KEGG   ORTHOLOGY: K00461
Entry
K00461                      KO                                     
Symbol
ALOX5
Name
arachidonate 5-lipoxygenase [EC:1.13.11.34]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04664  Fc epsilon RI signaling pathway
map04726  Serotonergic synapse
map04913  Ovarian steroidogenesis
map05145  Toxoplasmosis
Disease
H00079  Asthma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00461  ALOX5; arachidonate 5-lipoxygenase
 09150 Organismal Systems
  09151 Immune system
   04664 Fc epsilon RI signaling pathway
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00461  ALOX5; arachidonate 5-lipoxygenase
  09156 Nervous system
   04726 Serotonergic synapse
    K00461  ALOX5; arachidonate 5-lipoxygenase
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K00461  ALOX5; arachidonate 5-lipoxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.34  arachidonate 5-lipoxygenase
     K00461  ALOX5; arachidonate 5-lipoxygenase
Other DBs
RN: R01595 R03058 R08527
GO: 0004051
Genes
HSA: 240(ALOX5)
PTR: 450428(ALOX5)
PPS: 100979027(ALOX5)
GGO: 101135686(ALOX5)
PON: 100460538(ALOX5)
NLE: 100584513(ALOX5)
MCC: 707926(ALOX5)
MCF: 102132853(ALOX5)
MTHB: 126963209
CSAB: 103215810(ALOX5)
CATY: 105576135(ALOX5)
PANU: 101004229(ALOX5)
TGE: 112632137(ALOX5)
RRO: 104678173(ALOX5)
RBB: 108522174(ALOX5)
TFN: 117082071(ALOX5)
PTEH: 111529801(ALOX5)
CANG: 105517726(ALOX5)
CJC: 100386217(ALOX5)
SBQ: 101031793(ALOX5)
CSYR: 103256562(ALOX5)
LCAT: 123650024(ALOX5)
PCOQ: 105821653(ALOX5)
OGA: 100952067(ALOX5)
MMU: 11689(Alox5)
MCAL: 110297094(Alox5)
MPAH: 110315917(Alox5)
RNO: 25290(Alox5)
MCOC: 116099451(Alox5)
CGE: 100772492(Alox5)
MAUA: 101839970(Alox5)
PLEU: 114689650(Alox5)
MORG: 121438814(Alox5)
MFOT: 126505462
AAMP: 119807525(Alox5)
NGI: 103737907(Alox5)
HGL: 101700210(Alox5)
CPOC: 100718093(Alox5)
CCAN: 109700324(Alox5)
DORD: 106001013(Alox5)
DSP: 122122367(Alox5)
OCU: 100341714
OPI: 101534185(ALOX5)
TUP: 102480526(ALOX5)
GVR: 103597659(ALOX5)
CFA: 477753(ALOX5)
CLUD: 112671999(ALOX5)
VVP: 112913415(ALOX5)
VLG: 121483983(ALOX5)
AML: 100476416(ALOX5)
UMR: 103668062(ALOX5)
UAH: 113243124(ALOX5)
UAR: 123800343(ALOX5)
ELK: 111144974
LLV: 125085017
MPUF: 101684572(ALOX5)
ORO: 101381769(ALOX5)
EJU: 114205241(ALOX5)
ZCA: 113923418(ALOX5)
MLX: 118023026(ALOX5)
NSU: 110589221(ALOX5)
LWW: 102747716(ALOX5)
FCA: 101097422(ALOX5)
PYU: 121036944(ALOX5)
PBG: 122492984(ALOX5)
LRUF: 124506966
PTG: 102973009(ALOX5)
PPAD: 109264579(ALOX5)
AJU: 106989649(ALOX5)
HHV: 120232804(ALOX5)
BTA: 404074(ALOX5)
BOM: 102270550(ALOX5)
BIU: 109553923(ALOX5)
BBUB: 102400249(ALOX5)
BBIS: 104999056(ALOX5)
CHX: 102168425(ALOX5)
OAS: 101117390(ALOX5)
ODA: 120865494(ALOX5)
CCAD: 122446293(ALOX5)
SSC: 100156205(ALOX5)
CFR: 102507744(ALOX5)
CBAI: 105075631(ALOX5)
CDK: 105093424(ALOX5)
VPC: 102544906(ALOX5)
BACU: 103009115(ALOX5)
LVE: 103081267(ALOX5)
OOR: 101283796(ALOX5)
DLE: 111172567(ALOX5)
PCAD: 102987975(ALOX5) 114485528
PSIU: 116741371(ALOX5)
ECB: 100062042(ALOX5)
EPZ: 103553660(ALOX5)
EAI: 106846725(ALOX5)
MYB: 102249760(ALOX5)
MYD: 102754419(ALOX5)
MMYO: 118679341(ALOX5)
MLF: 102418693(ALOX5)
MNA: 107527950(ALOX5)
PKL: 118732103(ALOX5)
HAI: 109389501(ALOX5)
DRO: 112305481(ALOX5)
SHON: 118994142(ALOX5)
AJM: 119035943(ALOX5)
PDIC: 114496046(ALOX5)
PHAS: 123821021(ALOX5)
MMF: 118632052(ALOX5)
RFQ: 117036416(ALOX5)
PALE: 102898772(ALOX5)
PGIG: 120609662(ALOX5)
PVP: 105288958(ALOX5)
RAY: 107508911(ALOX5)
MJV: 108400689(ALOX5)
TOD: 119234526(ALOX5)
SARA: 101551293(ALOX5)
LAV: 100661336(ALOX5)
TMU: 101345496
ETF: 101653110(ALOX5)
DNM: 101433807(ALOX5)
MDO: 100013954(ALOX5)
GAS: 123236481(ALOX5)
SHR: 100932471(ALOX5)
PCW: 110213916(ALOX5)
OAA: 100077066(ALOX5)
GGA: 423769(ALOX5)
PCOC: 116238154(ALOX5)
MGP: 100542129(ALOX5)
CJO: 107315916(ALOX5)
NMEL: 110399270(ALOX5)
APLA: 101801930(ALOX5)
ACYG: 106049001(ALOX5)
AFUL: 116491605(ALOX5)
TGU: 100231888(ALOX5)
LSR: 110475663(ALOX5)
SCAN: 103813960(ALOX5)
PMOA: 120502228(ALOX5)
OTC: 121341694(ALOX5)
PRUF: 121350062(ALOX5)
GFR: 102035554(ALOX5)
FAB: 101813553(ALOX5)
PHI: 102112541(ALOX5)
PMAJ: 107207120(ALOX5)
CCAE: 111931122(ALOX5)
CCW: 104697933(ALOX5)
CBRC: 103624590(ALOX5)
ETL: 114054707(ALOX5)
ZAB: 102062876(ALOX5)
ACHL: 103800605(ALOX5)
FPG: 101914238(ALOX5)
FCH: 102053142(ALOX5)
CLV: 102085004(ALOX5)
EGZ: 104129027(ALOX5)
NNI: 104014074(ALOX5)
PLET: 104626025(ALOX5)
PCRI: 104029677(ALOX5)
PCAO: 104042894(ALOX5)
ACUN: 113481652(ALOX5)
TALA: 104365651(ALOX5)
PADL: 103914082(ALOX5)
AFOR: 103897820(ALOX5)
ACHC: 115348416(ALOX5)
HALD: 104320512(ALOX5)
HLE: 104829333(ALOX5)
AGEN: 126043077
GCL: 127017658
CCRI: 104162138(ALOX5)
CSTI: 104560045(ALOX5)
EHS: 104506301(ALOX5)
CMAC: 104486519(ALOX5)
MUI: 104535976(ALOX5)
FGA: 104076430(ALOX5)
GSTE: 104256524(ALOX5)
MNB: 103781231(ALOX5)
OHA: 104330385(ALOX5)
NNT: 104403581(ALOX5)
DPUB: 104297702(ALOX5)
ACAR: 104521858(ALOX5)
CPEA: 104391514(ALOX5)
AVIT: 104276083(ALOX5)
CVF: 104289812(ALOX5)
CUCA: 104067974(ALOX5)
BRHI: 104501850(ALOX5)
AAM: 106497785(ALOX5)
AROW: 112963900(ALOX5)
NPD: 112957209(ALOX5)
TGT: 104577674(ALOX5)
DNE: 112990662(ALOX5)
SCAM: 104146056(ALOX5)
ASN: 102371605(ALOX5)
AMJ: 102568608(ALOX5)
CPOO: 109324293(ALOX5)
GGN: 109287144(ALOX5)
PSS: 102462244(ALOX5)
CMY: 102944803(ALOX5)
CPIC: 101932214(ALOX5)
TST: 117880642(ALOX5)
CABI: 116823588(ALOX5)
MRV: 120369164(ALOX5)
ACS: 100556313(alox5)
PVT: 110090785
SUND: 121927518(ALOX5)
PMUR: 107292379(ALOX5)
CTIG: 120300245(ALOX5)
TSR: 106553343(ALOX5)
PGUT: 117661247(ALOX5)
VKO: 123029661(ALOX5)
PMUA: 114601080(ALOX5)
ZVI: 118079372(ALOX5)
GJA: 107113129(ALOX5)
STOW: 125443871(ALOX5)
XLA: 108696220(alox5.L) 108697207(alox5.S)
XTR: 100036609(alox5)
NPR: 108800085(ALOX5)
RTEM: 120947174(ALOX5)
BBUF: 121004372(ALOX5)
BGAR: 122940049(ALOX5)
DRE: 567204(alox5a) 573013(alox5b.1) 724056(alox5b.2)
IPU: 108263823(alox5a)
PHYP: 113546154(alox5)
SMEO: 124378204(alox5a)
TFD: 113639934(alox5a)
AMEX: 103035394(alox5)
EEE: 113587960(alox5)
LCO: 104930113(alox5)
NCC: 104946287(alox5)
CGOB: 115020076(alox5)
ELY: 117248563
EFO: 125903456(alox5a)
SLUC: 116054107(alox5a)
ECRA: 117960578(alox5a)
ESP: 116704939(alox5)
PFLV: 114572645(alox5)
GAT: 120820912(alox5a)
PPUG: 119213967(alox5a)
MSAM: 119916966(alox5a)
ALAT: 119034095(alox5a)
MZE: 101482427(alox5)
ONL: 100693453(alox5)
OAU: 116316616(alox5a)
OLA: 101160835(alox5) 101165738
OML: 112162158(alox5a)
XMA: 102230376(alox5)
XCO: 114137934(alox5)
XHE: 116712547(alox5)
PRET: 103476884(alox5)
PFOR: 103147712(alox5)
PLAI: 106955189(alox5)
PMEI: 106907603(alox5)
GAF: 122843057(alox5a)
CVG: 107091526(alox5)
CTUL: 119788547(alox5a)
GMU: 124858722(alox5a)
NFU: 107375698(alox5)
KMR: 108243211
ALIM: 106529456(alox5)
NWH: 119418429(alox5a)
AOCE: 111564375(alox5)
MCEP: 125018433(alox5a)
CSEM: 103387317(alox5)
POV: 109631496(alox5)
SSEN: 122781462(alox5a)
HHIP: 117775306(alox5a)
HSP: 118118901(alox5a)
LCF: 108884347(alox5a)
SDU: 111235185(alox5)
SLAL: 111654678(alox5)
XGL: 120796514(alox5a)
HCQ: 109509924 109509925(alox5)
BPEC: 110164412(alox5)
MALB: 109961016(alox5)
BSPL: 114870428(alox5a)
SASA: 100194803(lox5) 106613187
SALP: 111978799
ELS: 105010608(alox5)
SFM: 108921027(alox5) 108937538
LOC: 102697549(alox5)
PSPA: 121325182(alox5a)
ARUT: 117416027 117417615(alox5a)
PSEX: 120516309(alox5a)
LCM: 102353934(ALOX5)
CMK: 103185827(alox5a)
RTP: 109921931(alox5)
TPAL: 117644657
PVM: 113804806
PCLA: 123760292
PTRU: 123516860
DSV: 119449406
RSAN: 119382445
RMP: 119178021
PTEP: 107442379
SDM: 118200660
PCAN: 112558951
AQU: 100635761
MXA: MXAN_1744
CCX: COCOR_02733(loxA)
 » show all
Reference
PMID:2829172
  Authors
Matsumoto T, Funk CD, Radmark O, Hoog JO, Jornvall H, Samuelsson B
  Title
Molecular cloning and amino acid sequence of human 5-lipoxygenase.
  Journal
Proc Natl Acad Sci U S A 85:26-30 (1988)
DOI:10.1073/pnas.85.1.26
  Sequence
[hsa:240]
Reference
  Authors
Radmark O
  Title
Arachidonate 5-lipoxygenase.
  Journal
Prostaglandins Other Lipid Mediat 68-69:211-34 (2002)
DOI:10.1016/S0090-6980(02)00032-1

KEGG   ORTHOLOGY: K00458
Entry
K00458                      KO                                     
Symbol
ALOX12
Name
arachidonate 12-lipoxygenase [EC:1.13.11.31]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map01523  Antifolate resistance
map04726  Serotonergic synapse
map04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00458  ALOX12; arachidonate 12-lipoxygenase
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00458  ALOX12; arachidonate 12-lipoxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00458  ALOX12; arachidonate 12-lipoxygenase
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K00458  ALOX12; arachidonate 12-lipoxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.31  arachidonate 12-lipoxygenase
     K00458  ALOX12; arachidonate 12-lipoxygenase
Other DBs
RN: R01596
GO: 0004052
Genes
HSA: 239(ALOX12)
PTR: 455242(ALOX12) 455243
PPS: 100992721(ALOX12) 100993999
GGO: 101140132(ALOX12)
PON: 100435170 100448016
NLE: 100605486(ALOX12)
MCC: 713748(ALOX12)
MCF: 102136652(ALOX12) 102137290
MTHB: 126939829
CSAB: 103242265(ALOX12)
CATY: 105582822(ALOX12)
PANU: 101012932(ALOX12)
TGE: 112609056(ALOX12) 112609713
RRO: 104673348(ALOX12)
RBB: 108514395(ALOX12)
TFN: 117067814(ALOX12)
PTEH: 111521261(ALOX12)
CANG: 105523575(ALOX12)
CJC: 100400641(ALOX12)
SBQ: 101051396(ALOX12)
MMUR: 105878109(ALOX12) 105879294
LCAT: 123650840(ALOX12)
PCOQ: 105819472(ALOX12)
OGA: 100951876(ALOX12) 100961111
MMU: 11684(Alox12) 11685(Alox12e)
MCAL: 110304778(Alox12)
MPAH: 110331792(Alox12)
RNO: 287454(Alox12) 303252(Alox12e)
MCOC: 116077965
MUN: 110540751(Alox12)
CGE: 100764620(Alox12)
PLEU: 114693220(Alox12)
NGI: 103752172(Alox12)
HGL: 101702123(Alox12)
CPOC: 100719400
CCAN: 109682903(Alox12)
DORD: 105983295 105983533(Alox12)
DSP: 122100378(Alox12)
OCU: 100340525
OPI: 101518253(ALOX12)
TUP: 102493396(ALOX12) 102494779
GVR: 103587106(ALOX12)
CFA: 479476(ALOX12)
CLUD: 112647510
VVP: 112924805
VLG: 121500195
AML: 100471037(ALOX12)
UMR: 103660455(ALOX12)
UAH: 113271099(ALOX12)
UAR: 123792172(ALOX12)
ELK: 111161172
MPUF: 101684639(ALOX12)
ORO: 101379600(ALOX12)
EJU: 114225417(ALOX12)
ZCA: 113907925(ALOX12) 113939134
MLX: 117999898 117999978(ALOX12)
NSU: 110584560(ALOX12)
LWW: 102750079(ALOX12)
FCA: 101094304
PYU: 121016040(ALOX12)
PBG: 122484839
LRUF: 124519666
PTG: 102969788(ALOX12)
PPAD: 109245992
AJU: 106972408
HHV: 120231410(ALOX12)
BTA: 407169(ALOX12) 787450(ALOX12E)
BOM: 102284543(ALOX12)
BIU: 109574004(ALOX12)
BBUB: 102395651(ALOX12)
BBIS: 104993944 104993949(ALOX12)
CHX: 102187263(ALOX12)
OAS: 101113685(ALOX12)
ODA: 120866088(ALOX12)
CCAD: 122446320 122446338(ALOX12)
SSC: 100620614(ALOX12)
CFR: 102504047(ALOX12)
CBAI: 105077467(ALOX12)
CDK: 105103060(ALOX12)
VPC: 102533742(ALOX12)
BACU: 103020542(ALOX12)
LVE: 103074060(ALOX12)
OOR: 101279538(ALOX12)
DLE: 111185974(ALOX12)
PCAD: 102977395(ALOX12)
PSIU: 116745598(ALOX12)
ECB: 100072916
EPZ: 103561430(ALOX12)
EAI: 106844160(ALOX12)
MNA: 107544244(ALOX12)
HAI: 109394599(ALOX12)
DRO: 112308919(ALOX12)
SHON: 118979425(ALOX12)
AJM: 119037160(ALOX12)
PHAS: 123809459
RFQ: 117013802(ALOX12)
PALE: 102897481(ALOX12)
PGIG: 120612187(ALOX12)
PVP: 105291977(ALOX12)
RAY: 107509504(ALOX12)
MJV: 108401224(ALOX12)
TOD: 119232717
SARA: 101547220(ALOX12) 101547484
LAV: 100656524
TMU: 101341400
ETF: 101643858(ALOX12)
DNM: 101444550
SHR: 100933073
PCW: 110194257
OAA: 100079469
DRE: 322732(alox12)
SANH: 107669199
SGH: 107593795
CCAR: 109050063
PPRM: 120487640
MAMB: 125264591(alox12)
IPU: 108267744 108267745(alox12)
PHYP: 113539915
TFD: 113635137(alox12)
AMEX: 103037595
EEE: 113580793
TRU: 101070898
LCO: 104937156
NCC: 104948188
CGOB: 115023433
ELY: 117272669(alox12)
EFO: 125884070(alox12)
PLEP: 121962177(alox12)
SLUC: 116043997(alox12)
ECRA: 117934769(alox12)
ESP: 116707176
PFLV: 114545687
GAT: 120822087(alox12)
PPUG: 119222432(alox12)
MSAM: 119912247(alox12)
CUD: 121506630(alox12)
ALAT: 119026959(alox12)
MZE: 101479810
ONL: 100698983
OAU: 116321155(alox12)
OLA: 101174953
OML: 112155872(alox12)
XMA: 102224924
XCO: 114157899
XHE: 116733267
PRET: 103480141
PFOR: 103148853
PLAI: 106946955
PMEI: 106917266
GAF: 122820467(alox12)
CVG: 107103814
CTUL: 119775005(alox12)
GMU: 124880055(alox12)
NFU: 107384708(alox15)
KMR: 108242243(alox12)
ALIM: 106526983
NWH: 119414629(alox12)
AOCE: 111564179
MCEP: 125000804(alox12)
POV: 109637629
SSEN: 122766699(alox12)
HHIP: 117751994(alox12)
HSP: 118102186(alox12)
LCF: 108879679 108895226(alox12)
SDU: 111223569
SLAL: 111667993
XGL: 120797417(alox12)
BPEC: 110170766
MALB: 109957267
BSPL: 114849198(alox12)
SASA: 100380705(lox12) 106608934
OTW: 112214522(alox12) 112259738
OMY: 110500350(alox12) 110531448
OGO: 124008639 124013533(alox12)
SALP: 111952161
SNH: 120030395 120049296(alox12)
CCLU: 121554183 121571287(alox12)
ELS: 105027651
SFM: 108922837
PKI: 111846328
AANG: 118223344(alox12)
LOC: 102685586(alox12)
ARUT: 117426941
CMK: 103190915(alox12)
RTP: 109926716
MMER: 123540522
ATEN: 116304963
XEN: 124443531
 » show all
Reference
PMID:2244907
  Authors
Yoshimoto T, Yamamoto Y, Arakawa T, Suzuki H, Yamamoto S, Yokoyama C, Tanabe T, Toh H
  Title
Molecular cloning and expression of human arachidonate 12-lipoxygenase.
  Journal
Biochem Biophys Res Commun 172:1230-5 (1990)
DOI:10.1016/0006-291X(90)91580-L
  Sequence
[hsa:239]
Reference
  Authors
Yoshimoto T, Takahashi Y
  Title
Arachidonate 12-lipoxygenases.
  Journal
Prostaglandins Other Lipid Mediat 68-69:245-62 (2002)
DOI:10.1016/S0090-6980(02)00034-5

KEGG   ORTHOLOGY: K08021
Entry
K08021                      KO                                     
Symbol
ALOX12B
Name
arachidonate 12-lipoxygenase (R-type) [EC:1.13.11.-]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
Disease
H00734  Autosomal recessive congenital ichthyosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K08021  ALOX12B; arachidonate 12-lipoxygenase (R-type)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K08021  ALOX12B; arachidonate 12-lipoxygenase (R-type)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.-
     K08021  ALOX12B; arachidonate 12-lipoxygenase (R-type)
Other DBs
RN: R07038
Genes
HSA: 242(ALOX12B)
PTR: 455103(ALOX12B)
PPS: 100972159(ALOX12B)
GGO: 101142629(ALOX12B)
PON: 100445399(ALOX12B)
NLE: 100582770
MCC: 721936(ALOX12B)
MCF: 102132971(ALOX12B)
MTHB: 126939683
CSAB: 103242337(ALOX12B)
CATY: 105581980(ALOX12B)
PANU: 101014604(ALOX12B)
TGE: 112609668(ALOX12B)
RRO: 104661677(ALOX12B)
RBB: 108514451(ALOX12B)
TFN: 117067739(ALOX12B)
PTEH: 111527094(ALOX12B)
CANG: 105523639(ALOX12B)
CJC: 100390364(ALOX12B)
SBQ: 101049382(ALOX12B)
CSYR: 103263443(ALOX12B)
MMUR: 105877312(ALOX12B)
LCAT: 123650918(ALOX12B)
PCOQ: 105819409(ALOX12B)
OGA: 100958715(ALOX12B)
MMU: 11686(Alox12b)
MCAL: 110305580(Alox12b)
MPAH: 110332252(Alox12b)
RNO: 287425(Alox12b)
MCOC: 116078134(Alox12b)
MUN: 110551703(Alox12b)
CGE: 100761707(Alox12b)
MAUA: 101838730(Alox12b)
PLEU: 114693238(Alox12b)
MORG: 121456917(Alox12b)
MFOT: 126514035
AAMP: 119813029(Alox12b)
NGI: 103752101(Alox12b)
HGL: 101708945(Alox12b)
CPOC: 100731997(Alox12b)
CCAN: 109693920(Alox12b)
DORD: 105983341(Alox12b)
DSP: 122100425(Alox12b)
NCAR: 124980267
OCU: 100342574
OPI: 101524903(ALOX12B)
TUP: 102494376(ALOX12B)
GVR: 103582097(ALOX12B)
CFA: 489486(ALOX12B)
CLUD: 112647412(ALOX12B)
VVP: 112924741(ALOX12B)
VLG: 121500377(ALOX12B)
AML: 100474976(ALOX12B)
UMR: 103660487(ALOX12B)
UAH: 113271144(ALOX12B)
UAR: 123792056(ALOX12B)
ELK: 111161187
LLV: 125087374
MPUF: 101672054(ALOX12B)
ORO: 101382607(ALOX12B)
EJU: 114225448(ALOX12B)
ZCA: 113907919(ALOX12B)
MLX: 118000185(ALOX12B)
NSU: 110584581(ALOX12B)
LWW: 102728235(ALOX12B)
FCA: 101101263(ALOX12B)
PYU: 121015960(ALOX12B)
PBG: 122484920(ALOX12B)
LRUF: 124519644
PTG: 102959978(ALOX12B)
PPAD: 109245908(ALOX12B)
AJU: 106972446(ALOX12B)
HHV: 120231357(ALOX12B)
BTA: 504803(ALOX12B)
BOM: 102276175(ALOX12B)
BIU: 109573424(ALOX12B)
BBUB: 102407781(ALOX12B)
BBIS: 104990750(ALOX12B)
CHX: 102172933(ALOX12B)
OAS: 101105929(ALOX12B)
ODA: 120866021(ALOX12B)
CCAD: 122446067(ALOX12B)
SSC: 100526246(ALOX12B)
CFR: 102517584(ALOX12B)
CBAI: 105077529(ALOX12B)
CDK: 105103063(ALOX12B)
VPC: 102528596(ALOX12B)
ECB: 100062323(ALOX12B)
EPZ: 103564280(ALOX12B)
EAI: 106844233(ALOX12B)
MYB: 102249271(ALOX12B)
MYD: 102752260(ALOX12B)
MMYO: 118672107(ALOX12B)
MLF: 102443150(ALOX12B)
MNA: 107544536(ALOX12B)
PKL: 118726789
HAI: 109395128(ALOX12B)
DRO: 112308751(ALOX12B)
SHON: 118974693
AJM: 119049052(ALOX12B)
PDIC: 114515157
PHAS: 123809339(ALOX12B)
MMF: 118634659(ALOX12B)
RFQ: 117013596
PALE: 102892957(ALOX12B)
PGIG: 120589912(ALOX12B)
PVP: 105291239(ALOX12B)
RAY: 107515649(ALOX12B)
MJV: 108383385(ALOX12B)
TOD: 119232331(ALOX12B)
SARA: 101555717
LAV: 100671589(ALOX12B)
TMU: 101348682
ETF: 101660183
DNM: 101430353(ALOX12B)
MDO: 100013747(ALOX12B)
GAS: 123244064(ALOX12B)
SHR: 100934883(ALOX12B)
PCW: 110194205(ALOX12B)
OAA: 100087885
TST: 117869932
PKI: 111845825
BBEL: 109480516
BGT: 106077849
HRJ: 124286402
 » show all
Reference
  Authors
Yoshimoto T, Takahashi Y
  Title
Arachidonate 12-lipoxygenases.
  Journal
Prostaglandins Other Lipid Mediat 68-69:245-62 (2002)
DOI:10.1016/S0090-6980(02)00034-5
  Sequence
[rno:287425]

KEGG   ORTHOLOGY: K00460
Entry
K00460                      KO                                     
Symbol
ALOX15
Name
arachidonate 15-lipoxygenase [EC:1.13.11.33]
Pathway
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map01100  Metabolic pathways
map04216  Ferroptosis
map04217  Necroptosis
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K00460  ALOX15; arachidonate 15-lipoxygenase
   00591 Linoleic acid metabolism
    K00460  ALOX15; arachidonate 15-lipoxygenase
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K00460  ALOX15; arachidonate 15-lipoxygenase
   04217 Necroptosis
    K00460  ALOX15; arachidonate 15-lipoxygenase
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K00460  ALOX15; arachidonate 15-lipoxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.33  arachidonate 15-lipoxygenase
     K00460  ALOX15; arachidonate 15-lipoxygenase
Other DBs
RN: R01593 R03626
GO: 0050473
Genes
HSA: 246(ALOX15)
PTR: 748294(ALOX15) 750581
PPS: 100990568(ALOX15)
GGO: 101130490(ALOX15) 101138809
PON: 100174413(ALOX15)
NLE: 100598410(ALOX15) 100599862
MCC: 100425071 709212(ALOX15) 713683
MCF: 102124513(ALOX15)
MTHB: 126939685 126939687
CSAB: 103242192(ALOX15) 103242262
CATY: 105583615(ALOX15) 105584566
TGE: 112609437(ALOX15) 112610174
RRO: 104673354 104677212(ALOX15)
RBB: 108514294 108520722(ALOX15)
TFN: 117067819 117067883(ALOX15)
PTEH: 111521361
CJC: 100388086(ALOX15)
SBQ: 101031385(ALOX15)
CSYR: 103253284(ALOX15)
MMUR: 105879207(ALOX15) 105879210
LCAT: 123621261(ALOX15)
PCOQ: 105822846(ALOX15)
OGA: 100953458(ALOX15)
MMU: 11687(Alox15)
MCAL: 110305643
MPAH: 110332116
RNO: 81639(Alox15)
CGE: 100764916(Alox15)
MORG: 121456877(Alox15)
MFOT: 126514012
AAMP: 119812940(Alox15)
NGI: 103752179(Alox15)
CPOC: 100719677
CCAN: 109697448(Alox15)
NCAR: 124980592
OCU: 100009114(ALOX15)
OPI: 101518498(ALOX15)
CFA: 119871841 489458(ALOX15)
CLUD: 112647513(ALOX15)
VVP: 112924802(ALOX15) 112924804
VLG: 121500376
AML: 100479002(ALOX15)
UMR: 103660453(ALOX15)
UAH: 113271093(ALOX15)
UAR: 123792173(ALOX15)
ELK: 111161195
LLV: 125087857
ORO: 101379891 101380189(ALOX15)
ZCA: 113908304
MLX: 117999977
HHV: 120227740
BTA: 282139(ALOX15)
BOM: 102285373 102285661(ALOX15)
BIU: 109574003
BBUB: 102396987 102397311(ALOX15)
BBIS: 104993943
OAS: 101116587(ALOX15)
CCAD: 122446330
SSC: 396971(ALOX15)
CBAI: 105066404(ALOX15)
CDK: 105106001
VPC: 102544743(ALOX15)
BACU: 103006231(ALOX15)
LVE: 103073785(ALOX15)
OOR: 101281563(ALOX15)
DLE: 111185975(ALOX15)
PCAD: 102986457(ALOX15)
PSIU: 116745707(ALOX15)
ECB: 100072900(ALOX15)
EPZ: 103561432(ALOX15)
EAI: 106844159(ALOX15)
MYB: 102240358
MMYO: 118672418(ALOX15)
MNA: 107528023(ALOX15)
HAI: 109394595(ALOX15)
DRO: 112308861(ALOX15)
SHON: 119001049(ALOX15)
AJM: 119043192(ALOX15)
PDIC: 114515339(ALOX15)
PHAS: 123809317(ALOX15)
MMF: 118634572(ALOX15)
RFQ: 117013821(ALOX15)
PALE: 102896986(ALOX15)
PGIG: 120607865(ALOX15)
PVP: 105291746(ALOX15)
RAY: 107509499(ALOX15)
MJV: 108386766(ALOX15)
SARA: 101547759(ALOX15)
TMU: 101359454
DNM: 101445760
MDO: 100015976(ALOX15)
GAS: 123247523
PCW: 110194258
 » show all
Reference
  Authors
Kuhn H, Walther M, Kuban RJ
  Title
Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications.
  Journal
Prostaglandins Other Lipid Mediat 68-69:263-90 (2002)
DOI:10.1016/S0090-6980(02)00035-7
Reference
PMID:3202857
  Authors
Sigal E, Craik CS, Highland E, Grunberger D, Costello LL, Dixon RA, Nadel JA
  Title
Molecular cloning and primary structure of human 15-lipoxygenase.
  Journal
Biochem Biophys Res Commun 157:457-64 (1988)
DOI:10.1016/S0006-291X(88)80271-7
  Sequence
[hsa:246]

KEGG   ORTHOLOGY: K08022
Entry
K08022                      KO                                     
Symbol
ALOX15B
Name
arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type) [EC:1.13.11.33 1.13.11.-]
Pathway
map00590  Arachidonic acid metabolism
map01100  Metabolic pathways
map04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K08022  ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K08022  ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.13  Acting on single donors with incorporation of molecular oxygen (oxygenases)
   1.13.11  With incorporation of two atoms of oxygen
    1.13.11.33  arachidonate 15-lipoxygenase
     K08022  ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
    1.13.11.-
     K08022  ALOX15B; arachidonate 15-lipoxygenase (second type) / 8-lipoxygenase (S-type)
Other DBs
RN: R01593 R07053
GO: 0050473
Genes
HSA: 247(ALOX15B)
PTR: 455104(ALOX15B)
PPS: 100971127(ALOX15B)
GGO: 101141127(ALOX15B)
PON: 100443582(ALOX15B)
NLE: 115831495
MCC: 716764(ALOX15B)
MCF: 102114788(ALOX15B)
CSAB: 103242336(ALOX15B)
CATY: 105581986(ALOX15B)
PANU: 101017215(ALOX15B)
TGE: 112609407(ALOX15B)
RRO: 104661676(ALOX15B)
RBB: 108514291(ALOX15B)
TFN: 117067740(ALOX15B)
PTEH: 111527063(ALOX15B)
CANG: 105523638(ALOX15B)
CJC: 100411880(ALOX15B)
SBQ: 101048111(ALOX15B)
CSYR: 103263441(ALOX15B)
MMUR: 105877322(ALOX15B)
LCAT: 123650917(ALOX15B)
PCOQ: 105819392(ALOX15B)
OGA: 100959028(ALOX15B)
MMU: 11688(Alox8)
MCAL: 110306013(Alox15b)
MPAH: 110332396(Alox15b)
RNO: 266604(Alox15b)
MCOC: 116077201(Alox15b)
MUN: 110551727(Alox15b)
CGE: 100754473(Alox15b)
MAUA: 101838120(Alox15b)
PLEU: 114693239(Alox15b)
MORG: 121456903(Alox15b)
MFOT: 126514045
AAMP: 119813001(Alox15b)
NGI: 103752102(Alox15b)
HGL: 101698545
CPOC: 100732272(Alox15b)
CCAN: 109693912(Alox15b)
DORD: 105983401(Alox15b)
DSP: 122100427(Alox15b)
NCAR: 124980374
OCU: 100342479
OPI: 101525136(ALOX15B)
TUP: 102494778 102495182(ALOX15B)
GVR: 103593649(ALOX15B)
CFA: 489485(ALOX15B)
CLUD: 112647413(ALOX15B)
VVP: 112924740(ALOX15B)
VLG: 121500300(ALOX15B)
AML: 100475233(ALOX15B)
UMR: 103660486(ALOX15B)
UAH: 113271172(ALOX15B)
UAR: 123792117(ALOX15B)
ELK: 111161159
LLV: 125088107
MPUF: 101672354(ALOX15B)
ORO: 101382890(ALOX15B)
EJU: 114225420(ALOX15B)
ZCA: 113907894(ALOX15B)
MLX: 117999900(ALOX15B)
NSU: 110584661(ALOX15B)
LWW: 102739995(ALOX15B)
FCA: 101101264(ALOX15B)
PYU: 121015961(ALOX15B)
PBG: 122484919(ALOX15B)
LRUF: 124519595
PTG: 102971044(ALOX15B)
PPAD: 109245909(ALOX15B)
AJU: 106972510(ALOX15B)
HHV: 120231436(ALOX15B)
BTA: 286820(ALOX15B)
BOM: 102275513(ALOX15B) 102281419
BIU: 109574498
BBUB: 102407045(ALOX15B)
CHX: 102169702
OAS: 101121185
ODA: 120866022
CCAD: 122446170
SSC: 100525835
CFR: 102517336
CBAI: 105077528(ALOX15B)
CDK: 105102997(ALOX15B) 116157868
VPC: 102528849(ALOX15B)
BACU: 102998643(ALOX15B)
LVE: 103084519(ALOX15B)
OOR: 101281720
DLE: 111185769
PCAD: 102976974(ALOX15B)
PSIU: 116745711(ALOX15B)
ECB: 100073039(ALOX15B)
EPZ: 103564283(ALOX15B)
EAI: 106844231(ALOX15B)
HAI: 109395112
PALE: 102891969
MJV: 108383388(ALOX15B)
LAV: 100671025(ALOX15B)
SHR: 100921165(ALOX15B)
CJO: 107307257
LSR: 110483683
PMOA: 120511271
PBI: 103058994
CTIG: 120305738
TSR: 106553882
VKO: 123016663
CCAR: 109045230
CAUA: 113038431
PHYP: 113541501
EEE: 113573261
LCO: 104934305
ECRA: 117954393
PPUG: 119227035
MSAM: 119895614(zgc:152891) 119898927 119914853
OAU: 120436295
NFU: 107375272
NWH: 119408041 119420756(zgc:152891)
AOCE: 111570982
MCEP: 125003249 125003265 125021475(zgc:152891)
CSEM: 103383522
POV: 109638289
SSEN: 122760060 122770688 122779805(zgc:152891)
SLAL: 111655595
MALB: 109952244
SFM: 108934212
PKI: 111852905
RTP: 109917782
SKO: 100372903
HAME: 121878425
HRF: 124143004
CRG: 117692116
MMER: 123551204
OSN: 115215551
MGR: MGG_08499
 » show all
Reference
  Authors
Kuhn H, Walther M, Kuban RJ
  Title
Mammalian arachidonate 15-lipoxygenases structure, function, and biological implications.
  Journal
Prostaglandins Other Lipid Mediat 68-69:263-90 (2002)
DOI:10.1016/S0090-6980(02)00035-7
  Sequence
[rno:266604]

DBGET integrated database retrieval system