KEGG   ORTHOLOGY: K00660
Entry
K00660                      KO                                     
Symbol
CHS
Name
chalcone synthase [EC:2.3.1.74]
Pathway
map00941  Flavonoid biosynthesis
map00960  Tropane, piperidine and pyridine alkaloid biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04712  Circadian rhythm - plant
Module
M00137  Flavanone biosynthesis, phenylalanine => naringenin
M00940  Flavanone biosynthesis, p-coumaroyl-CoA => liquiritigenin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00941 Flavonoid biosynthesis
    K00660  CHS; chalcone synthase
   00960 Tropane, piperidine and pyridine alkaloid biosynthesis
    K00660  CHS; chalcone synthase
 09150 Organismal Systems
  09159 Environmental adaptation
   04712 Circadian rhythm - plant
    K00660  CHS; chalcone synthase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K00660  CHS; chalcone synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.74  chalcone synthase
     K00660  CHS; chalcone synthase
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide synthase (PKS)
  Type III PKS
   Plant type
    K00660  CHS; chalcone synthase
Other DBs
RN: R01613 R06568 R07987 R07988 R07989 R12117 R12915
GO: 0016210
Genes
BTAB: 109030945
ATH: AT5G13930(TT4)
ALY: 9309706
CSAT: 104705657 104735408 104769619
EUS: EUTSA_v10013745mg
BRP: 103836793 103846527 103850907 103854548 103856040
BNA: 106367233 106372253 106378767 106381815 106382265 106382267 106425116 106431192 111204286
BOE: 106312851 106313587 106324440 106324842 106327741 106328481
RSZ: 108814337 108818381 108833356 108843267 108847017 108847407
THJ: 104801099 104801109 104803980 104822426
GMX: 100170701(CHS8) 100775264(CHS13) 100779649(CHS4A) 100782897(CHS7) 100785554(CHS11) 100788048(CHS10) 100789075(CHS3C) 100790997(CHS9) 100791524(CHS3) 100792581(CHS4B) 100809433(CHS6) 102663074 106794283(CHS3B) 106799718(CHS5) 114827817(CHS2) 121175284 121175285 732575(CHS1)
LJA: Lj0g3v0107259.1(Lj0g3v0107259.1) Lj0g3v0129339.1(Lj0g3v0129339.1) Lj1g3v0116650.1(Lj1g3v0116650.1) Lj1g3v0116650.2(Lj1g3v0116650.2) Lj1g3v0898770.1(Lj1g3v0898770.1) Lj1g3v2626180.1(Lj1g3v2626180.1) Lj1g3v2626190.1(Lj1g3v2626190.1) Lj1g3v2626200.1(Lj1g3v2626200.1) Lj1g3v2626210.1(Lj1g3v2626210.1) Lj1g3v3918040.1(Lj1g3v3918040.1) Lj1g3v3918050.1(Lj1g3v3918050.1) Lj2g3v2124310.1(Lj2g3v2124310.1) Lj2g3v2124320.1(Lj2g3v2124320.1) Lj2g3v2124320.2(Lj2g3v2124320.2) Lj4g3v2574990.1(Lj4g3v2574990.1) Lj6g3v0933570.1(Lj6g3v0933570.1)
CSV: 101205211
CMO: 103491706
MCHA: 111009641
INI: 109161594(CHS-E) 109176547(CHS-D) 109189176(CHSB) 109189177(CHSA) 109189178
DOSA: Os07t0214900-00(Os07g0214900) Os11t0530600-01(Os11g0530600)
BDI: 100829639
PHAI: 112902744
AG: ABV54602(PKS4)
 » show all
Reference
PMID:3386631
  Authors
Feinbaum RL, Ausubel FM
  Title
Transcriptional regulation of the Arabidopsis thaliana chalcone synthase gene.
  Journal
Mol Cell Biol 8:1985-92 (1988)
DOI:10.1128/mcb.8.5.1985
  Sequence
[ath:AT5G13930]

KEGG   ENZYME: 2.3.1.74
Entry
EC 2.3.1.74                 Enzyme                                 
Name
chalcone synthase;
naringenin-chalcone synthase;
flavanone synthase;
6'-deoxychalcone synthase;
chalcone synthetase;
DOCS;
CHS
Class
Transferases;
Acyltransferases;
Transferring groups other than aminoacyl groups
Sysname
malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)
Reaction(IUBMB)
3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2 [RN:R01613]
Reaction(KEGG)
Substrate
malonyl-CoA [CPD:C00083];
4-coumaroyl-CoA [CPD:C00223]
Product
CoA [CPD:C00010];
naringenin chalcone [CPD:C06561];
CO2 [CPD:C00011]
Comment
The enzyme catalyses the first committed step in the biosynthesis of flavonoids. It can also act on dihydro-4-coumaroyl-CoA, forming phloretin.
History
EC 2.3.1.74 created 1984, modified 2018
Pathway
ec00941  Flavonoid biosynthesis
ec00960  Tropane, piperidine and pyridine alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00660  chalcone synthase
Genes
BTAB109030945
ATHAT5G13930(TT4)
ALY9309706
CSAT104705657 104735408 104769619
EUSEUTSA_v10013745mg
BRP103836793 103846527 103850907 103854548 103856040
BNA106367233 106372253 106378767 106381815 106382265 106382267 106425116 106431192 111204286
BOE106312851 106313587 106324440 106324842 106327741 106328481
RSZ108814337 108818381 108833356 108843267 108847017 108847407
THJ104801099 104801109 104803980 104822426
CPAP110813035 110814000
CIT102606708 102607309 102612856 102613437 102616330 102616623 102620619 102626778 102626876 102629616
CICCICLE_v10001395mg CICLE_v10001405mg CICLE_v10001413mg CICLE_v10001905mg CICLE_v10003127mg CICLE_v10005133mg CICLE_v10015535mg CICLE_v10028604mg CICLE_v10028605mg CICLE_v10030093mg CICLE_v10030398mg
PVY116105700 116105809 116105827 116105858 116106083 116106085 116106547 116106555 116107510 116107518 116107528 116108148 116113843 116114587 116121211 116126333 116132577 116134326 116139680
MINC123195779 123196014 123196898 123203564 123210196 123210197 123210199 123210200 123210201 123210440 123211678 123211679 123220371 123221035 123221036 123221037 123221038 123221039 123221040 123221042 123221909 123222546 123229290
TCC18592508 18598875 18601149 18602780
GRA105766053 105770782 105776651 105776697 105796566 105798009
GHI107888447 107888463 107897115 107897841 107897842 107912380 107914126 107914136 107914891 107914895 107915293 107927759 107934810 107934821 107957085
GAB108453147 108454524 108465827 108476011 108481961 108489252 108489255
DZI111279241 111287132 111299476 111307301 111311501 111315869
EGR104414362 104415137 104419089 104427578 104430945 104441583 104441585
GMX100170701(CHS8) 100775264(CHS13) 100779649(CHS4A) 100782897(CHS7) 100785554(CHS11) 100788048(CHS10) 100789075(CHS3C) 100790997(CHS9) 100791524(CHS3) 100792581(CHS4B) 100809433(CHS6) 102663074 106794283(CHS3B) 106799718(CHS5) 114827817(CHS2) 121175284 121175285 732575(CHS1)
GSJ114375749 114388436 114400554 114412891 114414190 114421657 114421658 114421659 114421661 114421662 114421663 114421664 114421665 114425794
PVUPHAVU_001G067800g PHAVU_001G083000g PHAVU_002G038600g PHAVU_002G038700g PHAVU_002G0389001 PHAVU_002G0390000 PHAVU_002G039100g PHAVU_002G039300g PHAVU_002G184300g PHAVU_009G131000g
VRA106753918 106754681 106766157 106766188 106775701 106777513 106777514 106778834 106779704
VAR108319876 108320820 108320822 108320823 108322624 108330437 108331740 108336026
VUN114164804 114168795 114168796 114169233 114170449 114173395 114173396 114173397 114173398 114173399 114173400 114173536 114175142 114187056 114187259 114190241 114195889
CCAJ109788092 109788891 109789638 109792457 109794831 109798137 109799422 109799561 109807857 109810862
APRC113849934 113849935 113853010 113853230 113861406 113861423 113864675 113868972
MTRMTR_1g097910 MTR_1g097935 MTR_1g098140 MTR_2g058470 MTR_3g083910 MTR_3g083920 MTR_3g086260 MTR_3g088675 MTR_5g007713 MTR_5g007717 MTR_5g007723 MTR_5g007730 MTR_5g007740 MTR_5g007760 MTR_5g007770 MTR_7g016700 MTR_7g016720 MTR_7g016780 MTR_7g016800 MTR_7g016820 MTR_7g084300 MTR_7g113405
CAM101489106 101503025 101503349 101513808 101514543 105852659(CHS1)
LJALj0g3v0107259.1(Lj0g3v0107259.1) Lj0g3v0129339.1(Lj0g3v0129339.1) Lj1g3v0116650.1(Lj1g3v0116650.1) Lj1g3v0116650.2(Lj1g3v0116650.2) Lj1g3v0898770.1(Lj1g3v0898770.1) Lj1g3v2626180.1(Lj1g3v2626180.1) Lj1g3v2626190.1(Lj1g3v2626190.1) Lj1g3v2626200.1(Lj1g3v2626200.1) Lj1g3v2626210.1(Lj1g3v2626210.1) Lj1g3v3918040.1(Lj1g3v3918040.1) Lj1g3v3918050.1(Lj1g3v3918050.1) Lj2g3v2124310.1(Lj2g3v2124310.1) Lj2g3v2124320.1(Lj2g3v2124320.1) Lj2g3v2124320.2(Lj2g3v2124320.2) Lj4g3v2574990.1(Lj4g3v2574990.1) Lj6g3v0933570.1(Lj6g3v0933570.1)
ADU107466501 107477342 107482389 107483281 107483282 107483283 107483284 107483285 107483286 107483289 107483290 107483324 107483325 107483326 107483328 107483329 107483331 107483332 107483333 107483335 107483336 107483337 107483338 107483339 107483341 107483344 107488455 107488457 107494609
AIP107604885 107605370 107605371 107623037 107629529 107636081 107638244 107638245 107638892 107638894 107638895 107638896 107638897 107638898 107638900 107638902 107638906 107638908 107638914 107638915 107638918 107638919 107638921 107638922 107638923 107638929 110270923
AHF112720208 112737218 112740947 112740948 112741542 112741543 112741544 112741550 112741555 112741556 112741558 112741559 112741560 112741561 112741570 112741573 112741574 112741575 112741579 112741580 112741581 112741585 112741586 112741587 112741589 112741590 112741591 112741592 112741594 112749796 112749797 112754970 112755722 112755723 112789292 112790504 112794638 112794644 112795670 112796250 112796251 112796253 112796254 112796255 112796256 112796257 112796258 112796259 112796261 112796262 112796265 112796266 112796268 112796272 112796273 112796274 112796275 112796277 112796278 112801347 112801348
LANG109331133 109331134 109332844 109335721 109337741 109339338 109348568 109355565 109355884 109362511
FVE101298162 101298456
RCN112175453 112175464 112175474 112200102
PPER18766147 18789485 18793306
PMUM103324313 103324314 103324315
PAVI110747066 110758924
PDUL117615385 117615386 117615387
MDM103421794 103443512 103443513 114820492
PXB103945020 103945021 103959489 103965055 103965056 103965057
ZJU107422581 107422582 107422583 107422595 107427575 107427576 107428003
MNT112091300 112091303 112094616 112094960 112095010 21397822 21400912 21400913 21411675 21411755 21411756 21411841 21412156 21412237 21412323 21412324 21412648 21412870 21412871 21412872 21412879 21412880
CSV101205211
CMO103491706
BHJ120073252 120081484 120092577
MCHA111009641
CMAX111481906 111481907 111498981
CMOS111441531 111441532 111460065
CPEP111791223 111791225 111806631
RCU8265625 8270959 8273082
JCU105630228 105639050
HBR110633200 110638830 110640364 110641350 110648892
MESC110612286 110612862 110625592 110625602 110625882 110625883 110626048
POP18099506 18103955 7460519 7460520 7466313 7486993 7493197 7493198 7493199
PEU105108112 105108716 105112214 105122966 105122969 105129633 105132582 105132584 105132585
PALZ118029373 118041789 118054210 118054544 118054545 118054546 118061441 118061446
JRE108981066 108988452 108992049 108995889 109001281 109014073 109020591
QSU111992239 111996007 112000526 112012479 112012481 112025740 112027584
QLO115956872 115961603 115976336 115994574
TWL119997372 120013024 120015179
VVI100232843(CHS) 100244710 100248612 100251425 100258106(CHS3) 100261156 100263443(CHS) 100267962 100854415
VRI117914849 117930736 117930802 117934313
SLY101245061 101263032 101266107 778294(CHS1) 778295(CHS2)
SPEN107006636 107020692 107020878 107031578
SOT102577598(CHS2) 102577871(CHS1A) 102580017 102590425 102595537 102595874 102600279 102605087
SSTN125851952 125852448 125861920 125861921 125861922 125866641 125870906
CANN107849641 107850995 107850996 107851498 107864266 107871238 107871256 107880044
NTA107801263 107801774 107809744 107813425 107813613 107826422 107832236
NSY104216563 104218372 104224903 104235448
NTO104102692 104102693 104109127 104111718
NAU109207770 109212385 109215849 109224243 109227353
INI109161594(CHS-E) 109176547(CHS-D) 109189176(CHSB) 109189177(CHSA) 109189178
ITR116015093 116016651 116018898 116019218 116020611
SIND105157017 105171852 105171853 105171854
OEU111374392 111374393 111379443 111393361
EGT105950456 105950466 105964201 105964209
SSPL121796009 121796010 121799715 121808330 121808642
HAN110878832 110879458 110889408 110889411 110889412 110895361 110908960 110908971 110916566 110936358 110937084 110937085
ECAD122595292 122602780 122603111 122603276 122605403 122605404 122605405
LSV111882072 111882075 111882076 111882082 111882088 111882089 111882091 111883451 111901848
CCAV112509926 112510064 112512134 112517352 112518894 112518895
DCR108193697 108196721 108200622 108202862 108212629 108215973 108220478 108222896 108222897 108222898 108223087
CSIN114265609 114270235 114270236 114270238 114282078 114293526 114322151 114323032
BVG104887630 104887632 104897651 104897756 104903734 104905365 104905366 104905367 109136247
SOE110774849 110774850 110776933 110784496 110784497 110785055 110799468 110799759 110800395
CQI110690211 110691988 110691990 110691992 110698020 110698032 110702053 110702055 110702057 110702060 110704372 110704577 110713099 110713105 110713113 110713558 110713686 110714094 110721471 110723210 110724462 110724467 110724468 110727182 110727183 110727184 110730649 110730710
NNU104591893 104602160(CHS3) 104602223 104602224 104602226
MING122061185 122061186 122061735 122065145 122065149 122065150 122065151 122066318 122066378 122066379 122066380 122068017 122068042 122070444 122070445 122071007 122072606 122075718 122076004 122077908 122078755 122078756 122084243 122088324 122090001 122090911 122090912 122090913 122090914 122091369 122091370 122091808 122091809 122091810 122091811 122091812 122091935 122092207
TSS122638405 122638406 122638407 122639730 122639731 122639733 122639735 122639736 122646665 122646666 122648418 122651293 122651468 122660784 122662841 122663603 122663604 122663605 122663606 122666282 122666283 122666284 122666285 122667850 122667851 122667852 122667853 122668381 122671923 122671926 122671927 122671928 122671929 122671931 122671932 122671933 122672359 122672441 122672467 122672721 122672723
PSOM113271507 113271508 113281217 113345230 113348195 113349173 113360844
NCOL116246995 116254980 116265292 116265581 116265582 116266355 116266356 116266357
OSA4342725 4350636
DOSAOs07t0214900-00(Os07g0214900) Os11t0530600-01(Os11g0530600)
OBR102700750 102701691
BDI100829639
ATS109739868 109739869 109743740 109743836 109752472 109752473 109752474 109758766 109768285 109768286 109775497 109775499 109775501 109780460 109787049
TDC119300036 119300456 119316879 119316888 119316897 119316912 119316920 119316929 119341264 119349646 119349729 119352754 119352759 119352829 119356930 119357412 119361794 119361861 119366176 119366541
TAES100037528 123040104 123047221 123047543 123048273 123049880 123051067 123051070 123055015 123071871 123073525 123085598 123104431 123104441 123104448 123104457 123104466 123104469 123104502 123123470 123123471 123157050 123159113 123159780 123163641 123179972 123179973 123184282 123186969 123186993 123187050 123190869 543104
TUA125530353 125531106 125534703 125535123 125535126 125537724 125540157
SBI8056975 8056976 8064814 8064815 8064816 8064817 8064818 8064819 8064820 8069670
ZMA100274415 100282642
SITA101760249 101773427 101774247 101774657 101783722
SVS117833598 117862883 117862884 117863212 117863578
PVIR120644569 120682828 120685353
PHAI112902744
PDA103698502 103700702 103712379 103720326 103720740 103720741 103723569 120105391 120111374 120111375 120111376 120111590 120111592 120111595 120111596
EGU105034198 105034617 105034618 105035716 105036364 105036416 105036921 105041005 105041539 105044627 105050962 105060373
MUS103968786 103968787 103968788 103968789 103968790 103972472 103977235 103986053 103987271 103987272 103987346 103987502 103987972 104000649 104000773 108952404
DCT110093469 110105072 110105073 110105791 110107833 110113809 110115249 110115253
PEQ110018302 110018892 110018893 110018896 110032208
AOF109823892 109829834 109836525 109850162
ATR105421766 18428598 18444038
SMOSELMODRAFT_230473 SELMODRAFT_230794 SELMODRAFT_233950 SELMODRAFT_270496 SELMODRAFT_271225 SELMODRAFT_403771
PPP112272830 112272842 112272843 112272845 112273835 112273837 112274269 112276778 112276782 112276927 112276928 112276938 112276939 112278882 112278883 112278884 112278885 112279075 112288360 112294401 112295755 112296040
FFUCLAFUR5_04816
 » show all
Reference
1  [PMID:3355160]
  Authors
Ayabe S, Udagawa A, Furuya T.
  Title
NAD(P)H-dependent 6'-deoxychalcone synthase activity in Glycyrrhiza echinata cells induced by yeast extract.
  Journal
Arch Biochem Biophys 261:458-62 (1988)
DOI:10.1016/0003-9861(88)90362-1
Reference
2  [PMID:7436427]
  Authors
Heller W, Hahlbrock K.
  Title
Highly purified "flavanone synthase" from parsley catalyzes the formation of naringenin chalcone.
  Journal
Arch Biochem Biophys 200:617-9 (1980)
DOI:10.1016/0003-9861(80)90395-1
Reference
3  [PMID:28482241]
  Authors
Yahyaa M, Ali S, Davidovich-Rikanati R, Ibdah M, Shachtier A, Eyal Y, Lewinsohn E, Ibdah M
  Title
Characterization of three chalcone synthase-like genes from apple (Malus x domestica Borkh.).
  Journal
Phytochemistry 140:125-133 (2017)
DOI:10.1016/j.phytochem.2017.04.022
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.3.1.74
IUBMB Enzyme Nomenclature: 2.3.1.74
ExPASy - ENZYME nomenclature database: 2.3.1.74
BRENDA, the Enzyme Database: 2.3.1.74
CAS: 56803-04-4

KEGG   REACTION: R07988
Entry
R07988                      Reaction                               
Name
malonyl-CoA:caffeoyl-CoA malonyltransferase (cyclizing)
Definition
Caffeoyl-CoA + 3 Malonyl-CoA <=> Eriodictyol chalcone + 4 CoA + 3 CO2
Equation
C00323 + 3 C00083 <=> C15525 + 4 C00010 + 3 C00011
Reaction class
RC00004  C00010_C00083  C00010_C00323
RC02726  C00323_C15525
Enzyme
Pathway
rn00941  Flavonoid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K00660  chalcone synthase [EC:2.3.1.74]

DBGET integrated database retrieval system