KEGG   ORTHOLOGY: K03851
Entry
K03851                      KO                                     
Symbol
tpa
Name
taurine-pyruvate aminotransferase [EC:2.6.1.77]
Pathway
map00430  Taurine and hypotaurine metabolism
map01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00430 Taurine and hypotaurine metabolism
    K03851  tpa; taurine-pyruvate aminotransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01007 Amino acid related enzymes
    K03851  tpa; taurine-pyruvate aminotransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.77  taurine---pyruvate aminotransferase
     K03851  tpa; taurine-pyruvate aminotransferase
Amino acid related enzymes [BR:ko01007]
 Aminotransferase (transaminase)
  Class III
   K03851  tpa; taurine-pyruvate aminotransferase
Other DBs
RN: R05652
GO: 0031299
Genes
VNA: PN96_16085
VEJ: VEJY3_24191
VAS: GT360_16445
VAQ: FIV01_09475(tpa)
PGB: H744_1c1564
PCQ: PcP3B5_40420(tpa_3)
PMAO: PMYSY11_0934(hpa_tpa)
COLW: A3Q33_11510
PIN: Ping_0051
AFUS: EYZ66_13865
GAI: IMCC3135_11690(tpa)
BPE: BP0721
BPC: BPTD_0724
BPER: BN118_0083
BPET: B1917_3102
BPEU: Q425_33090
BPAR: BN117_1002
BPA: BPP3675
BBR: BB4110
DVM: DvMF_0516
DDS: Ddes_0218
DBK: DGMP_28330(yhxA)
DWD: DSCW_03190(yhxA)
DALK: DSCA_12790
NEN: NCHU2750_31190(tpa)
MAQU: Maq22A_c21465(bioA)
MIND: mvi_53040(yhxA)
SIL: SPO0673(tpa)
RUT: FIU92_02275(tpa1)
RDE: RD1_0981(tpa)
RLI: RLO149_c001900(tpa)
DSH: Dshi_2042(tpa)
KVL: KVU_0494(yhxA) KVU_0941(tpa)
KVU: EIO_1453
KRO: BVG79_01142(tpa)
PGA: PGA1_c28770(tpa)
PGL: PGA2_c26710(tpa)
PGD: Gal_00552
PHP: PhaeoP97_00629(tpa)
PPIC: PhaeoP14_02649(tpa)
OAT: OAN307_c06270(tpa)
OAR: OA238_c35800(tpa)
OTM: OSB_27890(tpa_2)
LAQU: R2C4_14985
CID: P73_3057
MALG: MALG_00569
SINL: DSM14862_03101(tpa)
SPSE: SULPSESMR1_03483(tpa)
RMM: ROSMUCSMR3_02376(tpa)
RID: RIdsm_05064(tpa_5)
ROH: FIU89_00700(tpa1)
ROT: FIV09_01645(tpa1)
MALU: KU6B_42160(yhxA)
RSP: RSP_0943(yhxA)
RCP: RCAP_rcc02240(tpa)
PDE: Pden_4273
PPAN: ESD82_17110(tpa)
PTP: RCA23_c01520(tpa)
RHC: RGUI_0795
PALW: PSAL_028160(hpa_tpa)
GXL: H845_1617
TMO: TMO_c0442
BSU: BSU09260(yhxA)
BSR: I33_1053
BSL: A7A1_3801
BSH: BSU6051_09260(yhxA)
BSUT: BSUB_01021(yhxA)
BSUL: BSUA_01021(yhxA)
BSUS: Q433_05265
BSO: BSNT_07358(yhxA)
BSQ: B657_09260(yhxA)
BSX: C663_0949(yhxA)
BSS: BSUW23_04675(yhxA)
BST: GYO_1214
BAQ: BACAU_0912(yhxA)
BYA: BANAU_0857(yhxA)
BAMP: B938_04545
BQY: MUS_0963(yhxA)
BAML: BAM5036_0854(yhxA)
BAMA: RBAU_0915(yhxA)
BAMN: BASU_0891(yhxA)
BAMB: BAPNAU_2850(yhxA)
BAMT: AJ82_05330
BAMY: V529_08870(yhxA)
BMP: NG74_00959(tpa_1)
BAO: BAMF_1022(yhxA)
BAZ: BAMTA208_04320(yhxA)
BQL: LL3_01007(yhxA)
BXH: BAXH7_00902(yhxA)
BAMI: KSO_015115
BAMC: U471_09340
BAMF: U722_04800
BMOJ: HC660_09850(yhxA)
BAN: BA_1636
BAR: GBAA_1636
BAT: BAS1519
BAI: BAA_1709
BANT: A16_16770
BANR: A16R_16950
BANS: BAPAT_1551
BANV: DJ46_455
BCE: BC1610
BCA: BCE_1727
BCZ: BCE33L1481(bioA)
BCQ: BCQ_1668(bioA)
BCX: BCA_1667
BAL: BACI_c16570(bioA1)
BNC: BCN_1588
BCF: bcf_08105
BCER: BCK_00395
BTK: BT9727_1491(bioA)
BTL: BALH_1448(bioA)
BTT: HD73_1844
BTHI: BTK_09360
BTG: BTB_c16490(yhxA)
BTI: BTG_12680
BTW: BF38_2830
BWW: bwei_1477(tpa) bwei_3380(tpa)
BPU: BPUM_0880
BPUM: BW16_04795
BPUS: UP12_04780
BJS: MY9_1022
BMET: BMMGA3_06920(yhxA)
BACW: QR42_04590
BACP: SB24_05120
BACB: OY17_07440
BACY: QF06_03570
BACL: BS34A_10460(yhxA)
BALM: BsLM_0965
BGY: BGLY_1018
BFD: NCTC4823_01351(tpa_5) NCTC4823_02711(tpa_6)
BMQ: BMQ_4417
BMD: BMD_4403
BMEG: BG04_1334
BAG: Bcoa_0555
BCL: ABC3786
GKA: GK1427
GTN: GTNG_1286
GGH: GHH_c13390(yhxA)
GEA: GARCT_01455(tpa)
PCAL: BV455_00420(tpa)
ANM: GFC28_986
AAMY: GFC30_2204
ANL: GFC29_641
HLI: HLI_04685
VPN: A21D_02472(tpa)
PSYO: PB01_12610
BLEN: NCTC4824_02911(tpa)
PMS: KNP414_02471(yhxA)
PMW: B2K_13815
PSAB: PSAB_23050
PRI: PRIO_6435(yhxA)
PSWU: SY83_21850
AAC: Aaci_2668
AAD: TC41_2977
BTS: Btus_3087
SIV: SSIL_0757
PABS: JIR001_12150(yhxA)
AACX: DEACI_1230
NCD: ACONDI_01914(tpa)
STED: SPTER_40040(tpa)
AG: AAG50296(tpa)
 » show all
Reference
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur J Biochem 267:6841-8 (2000)
DOI:10.1046/j.1432-1033.2000.01782.x
  Sequence

KEGG   ENZYME: 2.6.1.77
Entry
EC 2.6.1.77                 Enzyme                                 
Name
taurine---pyruvate aminotransferase;
Tpa
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
taurine:pyruvate aminotransferase
Reaction(IUBMB)
taurine + pyruvate = L-alanine + 2-sulfoacetaldehyde [RN:R05652]
Reaction(KEGG)
R05652
Substrate
taurine [CPD:C00245];
pyruvate [CPD:C00022]
Product
L-alanine [CPD:C00041];
2-sulfoacetaldehyde [CPD:C00593]
Comment
The enzyme from the bacterium Bilophila wadsworthia requires pyridoxal 5'-phosphate as a cofactor, and catalyses a reversible reaction that starts an anaerobic taurine degradation pathway. beta-Alanine is also a significant amino group donor. The enzyme from the bacterium Pseudomonas denitrificans PD1222 can also use hypotaurine, producing 2-sulfinoacetaldehyde, which spontaneously hydrolyses to sulfite and acetaldehyde. Unlike, EC 2.6.1.55, taurine---2-oxoglutarate transaminase, 2-oxoglutarate cannot serve as an acceptor for the amino group.
History
EC 2.6.1.77 created 2003
Pathway
ec00430  Taurine and hypotaurine metabolism
ec01100  Metabolic pathways
Orthology
K03851  taurine-pyruvate aminotransferase
Genes
VNAPN96_16085
VEJVEJY3_24191
VASGT360_16445
VAQFIV01_09475(tpa)
PGBH744_1c1564
PCQPcP3B5_40420(tpa_3)
PMAOPMYSY11_0934(hpa_tpa)
COLWA3Q33_11510
PINPing_0051
AFUSEYZ66_13865
WOCBA177_02200
GAIIMCC3135_11690(tpa)
HHHCLM76_04195
MPCMar181_2033
MFOIJSY38_11935
MARSA8C75_19765
NJPNEJAP_1517 NEJAP_3251
TSNW908_04080
BPEBP0721
BPCBPTD_0724
BPERBN118_0083
BPETB1917_3102
BPEUQ425_33090
BPARBN117_1002
BPABPP3675
BBHBN112_4293
BBRBB4110
BBMBN115_3799
BBXBBS798_3903
DVMDvMF_0516
DDSDdes_0218
DFIAXF13_01545
DEFCNY67_13690
DOAAXF15_02700
DPSDP0541 DP0545
DEOCAY53_09710
DBKDGMP_28330(yhxA)
DOVDSCO28_21000
DWDDSCW_03190(yhxA)
DALKDSCA_12790
DEKDSLASN_46250
HOEIMCC20628_04174
KMNHW532_15990
RBANJ2J98_22620
NENNCHU2750_31190(tpa)
MAQUMaq22A_c21465(bioA)
MEEDA075_14980
MINDmvi_53040(yhxA)
LABPFJ695_09660
ACUTMRB58_08210
SILSPO0673(tpa)
SITTM1040_0159
RUAD1823_10950
RUTFIU92_02275(tpa1)
RDERD1_0981(tpa)
RLIRLO149_c001900(tpa)
RPONG3256_17135
DSHDshi_2042(tpa)
KVLKVU_0494(yhxA) KVU_0941(tpa)
KVUEIO_1453
KROBVG79_01142(tpa)
PGAPGA1_c28770(tpa)
PGLPGA2_c26710(tpa)
PGDGal_00552
PHPPhaeoP97_00629(tpa)
PPICPhaeoP14_02649(tpa)
PHQD1820_09080
OATOAN307_c06270(tpa)
OAROA238_c35800(tpa)
OTMOSB_27890(tpa_2)
LMDMETH_14885
LEJETW24_16500
LAQUR2C4_14985
CIDP73_3057
CEHCEW89_00680
MALGMALG_00569
YPACCEW88_11285
YANAYJ57_04665
TPROGa0080559_TMP1161
PABYGa0080574_TMP3122
SUAMBOO69_01270
SULZC1J03_02125
SULIC1J05_19075
SULDB5M07_15800
SPOTG6548_03215
SMEDJNX03_11915
SINLDSM14862_03101(tpa)
SPSESULPSESMR1_03483(tpa)
TOMBWR18_14615
RMMROSMUCSMR3_02376(tpa)
ROKRAK1035_0806
RIDRIdsm_05064(tpa_5)
ROMEI983_01930
ROHFIU89_00700(tpa1)
AHTANTHELSMS3_02105
SAGUCDO87_04525
THAACFI11_17995
ROTFIV09_01645(tpa1)
MALUKU6B_42160(yhxA)
TGLHFZ77_15445
RSPRSP_0943(yhxA)
RSHRsph17029_2602
RSQRsph17025_2972
RSKRSKD131_2333
CAZTLV780_13015
RCPRCAP_rcc02240(tpa)
RHPLPB142_00195
RBLB6K69_03585
PDEPden_4273
PAMIJCM7686_0076
PYEA6J80_08490
PAMNJCM7685_1928
PKDF8A10_12975
PPANESD82_17110(tpa)
PTPRCA23_c01520(tpa)
RHCRGUI_0795
RMBK529_018320
DONBSK21_02220
TECAKL02_013105
LVSLOKVESSMR4R_02315(tpa)
RBGBG454_06905
GEHHYN69_10755
GFUKM031_14015
TAWEI545_18660
SEDIEBB79_18515
HMLHmaOT1_18115
PSEBEOK75_19920
PPRUFDP22_21760
PAEDG5B38_09475
PSHQF3W81_15520 F3W81_16595
PALWPSAL_028160(hpa_tpa)
CACTHZ995_05005
RBZB9057_11330
THASC6Y53_15175
FAPGR316_08615 GR316_12565
FAQG5B39_16020
GXLH845_1617
RGIRGI145_19730
ROSCTJ15_00415
RMUCFOB66_02175
ATIAL072_26690
AZMDM194_19010
AOZHUE56_07530
TMOTMO_c0442
BSUBSU09260(yhxA)
BSRI33_1053
BSLA7A1_3801
BSHBSU6051_09260(yhxA)
BSYI653_04655
BSUTBSUB_01021(yhxA)
BSULBSUA_01021(yhxA)
BSUSQ433_05265
BSOBSNT_07358(yhxA)
BSNBSn5_16510
BSQB657_09260(yhxA)
BSXC663_0949(yhxA)
BSPU712_04715
BSSBSUW23_04675(yhxA)
BSTGYO_1214
BAYRBAM_009520
BAQBACAU_0912(yhxA)
BYABANAU_0857(yhxA)
BAMPB938_04545
BQYMUS_0963(yhxA)
BAMLBAM5036_0854(yhxA)
BAMARBAU_0915(yhxA)
BAMNBASU_0891(yhxA)
BAMBBAPNAU_2850(yhxA)
BAMTAJ82_05330
BAMYV529_08870(yhxA)
BMPNG74_00959(tpa_1)
BAOBAMF_1022(yhxA)
BAZBAMTA208_04320(yhxA)
BQLLL3_01007(yhxA)
BXHBAXH7_00902(yhxA)
BAMIKSO_015115
BAMCU471_09340
BAMFU722_04800
BSIACWD84_17010
BAEBATR1942_02230
BVMB9C48_04745
BSONS101395_03844
BHTDIC78_05020
BMOJHC660_09850(yhxA)
BTEQG4P54_04935
BIQAN935_04845
BANBA_1636
BARGBAA_1636
BATBAS1519
BAHBAMEG_2954
BAIBAA_1709
BAXH9401_1542
BANTA16_16770
BANRA16R_16950
BANSBAPAT_1551
BANHHYU01_08270
BANVDJ46_455
BCEBC1610
BCABCE_1727
BCZBCE33L1481(bioA)
BCRBCAH187_A1778
BCBBCB4264_A1673
BCUBCAH820_1704
BCGBCG9842_B3671
BCQBCQ_1668(bioA)
BCXBCA_1667
BALBACI_c16570(bioA1)
BNCBCN_1588
BCFbcf_08105
BCERBCK_00395
BCEFBcrFT9_01357
BCYBcer98_1331
BTKBT9727_1491(bioA)
BTLBALH_1448(bioA)
BTBBMB171_C1455
BTTHD73_1844
BTHRYBT1520_09185
BTHIBTK_09360
BTCCT43_CH1536
BTFYBT020_08700
BTMMC28_0855 MC28_2415
BTGBTB_c16490(yhxA)
BTIBTG_12680
BTNBTF1_05755
BTHTH175_ch1555
BTHUYBT1518_09350
BTWBF38_2830
BTHYAQ980_21750
BWEBcerKBAB4_1524 BcerKBAB4_3172
BWWbwei_1477(tpa) bwei_3380(tpa)
BMYOBG05_2542 BG05_4284
BTYBtoyo_0519 Btoyo_4240
BMYCDJ92_4255 DJ92_470
BBYCY96_07215
BWDCT694_08880
BTROFJR70_00735
BMOBMLA2C4_08405
BNTGSN03_08150 GSN03_16365
BPACLMD38_18350
BPUBPUM_0880
BPUMBW16_04795
BPUSUP12_04780
BJSMY9_1022
BACIB1NLA3E_11150
BIFN288_11940
BMETBMMGA3_06920(yhxA)
GSTHW35_01140
BACWQR42_04590
BACPSB24_05120
BACBOY17_07440
BACYQF06_03570
BACLBS34A_10460(yhxA)
BALMBsLM_0965
BGYBGLY_1018
BWHA9C19_17095
BXIBK049_03520
BALTCFN77_04705
BACSAUL54_05850
BSAFBSL056_04655
BITBIS30_15320
BACQDOE78_13265
BFDNCTC4823_01351(tpa_5) NCTC4823_02711(tpa_6)
BSHILGQ02_11045
BBADK7T73_04730 K7T73_07315
BCABEFK13_05275
BCOBcell_1318
BHKB4U37_15635
BCOHBC6307_05660 BC6307_15990
BMQBMQ_4417
BMDBMD_4403
BMHBMWSH_0815
BMEGBG04_1334
BEOBEH_08240 BEH_19305
BFXBC359_05665
PKSIE339_18395
BAGBcoa_0555
BCLABC3786
BLEBleG1_1854
BGIBGM20_19910
BPFBpOF4_09055
BONA361_16950
BKOCKF48_20610
CGOTJ1899_05040
OCNCUC15_19195
GKAGK1427
GTEGTCCBUS3UF5_16600
GTKGT3570_06840
GTMGT3921_12175
GLIGLN3_00615
GTNGTNG_1286
GWCGWCH70_1320
GYCGYMC61_2218
GYAGYMC52_1346
GCTGC56T3_2120
GMCGY4MC1_2463
GGHGHH_c13390(yhxA)
GJFM493_07270
GEAGARCT_01455(tpa)
GELIB49_17520
GSEGT50_00930
GSRGS3922_09480
GZAIC807_02995
GTHGeoth_2505
PTLAOT13_10110
PCALBV455_00420(tpa)
ANMGFC28_986
AAMYGFC30_2204
ANLGFC29_641
ANDGRQ40_07850
ACAIISX45_04860
ASEDIRT44_15600
LSPBsph_0922 Bsph_2005 Bsph_2223
LGYT479_02320
LFUHR49_15100 HR49_16385 HR49_21455
LYSLBYS11_02380 LBYS11_07100 LBYS11_07965
LYBC3943_03030
LYZDCE79_15110
LPAKGDS87_02470
LAGRFJQ98_03095
LMACI6G82_16040
HHDHBHAL_2651
HLIHLI_04685
VIRX953_14880
VHLBME96_14205
VILCFK37_09915 CFK37_10510
VNECFK40_05260 CFK40_05890
VPNA21D_02472(tpa)
LAOAOX59_17185 AOX59_17360
BSJUP17_09745 UP17_13145 UP17_14580
BMURABE28_010400 ABE28_012275
PBUTDTO10_00525 DTO10_23550 DTO10_26010
PPSRI6J18_03545
PSYOPB01_12610
RUEDT065_13485
SALEEPH95_13725
SCIBHUG20_01775
SCIAHUG15_02910
NMKCHR53_13300 CHR53_16990
MEKUHUW50_23990
MDGK8L98_09770
BLENNCTC4824_02911(tpa)
BVQFHE72_10400
BOUI5818_13050
CTHUHUR95_01420
GAJMY490_16380
BBEBBR47_32450
BFMBP422_11355
BAGRBA6348_14185
BCHSJNE38_16970
BCOPJD108_10800
PJDPjdr2_3936
PMSKNP414_02471(yhxA)
PMQPM3016_2727
PMWB2K_13815
PSABPSAB_23050
PDUPDUR_26250
PBDPBOR_26460 PBOR_34365
PGMPGRAT_30730
PODPODO_29205
PAENP40081_35700
PAEFR50345_29320
PAEQR50912_32310
PSTEPSTEL_25730
PAEAR70723_31155
PAEER70331_29910
PAEHH70357_33425
PAEJH70737_28960
PBJVN24_02850
PRIPRIO_6435(yhxA)
PSONJI735_06895
PNPIJ22_07270
PXLBS614_00435
PYGAWM70_15930
PSWUSY83_21850
PDHB9T62_30080
PALBEJC50_22530
PBACHUB98_14615
PRZGZH47_23950
PSOPKP014_01655
PTRIKDC22_31290
PTJJRJ22_27625
ANXACH33_08470 ACH33_09925
ATHEK3F53_09095 K3F53_10350
AACAaci_2668
AADTC41_2977
AACOK1I37_05775
BTSBtus_3087
KYRCVV65_15280
SIVSSIL_0757
SSILSOLI23_14920
SOBCSE16_07260
KURASO14_1690
SPSYAZE41_14385 AZE41_20715
SPORSporoP33_12160
SURESporoP32a_12830
SPAEE2C16_12375
PANCE2636_14835
VIJJNUCC6_00865
NTRB0W44_07245
PABSJIR001_12150(yhxA)
DDLDesdi_0270
DRUDesru_0589
AACXDEACI_1230
NCDACONDI_01914(tpa)
STEDSPTER_40040(tpa)
ACITHPK19_11250
RRDRradSPS_2821
 » show all
Reference
1  [PMID:11082195]
  Authors
Laue H, Cook AM.
  Title
Biochemical and molecular characterization of taurine:pyruvate aminotransferase from the anaerobe Bilophila wadsworthia.
  Journal
Eur J Biochem 267:6841-8 (2000)
DOI:10.1046/j.1432-1033.2000.01782.x
  Sequence
Reference
2  [PMID:12471498]
  Authors
Cook AM, Denger K.
  Title
Dissimilation of the C2 sulfonates.
  Journal
Arch Microbiol 179:1-6 (2002)
DOI:10.1007/s00203-002-0497-0
Reference
3  [PMID:11728723]
  Authors
Masepohl B, Fuhrer F, Klipp W.
  Title
Genetic analysis of a Rhodobacter capsulatus gene region involved in utilization of taurine as a sulfur source.
  Journal
FEMS Microbiol Lett 205:105-11 (2001)
DOI:10.1111/j.1574-6968.2001.tb10932.x
Reference
4  [PMID:23603744]
  Authors
Felux AK, Denger K, Weiss M, Cook AM, Schleheck D
  Title
Paracoccus denitrificans PD1222 utilizes hypotaurine via transamination followed  by spontaneous desulfination to yield acetaldehyde and, finally, acetate for growth.
  Journal
J Bacteriol 195:2921-30 (2013)
DOI:10.1128/JB.00307-13
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.77
IUBMB Enzyme Nomenclature: 2.6.1.77
ExPASy - ENZYME nomenclature database: 2.6.1.77
BRENDA, the Enzyme Database: 2.6.1.77
CAS: 51901-18-9

KEGG   REACTION: R05652
Entry
R05652                      Reaction                               
Name
taurine:pyruvate aminotransferase
Definition
Taurine + Pyruvate <=> Sulfoacetaldehyde + L-Alanine
Equation
Comment
Tpa, gb:AF269146
Reaction class
RC00008  C00022_C00041
RC00062  C00245_C00593
Enzyme
Pathway
rn00430  Taurine and hypotaurine metabolism
rn01100  Metabolic pathways
Orthology
K03851  taurine-pyruvate aminotransferase [EC:2.6.1.77]
Other DBs
RHEA: 10423

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