KEGG   ORTHOLOGY: K01654
Entry
K01654                      KO                                     

Symbol
neuB, nnaB
Name
N-acetylneuraminate synthase [EC:2.5.1.56]
Pathway
map00520  Amino sugar and nucleotide sugar metabolism
map00541  O-Antigen nucleotide sugar biosynthesis
map01100  Metabolic pathways
map01250  Biosynthesis of nucleotide sugars
Module
M00922  CMP-Neu5Ac biosynthesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00520 Amino sugar and nucleotide sugar metabolism
    K01654  neuB, nnaB; N-acetylneuraminate synthase
  09107 Glycan biosynthesis and metabolism
   00541 O-Antigen nucleotide sugar biosynthesis
    K01654  neuB, nnaB; N-acetylneuraminate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.56  N-acetylneuraminate synthase
     K01654  neuB, nnaB; N-acetylneuraminate synthase
Other DBs
RN: R01804 R04435
COG: COG2089
GO: 0050462
Genes
ECOO: ECRM13514_2762(nnaB)
ECOH: ECRM13516_2630(nnaB)
ESL: O3K_09230
ESO: O3O_16390
ESM: O3M_09195
ECK: EC55989_2295
ECV: APECO1_3471(neuB)
ECM: EcSMS35_3232(neuB)
ECT: ECIAI39_3443(neuB)
EOC: CE10_3481(neuB)
ECI: UTI89_C3372(neuB)
EIH: ECOK1_3369(neuB)
ECZ: ECS88_3330(neuB)
ECOI: ECOPMV1_03252(spsE)
SBZ: A464_2222
ETR: ETAE_1207(neuB)
ETD: ETAF_1122
ETE: ETEE_3151(neuB)
EDL: AAZ33_06215(neuB)
HPR: PARA_02850(nnaB)
MHT: D648_18140(neuB)
MHQ: D650_8020(neuB)
MHAT: B824_18220(neuB)
MHX: MHH_c26670(nnaB)
MHAE: F382_04090
MHAM: J450_03120
MHAO: J451_04330
MHAL: N220_10190
MHAQ: WC39_04015
MHAY: VK67_04015
MVR: X781_5990
MVE: X875_5510
MBOS: ICJ55_05335(neuB)
ADP: NCTC12871_01316(spsE)
RPNE: NCTC8284_01156(spsE)
RHEY: FEE42_11160(neuB)
VSA: VSAL_I3011(neuB)
MMAI: sS8_2961
NME: NMB0068(siaC)
NMP: NMBB_0073(siaC)
NMQ: NMBM04240196_0082(siaC)
NMZ: NMBNZ0533_0074(siaC)
NMC: NMC0052(siaC)
NMN: NMCC_0076(siaC)
NMT: NMV_0069(siaC)
NWE: SAMEA3174300_1366(siaC)
NBL: GJV52_06945(siaC)
BPSI: IX83_06875
CJE: Cj1141(neuB1)
CJB: BN148_1141(neuB1)
CJU: C8J_1339
CJI: CJSA_1083(neuB1)
CJEJ: N564_01107
CJEU: N565_01150
CJEN: N755_01145
CJEI: N135_01178
CJY: QZ67_01219(legI_1)
CIS: CINS_1205(neuB)
CSM: CSUB8521_1427(neuB)
CAVI: CAV_0275(neuB)
CUX: CUP3940_0880(neuB)
CMUC: CMCT_1128(neuB)
CNV: CNZW441b_1143(neuB)
DALK: DSCA_06450
HOH: Hoch_0346
LABT: FIU93_24290(neuB)
CAK: Caul_2713
SAG: SAG1161(neuB)
SAN: neuB
SAK: SAK_1250(neuB)
SGC: A964_1134(neuB)
SAGS: SaSA20_0983(neuB)
SAGL: GBS222_0993(neuB)
SAGM: BSA_12390
SAGI: MSA_12810
SAGR: SAIL_12810
SAGP: V193_05425
SAGC: DN94_05425
SAGE: EN72_06455
SAGG: EN73_05990
SAGN: W903_1244(neuB)
SSB: SSUBM407_1280(neuB)
SSI: SSU0535(neuB)
SSS: SSUSC84_0517(neuB)
SUP: YYK_02535
SSUT: TL13_1188(neuB)
SSUI: T15_1401(neuB)
CBK: CLL_A2336
RGN: RGna_11985(neuB)
MAUU: NCTC10437_01405(spsE)
SCO: SCO4881(2SCK8.07)
SALB: XNR_3962
SMA: SAVERM_3373(neuB)
SGR: SGR_2659
SGB: WQO_22260
SHY: SHJG_5999
SMAL: SMALA_3271
SCT: SCAT_3775
SFA: Sfla_2375
SBH: SBI_04660
SVE: SVEN_4550
SALS: SLNWT_4806
STRP: F750_4425
SFI: SFUL_4686
SALU: DC74_5067
SALL: SAZ_27045
STRE: GZL_03800
SLD: T261_3148
STRM: M444_21440
SPRI: SPRI_2992
SRW: TUE45_05421(legI)
SLE: sle_27930(sle_27930)
SRN: A4G23_03558(legI)
STRD: NI25_14545
SLAU: SLA_4740
SALJ: SMD11_2618
SLX: SLAV_09960(legI1) SLAV_15140(legI2)
SFK: KY5_4998
SGE: DWG14_03226(legI)
SRJ: SRO_2876
SNF: JYK04_05256(legI)
SHUN: DWB77_03039(legI)
SCYG: S1361_24370(legI)
SAUH: SU9_021505
MOO: BWL13_02917(legI)
MOY: CVS54_03075(legI)
JDE: Jden_0843
BLIN: BLSMQ_3040
MPH: MLP_28480
TFU: Tfu_0010
ATM: ANT_06470
ABAS: ACPOL_2207
SUS: Acid_2246
CTE: CT0825
CPC: Cpar_0852
CCH: Cag_1072
CLI: Clim_0797
PVI: Cvib_1025
PLT: Plut_1274
PPH: Ppha_1574
PAA: Paes_0910
CTS: Ctha_2574
IAL: IALB_1518(neuB)
MRO: MROS_1489
IFO: CVFO_1265(neuB)
AG: WP_005897390(neuB)
 » show all
Reference
PMID:15200387 (C.jejuni)
  Authors
Sundaram AK, Pitts L, Muhammad K, Wu J, Betenbaugh M, Woodard RW, Vann WF
  Title
Characterization of N-acetylneuraminic acid synthase isoenzyme 1 from Campylobacter jejuni.
  Journal
Biochem J 383:83-9 (2004)
DOI:10.1042/BJ20040218
Reference
PMID:12597896 (S.agalactiae)
  Authors
Suryanti V, Nelson A, Berry A
  Title
Cloning, over-expression, purification, and characterisation of N-acetylneuraminate synthase from Streptococcus agalactiae.
  Journal
Protein Expr Purif 27:346-56 (2003)
DOI:10.1016/S1046-5928(02)00633-2
Reference
  Authors
Lewis AL, Robinson LS, Agarwal K, Lewis WG
  Title
Discovery and characterization of de novo sialic acid biosynthesis in the phylum Fusobacterium.
  Journal
Glycobiology 26:1107-1119 (2016)
DOI:10.1093/glycob/cww068
  Sequence
Reference
  Authors
Feng L, Senchenkova SN, Tao J, Shashkov AS, Liu B, Shevelev SD, Reeves PR, Xu J, Knirel YA, Wang L
  Title
Structural and genetic characterization of enterohemorrhagic Escherichia coli O145 O antigen and development of an O145 serogroup-specific PCR assay.
  Journal
J Bacteriol 187:758-64 (2005)
DOI:10.1128/JB.187.2.758-764.2005

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