KEGG   ORTHOLOGY: K01471
Entry
K01471            Tight     KO                                     
Symbol
nylA
Name
6-aminohexanoate-cyclic-dimer hydrolase [EC:3.5.2.12]
Pathway
map00930  Caprolactam degradation
map01120  Microbial metabolism in diverse environments
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00930 Caprolactam degradation
    K01471  nylA; 6-aminohexanoate-cyclic-dimer hydrolase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.12  6-aminohexanoate-cyclic-dimer hydrolase
     K01471  nylA; 6-aminohexanoate-cyclic-dimer hydrolase
Other DBs
RN: R03448
GO: 0019874
Genes
AG: BAA05090(nylA)
Reference
  Authors
Negoro S
  Title
Biodegradation of nylon oligomers.
  Journal
Appl Microbiol Biotechnol 54:461-6 (2000)
DOI:10.1007/s002530000434
  Sequence
Reference
PMID:2722746
  Authors
Tsuchiya K, Fukuyama S, Kanzaki N, Kanagawa K, Negoro S, Okada H
  Title
High homology between 6-aminohexanoate-cyclic-dimer hydrolases of Flavobacterium and Pseudomonas strains.
  Journal
J Bacteriol 171:3187-91 (1989)
DOI:10.1128/JB.171.6.3187-3191.1989
  Sequence

KEGG   ENZYME: 3.5.2.12
Entry
EC 3.5.2.12                 Enzyme                                 
Name
6-aminohexanoate-cyclic-dimer hydrolase
Class
Hydrolases;
Acting on carbon-nitrogen bonds, other than peptide bonds;
In cyclic amides
Sysname
1,8-diazacyclotetradecane-2,9-dione lactamhydrolase
Reaction(IUBMB)
1,8-diazacyclotetradecane-2,9-dione + H2O = N-(6-aminohexanoyl)-6-aminohexanoate [RN:R03448]
Reaction(KEGG)
R03448
Substrate
1,8-diazacyclotetradecane-2,9-dione [CPD:C04277];
H2O [CPD:C00001]
Product
N-(6-aminohexanoyl)-6-aminohexanoate [CPD:C01255]
Comment
The cyclic dimer of 6-aminohexanoate is converted to the linear dimer.
History
EC 3.5.2.12 created 1983
Pathway
ec00930  Caprolactam degradation
ec01120  Microbial metabolism in diverse environments
Orthology
K01471  6-aminohexanoate-cyclic-dimer hydrolase
Reference
1  [PMID:923591]
  Authors
Kinoshita S, Negoro S, Muramatsu M, Bisaria VS, Sawada S, Okada H.
  Title
6-Aminohexanoic acid cyclic dimer hydrolase. A new cyclic amide hydrolase produced by Achromobacter guttatus KI74.
  Journal
Eur J Biochem 80:489-95 (1977)
DOI:10.1111/j.1432-1033.1977.tb11904.x
Other DBs
ExplorEnz - The Enzyme Database: 3.5.2.12
IUBMB Enzyme Nomenclature: 3.5.2.12
ExPASy - ENZYME nomenclature database: 3.5.2.12
UM-BBD (Biocatalysis/Biodegradation Database): 3.5.2.12
BRENDA, the Enzyme Database: 3.5.2.12
CAS: 60976-29-6

KEGG   REACTION: R03448
Entry
R03448                      Reaction                               
Name
1,8-diazacyclotetradecane-2,9-dione lactamhydrolase
Definition
1,8-Diazacyclotetradecane-2,9-dione + H2O <=> N-(6-Aminohexanoyl)-6-aminohexanoate
Equation
Reaction class
RC00931  C01255_C04277
Enzyme
Pathway
rn00930  Caprolactam degradation
rn01120  Microbial metabolism in diverse environments
Orthology
K01471  6-aminohexanoate-cyclic-dimer hydrolase [EC:3.5.2.12]
Other DBs
RHEA: 16228

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