KEGG   ORTHOLOGY: K00562
Entry
K00562                      KO                                     
Symbol
INMT, TEMT
Name
methyltransferase [EC:2.1.1.49 2.1.1.96]
Pathway
map00380  Tryptophan metabolism
map00450  Selenocompound metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00380 Tryptophan metabolism
    K00562  INMT, TEMT; methyltransferase
  09106 Metabolism of other amino acids
   00450 Selenocompound metabolism
    K00562  INMT, TEMT; methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.49  amine N-methyltransferase
     K00562  INMT, TEMT; methyltransferase
    2.1.1.96  thioether S-methyltransferase
     K00562  INMT, TEMT; methyltransferase
Other DBs
RN: R02174 R02910 R09370
GO: 0030748 0004790
Genes
HSA: 11185(INMT)
PTR: 463912(INMT)
PPS: 100986665(INMT)
GGO: 101143120(INMT)
PON: 100171421(INMT)
NLE: 100603670(INMT)
MCC: 694969(INMT)
MCF: 102139220(INMT)
CSAB: 103226272(INMT)
CATY: 105596176(INMT)
PANU: 100998123(INMT)
TGE: 112620035(INMT)
RRO: 104663737(INMT)
RBB: 108532381(INMT)
PTEH: 111522205(INMT)
CJC: 100387750(INMT)
SBQ: 101035075(INMT)
CSYR: 103254460(INMT)
MMUR: 105855099(INMT)
OGA: 100957733(INMT)
MMU: 21743(Inmt)
MCAL: 110296762(Inmt)
MPAH: 110317265(Inmt)
RNO: 368066(Inmt)
MCOC: 116098126(Inmt)
MUN: 110555148(Inmt)
CGE: 100773805(Inmt)
PLEU: 114689706(Inmt)
NGI: 103729450(Inmt)
HGL: 101710622(Inmt) 106008943
CPOC: 100724009
OCU: 100008695(INMT) 100338404
TUP: 102502473(INMT)
ORO: 105758206(INMT)
BTA: 527922(INMT)
BOM: 102270640(INMT)
BIU: 109557473(INMT)
BBUB: 102411712(INMT)
CHX: 102186084
OAS: 101123289
ODA: 120877395(INMT)
CCAD: 122438422(INMT)
SSC: 100512997(INMT)
CBAI: 105081898(INMT) 105082129
VPC: 102537199(INMT)
BACU: 103019292
LVE: 103070876
OOR: 101284322(INMT)
DLE: 111180005(INMT)
PCAD: 102980842(INMT)
PSIU: 116759859(INMT)
ECB: 100055070
EPZ: 103541247(INMT)
EAI: 106830978 106831065(INMT)
MNA: 107544372(INMT)
MJV: 108403655(INMT)
SARA: 101538793(INMT) 101539242
LAV: 100671921(INMT)
TMU: 101350596
DNM: 101412422(INMT)
OAA: 100081148(INMT)
ACS: 100553677
XTR: 100491548 496676(nnmt) 548447 594924(inmt)
SKO: 100367711
DSV: 119434542
MYI: 110462853
PMAX: 117341599
ADF: 107342266
AMIL: 114946916
PDAM: 113682356
 » show all
Reference
  Authors
Thompson MA, Moon E, Kim UJ, Xu J, Siciliano MJ, Weinshilboum RM
  Title
Human indolethylamine N-methyltransferase: cDNA cloning and expression, gene cloning, and chromosomal localization.
  Journal
Genomics 61:285-97 (1999)
DOI:10.1006/geno.1999.5960
  Sequence
[hsa:11185]

KEGG   ENZYME: 2.1.1.96
Entry
EC 2.1.1.96                 Enzyme                                 
Name
thioether S-methyltransferase;
S-adenosyl-L-methionine:thioether S-methyltransferase;
thioether methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium [RN:R02572]
Reaction(KEGG)
R02572;
(other) R09370
Substrate
S-adenosyl-L-methionine [CPD:C00019];
dimethyl sulfide [CPD:C00580]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
trimethylsulfonium [CPD:C01008]
Comment
Also acts on dimethyl selenide, dimethyl telluride, diethyl sulfide, 1,4-dithiane and many other thioethers.
History
EC 2.1.1.96 created 1990
Pathway
ec00450  Selenocompound metabolism
Orthology
K00562  methyltransferase
Genes
HSA11185(INMT)
PTR463912(INMT)
PPS100986665(INMT)
GGO101143120(INMT)
PON100171421(INMT)
NLE100603670(INMT)
MCC694969(INMT)
MCF102139220(INMT)
CSAB103226272(INMT)
CATY105596176(INMT)
PANU100998123(INMT)
TGE112620035(INMT)
RRO104663737(INMT)
RBB108532381(INMT)
PTEH111522205(INMT)
CJC100387750(INMT)
SBQ101035075(INMT)
CSYR103254460(INMT)
MMUR105855099(INMT)
OGA100957733(INMT)
MMU21743(Inmt)
MCAL110296762(Inmt)
MPAH110317265(Inmt)
RNO368066(Inmt)
MCOC116098126(Inmt)
MUN110555148(Inmt)
CGE100773805(Inmt)
PLEU114689706(Inmt)
NGI103729450(Inmt)
HGL101710622(Inmt) 106008943
CPOC100724009
OCU100008695(INMT) 100338404
OPI101526879 101531959
TUP102502473(INMT)
ORO105758206(INMT)
BTA527922(INMT)
BOM102270640(INMT)
BIU109557473(INMT)
BBUB102411712(INMT)
CHX102186084
OAS101123289
ODA120877395(INMT)
CCAD122438422(INMT)
SSC100512997(INMT)
CFR102503927 102504745
CBAI105081898(INMT) 105082129
CDK105095849 105106408 116154033
VPC102537199(INMT)
BACU103019292
LVE103070876
OOR101284322(INMT)
DLE111180005(INMT)
PCAD102980842(INMT)
PSIU116759859(INMT)
ECB100055070
EPZ103541247(INMT)
EAI106830978 106831065(INMT)
MNA107544372(INMT)
MJV108403655(INMT)
TOD119244139 119249740
SARA101538793(INMT) 101539242
LAV100671921(INMT)
TMU101350596
DNM101412422(INMT)
OAA100081148(INMT)
ACS100553677
XLA108696501 108696502 108697004 108697006 108699501 379432(nnmt.L) 399013(inmt.L)
XTR100491548 496676(nnmt) 548447 594924(inmt)
NPR108799420 108799728 108799731
RTEM120915490 120915491 120915492 120915493 120915505 120915524 120926873 120926876
BBUF120996795 120996849 120999241
BGAR122926837 122928942
BBEL109468493 109478432 109485111
SKO100367711
ISCIscW_ISCW001554 IscW_ISCW007034
DSV119434542
CSCU111615693 111641734
SDM118188870 118205359
NAINECAME_02876
GAE121366614 121377222 121378382 121378383 121378452 121379017 121379235
HRF124132441 124145666
HRJ124258498 124265701 124265717
MYI110462853
PMAX117341599
LAK106157416 106157421 106157433 106157912 106157913 106157914 106162346 106165307 106170527 106180314 106181959
ADF107342266
AMIL114946916
PDAM113682356
PBWD172_003270
 » show all
Reference
1  [PMID:3350800]
  Authors
Mozier NM, McConnell KP, Hoffman JL.
  Title
S-adenosyl-L-methionine:thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism.
  Journal
J Biol Chem 263:4527-31 (1988)
  Sequence
[mmu:21743]
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.96
IUBMB Enzyme Nomenclature: 2.1.1.96
ExPASy - ENZYME nomenclature database: 2.1.1.96
BRENDA, the Enzyme Database: 2.1.1.96
CAS: 114797-02-3

KEGG   REACTION: R09370
Entry
R09370                      Reaction                               
Name
S-adenosyl-L-methionine:dimethyl-selenide Se-methyltransferase
Definition
S-Adenosyl-L-methionine + Dimethyl selenide <=> S-Adenosyl-L-homocysteine + Trimethylselenonium
Equation
Reaction class
RC00003  C00019_C00021
RC02501  C02535_C18872
Enzyme
Pathway
rn00450  Selenocompound metabolism
Orthology
K00562  methyltransferase [EC:2.1.1.49 2.1.1.96]

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