KEGG   ORTHOLOGY: K00743
Entry
K00743                      KO                                     
Symbol
GGTA1
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase [EC:2.4.1.87]
Pathway
map00601  Glycosphingolipid biosynthesis - lacto and neolacto series
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00601 Glycosphingolipid biosynthesis - lacto and neolacto series
    K00743  GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00743  GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.87  N-acetyllactosaminide 3-alpha-galactosyltransferase
     K00743  GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  ABO blood group
   K00743  GGTA1; N-acetyllactosaminide 3-alpha-galactosyltransferase
Other DBs
RN: R05978 R06145 R06169
GO: 0003946
CAZy: GT6
Genes
MTHB: 126937962
RRO: 104655865
RBB: 108537074
TFN: 117098733
PTEH: 111550328
CJC: 100390928(GGTA1P)
SBQ: 101038827
CSYR: 103251189(GGTA1)
MMUR: 105875133
LCAT: 123646481(GGTA1)
OGA: 100961603
MMU: 14594(Ggta1)
MCAL: 110289655
MPAH: 110318488
RNO: 246766(Ggta1)
MCOC: 116090066
MUN: 110558641
CGE: 100754535(Ggta1)
MAUA: 101835276(Ggta1)
PLEU: 114704707(Ggta1)
MORG: 121462785(Ggta1)
MFOT: 126491232
AAMP: 119819136(Ggta1)
NGI: 103734487
HGL: 101705531
CPOC: 100719695
CCAN: 109692479
DORD: 105996167
DSP: 122107087(Ggta1)
NCAR: 124964685
OCU: 100348435
OPI: 101519151(GGTA1)
TUP: 102502371
CFA: 491357(GGTA1)
CLUD: 112677145(GGTA1)
VVP: 112927838
VLG: 121473075(GGTA1)
AML: 100482234
UMR: 103670365
UAH: 113266361
UAR: 123788010(GGTA1)
ELK: 111145926
LLV: 125083451
MPUF: 101677189
EJU: 114212923
ZCA: 113934462(GGTA1)
MLX: 118017738(GGTA1)
NSU: 110581480(GGTA1)
FCA: 493877(GGTA1)
PYU: 121034927(GGTA1)
PBG: 122475015(GGTA1)
LRUF: 124503702
PTG: 102965067
PPAD: 109269868
AJU: 106986621
HHV: 120233419(GGTA1)
BTA: 281780(GGTA1)
BOM: 102282898
BIU: 109566417
CHX: 102168270
OAS: 443282(GGTA2P)
ODA: 120851938(GGTA1)
CCAD: 122442105(GGTA1)
SSC: 396733(GGTA1P)
CFR: 102516521
CBAI: 105065260
CDK: 105104406
VPC: 102541625
BACU: 103006673
LVE: 103089836
OOR: 101277096(GLT6D1)
DLE: 111177259(GLT6D1)
PCAD: 102975905(GLT6D1)
PSIU: 116755327
ECB: 100067589
EPZ: 103555510
EAI: 106824198(GGTA1)
MYB: 102261921
MYD: 102751930
MMYO: 118667122(GGTA1)
MLF: 102418670
MNA: 107537664
DRO: 112306460
SHON: 118995989(GGTA1)
AJM: 119046898(GGTA1)
PDIC: 114497325
PHAS: 123819701
MMF: 118630216(GGTA1)
PALE: 102892029
PGIG: 120605761(GGTA1)
PVP: 105292696
RAY: 107516315
MJV: 108405129(GLT6D1)
TOD: 119232266(GGTA1)
SARA: 101550558
LAV: 100655343
TMU: 101350553
DNM: 101426740
GAS: 123233711 123237374(GGTA1)
OAA: 100089476
ACS: 103281997
PVT: 110078804
SUND: 121936010(GLT6D1)
PBI: 103058654
PMUR: 107295054
CTIG: 120308657
TSR: 106542602
PGUT: 117676609
VKO: 123028190
PMUA: 114589231(GLT6D1)
ZVI: 118083828(GLT6D1)
GJA: 107118477
STOW: 125441522
NPR: 108793736
RTEM: 120913257
RTP: 109918400
 » show all
Reference
PMID:2510162
  Authors
Larsen RD, Rajan VP, Ruff MM, Kukowska-Latallo J, Cummings RD, Lowe JB
  Title
Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning  by gene transfer.
  Journal
Proc Natl Acad Sci U S A 86:8227-31 (1989)
DOI:10.1073/pnas.86.21.8227
  Sequence
[mmu:14594]

KEGG   ENZYME: 2.4.1.87
Entry
EC 2.4.1.87                 Enzyme                                 
Name
N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]
Reaction(KEGG)
R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)
Substrate
UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R
Product
UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]
Comment
Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.
History
EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)
Pathway
ec00601  Glycosphingolipid biosynthesis - lacto and neolacto series
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase
K20736  alpha-1,3-galactosyltransferase 2
Genes
HSA127550(A3GALT2)
PTR104007284(A3GALT2)
PPS100975171(A3GALT2)
GGO101137879(A3GALT2)
PON100431438(A3GALT2)
NLE100586880(A3GALT2)
MCC711045(A3GALT2)
MCF102136396(A3GALT2)
MTHB126930244 126937962
CSAB103225947(A3GALT2)
CATY105594799(A3GALT2)
PANU101020613(A3GALT2)
TGE112625133(A3GALT2)
RRO104655865 104677306(A3GALT2)
RBB108537074 108537279(A3GALT2)
TFN117092920(A3GALT2) 117098733
PTEH111550328 111555868(A3GALT2)
CJC100390928(GGTA1P) 100414894(A3GALT2)
SBQ101033629(A3GALT2) 101038827
CSYR103251189(GGTA1) 103258027(A3GALT2)
MMUR105871787(A3GALT2) 105875133
LCAT123635805(A3GALT2) 123646481(GGTA1)
OGA100949731(A3GALT2) 100961603
MMU14594(Ggta1) 215493(A3galt2)
MCAL110289655 110292229(A3galt2)
MPAH110318488 110323213(A3galt2)
RNO171553(A3galt2) 246766(Ggta1)
MCOC116090066 116096681(A3galt2)
MUN110548184(A3galt2) 110558641
CGE100754535(Ggta1) 100774283(A3galt2)
MAUA101829635(A3galt2) 101835276(Ggta1)
PLEU114682033(A3galt2) 114704707(Ggta1)
MORG121448691(A3galt2) 121462785(Ggta1)
MFOT126491232 126507921
AAMP119818014(A3galt2) 119819136(Ggta1)
NGI103730905(A3galt2) 103734487
HGL101699219(A3galt2) 101705531
CPOC100719695 100725746(A3galt2)
CCAN109686855(A3galt2) 109692479
DORD105988804(A3galt2) 105996167
DSP122106733(A3galt2) 122107087(Ggta1)
NCAR124964685 124978089
OCU100339429(A3GALT2) 100348435
OPI101519151(GGTA1) 101523303(A3GALT2)
TUP102483559(A3GALT2) 102502371
CFA487298(A3GALT2) 491357(GGTA1)
CLUD112660251(A3GALT2) 112677145(GGTA1)
VVP112927838 112931709(A3GALT2)
VLG121473075(GGTA1) 121498202(A3GALT2)
AML100479995(A3GALT2) 100482234
UMR103670365
UAH113266361 113268332(A3GALT2)
UAR123782181(A3GALT2) 123788010(GGTA1)
ELK111143712 111145926
LLV125083451 125097516
MPUF101671456(A3GALT2) 101677189
ORO101365724(A3GALT2) 101367788 101371520
EJU114212923 114217073(A3GALT2)
ZCA113916273(A3GALT2) 113934462(GGTA1)
MLX118017738(GGTA1) 118019722(A3GALT2)
NSU110575416(A3GALT2) 110581480(GGTA1)
FCA101084042(A3GALT2) 493877(GGTA1)
PYU121025760(A3GALT2) 121034927(GGTA1)
PBG122475015(GGTA1) 122482124(A3GALT2)
LRUF124503702 124514376
PTG102965067 107180570(A3GALT2)
PPAD109255233 109255324 109269868
AJU106973174(A3GALT2) 106986621
HHV120232112(A3GALT2) 120233419(GGTA1)
BTA281780(GGTA1) 617693(A3GALT2)
BOM102276118(A3GALT2) 102282898
BIU109566417 109575981(A3GALT2)
BBUB102398588(GGTA1) 102402563(A3GALT2) 102405485 123333796
CHX102168270 108637492(A3GALT2)
OAS101103704(A3GALT2) 443282(GGTA2P)
ODA120851938(GGTA1) 120854762(A3GALT2)
CCAD122426222(A3GALT2) 122442105(GGTA1)
SSC100739829(A3GALT2) 396733(GGTA1P)
CFR102516495(A3GALT2) 102516521
CBAI105065260
CDK105104406 116156821(A3GALT2)
VPC102541625
BACU103006673
LVE103079826(A3GALT2) 103089836
OOR101277096(GLT6D1) 101279702(A3GALT2)
DLE111175451(A3GALT2) 111177259(GLT6D1)
PCAD102975905(GLT6D1) 102996822(A3GALT2)
PSIU116755327 116755462(A3GALT2)
ECB100067589 106782783(A3GALT2)
EPZ103555510 103557792(A3GALT2)
EAI106824198(GGTA1) 106829012(A3GALT2)
MYB102261921
MYD102751930 102753567(A3GALT2)
MMYO118667122(GGTA1) 118675052(A3GALT2)
MLF102418670 102418780(A3GALT2)
MNA107537664 107542062(A3GALT2)
PKL118724792(A3GALT2)
HAI109383944 109385732 109390838(A3GALT2)
DRO112299104(A3GALT2) 112306460
SHON118995989(GGTA1) 118997700(A3GALT2)
AJM119046898(GGTA1) 119052438(A3GALT2)
PDIC114497325 114497543(A3GALT2)
PHAS123819701 123831861(A3GALT2)
MMF118627073(A3GALT2) 118630216(GGTA1)
RFQ117020071 117027790(A3GALT2) 117032059
PALE102885392(A3GALT2) 102892029
PGIG120582036(A3GALT2) 120605761(GGTA1)
PVP105290602(A3GALT2) 105292696
RAY107513619(A3GALT2) 107516315
MJV108401813(A3GALT2) 108405129(GLT6D1)
TOD119232266(GGTA1) 119236484(A3GALT2)
SARA101537225(A3GALT2) 101550558
LAV100655343 100671107(A3GALT2)
TMU101350553 101352341
DNM101421783(A3GALT2) 101426740
MDO100016068 100016105
GAS123233711 123237374(GGTA1)
SHR100932826 100933356
PCW110211311 110211337
OAA100089476
PSS102447976(A3GALT2)
CMY102941601
ACS103281997
PVT110078804
SUND121936010(GLT6D1)
PBI103058654
PMUR107295054
CTIG120308657
TSR106542602
PGUT117676609
VKO123028190
PMUA114589231(GLT6D1)
ZVI118083828(GLT6D1)
GJA107118477
STOW125441522
NPR108793736
RTEM120913257
TRU101078261(a3galt2)
TNGGSTEN00027557G001
LCO104919360
NCC104957307(a3galt2)
CGOB115004723 115007798(a3galt2)
ELY117256487 117259063 117259076
EFO125879807 125879816 125889109
PLEP121939462 121945515 121945523 121959687
SLUC116037649 116051301 116057313 116067217 116067352
ECRA117943156 117945686 117945922 117948437 117948445
ESP116688624 116691062 116694142
PFLV114553924 114554441 114554518 114554598 114554673 114556077
GAT120834481 120835170
PPUG119195871 119230135
MSAM119885654 119890562
CUD121503700 121507200 121507410
ALAT119018129 119021141
MZE101476245(a3galt2)
ONL100691157 100696629 100699221 100706236 106098913 109204947
OAU116312925 116316519 116323213 116334247 116336518 120440900 120443130
OLA101158589 101158846 101159083 101159331 101159492 110014315
OML112145436 112161178 112161179 112161180
XMA102225862(a3galt2)
XCO114135833(a3galt2) 114142426
XHE116711175 116716720 116718494 116724797 116733252
PRET103462901 103464476(a3galt2)
PFOR103136623(a3galt2) 103144194
PLAI106945815(a3galt2) 106953116
PMEI106924734(a3galt2) 106927369
GAF122834004 122844420
CVG107087544 107094052 107098819
CTUL119772774 119796323 119796330
GMU124857033 124866475
NFU107372345 107385258 107385260
KMR108229171 108229172 108231546 108231617 108234809 119616584
ALIM106513849 106513851 106519097
NWH119412395 119412396 119412397 119426969
AOCE111574913 111588016(a3galt2)
MCEP125005723 125006159
CSEM103378785 103385676
POV109637219 109638603
SSEN122768615 122772585 122773138
HHIP117757446 117761542
HSP118105204 118112067
LCF108887790 108899900
SDU111224019
SLAL111658256
XGL120801819 120807446
BPEC110168737
MALB109958978
BSPL114852556 114856414
SASA106565705 106582820
STRU115150916 115207511
OTW112220697 112254318
OMY110494632 110527833
OGO124003325 124031534
ONE115136718 115143428
SALP111969813 111969849
SNH120020412 120065536
CCLU121574840 121578734
ELS105017413
SFM108918234(a3galt2) 108924914
PKI111857101 111859140
AANG118208254 118208255 118210928
LOC102684573(a3galt2)
PSPA121306694 121306703 121328869 121329372
ARUT117396907 117422694 117422696 117422697 117431939 117964722 117974010 117974011
LCM102357128
CMK103181344
RTP109918400 109924380(a3galt2)
 » show all
Reference
1  [PMID:4632915]
  Authors
Basu M, Basu S.
  Title
Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.
  Journal
J Biol Chem 248:1700-6 (1973)
Reference
2  [PMID:3932335]
  Authors
Blanken WM, Van den Eijnden DH.
  Title
Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.
  Journal
J Biol Chem 260:12927-34 (1985)
Reference
3  [PMID:6787040]
  Authors
Blake DA, Goldstein IJ.
  Title
An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).
  Journal
J Biol Chem 256:5387-93 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.87
IUBMB Enzyme Nomenclature: 2.4.1.87
ExPASy - ENZYME nomenclature database: 2.4.1.87
BRENDA, the Enzyme Database: 2.4.1.87
CAS: 128449-51-4

KEGG   REACTION: R05978
Entry
R05978                      Reaction                               
Definition
UDP-D-galactose + Paragloboside <=> UDP + nLc5Cer
Equation
Enzyme
Pathway
rn00601  Glycosphingolipid biosynthesis - lacto and neolacto series
rn01100  Metabolic pathways
Orthology
K00743  N-acetyllactosaminide 3-alpha-galactosyltransferase [EC:2.4.1.87]

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