KEGG   ORTHOLOGY: K00422
Entry
K00422                      KO                                     
Symbol
E1.10.3.1
Name
polyphenol oxidase [EC:1.10.3.1]
Pathway
map00350  Tyrosine metabolism
map00950  Isoquinoline alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00422  E1.10.3.1; polyphenol oxidase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K00422  E1.10.3.1; polyphenol oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.10  Acting on diphenols and related substances as donors
   1.10.3  With oxygen as acceptor
    1.10.3.1  catechol oxidase
     K00422  E1.10.3.1; polyphenol oxidase
Other DBs
RN: R00031 R00045 R02078
GO: 0004097
Genes
CPAP: 110813716 110813822 110817816 110817849 110817859 110820923 110824768
CIT: 102625572
CIC: CICLE_v10014693mg
PVY: 116112285 116112295 116118143
MINC: 123193265
TCC: 18596894 18596895 18596896 18596897 18596899 18607763
GRA: 105771487 105772626 105772676 105773953 105795312 105798965
GHI: 107886301 107888998 107891789 107901674 107901676 107908785 107923401 107927826 107940403 107941595 107945032 107955348 107960202 121230900
GAB: 108456176 108475875 108478462 108481031 108482137 108484704 108486759
DZI: 111278202 111278203 111282397 111286844 111308257 111318757
CAM: 101512236
LJA: Lj3g3v0278890.1(Lj3g3v0278890.1) Lj3g3v1729190.1(Lj3g3v1729190.1) Lj6g3v2044610.1(Lj6g3v2044610.1)
RCU: 8278545
MESC: 110605532
MING: 122093930
TSS: 122638648
DOSA: Os01t0793300-01(Os01g0793300) Os04t0624500-01(Os04g0624500)
AOF: 109821572
CTHE: Chro_1305
NDE: NIDE3206
 » show all
Reference
PMID:8098228
  Authors
Newman SM, Eannetta NT, Yu H, Prince JP, de Vicente MC, Tanksley SD, Steffens JC
  Title
Organisation of the tomato polyphenol oxidase gene family.
  Journal
Plant Mol Biol 21:1035-51 (1993)
DOI:10.1007/BF00023601
  Sequence
[sly:101259357]

KEGG   ENZYME: 1.10.3.1
Entry
EC 1.10.3.1                 Enzyme                                 
Name
catechol oxidase;
diphenol oxidase;
o-diphenolase;
polyphenol oxidase;
pyrocatechol oxidase;
dopa oxidase;
catecholase;
o-diphenol:oxygen oxidoreductase;
o-diphenol oxidoreductase
Class
Oxidoreductases;
Acting on diphenols and related substances as donors;
With oxygen as acceptor
Sysname
1,2-benzenediol:oxygen oxidoreductase
Reaction(IUBMB)
2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O [RN:R00058]
Reaction(KEGG)
R00058;
(other) R00031 R00045 R00080 R02078
Substrate
catechol [CPD:C00090];
O2 [CPD:C00007]
Product
1,2-benzoquinone [CPD:C02351];
H2O [CPD:C00001]
Comment
A type 3 copper protein that catalyses exclusively the oxidation of catechol (i.e., o-diphenol) to the corresponding o-quinone. The enzyme also acts on a variety of substituted catechols.
It is different from tyrosinase, EC 1.14.18.1, which can catalyse both the monooxygenation of monophenols and the oxidation of catechols.
History
EC 1.10.3.1 created 1961, deleted 1972, reinstated 1978
Pathway
ec00350  Tyrosine metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00422  polyphenol oxidase
Genes
CPAP110813716 110813822 110817816 110817849 110817859 110820923 110824768
CIT102625572
CICCICLE_v10014693mg
PVY116112285 116112295 116118143
MINC123193265
TCC18596894 18596895 18596896 18596897 18596899 18607763
GRA105771487 105772626 105772676 105773953 105795312 105798965
GHI107886301 107888998 107891789 107901674 107901676 107908785 107923401 107927826 107940403 107941595 107945032 107955348 107960202 121230900
GAB108456176 108475875 108478462 108481031 108482137 108484704 108486759
DZI111278202 111278203 111282397 111286844 111308257 111318757
EGR104428733 104441046 104442643
GMX100037473 100037474 100785410 100789730 100792012 100798184 100798709 100801369 100801754 100802289 100802763 100803171 100803874
GSJ114372888 114374382 114374480 114375449 114386424 114388593 114395219 114395358 114409392 114417060 114419512 114419514 114419515
PVUPHAVU_002G225600g PHAVU_006G188500g PHAVU_008G073200g
VRA106752962 106752977 106752978 106768984 106769290 106774639 106774966
VAR108327246 108341695 108342338
VUN114178711 114178844 114178845 114183813 114185767 114187957
CCAJ109789080 109789084 109802942 109804171 109804271
APRC113852069 113857975 113873457
MTR11425155 11430769 11437851 11446900
CAM101512236
LJALj3g3v0278890.1(Lj3g3v0278890.1) Lj3g3v1729190.1(Lj3g3v1729190.1) Lj6g3v2044610.1(Lj6g3v2044610.1)
ADU107468533 107468534 107480666 107480670 107481254 107486088 107486089
AIP107622676 107624139 107631016 107631017 107631911 107635197 107635199
AHF112714626 112714627 112733444 112733447 112734026 112744320 112744321 112783291 112784584 112791431 112791435 112791885 112797621 112797622
LANG109329642 109333626 109334359 109334478 109334479
FVE101298208 101299447 101301080 101301988 101314061 101314633
RCN112164787 112165281 112168392 112173416 112202851
PPER18778195 18778665 18781299 18781346 18781410
PMUM103324677 103324678 103324679 103324680 103324681 103324682 103324714 103335562
PAVI110770865 110770866 110770878 110770879 110770886 110770889 110774247
PDUL117623914 117625858 117625895 117626364
MDM103412438 103427845 103429692 103434747 103434748 103434754 103434755 103434757 103446443 103446446(PPO)
PXB103927236 103927322 103927471 103944270
ZJU107403375 107403559 107403631 107404000 107404302 107404493 107408734
MNT21384900 21384902 21385499 21385502 21395351 21395352 21395353 21395354 21395356 21395360
CSV101219021 101220458
CMO103486180 103489300 103489307
BHJ120082828 120089835
MCHA111010634 111010674
CMAX111490108 111495764 111495765
CMOS111434014 111434015 111456826
CPEP111782723 111783321 111802472
RCU8278545
HBR110641681 110641696 110642993 110650281 110651194
MESC110605532
POP112324931 112325657 112325658 18095455 18095457 18095458 18095460 18095465 18095467 18095468 7455937 7469999 7485450
PEU105109669 105117435 105118339 105118340 105120150 105134697 105139375 105142083
PALZ118031686 118038374 118039743 118043388 118043403 118043405 118063574
JRE108979139 109020781
QSU112008720 112025363 112034957
QLO115962886 115963398 115965867 115992180
TWL119990521 119991004
VVI100233086(PPO) 100257152 100266870
VRI117909091 117910836 117923832 117923999
SLY101258176(PPO) 101258774(PPO) 101259064 101259357 101260075 101261257 101263372 606710
SPEN107009413 107027272 107028061 107028377 107028378 107028682 107028683 114078350
SOT102577727(PPO) 102580718 102604380 102605738
SSTN125841588 125842195 125842199 125843031 125843059 125843271 125843272 125843273 125843274 125849194
CANN107851011 107853889 107854040 107860389 107871326 107871334 107871405
NTA107760231 107767076 107773093 107780127 107786520 107787563 107789348 107802629 107805360 107810500 107810501 107811292 107824883
NSY104218546 104221979 104223431 104223432 104231195 104238423
NTO104085920 104087343 104098486 104104551 104109162 104115752 104118749
NAU109207271 109207272 109207988 109213160 109222437 109231018
INI109150558 109156042 109156043 109156046 109158689 109158694 109169714 109169856 109175418 109175465 109175511 109175521 109176158 109176160 109176161
ITR115996200 115996264 115996290 115996923 115997453 116000043 116001412 116001413 116001682 116001887 116002463 116002464 116002681 116002933 116012643 116026282 116028913 116031017
SIND105160756 105165515 105165516 105165518 105165519 105165833 105168092 105175637 105176864 105176877 105176878 105176879
OEU111370179 111370180 111370324 111370878 111370879 111370974 111373885 111374154 111374156 111375158 111375161 111375437 111379758 111395580
EGT105961587 105961593 105961595 105961596 105961598 105968974 105970349 105970401 105970464
SSPL121767266 121767273 121767974 121768623 121768625 121768629 121769470 121771254 121772754 121773536 121774963 121775245 121791112 121803209
HAN110878549 110886042 110889777 110889779 110889780 110890445 110890448 110890449 110890452 110912646 110920507
ECAD122590875 122592478 122592578 122593590 122594051 122594199 122594535 122598293 122598372
LSV111877557 111882060 111886662 111889726 111889728 111889729 111889766 111905063 111905064 111911881 111911882 111911883 111912456 111914188 111914289 111914881 111920468
CCAV112500460 112501015 112501059 112504910 112505082 112505083 112506337 112506868 112507532 112523496
DCR108192978 108206452 108206527 108220626 108223815
CSIN114267949 114303710 114323507
BVG104895799 104895800 104895801 104900756 104900758 104900759 104900761 104900762 104900843 109135688
SOE110782963 110789071 110796902 110797322 110800926 110804604
CQI110693575 110693764 110706721 110706860 110725420
NNU104586461 104588895(PPOA) 104595657 104601839
MING122093930
TSS122638648
PSOM113276280 113276320 113276494 113278524 113284640 113284645 113287664 113288165 113288662 113290244 113291222 113291768 113304358 113306281 113310294 113313874 113317407 113318085 113318091 113320211 113321283 113322011 113325989 113326693 113330934 113335035 113339778 113339945 113344239 113344391 113345373 113349439 113353825 113358933
OSA4337055 9271853
DOSAOs01t0793300-01(Os01g0793300) Os04t0624500-01(Os04g0624500)
OBR102705861 102712958 102720877
BDI100822036 100824492 100825583 100825713 100830475 100846615
ATS109735375 109747401 109762318 109762325
TDC119282563 119293073 119293074 119300556 119323079 119326279 119342991 119345342 119346876 119356529 119356532 119368390
TAES100037533 123042120 123042123 123050074 123066832 123090411 123100742 123101851 123133116 123143190 123151850 123191900 543131 543156 543157
TUA125506531 125515314 125526934 125529122 125534117 125537903
SBI8054733 8056609 8057594 8067652 8071138 8071139 8071140 8079268
ZMA100275424 100281477 100283178 103641120 103641967 103651121
SITA101756663 101772954 101786101
SVS117853043 117856515 117861508 117865212
PVIR120640625 120675013 120676756 120677811 120677814 120681324 120689365 120708193 120711648
PHAI112891881 112894306 112896440 112897234 112897727 112897829 112898002 112898796 112900853
PDA103698020 103699052 103703733 103715357 103721490 103721493 120109336
EGU105036105 105036901 105036904 105045129 105048962
MUS103968782 103974846 103974847 103975144 103975145 103989846 103990742 103991111 103995522
DCT110099290 110103175 110105187 110105188 110112782 110116766
PEQ110020969 110021009 110027562 110032116 110032142 110036304
AOF109821572
SMOSELMODRAFT_101213 SELMODRAFT_116300 SELMODRAFT_11755 SELMODRAFT_132508 SELMODRAFT_164684 SELMODRAFT_170754 SELMODRAFT_175858 SELMODRAFT_175861 SELMODRAFT_178277 SELMODRAFT_178281 SELMODRAFT_185154 SELMODRAFT_230787 SELMODRAFT_429255 SELMODRAFT_94153
PPP112273973 112274361 112275375 112275501 112276371 112282396 112286873 112292229 112292734 112295060 112295660 112295790
EHXEMIHUDRAFT_197311
SCUSCE1572_16080 SCE1572_21150
BBARRHAL1_02925
CTHEChro_1305
PFERIRI77_19980
NDENIDE3206
 » show all
Reference
1
  Authors
Brown, F.C. and Ward, D.N.
  Title
Preparation of a soluble mammalian tyrosinase.
  Journal
J Am Chem Soc 79:2647-2648 (1957)
Reference
2
  Authors
Dawson, C.R. and Tarpley, W.B.
  Title
The copper oxidases.
  Journal
In: Sumner, J.B. and Myrback, K. (Eds.), The Enzymes, 1st ed., vol. 2, Academic Press, New York, 1951, p. 454-498.
Reference
3  [PMID:16742427]
  Authors
Gregory RP, Bendall DS
  Title
The purification and some properties of the polyphenol oxidase from tea (Camellia sinensis L.).
  Journal
Biochem J 101:569-81 (1966)
DOI:10.1042/bj1010569
Reference
4  [PMID:13288597]
  Authors
MASON HS.
  Title
Structures and functions of the phenolase complex.
  Journal
Nature 177:79-81 (1956)
DOI:10.1038/177079a0
Reference
5
  Authors
Mayer, A.M. and Harel, E.
  Title
Polyphenol oxidases in plants.
  Journal
Phytochemistry 18:193-215 (1979)
Reference
6  [PMID:5842066]
  Authors
Patil SS, Zucker M.
  Title
Potato phenolases. Purification and properties.
  Journal
J Biol Chem 240:3938-43 (1965)
Reference
7  [PMID:4965136]
  Authors
Pomerantz SH, Warner MC.
  Title
3,4-dihydroxy-L-phenylalanine as the tyrosinase cofactor. Occurrence in melanoma and binding constant.
  Journal
J Biol Chem 242:5308-14 (1967)
Reference
8
  Authors
Robb, D.A.
  Title
`Tyrosinase.
  Journal
In: Lontie, R. (Ed.), Copper Proteins and Copper Enzymes, vol. 2, CRC Press, Boca Raton, FL, 1984, p. 207-240.
Reference
9  [PMID:11900522]
  Authors
Gerdemann C, Eicken C, Krebs B
  Title
The crystal structure of catechol oxidase: new insight into the function of type-3 copper proteins.
  Journal
Acc Chem Res 35:183-91 (2002)
DOI:10.1021/ar990019a
Other DBs
ExplorEnz - The Enzyme Database: 1.10.3.1
IUBMB Enzyme Nomenclature: 1.10.3.1
ExPASy - ENZYME nomenclature database: 1.10.3.1
BRENDA, the Enzyme Database: 1.10.3.1
CAS: 9002-10-2

KEGG   REACTION: R00031
Entry
R00031                      Reaction                               
Name
1,2-benzenediol:oxygen oxidoreductase
Definition
Oxygen + 2 L-Tyrosine <=> 2 3,4-Dihydroxy-L-phenylalanine
Equation
C00007 + 2 C00082 <=> 2 C00355
Reaction class
RC00046  C00082_C00355
Enzyme
1.10.3.1        1.14.18.1
Pathway
rn00350  Tyrosine metabolism
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00422  polyphenol oxidase [EC:1.10.3.1]

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