KEGG   ORTHOLOGY: K00622
Entry
K00622                      KO                                     
Symbol
nat
Name
arylamine N-acetyltransferase [EC:2.3.1.5]
Pathway
map00232  Caffeine metabolism
map00633  Nitrotoluene degradation
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map05204  Chemical carcinogenesis - DNA adducts
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00232 Caffeine metabolism
    K00622  nat; arylamine N-acetyltransferase
  09111 Xenobiotics biodegradation and metabolism
   00633 Nitrotoluene degradation
    K00622  nat; arylamine N-acetyltransferase
   00983 Drug metabolism - other enzymes
    K00622  nat; arylamine N-acetyltransferase
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K00622  nat; arylamine N-acetyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.5  arylamine N-acetyltransferase
     K00622  nat; arylamine N-acetyltransferase
Other DBs
RN: R07940 R08036 R08248 R08250 R11902
COG: COG2162
GO: 0004060
Genes
HSA: 10(NAT2) 9(NAT1)
PTR: 464023(NAT1) 464024(NAT2)
PPS: 100990661(NAT2) 100991667(NAT1)
GGO: 101150362(NAT1) 101152545(NAT2)
PON: 100435042(NAT1) 100437283(NAT2)
NLE: 100580331(NAT1) 100580987(NAT2)
MCC: 704019(NAT1) 704357(NAT2)
MCF: 102119914(NAT1) 102121561
CSAB: 103215401(NAT1) 103215403(NAT2)
CATY: 105601399(NAT1) 105601400(NAT2)
PANU: 101009542(NAT1) 101010131
TGE: 112630309(NAT2) 112630315(NAT1)
TFN: 117092730(NAT1) 117092749
PTEH: 111545658 111545783(NAT2)
CJC: 100397995(NAT1)
SBQ: 101045716(NAT1) 101047286(NAT2)
MMU: 17960(Nat1) 17961(Nat2) 17962(Nat3)
RNO: 116631(Nat1) 116632(Nat2) 290681(Nat3)
CGE: 100689282(Nat2) 100755335
OCU: 100008974(NAT2) 100328959(NAT1)
TUP: 102486411(NAT1) 102487228
AML: 100480317
UMR: 103677031
UAH: 113245585
UAR: 123780321
ELK: 111156822
LLV: 125092831
MPUF: 101671731
ORO: 101367643
EJU: 114224832
MLX: 118009895
FCA: 101095575
PYU: 121044338
PBG: 122472729
PTG: 102955781(NAT1)
PPAD: 109262233
AJU: 106976139
HHV: 120233984
BTA: 512603(NAT1)
BOM: 102275700(NAT1)
BIU: 109553540
BBUB: 102403863
CHX: 102169935(NAT1)
OAS: 101120889
ODA: 120865875(NAT1)
CCAD: 122432509
SSC: 100511905
CFR: 102510309
CBAI: 105071173
CDK: 105086440
BACU: 102999256
LVE: 103082317
OOR: 101280132
DLE: 111173572
PSIU: 116746861
ECB: 100049837
EPZ: 103540532
EAI: 106833608
MNA: 107523940
SHON: 118984275
MMF: 118622555
RFQ: 117021026
PGIG: 120607072
RAY: 107503880
DNM: 101444633
MDO: 100027666
SHR: 100919466
PCW: 110212707
OAA: 100077007
GGA: 396283(PNAT10) 396537(NAT) 415809(PNAT3)
CMY: 102931077
PVT: 110090098
SUND: 121937445
PBI: 103059580
PMUR: 107287706
TSR: 106544720
PGUT: 117670905
GJA: 107109832 107109835(NAT1)
NPR: 108786559
RTEM: 120917951
DRE: 445194(zgc:101040) 449801(zgc:103601) 794381(si:dkey-78a14.4) 795256(si:dkey-78a14.5)
LCO: 104920774
NCC: 104955050
SLUC: 116037558
ECRA: 117952649
PFLV: 114558570
ONL: 100704032 100704303(nat1)
XMA: 102230777(nat1)
XCO: 114142912
PMEI: 106927342(nat1)
GAF: 122847283
CVG: 107088494
CTUL: 119781943(si:dkey-78a14.4)
KMR: 108243328
ALIM: 106536371
NWH: 119430146
AOCE: 111572268
CSEM: 103383261
SSEN: 122772820(si:dkey-78a14.4)
SDU: 111217696(nat1)
XGL: 120794177
HCQ: 109514002
SASA: 106562381(ARY1) 106587573(ARY1)
OMY: 110526592
OGO: 124033090
ONE: 115111137
SNH: 120056583
ELS: 105025705
PKI: 111832738
LOC: 102689755
CMK: 103172656
RTP: 109923912
BBEL: 109471601
MTU: Rv3566c(nat)
MTC: MT3671(nhoA)
MRA: MRA_3605(nat)
MTUR: CFBS_3782(nat)
MTO: MTCTRI2_3630(nat)
MTD: UDA_3566c(nat)
MTN: ERDMAN_3911(nat)
MTUC: J113_24975
MTUE: J114_19070
MTUH: I917_25040
MTUL: TBHG_04161
MTUT: HKBT1_3767(nat)
MTUU: HKBT2_3776(nat)
MTQ: HKBS1_3779(nat)
MBO: BQ2027_MB3596C(nat)
MBB: BCG_3630c(nat)
MBT: JTY_3631(nat)
MBM: BCGMEX_3628c(nat)
MAF: MAF_35780(nat)
MMIC: RN08_3943
MCE: MCAN_35771(nat)
MCQ: BN44_110058(nat)
MCV: BN43_90064(nat)
MCX: BN42_90063(nat)
MCZ: BN45_100065(nat)
MPA: MAP_0501(nhoA)
MAO: MAP4_3366
MAVI: RC58_16695
MAVU: RE97_16730
MAV: MAV_0595
MIT: OCO_05040
MIA: OCU_05080
MID: MIP_00946
MYO: OEM_05100
MIR: OCQ_05190
MMAN: MMAN_47990(nat)
MUL: MUL_4131(nat)
MMC: Mmcs_0211
MKM: Mkms_0221
MJL: Mjls_0201
MMI: MMAR_5055(nat)
MMAE: MMARE11_48700(nat)
MMM: W7S_02460
MLI: MULP_05313(nat)
MHAD: B586_04480
MFJ: MFLOJ_40720(nat)
MSTO: MSTO_44690(nat)
MSIM: MSIM_29140(nat)
MSAK: MSAS_29110(nat)
MCOO: MCOO_27240(nat)
MBAI: MB901379_04445(nat)
MSEO: MSEO_34500(nat)
MPSE: MPSD_52550(nat)
MSHO: MSHO_05370(nat)
MLJ: MLAC_47380(nat)
MBRD: MBRA_12980
MSHJ: MSHI_38690(nat)
MSG: MSMEI_0299(nat)
MVA: Mvan_0235
MGI: Mflv_0433
MAUU: NCTC10437_00240(nat)
MALV: MALV_32910
MARZ: MARA_36070
MGAD: MGAD_45510
MBOK: MBOE_15090
MFLV: NCTC10271_04893(nat)
MJD: JDM601_0190(nat)
MMIN: MMIN_19310
MHIB: MHIB_33190
GOM: D7316_01282(nat)
 » show all
Reference
  Authors
Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E
  Title
Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis.
  Journal
Biochem J 418:369-78 (2009)
DOI:10.1042/BJ20082011
  Sequence
[mtu:Rv3566c]
Reference
PMID:2340091
  Authors
Blum M, Grant DM, McBride W, Heim M, Meyer UA
  Title
Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression.
  Journal
DNA Cell Biol 9:193-203 (1990)
DOI:10.1089/dna.1990.9.193
  Sequence
[hsa:9]

KEGG   ENZYME: 2.3.1.5
Entry
EC 2.3.1.5                  Enzyme                                 
Name
arylamine N-acetyltransferase;
arylamine acetylase;
beta-naphthylamine N-acetyltransferase;
4-aminobiphenyl N-acetyltransferase;
acetyl CoA-arylamine N-acetyltransferase;
2-naphthylamine N-acetyltransferase;
arylamine acetyltransferase;
indoleamine N-acetyltransferase;
N-acetyltransferase (ambiguous);
p-aminosalicylate N-acetyltransferase;
serotonin acetyltransferase;
serotonin N-acetyltransferase
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
acetyl-CoA:arylamine N-acetyltransferase
Reaction(IUBMB)
acetyl-CoA + an arylamine = CoA + an N-acetylarylamine
Reaction(KEGG)
Substrate
acetyl-CoA [CPD:C00024];
arylamine [CPD:C00292]
Product
CoA [CPD:C00010];
N-acetylarylamine [CPD:C07565]
Comment
Wide specificity for aromatic amines, including serotonin; also catalyses acetyl-transfer between arylamines without CoA.
History
EC 2.3.1.5 created 1961
Pathway
ec00232  Caffeine metabolism
ec00633  Nitrotoluene degradation
ec00983  Drug metabolism - other enzymes
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00622  arylamine N-acetyltransferase
Genes
HSA10(NAT2) 9(NAT1)
PTR464023(NAT1) 464024(NAT2)
PPS100990661(NAT2) 100991667(NAT1)
GGO101150362(NAT1) 101152545(NAT2)
PON100435042(NAT1) 100437283(NAT2)
NLE100580331(NAT1) 100580987(NAT2)
MCC704019(NAT1) 704357(NAT2)
MCF102119914(NAT1) 102121561
CSAB103215401(NAT1) 103215403(NAT2)
CATY105601399(NAT1) 105601400(NAT2)
PANU101009542(NAT1) 101010131
TGE112630309(NAT2) 112630315(NAT1)
RRO104655225 104655226
RBB108526475 108526477
TFN117092730(NAT1) 117092749
PTEH111545658 111545783(NAT2)
CJC100397995(NAT1)
SBQ101045716(NAT1) 101047286(NAT2)
CSYR103262334 103263194
MMUR105882540 105882541 105882543
OGA100944436 100964262 100964577
MMU17960(Nat1) 17961(Nat2) 17962(Nat3)
MCAL110300118 110300659 110300688
MPAH110336889 110336987 110337099
RNO116631(Nat1) 116632(Nat2) 290681(Nat3)
MCOC116069400 116071440 116071442
MUN110564517 110564518 110564521
CGE100689282(Nat2) 100755335
PLEU114703125 114703126 114703138
NGI103745801 103745803 103745813
CPOC100723784 100724067(Nat1) 100724343
CCAN109680577 109701090 109701091
DORD105991867 105992221 105992232
DSP122126233 122126857 122126940
OCU100008974(NAT2) 100328959(NAT1)
OPI101523061 101527236
TUP102486411(NAT1) 102487228
AML100480317
UMR103677031
UAH113245585
UAR123780321
ELK111156822
LLV125092831
MPUF101671731
ORO101367643
EJU114224832
ZCA113924821 118356728
MLX118009895
FCA101095575
PYU121044338
PBG122472729
PTG102955781(NAT1)
PPAD109262233
AJU106976139
HHV120233984
BTA512603(NAT1)
BOM102275700(NAT1)
BIU109553540
BBUB102403863
CHX102169935(NAT1)
OAS101120889
ODA120865875(NAT1)
CCAD122432509
SSC100511905
CFR102510309
CBAI105071173
CDK105086440
VPC102525084 102532768
BACU102999256
LVE103082317
OOR101280132
DLE111173572
PCAD102994472 112061838
PSIU116746861
ECB100049837
EPZ103540532
EAI106833608
MYD102752765(NAT1) 102753338 102760162
MMYO118651804 118651805 118651806 118652085
MLF102423110 102423981 102426077 102432866 102433484 102433788
MNA107523940
PKL118729707 118730409 118730410
DRO112308289 112321515 112321529
SHON118984275
AJM119038484 119046537 119047229
PDIC114508650 114508709
PHAS123807498 123807795
MMF118622555
RFQ117021026
PGIG120607072
PVP105310958 105311124 105311126 105311249 105311413
RAY107503880
MJV108388000 108401168
TOD119256975 119257871
LAV100677179 100677461 100677744
TMU101354440 101354690
DNM101444633
MDO100027666
GAS123237038 123253986 123256592
SHR100919466
PCW110212707
OAA100077007
GGA396283(PNAT10) 396537(NAT) 415809(PNAT3)
PCOC116244056 116244057 116244058
MGP100548608 100548761 100549991
CJO107319387 107319388 107319389
NMEL110404203 110404204 110404205(NAT1)
APLA101791461 101791654 101791850
ACYG106044860 106044861 106044862
AFUL116494024 116494025 116494216
TGU100218405 100222183 100225095 115490547(NAT1)
LSR110476354 110476355 110476356(NAT1)
SCAN103816733 103816734 103816736
PMOA120506955 120507956 120507957 120507958
OTC121334052 121334053 121334054
PRUF121348889 121348890 121348891
GFR102038858 102039206 102040232
FAB101810372(NAT1) 101810563 101810753
PHI102102516 102102700 102102890
PMAJ107209900 107209901 107209902
CCAE111934448(NAT1) 111934450 111934451
CCW104691827 104691828 104691831(NAT1)
ETL114060984 114060995 114060998 114061034 114061043 114072393 114072394
ZAB102065473 102065658 102065843 102066138
FPG101913996 101915036 101915205
FCH102049096 102049271 102058986
CLV102085619(NAT1) 102086109 106145649
EGZ104133744 104133745 104133747
NNI104014602 104014613 104014733
ACUN113484381 113484382 113484384 113484499
TALA104357345 104357346 104357347
PADL103923868 103923870 103923871
ACHC115345663 115345664 115345665
AAM106483271 106483273 106483274 106483355
AROW112962676 112962682 112962715
NPD112949882 112949883 112949884
DNE112978850 112978870 112978871
ASN102378789 102379045 102379284
AMJ102574773 102575009 102575242
CPOO109310363 109310654 109310655
GGN109289318 109289459 109289460
PSS102453745 102457700
CMY102931077
CPIC101940914 101950692 112059549
TST117886635 117886745
CABI116816708 116816709
MRV120384422 120384755
ACS100565208 100565405
PVT110090098
SUND121937445
PBI103059580
PMUR107287706
TSR106544720
PGUT117670905
VKO123022336 123022377
PMUA114602208 114602209
ZVI118086513 118086514
GJA107109832 107109835(NAT1)
NPR108786559
RTEM120917951
DRE445194(zgc:101040) 449801(zgc:103601) 794381(si:dkey-78a14.4) 795256(si:dkey-78a14.5)
SRX107715136 107722424 107738535
SANH107679010 107692750 107696680
SGH107551480 107588554
CCAR109093152 109098442
CAUA113061297 113078644 113095182 113106067 113106068 113118583
IPU100528628(ary1) 108259233 108259370 108259371
PHYP113540997 113540999
SMEO124379781 124379782 124379783 124379784 124380209
AMEX103021503 103022041 103025468 111191620
EEE113576704 113576721 113576722
LCO104920774
NCC104955050
ELY117251663 117252379
PLEP121939460 121940038
SLUC116037558
ECRA117952649
PFLV114558570
GAT120812918 120834089
PPUG119221143 119226185 119226194
MSAM119889962 119890093
CUD121514049 121515489
MZE101481779 101482061
ONL100704032 100704303(nat1)
OAU116325620 116325644
OLA101157683 101165718
OML112160719 112160720
XMA102230777(nat1)
XCO114142912
XHE116718490 116718491
PRET103462640 103462641
PFOR103138061 103138062
PLAI106957721 106957722
PMEI106927342(nat1)
GAF122847283
CVG107088494
CTUL119781943(si:dkey-78a14.4)
GMU124867200 124867201 124867202
NFU107373583 107382082
KMR108243328
ALIM106536371
NWH119430146
AOCE111572268
CSEM103383261
SSEN122772820(si:dkey-78a14.4)
LCF108876876 108877018
SDU111217696(nat1)
SLAL111672246 111672358
XGL120794177
HCQ109514002
BPEC110171948 110175435 110175484
MALB109954313 109955857 109955859 109955860
SASA106562381(ARY1) 106587573(ARY1)
OTW112249348 121842893
OMY110526592
OGO124033090
ONE115111137
SALP111969532 111974736
SNH120056583
ELS105025705
SFM108932932 108932960
PKI111832738
AANG118214903 118214904 118214905 118214923
LOC102689755
PSPA121296609 121325857
ARUT117424387 117425908 117425909
CMK103172656
RTP109923912
BBEL109471601
SCLV120325539 120326277 120347517 120348690
DSV119462240 119462542
BEQBEWA_013780
SPPHKFK14_00460
MTURv3566c(nat)
MTVRVBD_3566c
MTCMT3671(nhoA)
MRAMRA_3605(nat)
MTFTBFG_13599
MTBTBMG_03605
MTKTBSG_03632
MTZTBXG_003580
MTGMRGA327_22015
MTIMRGA423_22535
MTECCDC5079_3307
MTURCFBS_3782(nat)
MTLCCDC5180_3259
MTOMTCTRI2_3630(nat)
MTDUDA_3566c(nat)
MTNERDMAN_3911(nat)
MTJJ112_19200
MTUBMT7199_3628
MTUCJ113_24975
MTUEJ114_19070
MTXM943_18330
MTUHI917_25040
MTULTBHG_04161
MTUTHKBT1_3767(nat)
MTUUHKBT2_3776(nat)
MTQHKBS1_3779(nat)
MBOBQ2027_MB3596C(nat)
MBBBCG_3630c(nat)
MBTJTY_3631(nat)
MBMBCGMEX_3628c(nat)
MBKK60_037040
MAFMAF_35780(nat)
MMICRN08_3943
MCEMCAN_35771(nat)
MCQBN44_110058(nat)
MCVBN43_90064(nat)
MCXBN42_90063(nat)
MCZBN45_100065(nat)
MPAMAP_0501(nhoA)
MAOMAP4_3366
MAVIRC58_16695
MAVURE97_16730
MAVMAV_0595
MITOCO_05040
MIAOCU_05080
MIDMIP_00946
MYOOEM_05100
MCHIAN480_02515
MIROCQ_05190
MMALCKJ54_02455
MMANMMAN_47990(nat)
MSAMycsm_00165
MULMUL_4131(nat)
MMCMmcs_0211
MKMMkms_0221
MJLMjls_0201
MMIMMAR_5055(nat)
MMAEMMARE11_48700(nat)
MMMW7S_02460
MLIMULP_05313(nat)
MKNMKAN_12065
MYVG155_01320
MGOAFA91_08360
MHADB586_04480
MFJMFLOJ_40720(nat)
MSTOMSTO_44690(nat)
MSIMMSIM_29140(nat)
MSAKMSAS_29110(nat)
MKUI2456_25660
MNVMNVI_19580
MPAGC0J29_27735
MNMMNVM_16320
MGORH0P51_25790
MCOOMCOO_27240(nat)
MBAIMB901379_04445(nat)
MSEOMSEO_34500(nat)
MPSEMPSD_52550(nat)
MSHOMSHO_05370(nat)
MGAUMGALJ_47190
MLJMLAC_47380(nat)
MBRDMBRA_12980
MSHJMSHI_38690(nat)
MKRMKOR_28740
MDFK0O62_01880
MMAMK3U93_22670
MHOLK3U96_25400
MHERK3U94_01120
MSENK3U95_01405
MSPGF6B93_20470
MOTLTS72_27935
MSMMSMEG_0306
MSGMSMEI_0299(nat)
MSBLJ00_01535
MSNLI99_01535
MSHLI98_01535
MVAMvan_0235
MGIMflv_0433
MSPMspyr1_03210
MNED174_02890
MYNMyAD_02825
MFTXA26_02810
MRHMycrhN_1510
MCHTMCHIJ_07140
MAUUNCTC10437_00240(nat)
MFXMFAL_05890
MALVMALV_32910
MTYMTOK_10520
MARZMARA_36070
MGADMGAD_45510
MMATMMAGJ_18890
MBOKMBOE_15090
MFGK6L26_30050
MSEIMSEDJ_15380
MFLVNCTC10271_04893(nat)
MJDJDM601_0190(nat)
MMINMMIN_19310
MHIBMHIB_33190
MPAKMIU77_17755
GOMD7316_01282(nat)
GAMGII34_13175
GPDGII33_12405
 » show all
Reference
1  [PMID:12980945]
  Authors
CHOU TC, LIPMANN F.
  Title
Separation of acetyl transfer enzymes in pigeon liver extract.
  Journal
J Biol Chem 196:89-103 (1952)
Reference
2  [PMID:4748369]
  Authors
Paul RC, Ratledge C.
  Title
Further studies on anthranilate N-acetyltransferase and the metabolism of N-acetylanthranilic acid in Aerobacter aerogenes.
  Journal
Biochim Biophys Acta 320:9-15 (1973)
DOI:10.1016/0304-4165(73)90160-8
Reference
3  [PMID:13084583]
  Authors
TABOR H, MEHLER AH, STADTMAN ER.
  Title
The enzymatic acetylation of amines.
  Journal
J Biol Chem 204:127-38 (1953)
Reference
4  [PMID:14005907]
  Authors
WEISSBACH H, REDFIELD BG, AXELROD J.
  Title
The exzymic acetylation of serotonin and other naturally occurring amines.
  Journal
Biochim Biophys Acta 54:190-2 (1961)
DOI:10.1016/0006-3002(61)90954-4
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.5
IUBMB Enzyme Nomenclature: 2.3.1.5
ExPASy - ENZYME nomenclature database: 2.3.1.5
UM-BBD (Biocatalysis/Biodegradation Database): 2.3.1.5
BRENDA, the Enzyme Database: 2.3.1.5
CAS: 9027-33-2

KEGG   REACTION: R07940
Entry
R07940                      Reaction                               
Definition
1,7-Dimethylxanthine <=> 5-Acetylamino-6-formylamino-3-methyluracil
Equation
Comment
N-acetyltransferase 2
Reaction class
RC02961  C13747_C16365
Enzyme
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00622  arylamine N-acetyltransferase [EC:2.3.1.5]

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