KEGG   ORTHOLOGY: K01705
Entry
K01705                      KO                                     
Symbol
LYS4
Name
homoaconitate hydratase [EC:4.2.1.36]
Pathway
map00300  Lysine biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01705  LYS4; homoaconitate hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.36  homoaconitate hydratase
     K01705  LYS4; homoaconitate hydratase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01705
Other DBs
RN: R04371
COG: COG1048
GO: 0004409
Genes
QSU: 112018819 112023082
SCE: YDR234W(LYS4)
SEUB: DI49_0416
SPAO: SPAR_D04320
AGO: AGOS_ABL106C
ERC: Ecym_5123
KLA: KLLA0_C15125g
KMX: KLMA_30527(LYS4)
LTH: KLTH0E10582g
VPO: Kpol_1031p57
NCS: NCAS_0B02660(NCAS0B02660)
NDI: NDAI_0C05030(NDAI0C05030)
TPF: TPHA_0L01150(TPHA0L01150)
TBL: TBLA_0A01460(TBLA0A01460)
TDL: TDEL_0B01800(TDEL0B01800)
KAF: KAFR_0E02730(KAFR0E02730)
KNG: KNAG_0A04240(KNAG0A04240)
PIC: PICST_88705(LYS4)
SPAA: SPAPADRAFT_58782(LYS4)
CAL: CAALFM_C404410CA(LYS4)
SLB: AWJ20_348(LYS4)
BNN: FOA43_001879(LYS4)
BBRX: BRETT_004628(LYS4)
NCR: NCU08898(lys-6)
NTE: NEUTE1DRAFT58933(NEUTE1DRAFT_58933)
MGR: MGG_04842
SSCK: SPSK_03952
CMT: CCM_07793
BFU: BCIN_14g00430(Bclys4)
MBE: MBM_05638
ANI: AN6521.2
ANG: ANI_1_1106134(An15g00350)
ALUC: AKAW2_60650A(LYS4)
ACHE: ACHE_50239A(LYS4)
APUU: APUU_10764A(LYS4)
ABE: ARB_04155
TVE: TRV_03936
PNO: SNOG_01131(SNOG_01129 SNOG_01130)
PTE: PTT_19520
SPO: SPAC343.16(lys2)
CNE: CNK00580
CNB: CNBK2910
TASA: A1Q1_04925
ABP: AGABI1DRAFT59676(AGABI1DRAFT_59676)
ABV: AGABI2DRAFT184036(AGABI2DRAFT_184036)
MORE: E1B28_011496(LYS4_2)
SCM: SCHCO_02541718(SCHCODRAFT_02541718)
MGL: MGL_3298
MRT: MRET_2395
SPAR: SPRG_03993
IAL: IALB_1150
MRO: MROS_2220
CABY: Cabys_582
 » show all
Reference
  Authors
Fazius F, Shelest E, Gebhardt P, Brock M
  Title
The fungal alpha-aminoadipate pathway for lysine biosynthesis requires two enzymes of the aconitase family for the isomerization of homocitrate to homoisocitrate.
  Journal
Mol Microbiol 86:1508-30 (2012)
DOI:10.1111/mmi.12076
  Sequence
[sce:YDR234W]

KEGG   ORTHOLOGY: K16792
Entry
K16792                      KO                                     
Symbol
aksD
Name
methanogen homoaconitase large subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16792  aksD; methanogen homoaconitase large subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16792  aksD; methanogen homoaconitase large subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16792  aksD; methanogen homoaconitase large subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16792
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0065
Genes
MMAX: LCQ47_06430
SSOI: I1A49_21970
AACD: LWP59_12505
RRS: RoseRS_1053
RCA: Rcas_3474
CAU: Caur_0329
CHL: Chy400_0354
CAG: Cagg_3602
HAU: Haur_3302
LEK: hrd7_27860(leuC_2)
DRA: DR_1610
DGE: Dgeo_1156
DFC: DFI_07080
DGA: DEGR_14160(leuC1)
TRA: Trad_1389
TTH: TT_C1547
TTJ: TTHA1911(TTHA1911)
TSC: TSC_c01880(hacA)
TAQ: TO73_0094
MRB: Mrub_2728
MJA: MJ_1003
MESG: MLAUSG7_0432(hacA)
MESA: MLASG1_0006(hacA)
MMP: MMP1480
MMD: GYY_08235
MMAK: MMKA1_17030(leuD)
MMAO: MMOS7_15860(leuD)
MMAD: MMJJ_13590(dmdA_1)
MAE: Maeo_0311
MVO: Mvol_1623
MTH: MTH_1631
MMG: MTBMA_c02160(leuC1)
MWO: MWSIV6_0177(hacA)
MTEE: MTTB_13810
METC: MTCT_1490
METE: tca_01581(dmdA_2)
MST: Msp_1100(leuC2)
MRU: mru_0384(aksD)
MSI: Msm_0723
MEB: Abm4_0180(aksD)
MMIL: sm9_2161(aksD)
MEYE: TL18_01065
MOL: YLM1_0055
METH: MBMB1_0289(leuC2)
MFC: BRM9_1986(aksD)
MFI: DSM1535_0178(leuC2)
MCUB: MCBB_0567(hacA)
MFV: Mfer_0965
MKA: MK1208(leuC_2)
MBAR: MSBR2_1672
MBAK: MSBR3_1673
MAC: MA_3085(leuC)
MMA: MM_0409
MMAC: MSMAC_0883
METM: MSMTP_2281
MTHR: MSTHT_2523
MTHE: MSTHC_0762
MHOR: MSHOH_1131
MBU: Mbur_2263(hacA)
MMET: MCMEM_0412
MMH: Mmah_0418
MPY: Mpsy_2821
MTP: Mthe_0788
MCJ: MCON_0444(leuC1)
MHI: Mhar_1525
MHU: Mhun_1800
MLA: Mlab_0233
MBG: BN140_1717(leuC3)
MEMA: MMAB1_2209(leuC)
MPI: Mpet_2489
MBN: Mboo_0599
MPL: Mpal_2143
MPD: MCP_1961
MEZ: Mtc_1559(leuC-2)
RCI: RCIX2646(leuC-2)
 » show all
Reference
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1003]

KEGG   ORTHOLOGY: K16793
Entry
K16793                      KO                                     
Symbol
aksE
Name
methanogen homoaconitase small subunit [EC:4.2.1.114]
Pathway
map00300  Lysine biosynthesis
map00680  Methane metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
map01240  Biosynthesis of cofactors
Module
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00680 Methane metabolism
    K16793  aksE; methanogen homoaconitase small subunit
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K16793  aksE; methanogen homoaconitase small subunit
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.114  methanogen homoaconitase
     K16793  aksE; methanogen homoaconitase small subunit
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K16793
Other DBs
RN: R03444 R04371 R09720 R10391 R10392 R10393 R10394 R10395 R10396
COG: COG0066
Genes
PASG: KSS96_22110
PEW: KZJ38_04415
BOH: AKI39_19115
RRS: RoseRS_1056
RCA: Rcas_3472
CAU: Caur_0330
CHL: Chy400_0355
CAG: Cagg_3601
HAU: Haur_3303
LEK: hrd7_27870(leuD_2)
DRA: DR_1614(leuD)
DGE: Dgeo_1154
DFC: DFI_07070
DGA: DEGR_14180(leuD1)
TRA: Trad_1390
TTH: TT_C1546
TTJ: TTHA1910(TTHA1910)
TSC: TSC_c01890(hacB)
TAQ: TO73_0095
MRB: Mrub_2727
MJA: MJ_1271
MESG: MLAUSG7_0025(hacB)
MESA: MLASG1_1205(hacB)
MMP: MMP0381
MMAK: MMKA1_04000(leuD)
MMAO: MMOS7_03940(leuD)
MMAD: MMJJ_06580(dmdB_1)
MAE: Maeo_0652
MVO: Mvol_1671
MTH: MTH_829
MMG: MTBMA_c12270(leuD1)
MWO: MWSIV6_1206(hacB)
MTEE: MTTB_05450
METC: MTCT_0743
METE: tca_00796(DmdB_1)
MST: Msp_0374(leuD2)
MRU: mru_1689(aksE)
MSI: Msm_0847
MEB: Abm4_0514(aksE)
MMIL: sm9_1773(aksE)
MEYE: TL18_07930
MOL: YLM1_1157
METH: MBMB1_0696(leuD1)
MFC: BRM9_1499(aksE)
MFI: DSM1535_2193(leuD1)
MCUB: MCBB_0707(hacB)
MFV: Mfer_0205
MKA: MK1206(leuD_2)
MAC: MA_1223(leuC) MA_3751(leuD)
MMA: MM_0645
MMAC: MSMAC_0666
METM: MSMTP_0731
MTHR: MSTHT_2374
MTHE: MSTHC_0906
MHOR: MSHOH_0786
MBU: Mbur_1578
MMET: MCMEM_2089
MMH: Mmah_0127
MPY: Mpsy_2354
MTP: Mthe_0853
MCJ: MCON_1922(leuD1)
MHI: Mhar_2395
MHU: Mhun_1799
MLA: Mlab_0234
MBG: BN140_1716(leuD3)
MPI: Mpet_2490
MBN: Mboo_0600
MPL: Mpal_2144
MPD: MCP_1962
MEZ: Mtc_1558(leuD-2)
RCI: RCIX2645(leuD-2)
CDIV: CPM_1676
 » show all
Reference
  Authors
Drevland RM, Jia Y, Palmer DR, Graham DE
  Title
Methanogen homoaconitase catalyzes both hydrolyase reactions in coenzyme B biosynthesis.
  Journal
J Biol Chem 283:28888-96 (2008)
DOI:10.1074/jbc.M802159200
  Sequence
[mja:MJ_1271]

KEGG   REACTION: R04371
Entry
R04371                      Reaction                               
Name
Homoisocitrate hydro-lyase
Definition
Homoisocitrate <=> (Z)-But-1-ene-1,2,4-tricarboxylate + H2O
Equation
Comment
second step of two-step reaction (see R09720, R03444+R04371)
Reaction class
RC00618  C04002_C05662
Enzyme
4.2.1.36        4.2.1.114
Pathway
rn00300  Lysine biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K01705  homoaconitate hydratase [EC:4.2.1.36]
K16792  methanogen homoaconitase large subunit [EC:4.2.1.114]
K16793  methanogen homoaconitase small subunit [EC:4.2.1.114]
Other DBs
RHEA: 15488

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