SPARSPRG_09685
GTTGUITHDRAFT_161824
NGRNAEGRDRAFT_80401
SCLsce4023
SCUSCE1572_24240
NENNCHU2750_43570(uaZ)
BQBJ4P68_0017380(pucL)
RBKE0H22_18805(pucL)
VGOGJW-30_1_02473(uox)
TRBHB776_14910(pucL)
SNOSnov_3388
STARG3545_19125(pucL)
ANCGBB76_11060(pucL)
APRAG3A50_10785(pucL)
APOLK9D25_07670(pucL)
MRDMrad2831_0199
METM446_5249
MNOMnod_5813
MORMOC_0208(pucL)
MAQUMaq22A_1p31805
MPHYMCBMB27_05183
MEEDA075_04800(pucL)
METXA3862_01265
METSDK389_23800(pucL)
METIDK427_21980(pucL)
MMESMMSR116_07040(pucL)
MTEADK419_18885(pucL)
MINDmvi_57850
MOGMMB17_23025(pucL)
MTADM6G65_01020(pucL)
BBARRHAL1_01325
PSINCAK95_13210
LIZLGH83_16080(pucL)
BSUBSU32450(pucL)
BSRI33_3345(pucL)
BSLA7A1_2459
BSHBSU6051_32450(pucL)
BSYI653_15640
BSUTBSUB_03463(pucL)
BSULBSUA_03463(pucL)
BSUSQ433_17750
BSOBSNT_09727(pucL)
BSNBSn5_07115
BSQB657_32450(pucL)
BSXC663_3103(pucL)
BSPU712_16180
BSSBSUW23_15825(pucL)
BSTGYO_3538(pucL)
BSIACWD84_04465
BHTDIC78_14975
BMOJHC660_31270(pucL)
BTEQG4P54_16535(pucL)
BIQAN935_16280
BSMBSM4216_2147
BITBIS30_05785
BCABEFK13_16635(pucL)
BRYM0696_16330(pucL)
BJSMY9_3258
BACIB1NLA3E_12615
BACYQF06_14540
BACLBS34A_35410(pucL)
BALMBsLM_3241
BACSAUL54_14940
BEOBEH_09915
BFXBC359_11590
BHABH0759
BCLABC3735
BGIBGM20_10325
GGHGHH_c21820(pucL)
GEAGARCT_02054(uao)
PCALBV455_03585(uao)
BMURABE28_003430
PFRIL8956_22270(pucL)
SCIAHUG15_17705(pucL)
MEKUHUW50_12970(pucL)
MLITKDJ21_024500(pucL)
BBEVBBEV_2689(uao)
BSEBsel_0582
PJDPjdr2_3315
PMSKNP414_03236(uao)
PMQPM3016_3460
PMWB2K_17880
PODPODO_06605
PAEFR50345_07070
PAEJH70737_06880
PNPIJ22_16630
PXLBS614_20795
PYGAWM70_00910
PSWUSY83_16740
PCXLPB68_13750
PPSCEHS13_20750(pucL)
PALBEJC50_19205(pucL)
PRZGZH47_00525(pucL)
PLYCGXP70_15750(pucL)
CHEBHH215_09665(pucL)
BTSBtus_2019
KPULGXN76_09800(pucL)
KEBGXN75_10260(pucL)
MGOAFA91_32355
MDXBTO20_17345
MGROFZ046_12950(pucL)
MKRMKOR_07400
MSPGF6B93_21710(pucL)
MSMMSMEG_1296
MSGMSMEI_1258
MSBLJ00_06455
MSNLI99_06455
MSHLI98_06455
MMAGMMAD_14320
MARZMARA_24760
MAUBMAUB_52830
MMUCC1S78_010080(pucL)
MMATMMAGJ_63580
MBOKMBOE_38490
MSEIMSEDJ_03270
MABMAB_2929c
MMVMYCMA_1623
MABBMASS_2864
MABLMMASJCM_2938
MCHEBB28_14755
MIZBAB75_15845
MSTEMSTE_02898
MSAOMYCSP_13255
MSALDSM43276_02713(uox)
ASDAS9A_4198
MPAKMIU77_08040(pucL)
CCYCSCMU_33800
NFANFA_52420
NFRERS450000_04639(uox)
NBRO3I_016180 O3I_039235
NSLBOX37_30035
NSRNS506_06726
NTPCRH09_09400(pucL) CRH09_28995(pucL)
NOZDMB37_18055(pucL) DMB37_37640(pucL)
NODFOH10_19465(pucL) FOH10_19505(pucL) FOH10_22330(pucL)
NAHF5544_19135(pucL) F5544_19190(pucL) F5544_41710(pucL)
NADNCTC11293_00174(uox)
NWLNWFMUON74_18950 NWFMUON74_55710
NIEKV110_18175(pucL) KV110_38435(pucL)
NTCKHQ06_14250(pucL) KHQ06_34870(pucL)
NHUH0264_26720(pucL) H0264_26810(pucL) H0264_33950(pucL)
NYALTV02_07860(pucL) LTV02_39005(pucL)
NGPLTT66_09200(pucL)
RHARHA1_ro01568 RHA1_ro04509
RERRER_21140
REYO5Y_10090
REBXU06_10315
RQIC1M55_10755(pucL)
ROPROP_12690 ROP_44290
ROAPd630_LPD00958 Pd630_LPD05707
RPYY013_22670
RBYCEJ39_08885(pucL)
RHBNY08_1727 NY08_3502
RAVAAT18_25545
RFAA3L23_00088(uox)
RHSA3Q41_03326(uox)
RHQIM25_12100
RHODAOT96_20935
RRT4535765_01297(uox)
RCRNCTC10994_02749(uox)
RTMG4H71_07535(pucL)
RKOJWS14_08055(pucL) JWS14_24360(pucL)
RGOKYT97_07985(pucL)
ROZCBI38_03995
RPSKJWS13_20565(pucL) JWS13_38140(pucL)
GAMGII34_19405(pucL)
TSMASU32_07280
TPULTPB0596_33050
SCOSCO6211(SC2G5.32)
SALBXNR_0633
SMASAVERM_2018(pucL)
SGRSGR_1309
SGBWQO_28725
SCBSCAB_18521
SSXSACTE_5453
SVLStrvi_2410
SHYSHJG_7271
SHOSHJGH_7031
SRCM271_13630
SMALSMALA_6025
SSOII1A49_33990(pucL)
SFASfla_1052
SBHSBI_02950
SVESVEN_2512 SVEN_6093
SDVBN159_2098(uox)
SALSSLNWT_0615
STRPF750_5793
SFISFUL_6171
SCIB446_29175
SLVSLIV_07080
SGUSGLAU_26725
SVTSVTN_13450 SVTN_30295
STREGZL_02614
SCWTU94_26730
SLDT261_1848
SLCSL103_25185
SXISXIM_47140
STRMM444_18340 M444_27195
STRCAA958_28425
SAMBSAM23877_5951(uox)
SPRISPRI_1552
SCZABE83_05550
SCXAS200_11350
SRWTUE45_06834(uox)
STRFASR50_28400
SLEsle_14680(sle_14680)
SPAVSpa2297_26325
STRTA8713_25925
SCLFBB341_03990
SGSAVL59_12990
STSIA4E84_32100
SKYD0C37_04465(pucL)
SALWCP975_29065(pucL)
SGMGCM10017557_15640
SCADDN051_10065(pucL)
SPHWNFX46_10560(pucL)
SLSSLINC_6745
SNRSNOUR_11160
SALUDC74_6400
SALLSAZ_32150
SPLULK06_027275
STRDNI25_08290
SNWBBN63_05825
SAUOBV401_33935
SSIAA7J05_07840
SVUB1H20_29460
SPUNBFF78_10110
SGVB1H19_31945
SLAUSLA_6161
SALFSMD44_06844
SALJSMD11_1431
SLXSLAV_08750(uox1) SLAV_19850(uox2)
STROSTRMOE7_30430
SFKKY5_6544
SNZDC008_27920(pucL)
SGEDWG14_01832(uox)
SRJSRO_1626
SLKSLUN_31845(pucL)
SDXC4B68_08275(pucL)
SGDELQ87_07305(pucL)
SQZFQU76_27825(pucL)
SCYAEJ357_37535(pucL)
SASTCD934_05370(pucL)
STIRDDW44_25770(pucL)
SKACP970_08370(pucL)
SGZC0216_00835(pucL) C0216_09630(pucL)
SVNCP980_06850(pucL) CP980_16355(pucL)
SNKCP967_04940(pucL)
SHAWCEB94_32780(pucL)
SRKFGW37_25900(pucL)
SFICEIZ62_05855(pucL)
SGALCP966_29230(pucL)
SSPODDQ41_27250(pucL)
SVRCP971_05920(pucL)
SPADDVK44_29130(pucL)
SFYGFH48_10320(pucL)
SAQUEJC51_37370(pucL)
SGFHEP81_01812(pucL)
SCAVCVT27_28220(pucL)
SSEOD0Z67_23530(pucL)
SBYH7H31_05850(pucL)
SRIMCP984_07770(pucL)
SSUBCP968_07340(pucL) CP968_16230(pucL)
SPHVF9278_39005(pucL)
SCINCP977_12085(pucL) CP977_27595(pucL)
SFUGCNQ36_26555(pucL)
SPACB1H29_07330
STSUB7R87_28210
SCHACP983_08880(pucL)
SGXH4W23_14535(pucL) H4W23_31460(pucL)
SCOECP976_34700(pucL)
SBATG4Z16_05235(pucL)
SSPBCP982_32520(pucL)
SNFJYK04_04550(uox_1) JYK04_06648(uox_2)
SPLACP981_30710(pucL)
SBROGQF42_33475(pucL)
STUIGCM10017668_57370
SATAC5746_33465(pucL)
SCHFIPT68_29600(pucL)
SHUNDWB77_01706(uox)
SHARHUT13_23620(pucL)
SCYGS1361_31105(uox)
SFEUIM697_31620(pucL)
SLIAHA039_06290(pucL)
SDWK7C20_29340(pucL)
SVDCP969_30170(pucL)
SCALI6J39_29300(pucL)
SAUHSU9_028245(pucL)
SMOBJ7W19_25710(pucL)
SPRACP972_28745(pucL)
SPEUCGZ69_29805(pucL)
SROIIAG44_08030(pucL)
SXNIAG42_07000(pucL) IAG42_33225(pucL)
SGJIAG43_26550(pucL)
SHKJ2N69_30500(pucL)
SANUK7396_07820(pucL)
STRYEQG64_29500(pucL)
SDDD9753_06965(pucL)
SACTDMT42_30625(pucL)
SMAOCAG99_03235
SGOBtest1122_22950(pucL)
SINEKI385_35295(pucL)
SLFJEQ17_11085(pucL)
SDECL3078_37050(pucL)
SAOVG3H79_06600(pucL)
SDURM4V62_10215(pucL)
SYANNRK68_17710(pucL) NRK68_27690(pucL)
SRUGF0345_24495(pucL)
SAKBK1J60_09385(pucL)
STAALDH80_08970(pucL)
SCTSCAT_4779
SCYSCATT_47730
KSKKSE_63370
KABB7C62_30590
KAUB6264_01120
KITCFP65_6316
KISHUT16_29980(pucL)
STRIC7M71_005125(pucL)
STRHGXP74_11090(pucL)
ABRYNYE86_24550(pucL)
LXLKDY119_03106
PSICJ4E96_12620(pucL)
CMCCMN_00267
CCAFFGD68_03405(pucL)
MIOAOA12_01320
MCWA8L33_04275
MLVCVS47_02416(uox)
MCHNHCR76_11440(pucL)
MRNK8F61_18255(pucL)
RTNA6122_1518
RRYC1O28_06925(pucL)
RIAC7V51_05370(pucL)
RFSC1I64_04450(pucL)
RTEGSU10_08445(pucL)
CUMNI26_12225
CUBBJK06_04275
CUGC1N91_12385(pucL)
FRPAX769_03080
AGYATC03_05300
AGMDCE93_10615(pucL)
AMAUDSM26151_07360(uox)
ASOIMTP13_00050(pucL)
CARTPA27867_1468
CRYB7495_07110(pucL)
CPHYB5808_11810
HUMDVJ78_09150(pucL)
GRYD7I44_02135(pucL) D7I44_04275(pucL)
MANTBHD05_06545
HEAHL652_10655(pucL)
HEHL3i23_01990
FRNF1C15_05910(pucL)
GLNF1C58_03565(pucL)
AGXAGREI_1041(uox)
SUBTKPL76_08265(pucL)
SUBALQ955_09995(pucL)
ARTArth_3427
ARRARUE_c35390(uox)
ARLAFL94_16680
AREAL755_03375
ARWMB46_14750
ARYATC04_01015
ARZAUT26_16280
ARUASPU41_03895
ARQBWQ92_13885
ARNCGK93_19080(pucL)
ARXARZXY2_326
ACRYAC20117_05940
ARTHC3B78_16720(pucL)
AJGKKR91_16125(pucL)
ASUNKG104_17015(pucL)
ASUFMNQ99_01645(pucL)
APOAJ0916_01035(pucL)
AAUAAur_3402
PUEFV140_18025(pucL)
PNVJMY29_16285(pucL)
ACHAchl_3208
APNAsphe3_33450
PSULAU252_13710
PSNINIBR502771_08300(pucL)
PSEYGU243_13025(pucL)
AAIAARI_33710
GARAOZ07_17635
GCRGcLGCM259_2798
GLUF0M17_16430(pucL)
GPRJQN66_17120(pucL)
GMINMP99_17010(pucL)
GMYXH9_08860(pucL)
KRHKRH_19780
KFVAS188_04945
KRSEQG70_15655(pucL)
KVRCIB50_0001106(uox)
SATKSA2016_3345
PAEYKUF55_18075(pucL)
BFABfae_08250
BRVCFK39_12195(pucL)
BRZCFK38_15305(pucL)
BRRC1N80_00895(pucL)
LMOIVV02_25695
YIMJ5M86_13145(pucL)
ALXLVQ62_04540(pucL)
CETB8281_09725
CCEUCBR64_01400
CPRTFIC82_008685(pucL)
CFLCfla_2783
CDONKKR89_13785(pucL)
CWANKG103_14115(pucL)
CFENKG102_05300(pucL)
PSEIGCE65_05025(pucL)
SERJSGUI_2186
ORNDV701_17990(pucL)
ORZFNH13_01510(pucL)
BLYA2T55_04520
BLINBLSMQ_0835
BLUTEW640_09275(pucL)
BCAUI6G59_07265(pucL)
GYUFE374_12735(pucL)
MPHMLP_22140
NCANoca_1142
NOYEXE57_07460(pucL)
NSNEXE58_12285(pucL)
NANOG5V58_13160(pucL)
NAROCFH99_02280(pucL)
NCQK6T13_03965(pucL)
AERAERYTH_00570
MUZH4N58_17085(pucL)
KQIF1D05_01410(pucL)
NDANdas_0718
NALB005_3625(pucL)
NGVCDO52_20165(pucL)
NEXNE857_10685(pucL)
SNAHOUQ99_23580(pucL)
SAIUJ4H86_24115(pucL)
ACTWF7P10_32560(pucL)
AGRAAGRA3207_006116(pucL)
SROSros_2773
NOABKM31_28615
NOWGBF35_17930(pucL)
NCXNocox_14920(uox)
NGNLCN96_17925(pucL)
TBITbis_2592
FRAFrancci3_1910
FREFranean1_2243
FRIFraEuI1c_4801
FALFRAAL4508
FSYFsymDg_1782
NMLNamu_0238 Namu_0250
GOBGobs_2838
BLAPMVA48_15790(pucL)
MMARMODMU_0113(uox)
KRAKrad_2071
SENSACE_6736
SACGFDZ84_08590(pucL)
AMDAMED_1926
AMNRAM_09770
AMMAMES_1910
AMZB737_1912
AOIAORI_5946
AJAAJAP_09695(uox)
AMQAMETH_1603
AMYCCU254_07830(pucL) CU254_30640(pucL)
AMYBBKN51_23245
AABA4R43_06035 A4R43_18575
AMYYYIM_11225(uox1) YIM_19285(uox2)
AORISD37_29145
AACDLWP59_08070(pucL)
APRTMUY14_26865(pucL)
AROONQK81_36965(pucL)
ATHML1857_10665(pucL) L1857_22270(pucL)
PDXPsed_1766
PSEAWY02_01130
PSEEFRP1_13340
PSEHXF36_13125
PSEQAD006_21020
PECQAD017_00600
PHHAFB00_24820
PBROHOP40_08910(pucL) HOP40_22150(pucL)
PPELH6H00_24935(pucL)
APRECNX65_29160(pucL)
AMIAmir_5939
SESPBN6_71160(uox)
SSYIEKG83_39890(pucL)
KALKALB_4480
KPHYAOZ06_19875
LEDBBK82_21895
ALOCRK55966
PMADBAY61_06850
SACEGIY23_11935(pucL)
ACTUActkin_01818(uox)
MCABHXZ27_12115(pucL)
AMSAMIS_63790
ACTNL083_6156
AFSAFR_31535
AIHAiant_23910
ACTRAsp14428_70580
PLABC6361_23935(pucL)
PLATC6W10_32815(pucL)
PFLAPflav_051020
PSUUPsuf_008750
ATLAthai_18200
ASERAsera_56240
CATICS0771_69290
DVCDvina_12145(pucL)
DFUDfulv_11265(pucL)
DROSDrose_11010(pucL) Drose_25530(pucL)
DAURDaura_11405(pucL)
DMATDmats_11725(pucL)
CCAZCOUCH_12645(pucL)
CAICaci_4737
SNASnas_2538
AEYCDG81_19595(pucL)
JTLM6D93_19090(pucL)
RXYRxyl_2843
RRDRradSPS_1305
RUBGBA63_15660(pucL)
RMARGBA65_15320(pucL)
ERZER308_09430(pucL)
EUZDVS28_a3619
KBSEPA93_23380(pucL)
DRADR_1160
DGEDgeo_2601
DGODGo_PA0216
DPDDeipe_0078
DSWQR90_03870
DPUSU48_09955
DEINDAAJ005_13635(pucL)
DGADEGR_34670
DPHEHF33_16910(pucL)
DAHDAETH_43800
TRATrad_1503
LUOHHL09_09775(pucL)
MFFMFFC18_06180(uox)
AAGGETAA8_33800(uox)
LPAVPLANPX_2074
PNDPla175_41560(uox)
AMOBHG15A2_03670(uox)
SACISinac_4646
PHMPSMK_30590
ACMAciX9_2872
GMAAciX8_0720
GRWFTO74_13545(pucL)
GRBGOB94_05375(pucL)
TSAAciPR4_3479
TRSTerro_0864
TALBFTW19_00715(pucL)
ABASACPOL_2451
ADINH7849_02395(pucL)
SUSAcid_0359
ABACLuPra_02263(pucL_1)
CPICpin_6768
CHIHGWR21_13205(pucL)
CFILMYF79_29545(pucL)
NKONiako_0442
SPIKEXU85_15930(pucL)
SPIBG8759_09020(pucL)
HYPA0257_17680
HYZAXW84_04225
HYJFHG12_10350(pucL)
HQIH9L05_03275(pucL)
HTSHMJ29_15970(pucL)
HJEHacjB3_16061
HAADMW046_18160(pucL)
NMONmlp_3624(pucL1)
HDOMUK72_06530(pucL)
HWCHqrw_2223(pucL1)
HVOHVO_B0300(pucL1)
HALEG3A49_07345(pucL)
HAQDU484_08165(pucL)
HAJDU500_08200(pucL)
HAEhalTADL_2613
NVRFEJ81_21285(pucL)
NOUNatoc_3147
 » show all
Reference
1  [PMID:13363909]
  Authors
HUDSON PB, LONDON M.
  Title
Purification and properties of solubilized uricase.
  Journal
Biochim Biophys Acta 21:290-8 (1956)
DOI:10.1016/0006-3002(56)90010-5
Reference
2  [PMID:13271340]
  Authors
MAHLER HR, HUBSCHER G, BAUM R.
  Title
Studies on uricase.  I.  Preparation, purification, and properties of a cuproprotein.
  Journal
J Biol Chem 216:625-41 (1955)
Reference
3  [PMID:13252004]
  Authors
ROBBINS KC, BARNETT EL, GRANT NH.
  Title
Partial pruficiation of procine liver uricase.
  Journal
J Biol Chem 216:27-35 (1955)
Reference
4  [PMID:9709003]
  Authors
Kahn K, Tipton PA.
  Title
Spectroscopic characterization of intermediates in the urate oxidase reaction.
  Journal
Biochemistry 37:11651-9 (1998)
DOI:10.1021/bi980446g
Reference
5  [PMID:9360612]
  Authors
Colloc'h N, el Hajji M, Bachet B, L'Hermite G, Schiltz M, Prange T, Castro B, Mornon JP
  Title
Crystal structure of the protein drug urate oxidase-inhibitor complex at 2.05 A resolution.
  Journal
Nat Struct Biol 4:947-52 (1997)
DOI:10.1038/nsb1197-947
  Sequence
Reference
6  [PMID:12680763]
  Authors
Imhoff RD, Power NP, Borrok MJ, Tipton PA.
  Title
General base catalysis in the urate oxidase reaction: evidence for a novel Thr-Lys catalytic diad.
  Journal
Biochemistry 42:4094-100 (2003)
DOI:10.1021/bi027377x
Other DBs
ExplorEnz - The Enzyme Database: 1.7.3.3
IUBMB Enzyme Nomenclature: 1.7.3.3
ExPASy - ENZYME nomenclature database: 1.7.3.3
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.3.3
BRENDA, the Enzyme Database: 1.7.3.3
CAS: 9002-12-4

KEGG   REACTION: R07981
Entry
R07981                      Reaction                               
Definition
1,3,7-Trimethyluric acid + Oxygen + 2 H2O <=> 3,6,8-Trimethylallantoin + CO2 + Hydrogen peroxide
Equation
Comment
urate oxidase
Reaction class
RC02107  C16361_C16362
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01120  Microbial metabolism in diverse environments
Orthology
K00365  urate oxidase [EC:1.7.3.3]
K16838  urate oxidase / 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase [EC:1.7.3.3 4.1.1.97]

DBGET integrated database retrieval system