KEGG   ORTHOLOGY: K00587
Entry
K00587                      KO                                     
Symbol
ICMT, STE14
Name
protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100]
Pathway
map00900  Terpenoid backbone biosynthesis
map01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K00587  ICMT, STE14; protein-S-isoprenylcysteine O-methyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.100  protein-S-isoprenylcysteine O-methyltransferase
     K00587  ICMT, STE14; protein-S-isoprenylcysteine O-methyltransferase
Other DBs
RN: R04496
COG: COG2020
GO: 0004671
Genes
HSA: 23463(ICMT)
PTR: 469782(ICMT)
PPS: 100978940(ICMT)
GGO: 101151352(ICMT)
PON: 100456656(ICMT)
NLE: 100583818(ICMT)
MCC: 702925(ICMT)
MCF: 102143064(ICMT)
CSAB: 103225698(ICMT)
CATY: 105580946(ICMT)
PANU: 101007709(ICMT)
TGE: 112623656(ICMT)
RRO: 104657578(ICMT)
RBB: 108517923(ICMT)
TFN: 117093405(ICMT)
PTEH: 111544672(ICMT)
CJC: 100407809(ICMT)
SBQ: 101033335(ICMT)
CSYR: 103252564(ICMT)
MMUR: 105886119(ICMT)
LCAT: 123634554(ICMT)
OGA: 100944414(ICMT)
MMU: 57295(Icmt)
MCAL: 110292612(Icmt)
MPAH: 110323024(Icmt)
RNO: 170818(Icmt)
MCOC: 116097095(Icmt)
MUN: 110552727(Icmt)
CGE: 100765763(Icmt)
MAUA: 101844941(Icmt)
PLEU: 114702613(Icmt)
MORG: 121448923(Icmt)
MFOT: 126508181
AAMP: 119816841(Icmt) 119826071
NGI: 103725122(Icmt)
HGL: 101708049(Icmt)
CPOC: 100725749(Icmt)
CCAN: 109688359(Icmt)
DORD: 105997258(Icmt)
DSP: 122102217(Icmt)
NCAR: 124967394
OCU: 100354959(ICMT)
TUP: 102481076(ICMT)
CFA: 489628(ICMT)
CLUD: 112646932(ICMT)
VVP: 112924563(ICMT)
VLG: 121499987(ICMT)
AML: 100473805(ICMT)
UMR: 103666895(ICMT)
UAH: 113270577(ICMT)
UAR: 123796154(ICMT)
ELK: 111154890
LLV: 125097842
MPUF: 101694273(ICMT)
ORO: 101378501(ICMT)
EJU: 114213274(ICMT)
ZCA: 113931985(ICMT)
MLX: 118020069(ICMT)
NSU: 110574629(ICMT)
FCA: 101093374(ICMT)
PYU: 121019904(ICMT)
PBG: 122479858(ICMT)
LRUF: 124515556
PTG: 102972150(ICMT)
PPAD: 109274017(ICMT)
AJU: 106982168(ICMT)
HHV: 120245986(ICMT)
BTA: 785548(ICMT)
BOM: 102284128(ICMT)
BIU: 109570158(ICMT)
BBUB: 102389281(ICMT)
CHX: 102181140(ICMT)
OAS: 101117687(ICMT)
ODA: 120880137(ICMT)
CCAD: 122451927(ICMT)
SSC: 100514410(ICMT)
CFR: 102506005(ICMT)
CBAI: 105071018(ICMT)
CDK: 105104720(ICMT)
VPC: 102541081(ICMT)
BACU: 102998274(ICMT)
LVE: 103075548(ICMT)
OOR: 101269224(ICMT)
DLE: 111187160(ICMT)
PCAD: 102984361(ICMT) 112067426
PSIU: 116752747(ICMT)
ECB: 100059680(ICMT)
EPZ: 103558992(ICMT)
EAI: 106844258(ICMT)
MYB: 102243859(ICMT)
MYD: 102752083(ICMT)
MMYO: 118676320 118676598(ICMT)
MLF: 102422066(ICMT)
MNA: 107538334(ICMT)
PKL: 118731986(ICMT)
HAI: 109392161(ICMT)
DRO: 112299056(ICMT)
SHON: 118998146(ICMT)
AJM: 119055943(ICMT)
PDIC: 114496260(ICMT)
PHAS: 123831688(ICMT)
MMF: 118626903(ICMT)
RFQ: 117027188(ICMT)
PALE: 102888174(ICMT)
PGIG: 120585878(ICMT)
PVP: 111744846(ICMT)
RAY: 107521009(ICMT)
MJV: 108393173(ICMT)
TOD: 119236063(ICMT)
SARA: 101544947(ICMT)
LAV: 100667691(ICMT)
TMU: 101352144
DNM: 101419305(ICMT)
MDO: 100026574(ICMT)
GAS: 123243071(ICMT)
SHR: 100922116(ICMT)
PCW: 110200025(ICMT)
OAA: 100082737(ICMT)
GGA: 419373(ICMT)
PCOC: 116242512(ICMT)
CJO: 107323474(ICMT)
NMEL: 110408696(ICMT)
APLA: 101796351(ICMT)
ACYG: 106047254(ICMT)
AFUL: 116497718(ICMT)
TGU: 100226385(ICMT)
LSR: 110472535(ICMT)
SCAN: 103820933(ICMT)
PMOA: 120511058(ICMT)
OTC: 121344109(ICMT)
PRUF: 121358410(ICMT)
GFR: 102035025(ICMT)
FAB: 101807717(ICMT)
PHI: 102099231(ICMT)
PMAJ: 107213586(ICMT)
CCAE: 111938471(ICMT)
CCW: 104693277(ICMT)
CBRC: 103616146(ICMT)
ETL: 114060109(ICMT)
ZAB: 102070022(ICMT)
FPG: 101917928(ICMT)
FCH: 102051478(ICMT)
CLV: 102091468(ICMT)
EGZ: 104132051(ICMT)
NNI: 104009029(ICMT)
PLET: 104618601(ICMT)
ACUN: 113487801(ICMT)
TALA: 104364211(ICMT)
PADL: 103916263(ICMT)
AFOR: 103894757(ICMT)
ACHC: 115342665(ICMT)
CCRI: 104167445(ICMT)
CSTI: 104554373(ICMT)
EHS: 104509644(ICMT)
MNB: 103771570(ICMT)
OHA: 104333813(ICMT)
NNT: 104400155(ICMT)
DPUB: 104309939(ICMT)
PGUU: 104461502(ICMT)
AAM: 106492669(ICMT)
AROW: 112975500(ICMT)
NPD: 112957483(ICMT)
TGT: 104570537(ICMT)
DNE: 112991764(ICMT)
SCAM: 104141970(ICMT)
ASN: 102370476(ICMT)
AMJ: 102558543(ICMT)
CPOO: 109314482(ICMT)
GGN: 109293594(ICMT)
PSS: 102445166(ICMT)
CMY: 102930965(ICMT)
CPIC: 101940078(ICMT)
TST: 117867781(ICMT)
CABI: 116815420(ICMT)
MRV: 120387722(ICMT)
PVT: 110082455(ICMT)
SUND: 121937010(ICMT)
PBI: 103060255(ICMT)
PMUR: 107284654(ICMT)
CTIG: 120318978(ICMT)
PGUT: 117669638(ICMT)
VKO: 123017967(ICMT)
PMUA: 114602348(ICMT)
ZVI: 118087273(ICMT)
GJA: 107126275(ICMT)
STOW: 125445995(ICMT)
XLA: 108696603(icmt.L) 397717(icmt.S)
XTR: 100127802(icmt)
NPR: 108783712(ICMT)
RTEM: 120915759(ICMT)
BBUF: 120998790(ICMT)
BGAR: 122928865(ICMT)
DRE: 550281(icmt)
PPRM: 120463500(icmt)
MAMB: 125259798(icmt)
IPU: 100528610(icmt)
PHYP: 113530714(icmt)
TFD: 113658308(icmt)
AMEX: 103047473(icmt)
EEE: 113570032(icmt)
TRU: 101073203(icmt)
LCO: 104939109(icmt)
NCC: 104943661(icmt)
CGOB: 115018211(icmt)
ELY: 117258868(icmt)
EFO: 125892034(icmt)
PLEP: 121947023(icmt)
SLUC: 116058806(icmt)
ESP: 116691947(icmt)
PFLV: 114559062(icmt)
GAT: 120829231(icmt)
PPUG: 119200286 119222321(icmt)
MSAM: 119904980(icmt)
CUD: 121516989(icmt)
ALAT: 119023396(icmt)
MZE: 101470789(icmt)
ONL: 100700130(icmt)
OAU: 116330569(icmt)
OLA: 101174897(icmt)
OML: 112140878(icmt)
XMA: 102236165(icmt)
XCO: 114142415(icmt)
XHE: 116721390(icmt)
PRET: 103466978(icmt)
PFOR: 103154230(icmt)
PLAI: 106960222(icmt)
PMEI: 106931530(icmt)
CVG: 107100394(icmt)
CTUL: 119799191(icmt)
GMU: 124868374(icmt)
NFU: 107391379(icmt)
KMR: 108250891(icmt)
ALIM: 106529330(icmt)
NWH: 119417217(icmt)
AOCE: 111574444(icmt)
MCEP: 125004055(icmt)
CSEM: 103384860(icmt)
POV: 109630969(icmt)
SSEN: 122777803(icmt)
HHIP: 117765161(icmt)
HSP: 118111296(icmt)
LCF: 108900467
SDU: 111233790(icmt)
SLAL: 111658859(icmt)
XGL: 120804059(icmt)
HCQ: 109528364(icmt)
BPEC: 110165621(icmt)
MALB: 109951050(icmt)
BSPL: 114858333(icmt)
OTW: 112222082(icmt) 112233080
ELS: 105013890
SFM: 108918346 108933493(icmt)
AANG: 118207805(icmt) 118211252
LOC: 102685779(icmt)
RTP: 109931576(rpl22)
BFO: 118431059
BBEL: 109472678
CIN: 100180736
SPU: 590850
APLC: 110990580
SKO: 100367732
DME: Dmel_CG11268(ste14)
DER: 6544938
DSE: 6605523
DSI: Dsimw501_GD14422(Dsim_GD14422)
DAN: 6507260
DSR: 110177511
DPO: 4812848
DPE: 6595775
DMN: 108152572
DWI: 6639514
DGR: 6570380
DAZ: 108614435
DNV: 108651467
DHE: 111597308
CCAT: 101450435
BOD: 106621990
RZE: 108361649
MDE: 101892329
SCAC: 106087994
LCQ: 111677116
LSQ: 119604556
ACOZ: 120948412
AARA: 120893420
ASTE: 118507624
AAG: 5575637
CPII: 120423827
CNS: 116342292
BCOO: 119084221
AME: 726380
ACER: 108001668
ALAB: 122717175
BIM: 100742012
BBIF: 117217135
BVK: 117242531
BVAN: 117154608
BTER: 100643105
BPYO: 122576588
CCAL: 108622574
OBB: 114879958
MGEN: 117220994
NMEA: 116425955
CGIG: 122401739
SOC: 105197150
MPHA: 105837712
AEC: 105145975
ACEP: 105622214
PBAR: 105429358
VEM: 105560211
HST: 105185274
DQU: 106746204
CFO: 105256735
LHU: 105671850
PGC: 109855265
OBO: 105279718
PCF: 106788840
PFUC: 122525092
VPS: 122627853
NVI: 100120654(Icmt)
CSOL: 105360746
TPRE: 106652321
MDL: 103575965
CGLO: 123261701
FAS: 105265777
DAM: 107040639
AGIF: 122858716
LHT: 122507862
CCIN: 107270344
TCA: 663323
DPA: 109539963
SOY: 115886443
ATD: 109601490
CSET: 123311034
AGB: 108915954
NVL: 108569044
APLN: 108733056
PPYR: 116170419
OTU: 111424757
BMOR: 101739673
BMAN: 114240968
MSEX: 115447058
BANY: 112046477
NIQ: 126774060
PMAC: 106710357
PPOT: 106108761
PXU: 106119613
PRAP: 110997181
ZCE: 119838733
HAW: 110383716
HZE: 124637727
TNL: 113501825
SLIU: 111347843
OFU: 114363522
PXY: 105384312
API: 100164090
DNX: 107163542
AGS: 114119728
RMD: 113554961
BTAB: 109038542
CLEC: 106671913
HHAL: 106686637
NLU: 111044299
FOC: 113211424
TPAL: 117643237
ZNE: 110832892
FCD: 110846976
DMK: 116918802
PVM: 113806295
PJA: 122242322
PCHN: 125038725
HAME: 121871045
PCLA: 123759702
PTRU: 123510510
HAZT: 108667756
EAF: 111717850
LSM: 121131769
DSV: 119446832
RSAN: 119389353
RMP: 119183758
VJA: 111261737
TUT: 107363991
DPTE: 113791187
DFR: 124498315
CSCU: 111625561
PTEP: 107442040
SDM: 118183229
CEL: CELE_F21F3.3(icmt-1) CELE_M01E11.1(M01E11.1)
CBR: CBG_14895
BMY: BM_BM18573(Bm18573)
TSP: Tsp_01153
PCAN: 112557095
BGT: 106056057
GAE: 121390182
HRF: 124152486
HRJ: 124287477
CRG: 105346111
MYI: 110462725
PMAX: 117345408
MMER: 123528284
OBI: 106868383
OSN: 115224886
LAK: 106174929
EPA: 110237603
ATEN: 116308219
ADF: 107355711
AMIL: 114967500
PDAM: 113680524
SPIS: 111345496
DGT: 114518340
XEN: 124444777
HMG: 100212062
AQU: 100636862
ATH: AT5G08335(ATSTE14B) AT5G23320(STE14A)
BOE: 106336082
THJ: 104800704
CPAP: 110814012
CIT: 102617349
GMX: 100784645
GSJ: 114390988
VRA: 106764479
VAR: 108344723
VUN: 114181981
CCAJ: 109812098
APRC: 113867750
MTR: 25496684
CAM: 101506180
LJA: Lj0g3v0167899.1(Lj0g3v0167899.1) Lj2g3v1717600.1(Lj2g3v1717600.1) Lj5g3v2246100.1(Lj5g3v2246100.1)
ADU: 107490573
AIP: 107644074
FVE: 101310986
RCN: 112197795
PPER: 18790090
PMUM: 103321092
PAVI: 110754619
PDUL: 117629876
PXB: 103943223
ZJU: 107412754
CSV: 101223195
CMO: 103499053
JCU: 105648964
MESC: 110620247
TWL: 119991566
SLY: 101267014
SPEN: 107015732
SOT: 102586096
SSTN: 125855577
CANN: 107870370
NSY: 104239723
NTO: 104120910
NAU: 109210243
INI: 109160050
SIND: 105168244
ECAD: 122607575
NNU: 104612300
TSS: 122655985
NCOL: 116246138
OSA: 4336894
OBR: 102707769
BDI: 100846368
ATS: 109739451
SBI: 8085675
ZMA: 100284671
SITA: 101778469
SVS: 117864316
PHAI: 112901019
MUS: 103991185
DCT: 110111382
PEQ: 110024627
ATR: 18435584
PPP: 112280103
APRO: F751_1413
MIS: MICPUN_58408(ICMT)
MPP: MICPUCDRAFT_15590(ICMT)
SCE: YDR410C(STE14)
SEUB: DI49_0584
ERC: Ecym_5461
KMX: KLMA_30652(STE14)
NCS: NCAS_0A12100(NCAS0A12100)
NDI: NDAI_0A04160(NDAI0A04160)
TPF: TPHA_0E02030(TPHA0E02030)
TBL: TBLA_0A06820(TBLA0A06820)
TDL: TDEL_0A03740(TDEL0A03740)
KAF: KAFR_0E03400(KAFR0E03400)
KNG: KNAG_0C04460(KNAG0C04460)
CAL: CAALFM_C601120CA(CaO19.119) CAALFM_C601130WA(CaO19.120)
NCR: NCU00034
MGR: MGG_05331
SSCK: SPSK_02638
MAW: MAC_07177
MAJ: MAA_07087
CMT: CCM_05030
MBE: MBM_04463
ANI: AN6162.2
ANG: ANI_1_1694104(An12g03660)
ABE: ARB_04882
TVE: TRV_06581
SPO: SPAC10F6.12c(mam4)
CNE: CNC01050
CNB: CNBC6220
TASA: A1Q1_04488
SCM: SCHCO_02687541(SCHCODRAFT_02687541)
MGL: MGL_0263
MRT: MRET_1048
DDI: DDB_G0272799(icmA-1) DDB_G0273995(icmA-2)
EHI: EHI_006100(83.t00023) EHI_045150(3.t00074)
SMIN: v1.2.027086.t1(symbB.v1.2.027086.t1) v1.2.037642.t1(symbB.v1.2.037642.t1)
SPAR: SPRG_05716
XCC: XCC0107
XCB: XC_0112
XCP: XCR_0125
XOM: XOO0023(XOO0023)
XOO: XOO0023(STE14)
 » show all
Reference
PMID:8289819
  Authors
Sapperstein S, Berkower C, Michaelis S
  Title
Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export.
  Journal
Mol Cell Biol 14:1438-49 (1994)
DOI:10.1128/MCB.14.2.1438
  Sequence
[sce:YDR410C]
Reference
  Authors
Chen Y, McQuade KJ, Guan XJ, Thomason PA, Wert MS, Stock JB, Cox EC
  Title
Isoprenylcysteine carboxy methylation is essential for development in Dictyostelium discoideum.
  Journal
Mol Biol Cell 18:4106-18 (2007)
DOI:10.1091/mbc.E06-11-1006
  Sequence
Reference
  Authors
Huizinga DH, Omosegbon O, Omery B, Crowell DN
  Title
Isoprenylcysteine methylation and demethylation regulate abscisic acid signaling in Arabidopsis.
  Journal
Plant Cell 20:2714-28 (2008)
DOI:10.1105/tpc.107.053389
  Sequence

KEGG   ORTHOLOGY: K15889
Entry
K15889                      KO                                     
Symbol
PCME
Name
prenylcysteine alpha-carboxyl methylesterase [EC:3.1.1.-]
Pathway
map00900  Terpenoid backbone biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00900 Terpenoid backbone biosynthesis
    K15889  PCME; prenylcysteine alpha-carboxyl methylesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.-
     K15889  PCME; prenylcysteine alpha-carboxyl methylesterase
Other DBs
RN: R09846
GO: 0010296
Genes
ATH: AT1G26120(ICME-LIKE1) AT3G02410(ICME-LIKE2) AT5G15860(PCME)
ALY: 9309814 9318295 9326739
CRB: 17884187 17893037 17899967
CSAT: 104705870 104735610 104741260 104744314 104756931 104763804 104764554 104769834 104776676
EUS: EUTSA_v10007556mg EUTSA_v10013599mg EUTSA_v10020771mg
BRP: 103835473 103840600 103851010 103870917
BNA: 106347140 106361851 106361919 106368235 106382866 106390403 106401324
BOE: 106292436 106293466 106295414 106322601 106331625
RSZ: 108807970 108819585 108829064 108835250 108837247 108863159
THJ: 104820970 104821972
TCC: 18610569
LJA: Lj0g3v0108279.1(Lj0g3v0108279.1) Lj0g3v0108279.2(Lj0g3v0108279.2) Lj0g3v0115339.1(Lj0g3v0115339.1)
TSS: 122665347
DOSA: Os01t0642000-01(Os01g0642000) Os05t0577200-01(Os05g0577200) Os06t0708100-01(Os06g0708100)
DCT: 110115872
PEQ: 110037285
AOF: 109829020
ATR: 18439467
APRO: F751_2712
SMIN: v1.2.004372.t1(symbB.v1.2.004372.t1)
SPAR: SPRG_13991
 » show all
Reference
  Authors
Deem AK, Bultema RL, Crowell DN
  Title
Prenylcysteine methylesterase in Arabidopsis thaliana.
  Journal
Gene 380:159-66 (2006)
DOI:10.1016/j.gene.2006.05.023
  Sequence
[ath:AT5G15860]

KEGG   ENZYME: 2.1.1.100
Entry
EC 2.1.1.100                Enzyme                                 
Name
protein-S-isoprenylcysteine O-methyltransferase;
farnesyl cysteine C-terminal methyltransferase;
farnesyl-protein carboxymethyltransferase;
protein C-terminal farnesylcysteine O-methyltransferase;
farnesylated protein C-terminal O-methyltransferase;
isoprenylated protein methyltransferase;
prenylated protein methyltransferase;
protein S-farnesylcysteine C-terminal methyltransferase;
S-farnesylcysteine methyltransferase;
prenylcysteine carboxylmethyltransferase [misleading];
prenylcysteine carboxymethyltransferase [misleading];
prenylcysteine methyltransferase
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester [RN:R04496]
Reaction(KEGG)
R04496
Substrate
S-adenosyl-L-methionine [CPD:C00019];
protein C-terminal S-farnesyl-L-cysteine [CPD:C04506]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
protein C-terminal S-farnesyl-L-cysteine methyl ester [CPD:C04748]
Comment
C-terminal S-geranylgeranylcysteine and S-geranylcysteine residues are also methylated, but more slowly.
History
EC 2.1.1.100 created 1992 (EC 2.1.1.24 created 1972, modified 1983, modified 1989, part incorporated 1992)
Pathway
ec00900  Terpenoid backbone biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K00587  protein-S-isoprenylcysteine O-methyltransferase
Genes
HSA23463(ICMT)
PTR469782(ICMT)
PPS100978940(ICMT)
GGO101151352(ICMT)
PON100456656(ICMT)
NLE100583818(ICMT)
MCC702925(ICMT)
MCF102143064(ICMT)
CSAB103225698(ICMT)
CATY105580946(ICMT)
PANU101007709(ICMT)
TGE112623656(ICMT)
RRO104657578(ICMT)
RBB108517923(ICMT)
TFN117093405(ICMT)
PTEH111544672(ICMT)
CJC100407809(ICMT)
SBQ101033335(ICMT)
CSYR103252564(ICMT)
MMUR105886119(ICMT)
LCAT123634554(ICMT)
OGA100944414(ICMT)
MMU57295(Icmt)
MCAL110292612(Icmt)
MPAH110323024(Icmt)
RNO170818(Icmt)
MCOC116097095(Icmt)
MUN110552727(Icmt)
CGE100765763(Icmt)
MAUA101844941(Icmt)
PLEU114702613(Icmt)
MORG121448923(Icmt)
MFOT126508181
AAMP119816841(Icmt) 119826071
NGI103725122(Icmt)
HGL101708049(Icmt)
CPOC100725749(Icmt)
CCAN109688359(Icmt)
DORD105997258(Icmt)
DSP122102217(Icmt)
NCAR124967394
OCU100354959(ICMT)
TUP102481076(ICMT)
CFA489628(ICMT)
CLUD112646932(ICMT)
VVP112924563(ICMT)
VLG121499987(ICMT)
AML100473805(ICMT)
UMR103666895(ICMT)
UAH113270577(ICMT)
UAR123796154(ICMT)
ELK111154890
LLV125097842
MPUF101694273(ICMT)
ORO101378501(ICMT)
EJU114213274(ICMT)
ZCA113931985(ICMT)
MLX118020069(ICMT)
NSU110574629(ICMT)
FCA101093374(ICMT)
PYU121019904(ICMT)
PBG122479858(ICMT)
LRUF124515556
PTG102972150(ICMT)
PPAD109274017(ICMT)
AJU106982168(ICMT)
HHV120245986(ICMT)
BTA785548(ICMT)
BOM102284128(ICMT)
BIU109570158(ICMT)
BBUB102389281(ICMT)
CHX102181140(ICMT)
OAS101117687(ICMT)
ODA120880137(ICMT)
CCAD122451927(ICMT)
SSC100514410(ICMT)
CFR102506005(ICMT)
CBAI105071018(ICMT)
CDK105104720(ICMT)
VPC102541081(ICMT)
BACU102998274(ICMT)
LVE103075548(ICMT)
OOR101269224(ICMT)
DLE111187160(ICMT)
PCAD102984361(ICMT) 112067426
PSIU116752747(ICMT)
ECB100059680(ICMT)
EPZ103558992(ICMT)
EAI106844258(ICMT)
MYB102243859(ICMT)
MYD102752083(ICMT)
MMYO118676320 118676598(ICMT)
MLF102422066(ICMT)
MNA107538334(ICMT)
PKL118731986(ICMT)
HAI109392161(ICMT)
DRO112299056(ICMT)
SHON118998146(ICMT)
AJM119055943(ICMT)
PDIC114496260(ICMT)
PHAS123831688(ICMT)
MMF118626903(ICMT)
RFQ117027188(ICMT)
PALE102888174(ICMT)
PGIG120585878(ICMT)
PVP111744846(ICMT)
RAY107521009(ICMT)
MJV108393173(ICMT)
TOD119236063(ICMT)
SARA101544947(ICMT)
LAV100667691(ICMT)
TMU101352144
DNM101419305(ICMT)
MDO100026574(ICMT)
GAS123243071(ICMT)
SHR100922116(ICMT)
PCW110200025(ICMT)
OAA100082737(ICMT)
GGA419373(ICMT)
PCOC116242512(ICMT)
CJO107323474(ICMT)
NMEL110408696(ICMT)
APLA101796351(ICMT)
ACYG106047254(ICMT)
AFUL116497718(ICMT)
TGU100226385(ICMT)
LSR110472535(ICMT)
SCAN103820933(ICMT)
PMOA120511058(ICMT)
OTC121344109(ICMT)
PRUF121358410(ICMT)
GFR102035025(ICMT)
FAB101807717(ICMT)
PHI102099231(ICMT)
PMAJ107213586(ICMT)
CCAE111938471(ICMT)
CCW104693277(ICMT)
CBRC103616146(ICMT)
ETL114060109(ICMT)
ZAB102070022(ICMT)
FPG101917928(ICMT)
FCH102051478(ICMT)
CLV102091468(ICMT)
EGZ104132051(ICMT)
NNI104009029(ICMT)
PLET104618601(ICMT)
ACUN113487801(ICMT)
TALA104364211(ICMT)
PADL103916263(ICMT)
AFOR103894757(ICMT)
ACHC115342665(ICMT)
CCRI104167445(ICMT)
CSTI104554373(ICMT)
EHS104509644(ICMT)
MNB103771570(ICMT)
OHA104333813(ICMT)
NNT104400155(ICMT)
DPUB104309939(ICMT)
PGUU104461502(ICMT)
AAM106492669(ICMT)
AROW112975500(ICMT)
NPD112957483(ICMT)
TGT104570537(ICMT)
DNE112991764(ICMT)
SCAM104141970(ICMT)
ASN102370476(ICMT)
AMJ102558543(ICMT)
CPOO109314482(ICMT)
GGN109293594(ICMT)
PSS102445166(ICMT)
CMY102930965(ICMT)
CPIC101940078(ICMT)
TST117867781(ICMT)
CABI116815420(ICMT)
MRV120387722(ICMT)
PVT110082455(ICMT)
SUND121937010(ICMT)
PBI103060255(ICMT)
PMUR107284654(ICMT)
CTIG120318978(ICMT)
PGUT117669638(ICMT)
VKO123017967(ICMT)
PMUA114602348(ICMT)
ZVI118087273(ICMT)
GJA107126275(ICMT)
STOW125445995(ICMT)
XLA108696603(icmt.L) 397717(icmt.S)
XTR100127802(icmt)
NPR108783712(ICMT)
RTEM120915759(ICMT)
BBUF120998790(ICMT)
BGAR122928865(ICMT)
DRE550281(icmt)
SRX107712690 107737573
SANH107687399 107703075
SGH107591113 107593379
CCAR109055075 109090473
CAUA113068376 113068872
PPRM120463500(icmt)
MAMB125259798(icmt)
IPU100528610(icmt)
PHYP113530714(icmt)
TFD113658308(icmt)
AMEX103047473(icmt)
EEE113570032(icmt)
TRU101073203(icmt)
TNGGSTEN00000682G001 GSTEN00005170G001 GSTEN00008053G001
LCO104939109(icmt)
NCC104943661(icmt)
CGOB115018211(icmt)
ELY117258868(icmt)
EFO125892034(icmt)
PLEP121947023(icmt)
SLUC116058806(icmt)
ESP116691947(icmt)
PFLV114559062(icmt)
GAT120829231(icmt)
PPUG119200286 119222321(icmt)
MSAM119904980(icmt)
CUD121516989(icmt)
ALAT119023396(icmt)
MZE101470789(icmt)
ONL100700130(icmt)
OAU116330569(icmt)
OLA101174897(icmt)
OML112140878(icmt)
XMA102236165(icmt)
XCO114142415(icmt)
XHE116721390(icmt)
PRET103466978(icmt)
PFOR103154230(icmt)
PLAI106960222(icmt)
PMEI106931530(icmt)
GAF122821835 122833551
CVG107100394(icmt)
CTUL119799191(icmt)
GMU124868374(icmt)
NFU107391379(icmt)
KMR108250891(icmt)
ALIM106529330(icmt)
NWH119417217(icmt)
AOCE111574444(icmt)
MCEP125004055(icmt)
CSEM103384860(icmt)
POV109630969(icmt)
SSEN122777803(icmt)
HHIP117765161(icmt)
HSP118111296(icmt)
LCF108900467
SDU111233790(icmt)
SLAL111658859(icmt)
XGL120804059(icmt)
HCQ109528364(icmt)
BPEC110165621(icmt)
MALB109951050(icmt)
BSPL114858333(icmt)
SASA106566808 106572246
STRU115166273 115168276
OTW112222082(icmt) 112233080
OMY110492296 110532118
OGO124031793 124045767
ONE115101646 115132001
SALP111966305 111977275
SNH120059433 120060734
CCLU121538185 121546556
ELS105013890
SFM108918346 108933493(icmt)
PKI111832873 111859093
AANG118207805(icmt) 118211252
LOC102685779(icmt)
PSPA121329121 121329172
ARUT117425459 117963633 117963806 117963818
RTP109931576(rpl22)
BFO118431059
BBEL109472678
CIN100180736
SCLV120345655 120346346
SPU590850
APLC110990580
SKO100367732
DMEDmel_CG11268(ste14)
DER6544938
DSE6605523
DSIDsimw501_GD14422(Dsim_GD14422)
DYADyak_GE21944
DAN6507260
DSR110177511
DPO4812848
DPE6595775
DMN108152572
DWI6639514
DGR6570380
DMODmoj_GI11680
DAZ108614435
DNV108651467
DHE111597308
DVI116649858 116650466 6622593
CCAT101450435
BOD106621990
RZE108361649
MDE101892329
SCAC106087994
LCQ111677116
LSQ119604556
AGAAgaP_AGAP001310
ACOZ120948412
AARA120893420
ASTE118507624
AAG5575637
AALB109415717 109429495
CQUCpipJ_CPIJ014820
CPII120423827
CNS116342292
BCOO119084221
AME726380
ACER108001668
ALAB122717175
BIM100742012
BBIF117217135
BVK117242531
BVAN117154608
BTER100643105
BPYO122576588
CCAL108622574
OBB114879958
MGEN117220994
NMEA116425955
CGIG122401739
SOC105197150
MPHA105837712
AEC105145975
ACEP105622214
PBAR105429358
VEM105560211
HST105185274
DQU106746204
CFO105256735
FEX115239503 115242747
LHU105671850
PGC109855265
OBO105279718
PCF106788840
PFUC122525092
VPS122627853
NVI100120654(Icmt)
CSOL105360746
TPRE106652321
MDL103575965
CGLO123261701
FAS105265777
DAM107040639
AGIF122858716
LHT122507862
CCIN107270344
TCA663323
DPA109539963
SOY115886443
ATD109601490
CSET123311034
AGB108915954
NVL108569044
APLN108733056
PPYR116170419
OTU111424757
BMOR101739673
BMAN114240968
MSEX115447058
DPLKGM_207442
BANY112046477
NIQ126774060
PMAC106710357
PPOT106108761
PXU106119613
PRAP110997181
ZCE119838733
HAW110383716
HZE124637727
TNL113501825
SLIU111347843
OFU114363522
PXY105384312
API100164090
DNX107163542
AGS114119728
RMD113554961
BTAB109038542
CLEC106671913
HHAL106686637
NLU111044299
PHUPhum_PHUM396510
FOC113211424
TPAL117643237
ZNE110832892
CSEC111872397 111873445
FCD110846976
DPXDAPPUDRAFT_300937
DMK116918802
PVM113806295
PJA122242322
PCHN125038725
HAME121871045
PCLA123759702
PTRU123510510
HAZT108667756
EAF111717850
LSM121131769
PPOI119096734 119096988
ISCIscW_ISCW020027
DSV119446832
RSAN119389353
RMP119183758
VJA111261737
TUT107363991
DPTE113791187
DFR124498315
CSCU111625561
PTEP107442040
SDM118183229
CELCELE_F21F3.3(icmt-1) CELE_M01E11.1(M01E11.1)
CBRCBG_14895
BMYBM_BM18573(Bm18573)
LOALOAG_09538
NAINECAME_15226
TSPTsp_01153
HROHELRODRAFT_105479
LGILOTGIDRAFT_217923
PCAN112557095
BGT106056057
GAE121390182
HRF124152486
HRJ124287477
CRG105346111
MYI110462725
PMAX117345408
MMER123528284
OBI106868383
OSN115224886
LAK106174929
SMMSmp_080130.1
NVE5498046 5520109
EPA110237603
ATEN116308219
ADF107355711
AMIL114967500
PDAM113680524
SPIS111345496
DGT114518340
XEN124444777
HMG100212062
TADTRIADDRAFT_57388
AQU100636862
ATHAT5G08335(ATSTE14B) AT5G23320(STE14A)
ALY9307390 9308120
CRB111830246 17881773
CSAT104706633 104708256 104708259 104709881 104736348 104769041 104770687
EUSEUTSA_v10014725mg
BRP103855776 103874203
BNA106384974 106444267 111210460 111213343
BOE106336082
RSZ108843546 108847414
THJ104800704
CPAP110814012
CIT102617349
CICCICLE_v10016775mg
PVY116126840 116134032
MINC123192430 123214562 123218729
TCC18599782 18608459
GRA105764129 105804388
GHI107891127 107913618 107931206 107946091
GAB108470715 108477389
DZI111276999 111296868 111308390
EGR104454027 104454077
GMX100784645
GSJ114390988
PVUPHAVU_004G144800g
VRA106764479
VAR108344723
VUN114181981
CCAJ109812098
APRC113867750
MTR25496684
CAM101506180
LJALj0g3v0167899.1(Lj0g3v0167899.1) Lj2g3v1717600.1(Lj2g3v1717600.1) Lj5g3v2246100.1(Lj5g3v2246100.1)
ADU107490573
AIP107644074
AHF112750849 112802414
LANG109338560 109339638
FVE101310986
RCN112197795
PPER18790090
PMUM103321092
PAVI110754619
PDUL117629876
MDM103403394 103423699
PXB103943223
ZJU107412754
MNT21404554 21405891 21405892
CSV101223195
CMO103499053
BHJ120068867 120069537
MCHA111016968 111023074
CMAX111486321 111499352
CMOS111435324 111460045
CPEP111794078 111806805
RCU8261997 8285750
JCU105648964
HBR110649076 110655103
MESC110620247
POP7456294 7477153
PEU105116588 105123921
PALZ118038814 118049622
JRE108988463 108997247
QSU111999647 112005935 112027748 112034059
QLO115983392 115983441
TWL119991566
VVI100241181 100245637 100267959
VRI117923481 117924108 117926662
SLY101267014
SPEN107015732
SOT102586096
SSTN125855577
CANN107870370
NTA107811658 107821842
NSY104239723
NTO104120910
NAU109210243
INI109160050
ITR116003753 116024691
SIND105168244
OEU111373346 111401163
EGT105964847 105974620
SSPL121774598 121777764 121804340 121807567
HAN110873873 110936936
ECAD122607575
LSV111892814 111907512
CCAV112513702 112518738
DCR108194218 108197790
CSIN114267332 114283090 114302848 114309538 114310834
BVG104903799 104908812
SOE110791090 110803399
CQI110687767 110734575 110738183
NNU104612300
MING122065419 122075880
TSS122655985
PSOM113302709 113356093
NCOL116246138
OSA4336894
OBR102707769
BDI100846368
ATS109739451
TDC119356308 119365476
TAES123046537 123054395 123190282
TUA125509512 125539581
SBI8085675
ZMA100284671
SITA101778469
SVS117864316
PVIR120641677 120682740
PHAI112901019
PDA103707074 103718044 120107658
EGU105039667 105050387
MUS103991185
DCT110111382
PEQ110024627
AOF109840164 109840424
ATR18435584
SMOSELMODRAFT_124841 SELMODRAFT_91230
PPP112280103
VCNVOLCADRAFT_77213
CSLCOCSUDRAFT_32207
CVRCHLNCDRAFT_50320
APROF751_1413
OLUOSTLU_86391
OTAOT_ostta02g03660
BPGBathy03g02120
MISMICPUN_58408(ICMT)
MPPMICPUCDRAFT_15590(ICMT)
CMECYME_CMH202C
CCPCHC_T00007107001
SCEYDR410C(STE14)
SEUBDI49_0584
SPAOSPAR_D05980
AGOAGOS_AAR122C
ERCEcym_5461
KLAKLLA0_A02167g
KMXKLMA_30652(STE14)
LTHKLTH0G03234g
VPOKpol_286p4
ZROZYRO0D12100g
CGRCAGL0F02805g
NCSNCAS_0A12100(NCAS0A12100)
NDINDAI_0A04160(NDAI0A04160)
TPFTPHA_0E02030(TPHA0E02030)
TBLTBLA_0A06820(TBLA0A06820)
TDLTDEL_0A03740(TDEL0A03740)
TGBHG536_0A05280
KAFKAFR_0E03400(KAFR0E03400)
KNGKNAG_0C04460(KNAG0C04460)
ZMKHG535_0D04770
PPAPAS_chr3_0130
DHADEHA2G05368g DEHA2G05390g
PICPICST_60928
PGUPGUG_02926 PGUG_02927
SPAASPAPADRAFT_143525
LELLELG_04623 LELG_04624
CALCAALFM_C601120CA(CaO19.119) CAALFM_C601130WA(CaO19.120)
CTPCTRG_02976 CTRG_02977
COTCORT_0F04700 CORT_0F04710
CDUCD36_61230 CD36_61240
CTENCANTEDRAFT_106733 CANTEDRAFT_98208
YLIYALI0E22913g
CLUCLUG_01580 CLUG_01581
CLUSA9F13_13g00198
CAURCJI97_004863
PKZC5L36_0D03240
BBRXBRETT_005069
OPAHPODL_03426
SLUDSCDLUD_003288
NCRNCU00034
SMPSMAC_00124
PANPODANSg5374
TTTTHITE_2119827
MTMMYCTH_2303882
CTHRCTHT_0069440
MGRMGG_05331
PPEIPpBr36_03715
TMNUCRPA7_365
SSCKSPSK_02638
FGRFGSG_06689
FPUFPSE_01557
FVRFVEG_05425
FOXFOXG_02251
NHENECHADRAFT_79411
TRETRIREDRAFT_31134
TRRM419DRAFT_99653
MAWMAC_07177
MAJMAA_07087
CMTCCM_05030
PLJVFPFJ_05772
VDAVDAG_06443
CFJCFIO01_03367
CLUPCLUP02_03745
CHIGCH63R_02760
ELAUCREL1_4468
PFYPFICI_07492
BFUBCIN_16g01230
MBEMBM_04463
PSCOLY89DRAFT_683042
GLZGLAREA_07821
ANIAN6162.2
AFMAFUA_2G08420
ACTACLA_080250
NFINFIA_084050
AORAO090011000860
ANGANI_1_1694104(An12g03660)
AFVAFLA_008250
ALUCAKAW2_60786A
ACHEACHE_50372A
APUUAPUU_51093A
PCSPc13g04360
PDPPDIP_84970
TMFPMAA_070760
TRGTRUGW13939_06222
CIMCIMG_00855
CPWCPC735_054590
UREUREG_00813
PBLPAAG_07523
PBNPADG_05218
ABEARB_04882
TVETRV_06581
BGHBDBG_08109
PNOSNOG_12797
BSCCOCSADRAFT_37331
AALTCC77DRAFT_923615
ZTRMYCGRDRAFT_69522
PFJMYCFIDRAFT_65082
FFUCLAFUR5_06442
BCOMBAUCODRAFT_102980
NPAUCRNP2_2959
TMLGSTUM_00010209001
SPOSPAC10F6.12c(mam4)
CNECNC01050
CNBCNBC6220
CNGCNAG_01592
CGICGB_C1560W
TMSTREMEDRAFT_34839
TASAA1Q1_04488
PPLPOSPLDRAFT_134684
TVSTRAVEDRAFT_163722
DSQDICSQDRAFT_147256
SHSSTEHIDRAFT_53867
HIRHETIRDRAFT_312857
PSQPUNSTDRAFT_99937
FMEFOMMEDRAFT_135463
GTRGLOTRDRAFT_35073
LBCLACBIDRAFT_311929
CCICC1G_00396
PCUBJR316_0004668
MRRMoror_7451
MOREE1B28_004248
SCMSCHCO_02687541(SCHCODRAFT_02687541)
SLASERLADRAFT_414065
WSEWALSEDRAFT_35025
UMAUMAG_11682
PFPPFL1_05882
MGLMGL_0263
MRTMRET_1048
MSYMMSY001_2751
PGRPGTG_17481 PGTG_18534
MLRMELLADRAFT_49864
ECUECU01_1350
EINEint_011290
EROEROM_011190
MBRMONBRDRAFT_7483
SREPTSG_04137
DDIDDB_G0272799(icmA-1) DDB_G0273995(icmA-2)
DPPDICPUDRAFT_58140
EHIEHI_006100(83.t00023) EHI_045150(3.t00074)
EDIEDI_198890 EDI_245230
EIVEIN_194630 EIN_372090
ACANACA1_183980
TETTTHERM_00141010
PTMGSPATT00010834001
SMINv1.2.027086.t1(symbB.v1.2.027086.t1) v1.2.037642.t1(symbB.v1.2.037642.t1)
PTIPHATRDRAFT_9832
FCYFRACYDRAFT_161670
TPSTHAPSDRAFT_33310
AAFAURANDRAFT_4868
PIFPITG_14497 PITG_19488
PSOJPHYSODRAFT_310585
SPARSPRG_05716
EHXEMIHUDRAFT_235099
GTTGUITHDRAFT_157934
TBRTb09.211.3640
TBGTbgDal_IX7750
TCR510659.264 510743.40
LMALMJF_35_3030
LIFLINJ_35_3080
LDOLDBPK_353080
LMILMXM_34_3030
LBZLBRM_34_2940
LPANLPMP_342880
NGRNAEGRDRAFT_38043
TVATVAG_2v0266120 TVAG_2v0394670 TVAG_2v0553540
XCCXCC0107
XCBXC_0112
XCPXCR_0125
XOMXOO0023(XOO0023)
XOOXOO0023(STE14)
XTNFD63_00170
XHDLMG31886_01210
XPRMUG10_09760
MELLIVG45_20605
AFPK1Y48_05065
 » show all
Reference
1  [PMID:3290900]
  Authors
Clarke S, Vogel JP, Deschenes RJ, Stock J.
  Title
Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.
  Journal
Proc Natl Acad Sci U S A 85:4643-7 (1988)
DOI:10.1073/pnas.85.13.4643
Reference
2  [PMID:2753892]
  Authors
Ota IM, Clarke S.
  Title
Enzymatic methylation of 23-29-kDa bovine retinal rod outer segment membrane proteins. Evidence for methyl ester formation at carboxyl-terminal cysteinyl residues.
  Journal
J Biol Chem 264:12879-84 (1989)
Reference
3  [PMID:2398053]
  Authors
Stephenson RC, Clarke S.
  Title
Identification of a C-terminal protein carboxyl methyltransferase in rat liver membranes utilizing a synthetic farnesyl cysteine-containing peptide substrate.
  Journal
J Biol Chem 265:16248-54 (1990)
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.100
IUBMB Enzyme Nomenclature: 2.1.1.100
ExPASy - ENZYME nomenclature database: 2.1.1.100
BRENDA, the Enzyme Database: 2.1.1.100
CAS: 130731-20-3

KEGG   REACTION: R04496
Entry
R04496                      Reaction                               
Name
S-Adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase
Definition
S-Adenosyl-L-methionine + Protein C-terminal S-farnesyl-L-cysteine <=> S-Adenosyl-L-homocysteine + Protein C-terminal S-farnesyl-L-cysteine methyl ester
Equation
Reaction class
RC00003  C00019_C00021
RC00460  C04506_C04748
Enzyme
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K00587  protein-S-isoprenylcysteine O-methyltransferase [EC:2.1.1.100]
Other DBs
RHEA: 21675

KEGG   REACTION: R09846
Entry
R09846                      Reaction                               
Name
prenylcycteine methylesterase
Definition
Protein C-terminal S-farnesyl-L-cysteine + Methanol <=> Protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O
Equation
Reaction class
RC00460  C04506_C04748
RC00461  C00132_C04748
Enzyme
3.1.1.-
Pathway
rn00900  Terpenoid backbone biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K15889  prenylcysteine alpha-carboxyl methylesterase [EC:3.1.1.-]
Other DBs
RHEA: 48523

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