KEGG   ORTHOLOGY: K00445
Entry
K00445                      KO                                     
Symbol
WNT6
Name
wingless-type MMTV integration site family, member 6
Pathway
map04150  mTOR signaling pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map04916  Melanogenesis
map04934  Cushing syndrome
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05217  Basal cell carcinoma
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   04390 Hippo signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   04150 mTOR signaling pathway
    K00445  WNT6; wingless-type MMTV integration site family, member 6
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K00445  WNT6; wingless-type MMTV integration site family, member 6
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K00445  WNT6; wingless-type MMTV integration site family, member 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05205 Proteoglycans in cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05226 Gastric cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05217 Basal cell carcinoma
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05224 Breast cancer
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00445  WNT6; wingless-type MMTV integration site family, member 6
   05022 Pathways of neurodegeneration - multiple diseases
    K00445  WNT6; wingless-type MMTV integration site family, member 6
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00445  WNT6; wingless-type MMTV integration site family, member 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K00445  WNT6; wingless-type MMTV integration site family, member 6
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Morphogens
   K00445  WNT6; wingless-type MMTV integration site family, member 6
Other DBs
GO: 0005109
Genes
HSA: 7475(WNT6)
PTR: 742467(WNT6)
PPS: 100987794(WNT6)
GGO: 101132496(WNT6)
PON: 100440643(WNT6)
NLE: 100606818(WNT6)
MCC: 700573(WNT6)
MCF: 102132660(WNT6)
CSAB: 103217884(WNT6)
CATY: 105587053(WNT6)
PANU: 100997506(WNT6)
TGE: 112636290(WNT6)
RRO: 104660036(WNT6)
RBB: 108518481(WNT6)
TFN: 117094509(WNT6)
PTEH: 111546073(WNT6)
CJC: 100394855(WNT6)
SBQ: 101028364(WNT6)
CSYR: 103261268(WNT6)
MMUR: 105857713(WNT6)
OGA: 100947622(WNT6)
MMU: 22420(Wnt6)
MCAL: 110299810(Wnt6)
MPAH: 110321884(Wnt6)
RNO: 316526(Wnt6)
MCOC: 116088584(Wnt6)
MUN: 110566399(Wnt6)
CGE: 100751289(Wnt6)
PLEU: 114709311(Wnt6)
NGI: 103727729(Wnt6)
HGL: 101698823(Wnt6)
CPOC: 100713618(Wnt6)
CCAN: 109693790(Wnt6)
DORD: 106003030(Wnt6)
DSP: 122107573(Wnt6)
NCAR: 124981136
OCU: 100348986(WNT6)
OPI: 101518428(WNT6)
TUP: 102483667(WNT6)
CFA: 488527(WNT6)
VVP: 112922542(WNT6)
VLG: 121480717(WNT6)
AML: 100467896(WNT6)
UAH: 113250444(WNT6)
UAR: 123779462(WNT6)
ELK: 111145739
LLV: 125095143
MPUF: 101692089(WNT6)
ORO: 101374890(WNT6)
EJU: 114200140(WNT6)
ZCA: 113920632(WNT6)
MLX: 118011751(WNT6)
FCA: 101099392(WNT6)
PYU: 121031083(WNT6)
PBG: 122481782(WNT6)
PPAD: 109265051(WNT6)
AJU: 106970073(WNT6)
HHV: 120232462(WNT6)
BTA: 505075(WNT6)
BOM: 102286828(WNT6)
BIU: 109570782(WNT6)
BBUB: 102407032(WNT6)
CHX: 108637658(WNT6)
OAS: 101111785(WNT6)
ODA: 120854363(WNT6)
CCAD: 122426705(WNT6)
SSC: 100622044(WNT6)
CFR: 102511574(WNT6)
CBAI: 105064094(WNT6)
CDK: 105096131(WNT6)
VPC: 102527223(WNT6)
BACU: 102997453(WNT6)
LVE: 103079243(WNT6)
OOR: 101288015(WNT6)
DLE: 111172090(WNT6)
PCAD: 102993713(WNT6)
PSIU: 116756869(WNT6)
ECB: 100058824(WNT6)
EPZ: 103567913(WNT6)
EAI: 106838461(WNT6)
MYB: 102256374(WNT6)
MYD: 102757803(WNT6)
MMYO: 118662211(WNT6)
MLF: 102420490(WNT6)
MNA: 107524769(WNT6)
PKL: 118709830(WNT6)
HAI: 109380535(WNT6)
DRO: 112308052(WNT6)
SHON: 118975399(WNT6)
AJM: 119056890(WNT6)
PDIC: 114494424(WNT6)
PHAS: 123829242(WNT6)
MMF: 118625699(WNT6)
RFQ: 117025515(WNT6)
PALE: 102882368(WNT6)
PGIG: 120587668(WNT6)
PVP: 105291052(WNT6)
RAY: 107516780(WNT6)
MJV: 108390505(WNT6)
TOD: 119256219(WNT6)
SARA: 101552930(WNT6)
LAV: 100675069(WNT6)
TMU: 101341737
DNM: 101415471(WNT6)
MDO: 100010861(WNT6)
GAS: 123241934(WNT6)
SHR: 100933826(WNT6)
PCW: 110219493(WNT6)
OAA: 100089786(WNT6)
GGA: 395235(WNT6)
PCOC: 116227318(WNT6)
MGP: 100540128(WNT6)
CJO: 107317037(WNT6)
NMEL: 110400365(WNT6)
APLA: 101803438(WNT6)
ACYG: 106039313(WNT6)
AFUL: 116490876(WNT6)
TGU: 100230318(WNT6)
LSR: 110468403(WNT6)
SCAN: 103814356(WNT6)
PMOA: 120496894(WNT6)
OTC: 121335765(WNT6)
PRUF: 121356613(WNT6)
GFR: 102035490(WNT6)
FAB: 101819686(WNT6)
PHI: 102100841(WNT6)
PMAJ: 107207801(WNT6)
CCAE: 111931742(WNT6) 111943653
CCW: 104693964(WNT6)
ETL: 114055668(WNT6)
ZAB: 102065522(WNT6)
FPG: 101921385(WNT6)
FCH: 102054753(WNT6)
CLV: 102085008(WNT6)
EGZ: 104132404(WNT6)
NNI: 104010067(WNT6)
ACUN: 113482396(WNT6)
TALA: 104358758(WNT6)
PADL: 103917663(WNT6)
ACHC: 115343354(WNT6)
AAM: 106499139(WNT6)
AROW: 112972031(WNT6)
NPD: 112942802(WNT6)
DNE: 112980272(WNT6)
ASN: 102377243(WNT6)
AMJ: 106737397(WNT6)
CMY: 114019617(WNT6)
CPIC: 101949600(WNT6)
CABI: 116815230(WNT6)
MRV: 120374730(WNT6)
ACS: 100565609(wnt6)
PVT: 110078170(WNT6)
SUND: 121937348(WNT6)
PBI: 103054454(WNT6)
PMUR: 107292513(WNT6)
TSR: 106540757(WNT6)
PGUT: 117675267(WNT6)
VKO: 123027422(WNT6)
PMUA: 114603052(WNT6)
ZVI: 118090869(WNT6)
GJA: 107107564(WNT6)
STOW: 125427400
XLA: 108701298(wnt6.L) 378676(wnt6.S)
XTR: 101733784(wnt6)
NPR: 108801546(WNT6)
RTEM: 120944204(WNT6)
BBUF: 121007458(WNT6)
BGAR: 122944945(WNT6)
DRE: 100332722(wnt6a) 561831(wnt6b)
PPRM: 120466700(wnt6b) 120491709(wnt6a)
MAMB: 125270047(wnt6b) 125274299(wnt6a)
IPU: 108266110(wnt6b) 108273177(wnt6a)
PHYP: 113523750(wnt6) 113538450
SMEO: 124383390(wnt6b) 124392807(wnt6a)
TFD: 113634433(wnt6a) 113644038(wnt6b)
AMEX: 103038704 103041984(wnt6)
EEE: 113574053 113591172(wnt6)
TRU: 101062888(wnt6)
LCO: 104919603(wnt6)
NCC: 104943745(wnt6)
CGOB: 115026789(wnt6)
ELY: 117251051(wnt6b)
PLEP: 121949226(wnt6b)
SLUC: 116037787(wnt6b)
ECRA: 117953529(wnt6b)
PFLV: 114564177(wnt6)
GAT: 120834467(wnt6b)
PPUG: 119229296(wnt6b)
MSAM: 119903884(wnt6b)
CUD: 121522835(wnt6b)
MZE: 101474169(wnt6)
ONL: 100695021(wnt6)
OAU: 116312607(wnt6b)
OLA: 101174712(wnt6)
OML: 112155468(wnt6b)
XMA: 102234174(wnt6)
XCO: 114148282(wnt6)
XHE: 116723283(wnt6)
PRET: 103460530(wnt6)
PFOR: 103145323(wnt6)
PLAI: 106948454(wnt6)
PMEI: 106917208(wnt6)
GAF: 122840212(wnt6b)
CVG: 107092662(wnt6)
CTUL: 119785174(wnt6b)
GMU: 124871939(wnt6b)
NFU: 107390192(wnt6)
KMR: 108238486(wnt6b)
ALIM: 106523158(wnt6)
NWH: 119419040(wnt6b)
AOCE: 111580967(wnt6)
CSEM: 103392496
POV: 109631098(wnt6)
SSEN: 122760557(wnt6b)
HHIP: 117754979(wnt6b)
LCF: 108902815(wnt6)
SDU: 111218508(wnt6)
SLAL: 111668743(wnt6)
XGL: 120801651(wnt6b)
HCQ: 109522420(wnt6)
BPEC: 110156189(wnt6)
MALB: 109964395(wnt6)
SASA: 106581837(wnt6) 106586152
SALP: 111972696 111974089(wnt6)
ELS: 105029531(wnt6)
SFM: 108927964(wnt6)
PKI: 111848415(wnt6) 111858301
LOC: 102696070(wnt6)
PSPA: 121321402 121322785(wnt6b)
LCM: 102350297 102352652(WNT6)
CMK: 103188488(wnt6b) 103190982
BFO: 118405738
BBEL: 109465440
CIN: 778723
SCLV: 120329347
SPU: 585147
APLC: 110984744
SKO: 100313763(Wnt6)
DME: Dmel_CG4969(Wnt6)
DER: 6542672
DSE: 6611515
DSI: Dsimw501_GD23460(Dsim_wg)
DAN: 6498657
DSR: 110182670
DPE: 6589315
DMN: 108162806
DWI: 6644099
DGR: 6567090
DAZ: 108611686
DNV: 108658171
DHE: 111602345
DVI: 6628631
MDE: 101898284
SCAC: 106087683
LCQ: 111677056
ACOZ: 120957063
AARA: 120902476
AAG: 5564830
CPII: 120423995
CNS: 116340784
AME: 413501
ACER: 107993075
ALAB: 122718377
BIM: 100745430
BBIF: 117211507
BVK: 117235048
BVAN: 117153536
BTER: 100647833
CCAL: 108622250
OBB: 114871802
MGEN: 117221804
NMEA: 116433949
CGIG: 122399841
SOC: 105200052
MPHA: 105838834
AEC: 105150855
ACEP: 105618731
PBAR: 105429522
VEM: 105566204
HST: 105189290
DQU: 106746483
CFO: 105258968
FEX: 115246364
LHU: 105676116
PGC: 109859095
OBO: 105285325
PCF: 106792536
PFUC: 122523130
VPS: 122630258
NVI: 100119613
CSOL: 105367707
TPRE: 106658905
FAS: 105264182
DAM: 107042203
AGIF: 122852821
CCIN: 107275112
TCA: 656429(Wnt6)
DPA: 109545719
SOY: 115886424
CSET: 123312318
LDC: 111506601
NVL: 108563654
APLN: 108739210
OTU: 111424833
BMOR: 101741216
BMAN: 114248774
BANY: 112058531
PMAC: 106714253
PPOT: 106099738
PXU: 106127664
PRAP: 110994201
ZCE: 119831404
HAW: 110371053
TNL: 113501221
SLIU: 111352477
OFU: 114355137
PXY: 105397939
BTAB: 109044640
DCI: 103510156
NLU: 111056936
FOC: 113214203
ZNE: 110828845
CSEC: 111861269
FCD: 110849830
DPX: DAPPUDRAFT_290641(WNT6)
DMK: 116915929
PJA: 122247723
PCHN: 125031284
HAME: 121874269
PCLA: 123748831
PTRU: 123510867
DSV: 119442520
RMP: 119159437
DPTE: 113795868
DFR: 124499713
PTEP: 107438387
SDM: 118191577
PCAN: 112559562
BGT: 106057250
GAE: 121387828
HRF: 124119862
HRJ: 124267460
CRG: 105348241
MYI: 110462024
PMAX: 117317763
OBI: 106878314
OSN: 115223602
LAK: 106180551
EPA: 110250756
ATEN: 116298349
ADF: 107333377
AMIL: 114957169
PDAM: 113671496
SPIS: 111330934
DGT: 114517724
XEN: 124452995
 » show all
Reference
  Authors
Kirikoshi H, Sekihara H, Katoh M
  Title
WNT10A and WNT6, clustered in human chromosome 2q35 region with head-to-tail manner, are strongly coexpressed in SW480 cells.
  Journal
Biochem Biophys Res Commun 283:798-805 (2001)
DOI:10.1006/bbrc.2001.4855
  Sequence
[hsa:7475]
Reference
  Authors
Yuan G, Regel I, Lian F, Friedrich T, Hitkova I, Hofheinz RD, Strobel P, Langer R, Keller G, Rocken C, Zimmermann W, Schmid RM, Ebert MP, Burgermeister E
  Title
WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells.
  Journal
Oncogene 32:375-87 (2013)
DOI:10.1038/onc.2012.40
  Sequence
[hsa:7475]

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