KEGG   ORTHOLOGY: K00513
Entry
K00513                      KO                                     

Symbol
CYP21A
Name
steroid 21-monooxygenase [EC:1.14.14.16]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04925  Aldosterone synthesis and secretion
map04927  Cortisol synthesis and secretion
map04934  Cushing syndrome
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  Congenital adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00513  CYP21A; steroid 21-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
   04927 Cortisol synthesis and secretion
    K00513  CYP21A; steroid 21-monooxygenase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00513  CYP21A; steroid 21-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00513  CYP21A; steroid 21-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.16  steroid 21-monooxygenase
     K00513  CYP21A; steroid 21-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP21 family
   K00513  CYP21A; steroid 21-monooxygenase
Other DBs
RN: R02213 R02838 R03326 R03784 R03849 R04675
GO: 0004509
Genes
HSA: 1589(CYP21A2)
PTR: 107973061 745345
GGO: 101147473 109023079
PON: 100461354 112131288
NLE: 100579180
MCC: 717020(CYP21A2)
MCF: 102130610
CSAB: 103221724(CYP21A2)
CATY: 105574106
PANU: 101025297
RRO: 104674109
RBB: 108519899
TFN: 117086985
PTEH: 111526288
CJC: 100395918(CYP21A2)
SBQ: 101047673
MMUR: 105858145
MMU: 13079(Cyp21a1)
MCAL: 110312588
MPAH: 110335614
RNO: 24298(Cyp21a1)
MCOC: 116074685
MUN: 110560117
CGE: 100767691
PLEU: 114705894
NGI: 103724459
HGL: 101717066
CCAN: 109689568
OCU: 100342636
OPI: 101536144
TUP: 102491327
CFA: 415124(CYP21A2)
VVP: 112913634
VLG: 121500818
AML: 100478117
UMR: 103682334
UAH: 113243763
ORO: 101381142
ELK: 111152239
MPUF: 101689319
EJU: 114222188
MLX: 118027311
FCA: 101094596
PYU: 121022330
PBG: 122478273
PTG: 102966729
PPAD: 109260501
AJU: 106983476
HHV: 120221929
BTA: 281741(CYP21)
BOM: 102267885
BIU: 109576856
CHX: 102174710
ODA: 120870583
CCAD: 122429310
SSC: 403337(CYP21A2)
CFR: 102506530
CBAI: 105074032
CDK: 105087514
BACU: 103003841
LVE: 103069558
OOR: 101278959
DLE: 111170705
PCAD: 102985160
ECB: 100059277
EPZ: 103563302
EAI: 106831008
MYB: 102254156
MMYO: 118679567
MNA: 107538945
PKL: 118705357
HAI: 109373090
DRO: 112302380
SHON: 118979545
AJM: 119053733
MMF: 118621110
PALE: 102898380
PGIG: 120618892
RAY: 107498441
MJV: 108393999
TOD: 119252239
LAV: 100658069
TMU: 101359524
MDO: 100025565
SHR: 100932451
PCW: 110199314
OAA: 100086194
GGA: 429828(CYP21A1)
PCOC: 116236742
MGP: 100538455
CJO: 107321560
NMEL: 110406665
APLA: 101794100
ACYG: 106049851
TGU: 116807644
LSR: 110478274
SCAN: 103822718
PMOA: 120505792
OTC: 121346758
PRUF: 121359571
GFR: 102042267
FAB: 101816789
PHI: 102108296
PMAJ: 107213983
CCAE: 111938931
CCW: 104683162
ETL: 114070275
EGZ: 104133716
DNE: 112981956
ASN: 112548178
AMJ: 102575314(CYP21A2)
CPIC: 101950331
CABI: 116839812
ACS: 100552382
PVT: 110090188
PBI: 103054275
PMUR: 107293207
PGUT: 117663177
PMUA: 114592264
GJA: 107107307
XLA: 447267(cyp21a2.1.L)
XTR: 100489813(cyp21a2.1)
NPR: 108786530
DRE: 793249(cyp21a2)
SRX: 107743211
SANH: 107685595
SGH: 107596711
CCAR: 109104569
CAUA: 113116301
IPU: 108261472
PHYP: 113542548
AMEX: 103037969
EEE: 113570604
TRU: 101065814
LCO: 104922752
NCC: 104966285
CGOB: 115021585
ELY: 117266380
PLEP: 121946285
SLUC: 116049375
ECRA: 117945986
PFLV: 114557620
GAT: 120811016
PPUG: 119197193
MSAM: 119897775
CUD: 121513960
MZE: 101472385
ONL: 100703376
OAU: 116319787
OLA: 101157155
OML: 112143388
XMA: 102218645
XCO: 114140790
XHE: 116716989
PRET: 103478543
CVG: 107102538
CTUL: 119772817
NFU: 107372377
ALIM: 106517731
AOCE: 111588846
CSEM: 103388483
POV: 109633161
LCF: 108885898
SDU: 111238796
SLAL: 111668816
XGL: 120784356
HCQ: 109517589
BPEC: 110171734
MALB: 109971672
SASA: 106606086
OTW: 112225325
SALP: 112079040
SNH: 120036659
ELS: 105018837
SFM: 108927404
PKI: 111839059
AANG: 118231182
PSPA: 121299051
LCM: 102346130
RTP: 109925585
 » show all
Reference
PMID:3038528 (CYP21A2)
  Authors
Rodrigues NR, Dunham I, Yu CY, Carroll MC, Porter RR, Campbell RD
  Title
Molecular characterization of the HLA-linked steroid 21-hydroxylase B gene from an individual with congenital adrenal hyperplasia.
  Journal
EMBO J 6:1653-61 (1987)
DOI:10.1002/j.1460-2075.1987.tb02414.x
  Sequence
[hsa:1589]
Reference
  Authors
Luu-The V, Pelletier G, Labrie F
  Title
Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.
  Journal
J Steroid Biochem Mol Biol 93:269-76 (2005)
DOI:10.1016/j.jsbmb.2005.01.003

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