KEGG   ORTHOLOGY: K01080
Entry
K01080                      KO                                     

Symbol
PLPP1_2_3
Name
phosphatidate phosphatase [EC:3.1.3.4]
Pathway
map00561  Glycerolipid metabolism
map00564  Glycerophospholipid metabolism
map00565  Ether lipid metabolism
map00600  Sphingolipid metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04072  Phospholipase D signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04975  Fat digestion and absorption
map05231  Choline metabolism in cancer
Module
M00089  Triacylglycerol biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00561 Glycerolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00564 Glycerophospholipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00565 Ether lipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
   00600 Sphingolipid metabolism
    K01080  PLPP1_2_3; phosphatidate phosphatase
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K01080  PLPP1_2_3; phosphatidate phosphatase
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K01080  PLPP1_2_3; phosphatidate phosphatase
  09154 Digestive system
   04975 Fat digestion and absorption
    K01080  PLPP1_2_3; phosphatidate phosphatase
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K01080  PLPP1_2_3; phosphatidate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.4  phosphatidate phosphatase
     K01080  PLPP1_2_3; phosphatidate phosphatase
Other DBs
RN: R02239 R04162 R06520 R06521 R06522
GO: 0008195
Genes
HSA: 8611(PLPP1) 8612(PLPP2) 8613(PLPP3)
PTR: 455525(PLPP2) 456884(PLPP3) 461869(PLPP1)
PPS: 100975594(PLPP3) 100975798(PLPP2) 100987060(PLPP1)
GGO: 101127981(PLPP2) 101137498(PLPP3) 101146159(PLPP1)
PON: 100442989(PLPP2) 100448168(PLPP1) 100455097(PLPP3)
NLE: 100580386 100581368(PLPP3) 100606664(PLPP1) 115830389(PLPP2) 115834360 115835047
MCC: 706539(PLPP1) 715993(PLPP3) 721004(PLPP2)
MCF: 102126222(PLPP2) 102135864(PLPP3) 102145183(PLPP1)
CSAB: 103221500(PLPP1) 103224742(PLPP3) 103233553(PLPP2)
CATY: 105591665(PPAP2C) 105595985(PPAP2B) 105597707(PPAP2A)
RRO: 104664269(PLPP3) 104673869 104680488(PLPP1) 115899223(PLPP2)
RBB: 108530983(PLPP1) 108531774(PLPP2) 108532937(PLPP3)
TFN: 117065131(PLPP1) 117076323(PLPP2) 117091971(PLPP3)
PTEH: 111523286(PLPP3) 111528880(PLPP2) 111533512 111541632(PLPP1)
CJC: 100395846(PLPP3) 100401080(PLPP1) 100410546(PLPP2) 100410701 100410935
SBQ: 101033570(PPAP2A) 101048272(PPAP2B) 101052893(PPAP2C)
MMUR: 105860849(PLPP2) 105869677 105877296(PLPP1) 105882571(PLPP3)
MMU: 19012(Plpp1) 50784(Plpp2) 67916(Plpp3)
MCAL: 110292859(Plpp3) 110303185(Plpp2) 110307554(Plpp1)
MPAH: 110323294(Plpp3) 110326500(Plpp2) 110328777(Plpp1)
RNO: 192270(Plpp3) 246115(Plpp2) 64369(Plpp1)
MCOC: 116075807(Plpp2) 116083513(Plpp1) 116096330(Plpp3)
MUN: 110551382(Plpp2) 110556364(Plpp3) 110558764(Plpp1)
CGE: 100771106(Plpp1) 100774295(Plpp2) 100774527(Plpp3)
PLEU: 114689172(Plpp2) 114703628(Plpp1) 114705854(Plpp3)
NGI: 103734095(Plpp3) 103737371(Plpp2) 103739918(Plpp1)
HGL: 101699454(Plpp3) 101724889(Plpp1) 101725640(Plpp2)
CCAN: 109678789 109686126(Plpp2) 109687259(Plpp3) 109691754(Plpp1)
OCU: 100008821(PLPP1) 100338249(PLPP3) 100351889(PLPP2)
OPI: 101522587(PLPP2) 101527889(PLPP1) 101528957(PLPP3)
TUP: 102489550(PLPP2) 102499580(PLPP1) 102500387(PLPP3)
CFA: 100856443(PLPP2) 479557(PLPP3) 607962(PLPP1)
VVP: 112926099(PLPP3) 112935158(PLPP1) 112935627(PLPP2)
VLG: 121494910(PLPP2) 121496855(PLPP1) 121499447(PLPP3)
AML: 100475075(PLPP2) 100479871(PLPP1) 100481127(PLPP3)
UMR: 103663676(PLPP1) 103670677(PLPP3) 103681620(PLPP2)
UAH: 113242688(PLPP2) 113254620(PLPP3) 113255329(PLPP1)
ORO: 101370883(PPAP2A) 101378709(PPAP2B) 101384673(PPAP2C)
MPUF: 101670217(PPAP2B) 101670341(PPAP2C) 101670869(PPAP2A)
EJU: 114212111(PLPP3) 114221020(PLPP1) 114226349(PLPP2)
MLX: 118005337(PLPP2) 118016791(PLPP1) 118019368(PLPP3)
FCA: 101088547(PLPP1) 101088986(PLPP2) 101095760(PLPP3)
PYU: 121015910(PLPP1) 121021879(PLPP2) 121027197(PLPP3)
PBG: 122480558(PLPP3) 122486596(PLPP2) 122488962(PLPP1)
PTG: 102971478(PLPP1) 102971527(PLPP3) 102971652(PLPP2)
PPAD: 109246335(PLPP1) 109257719(PLPP2) 109266799(PLPP3)
AJU: 106975062(PLPP3) 106978113(PLPP2) 106987316(PLPP1)
HHV: 120235544(PLPP3) 120239969(PLPP1) 120242417(PLPP2)
BTA: 101905992 504545(PLPP2) 617172(PLPP1) 617707(PLPP3)
BOM: 102270713(PLPP3) 102277289(PLPP2) 102278931(PLPP1)
BIU: 109556245(PLPP3) 109561957(PLPP2) 109574777(PLPP1)
BBUB: 102404075(PLPP2) 102407729(PLPP1) 102409556 102409796(PLPP3)
CHX: 102171567(PLPP3) 102181946(PLPP2) 102183913(PLPP1)
OAS: 101102020(PLPP3) 101106938(PLPP2) 101115312(PLPP1)
ODA: 120856089(PLPP3) 120863745(PLPP2) 120879519(PLPP1)
CCAD: 122436919(PLPP3) 122440305 122454272(PLPP1)
SSC: 100233200(PLPP2) 100512419(PLPP3) 100515451(PLPP1)
CFR: 102507880(PLPP1) 102510542(PLPP3) 102517507(PLPP2)
CBAI: 105071666(PPAP2B) 105077809(PPAP2A) 105078096(PPAP2C)
CDK: 105087144(PLPP1) 105092818(PLPP3) 105093401(PLPP2)
BACU: 102997391(PLPP1) 103007844(PLPP2) 103018691(PLPP3)
LVE: 103068920(PLPP3) 103077334(PLPP1) 103089367(PLPP2)
OOR: 101269638(PPAP2B) 101281392(PPAP2C) 101285196(PPAP2A)
DLE: 111166071 111170478(PLPP2) 111175860(PLPP3) 111186684(PLPP1)
PCAD: 102975027(PLPP1) 102991729 102994205(PLPP2) 102994990
ECB: 100049896(PLPP3) 100062257(PLPP1) 100147309(PLPP2)
EAI: 106833476(PLPP3) 106843361(PLPP1) 106846459(PLPP2)
MYB: 102248875(PLPP3) 102250749(PLPP1) 102258225(PLPP2)
MYD: 102751980(PLPP1) 102758376(PLPP2) 102774584(PLPP3)
MMYO: 118655937(PLPP1) 118658918(PLPP2) 118677424(PLPP3)
MNA: 107527147(PLPP1) 107530656(PLPP3) 107538563(PLPP2)
PKL: 118702798(PLPP1) 118710854(PLPP2) 118724935(PLPP3) 118731440
HAI: 109374015(PLPP3) 109382141(PLPP1) 109390650(PLPP2)
DRO: 112312254 112312406(PLPP2) 112314639(PLPP3) 112315303(PLPP1)
SHON: 118981721(PLPP1) 118984365(PLPP2) 118984948(PLPP3)
AJM: 119044622(PLPP2) 119049178(PLPP1) 119055711(PLPP3)
MMF: 118616127(PLPP2) 118627180(PLPP3) 118641651(PLPP1)
PALE: 102879242(PLPP1) 102893849(PLPP3) 102895617(PLPP2)
PGIG: 120599576(PLPP2) 120608183(PLPP1) 120621720(PLPP3)
RAY: 107500958(PLPP2) 107509645(PLPP1) 107518343(PLPP3)
MJV: 108384186(PLPP1) 108391746(PLPP2) 108391870(PLPP3)
TOD: 119235983(PLPP3) 119240459(PLPP2) 119253210 119260441(PLPP1)
LAV: 100666604(PLPP2) 100668340(PLPP1) 100671563(PLPP3)
MDO: 100025143(PLPP2) 100031858(PLPP1) 100032239(PLPP3) 103102185
SHR: 100926398(PLPP3) 100927244(PLPP2) 100934490(PLPP1) 111719176
PCW: 110201323(PLPP3) 110215613(PLPP1) 110223464(PLPP2)
OAA: 100084258(PLPP1) 100087743(PLPP2) 100090109 114805419(PLPP3)
GGA: 100858471(PLPP2) 424666(PLPP3) 427138(PLPP1)
PCOC: 116235210(PLPP3) 116236157(PLPP2) 116239412(PLPP1)
MGP: 100547177(PLPP3) 100550008(PLPP1) 100551396
CJO: 107305985(PLPP1) 107317705(PLPP3) 107325607(PLPP2)
NMEL: 110388949(PLPP2) 110389343(PLPP1) 110402871(PLPP3)
APLA: 101799557(PLPP1) 101801518(PLPP2) 101802813(PLPP3)
ACYG: 106032990(PPAP2B) 106035619(PPAP2A) 106049096(PPAP2C)
TGU: 100220959(PLPP1) 100227047(PLPP3) 105758944(PLPP2)
LSR: 110472552(PLPP1) 110475755(PLPP2) 110476823(PLPP3)
SCAN: 103815204(PLPP3) 103821097(PLPP1) 103821938(PLPP2)
PMOA: 120498104(PLPP2) 120502327(PLPP1) 120503176(PLPP3)
OTC: 121342337(PLPP2) 121345010(PLPP3) 121346607(PLPP1)
PRUF: 121355315(PLPP1) 121361520(PLPP2) 121361956(PLPP3)
GFR: 102031614(PLPP3) 102036933(PLPP1) 102043918(PLPP2)
FAB: 101805764(PLPP1) 101813170(PLPP3) 101819263(PLPP2)
PHI: 102101243(PLPP2) 102107198(PLPP1) 102111145(PLPP3)
PMAJ: 107207902(PLPP3) 107215342(PLPP2) 107216077(PLPP1)
CCAE: 111932890(PLPP3) 111940297(PLPP2) 111941443(PLPP1)
CCW: 104686671(PLPP1) 104695166(PLPP3) 104697003(PLPP2)
ETL: 114055191(PLPP3) 114065910(PLPP1) 114066415(PLPP2)
FPG: 101914539(PLPP1) 101919468(PLPP3) 101924183(PLPP2)
FCH: 102049189(PLPP3) 102049436(PLPP2) 102053348(PLPP1)
CLV: 102083991(PLPP2) 102087921(PLPP3) 102096477(PLPP1)
EGZ: 104123890(PPAP2B) 104124383(PPAP2C) 104134698(PPAP2A)
NNI: 104009343(PPAP2B) 104013735(PPAP2A) 104016268(PPAP2C)
ACUN: 113482802(PLPP3) 113489374(PLPP2) 113489583(PLPP1)
PADL: 103913360(PPAP2B) 103919442(PPAP2A) 103923468(PPAP2C)
AROW: 112964502(PLPP1) 112972833(PLPP3) 112973892(PLPP2)
NPD: 112943461(PLPP3) 112945747(PLPP1) 112946886(PLPP2)
DNE: 112986123(PLPP3) 112988092(PLPP2) 112995756(PLPP1)
ASN: 102371394(PLPP3) 102383543 102384747(PLPP2) 102385252(PLPP1)
AMJ: 102558172(PLPP1) 102561392 102571973(PLPP3) 109282348(PLPP2)
CPOO: 109307014(PLPP3) 109307912(PLPP1) 109320472(PLPP2)
GGN: 109286604(PLPP3) 109294907(PLPP2) 109298125(PLPP1)
PSS: 102452592(PLPP3) 102456134 102457256(PLPP1) 102460931(PLPP2)
CMY: 102933032 102937547(PLPP1) 102939201(PLPP3) 102945370(PLPP2)
CPIC: 101934148(PLPP1) 101945684(PLPP2) 101948636(PLPP3) 101949714
TST: 117868947(PLPP2) 117878997(PLPP1) 117881328(PLPP3) 117888966
CABI: 116818258(PLPP1) 116825271(PLPP2) 116830785 116838122(PLPP3)
ACS: 100552130(plpp3) 100552631(plpp2) 100557280 100562534(plpp1)
PVT: 110077116(PLPP3) 110079297(PLPP2) 110085398(PLPP1) 110091305
PBI: 103049864(PLPP1) 103064697(PLPP3) 103064795(PLPP2) 103067987
PMUR: 107286640(PLPP3) 107287995 107294978(PLPP1) 107295330(PLPP2)
TSR: 106540415(PPAP2B) 106546268(PPAP2A)
PGUT: 117664281(PLPP3) 117668571(PLPP2) 117675610 117679194(PLPP1)
PMUA: 114587688 114598944(PLPP3) 114606651(PLPP1)
ZVI: 118077148(PLPP1) 118087507(PLPP2) 118088219(PLPP3) 118097538
GJA: 107116100 107120510(PLPP1) 107120594(PLPP2) 107124049(PLPP3)
XLA: 108703504(XB5961369.S) 108711730(plpp3l.L) 443680(plpp2.L) 443763(plpp2.S) 444206 447215(plpp3.L) 447319(plpp3.S) 735106(plpp1.L)
XTR: 100135382 394722(plpp2) 496488(plpp1) 549612(plpp3)
NPR: 108788162(PLPP3) 108791241(PLPP2) 108791487 108796685(PLPP1)
DRE: 335485(plpp2b) 557680(plpp3) 559124(ppap2d) 563806(plpp2a) 569053(plpp1a) 794598
ELY: 117251873 117254096(plpp2b) 117254211(plpp3) 117255053 117267528(plpp2a) 117268905(ppap2d) 117269630(plpp1a) 117272018
PLEP: 121938127(plpp2b) 121940033(plpp3) 121951529 121953516(plpp2a) 121956235 121959478(plpp1a)
SLUC: 116042817 116045568 116054199 116055344(plpp2b) 116057358(plpp2a) 116058894(plpp3) 116059461(ppap2d) 116062910(plpp1a)
ECRA: 117935971(plpp2a) 117944222 117950170(plpp3) 117950539(plpp2b) 117954286 117958040(ppap2d) 117959273 117959428(plpp1a)
GAT: 120814816(plpp3) 120815689 120824229(plpp2b) 120824879 120827610(ppap2d) 120830862 120831999(plpp1a) 120832659(plpp2a)
CUD: 121503894(ppap2d) 121507728 121509271 121512113(plpp2b) 121512475(plpp3) 121520627 121524983(plpp1a) 121525798(plpp2a)
OAU: 116310510 116310564 116314746 116317340(plpp2b) 116317637(ppap2d) 116318021(plpp2a) 116331101(plpp3) 116331695(plpp1a)
OML: 112146851(ppap2d) 112147569 112148919 112150281(plpp2a) 112150876(plpp2b) 112156050(plpp3) 112163484(plpp1a)
CTUL: 119772358(plpp3) 119775715(plpp2a) 119776550(plpp1a) 119779300 119785322(ppap2d) 119794277(plpp2b) 119798021 119798598
KMR: 108230566(plpp2b) 108231011(plpp1a) 108232898(plpp2a) 108233558 108238297 108241330(ppap2d) 108241453 108243395(plpp3)
XGL: 120784860(ppap2d) 120790755(plpp3) 120790890(plpp2b) 120795922(plpp2a) 120798925 120800282 120805288 120806400(plpp1a)
LOC: 102683657 102687719(plpp2) 102687877(plpp1) 102693363(plpp3)
LCM: 102349675 102352131(PLPP2) 102361613(PLPP1) 102365207(PLPP3)
CMK: 103177820(plpp1a) 103182070(plpp2a) 103182773(plpp3) 103187548
CIN: 100177985
DME: Dmel_CG11425(CG11425) Dmel_CG11426(CG11426) Dmel_CG11437(CG11437) Dmel_CG11438(CG11438) Dmel_CG11440(laza) Dmel_CG8804(wun) Dmel_CG8805(wun2)
DSI: Dsimw501_GD10076(Dsim_GD10076) Dsimw501_GD10653(Dsim_GD10653) Dsimw501_GD12067(Dsim_GD12067) Dsimw501_GD15029(Dsim_GD15029) Dsimw501_GD15030(Dsim_GD15030) Dsimw501_GD15031(Dsim_GD15031) Dsimw501_GD15032(Dsim_GD15032)
FAS: 105273627
DAM: 107038816
HHAL: 106688541
CEL: CELE_F13E6.5(plpp-1.3) CELE_F53C3.13(plpp-1.1) CELE_T28D9.3(plpp-1.2)
BMY: BM_BM4298(Bma-plpp-1.1)
TSP: Tsp_06576
LAK: 106171462
DGT: 114517111
AQU: 100632908
FTL: FTL_1728
FTH: FTH_1667
 » show all
Reference
  Authors
Carman GM, Han GS
  Title
Phosphatidic acid phosphatase, a key enzyme in the regulation of lipid synthesis.
  Journal
J Biol Chem 284:2593-7 (2009)
DOI:10.1074/jbc.R800059200
Reference
  Authors
Brindley DN, Pilquil C, Sariahmetoglu M, Reue K
  Title
Phosphatidate degradation: phosphatidate phosphatases (lipins) and lipid phosphate phosphatases.
  Journal
Biochim Biophys Acta 1791:956-61 (2009)
DOI:10.1016/j.bbalip.2009.02.007
Reference
  Authors
Smyth SS, Sciorra VA, Sigal YJ, Pamuklar Z, Wang Z, Xu Y, Prestwich GD, Morris AJ
  Title
Lipid phosphate phosphatases regulate lysophosphatidic acid production and signaling in platelets: studies using chemical inhibitors of lipid phosphate phosphatase activity.
  Journal
J Biol Chem 278:43214-23 (2003)
DOI:10.1074/jbc.M306709200
  Sequence
[hsa:8611]

DBGET integrated database retrieval system