KEGG   ORTHOLOGY: K00488
Entry
K00488                      KO                                     

Name
CYP27A1
Definition
cholestanetriol 26-monooxygenase [EC:1.14.15.15]
Pathway
ko00120  Primary bile acid biosynthesis
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
ko04979  Cholesterol metabolism
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Disease
H00151  Cerebrotendinous xanthomatosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
  09154 Digestive system
   04979 Cholesterol metabolism
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00488  CYP27A1; cholestanetriol 26-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.15  cholestanetriol 26-monooxygenase
     K00488  CYP27A1; cholestanetriol 26-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K00488  CYP27A1; cholestanetriol 26-monooxygenase
Other DBs
RN: R04806 R04807 R08505 R08758 R08759 R08760 R08761 R11142
GO: 0047749
Genes
HSA: 1593(CYP27A1)
PTR: 459951
PPS: 100989602
GGO: 101131774
PON: 100451841
NLE: 100606147
MCC: 700192(CYP27A1)
MCF: 102129822(CYP27A1)
CSAB: 103217882(CYP27A1)
CATY: 105587055
PANU: 100999256
RRO: 104660034
RBB: 108518476
TFN: 117094510
CJC: 100393783(CYP27A1)
SBQ: 101029011
MMUR: 105857702
MMU: 104086(Cyp27a1)
MCAL: 110290578
MPAH: 110322436
RNO: 301517(Cyp27a1)
MCOC: 116088582
MUN: 110566769
CGE: 100751584
PLEU: 114709306
NGI: 103727727
HGL: 101700018
CCAN: 109679372
OCU: 100348736(CYP27A1)
TUP: 102471009
CFA: 610489(CYP27A1)
VVP: 112922543
VLG: 121480575
AML: 100480153
UMR: 103662754
UAH: 113250446
ORO: 101374314
ELK: 111142401
MPUF: 101690391
EJU: 114200186
MLX: 118012034
FCA: 101091962
PTG: 102958835
PPAD: 109265055
AJU: 106970103
HHV: 120232403
BTA: 511960(CYP27A1)
BOM: 102275770
BIU: 109570716
BBUB: 102408966
CHX: 102177672
OAS: 101111528
ODA: 120854365
SSC: 100126282(CYP27A1)
CFR: 102517717
CDK: 105096090
BACU: 102999025
LVE: 103080163
OOR: 101288855
DLE: 111171838
PCAD: 102992597
ECB: 100055936(CYP27A1)
EPZ: 103567914
EAI: 106838458
MYB: 102255768
MYD: 102761397
MMYO: 118661548
MNA: 107524820
HAI: 109380589
DRO: 112307709
SHON: 118975441
AJM: 119056899
MMF: 118625177
PALE: 102883032
RAY: 107516735
MJV: 108390517
LAV: 100662261
TMU: 101347420
MDO: 100011045(CYP27A1)
SHR: 100918281
PCW: 110219429
OAA: 100093207
GGA: 431683(CYP27A1)
PCOC: 116227314
MGP: 100539204
CJO: 107317020
NMEL: 110400531
APLA: 101802865
ACYG: 106039314
TGU: 100232323
LSR: 110468382
SCAN: 103814667
PMOA: 120496874
GFR: 102036968
FAB: 101815213
PHI: 102102670
PMAJ: 107207520
CCAE: 111932181
CCW: 104693966
ETL: 114055287
FPG: 101912381
FCH: 102046779
CLV: 102085729
EGZ: 104132432
NNI: 104010100
ACUN: 113482393
PADL: 103917680
AAM: 106499073
ASN: 102377709
AMJ: 102562954
CPOO: 109322499
GGN: 109301588
CMY: 102937044
CPIC: 101943409
CABI: 116832589
ACS: 100565025
PVT: 110078231
PBI: 103054208
PMUR: 107292512
TSR: 106540772
PGUT: 117675268
PMUA: 114603027
ZVI: 118090854
XLA: 100381137(cyp27a1) 108702937 446987(XB984297.L)
DRE: 322341(cyp27a1.4) 402831(cyp27a7) 558239(si:ch211-113j14.1) 565876(si:dkey-91i10.3) 723999(zgc:136333) 795106(cyp27a1.2)
IPU: 108261037 108261972(CYP27A16) 108266301 108266489(CYP27A15) 108266490(CYP27A17) 108266491 108272717
ELY: 117249878(si:ch211-113j14.1) 117251494(si:dkey-91i10.3) 117251800
PLEP: 121949258(si:dkey-91i10.3) 121949317 121962951(si:ch211-113j14.1)
SLUC: 116033996(si:dkey-91i10.3) 116044772(si:ch211-113j14.1)
MSAM: 119900367(si:ch211-113j14.1) 119903811 119904427(si:dkey-91i10.3)
CUD: 121506513(si:ch211-113j14.1) 121522777 121522982(si:dkey-91i10.3)
OAU: 116314781(si:dkey-91i10.3) 116317150(si:ch211-113j14.1) 116334070
OML: 112154786 112155582(si:dkey-91i10.3) 112156772(si:ch211-113j14.1)
KMR: 108238813(si:dkey-91i10.3) 108244283
XGL: 120798148(si:ch211-113j14.1) 120801357(si:dkey-91i10.3) 120801379
PSPA: 121322499 121323017 121323418 121323529(si:dkey-91i10.3)
CMK: 103189020
PMAX: 117337915
ATEN: 116287947
 » show all
Reference
PMID:1708392
  Authors
Cali JJ, Russell DW
  Title
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
  Journal
J Biol Chem 266:7774-8 (1991)
  Sequence
[hsa:1593]

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