KEGG   ORTHOLOGY: K04353
Entry
K04353                      KO                                     

Symbol
RAP1A
Name
Ras-related protein Rap-1A
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04510  Focal adhesion
map04530  Tight junction
map04611  Platelet activation
map04670  Leukocyte transendothelial migration
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04934  Cushing syndrome
map04972  Pancreatic secretion
map05211  Renal cell carcinoma
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04014 Ras signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04015 Rap1 signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
   04024 cAMP signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04353  RAP1A; Ras-related protein Rap-1A
   04530 Tight junction
    K04353  RAP1A; Ras-related protein Rap-1A
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04353  RAP1A; Ras-related protein Rap-1A
   04670 Leukocyte transendothelial migration
    K04353  RAP1A; Ras-related protein Rap-1A
   04062 Chemokine signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
  09154 Digestive system
   04972 Pancreatic secretion
    K04353  RAP1A; Ras-related protein Rap-1A
  09156 Nervous system
   04720 Long-term potentiation
    K04353  RAP1A; Ras-related protein Rap-1A
   04722 Neurotrophin signaling pathway
    K04353  RAP1A; Ras-related protein Rap-1A
 09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K04353  RAP1A; Ras-related protein Rap-1A
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04353  RAP1A; Ras-related protein Rap-1A
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04353  RAP1A; Ras-related protein Rap-1A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04353  RAP1A; Ras-related protein Rap-1A
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K04353  RAP1A; Ras-related protein Rap-1A
Genes
HSA: 5906(RAP1A)
PTR: 469408(RAP1A)
PPS: 100980934(RAP1A)
GGO: 101125618(RAP1A)
PON: 100433839(RAP1A)
NLE: 100603891(RAP1A)
MCC: 704404(RAP1A)
MCF: 102144586(RAP1A)
CSAB: 103224221(RAP1A)
CATY: 105594391(RAP1A)
PANU: 101002054(RAP1A)
RRO: 104658932(RAP1A)
RBB: 108525739 108528085(RAP1A)
TFN: 117076028(RAP1A)
PTEH: 111556041(RAP1A)
CJC: 100393183(RAP1A)
SBQ: 101048450(RAP1A)
MMUR: 105878770(RAP1A)
MMU: 109905(Rap1a)
MCAL: 110290796(Rap1a)
MPAH: 110319932(Rap1a)
RNO: 295347(Rap1a)
MCOC: 116092927 116093571(Rap1a)
MUN: 110549551(Rap1a)
CGE: 100751497(Rap1a)
PLEU: 114707256(Rap1a)
NGI: 103734905(Rap1a)
HGL: 101698757(Rap1a)
CCAN: 109695156(Rap1a)
OCU: 100351588(RAP1A)
TUP: 102475072(RAP1A)
CFA: 483225(RAP1A)
VVP: 112907935(RAP1A)
VLG: 121490661(RAP1A)
AML: 100471801(RAP1A)
UMR: 103675043(RAP1A)
UAH: 113244427(RAP1A)
ORO: 101375466(RAP1A)
ELK: 111143648
MPUF: 101684587(RAP1A)
EJU: 114207895(RAP1A)
MLX: 118010439 118019003(RAP1A)
FCA: 101094942(RAP1A)
PTG: 102963243(RAP1A)
PPAD: 109272045(RAP1A)
AJU: 106969628(RAP1A)
HHV: 120247125(RAP1A)
BTA: 282031(RAP1A)
BOM: 102286224(RAP1A)
BIU: 109555931(RAP1A)
BBUB: 102394947(RAP1A)
CHX: 102176930(RAP1A)
OAS: 101115080(RAP1A)
ODA: 120856682(RAP1A)
SSC: 100153199(RAP1A)
CFR: 102516450(RAP1A)
CBAI: 105063692(RAP1A)
CDK: 105102039(RAP1A)
BACU: 103017880(RAP1A)
LVE: 103069239(RAP1A)
OOR: 101287340(RAP1A)
DLE: 111180034(RAP1A)
PCAD: 102985661(RAP1A)
ECB: 100049912 100058930(RAP1A)
EPZ: 103547802(RAP1A)
EAI: 106828599(RAP1A)
MYB: 102258771(RAP1A)
MYD: 102774675(RAP1A)
MMYO: 118672699(RAP1A)
MNA: 107545324(RAP1A)
HAI: 109373546(RAP1A)
DRO: 112313714(RAP1A)
SHON: 118982036(RAP1A)
AJM: 119054595(RAP1A)
MMF: 118637043(RAP1A)
PALE: 102879271(RAP1A)
PGIG: 120585025(RAP1A)
RAY: 107499843(RAP1A)
MJV: 108395546(RAP1A)
TOD: 119235568(RAP1A)
LAV: 100676220(RAP1A)
TMU: 101352801
MDO: 100033128(RAP1A)
SHR: 100935403(RAP1A)
PCW: 110218764(RAP1A)
OAA: 100076731(RAP1A)
GGA: 419867(RAP1A)
PCOC: 116237094(RAP1A)
MGP: 100151696(RAP1A)
CJO: 107324916(RAP1A)
NMEL: 110388047(RAP1A)
APLA: 101800296(RAP1A)
ACYG: 106041314(RAP1A)
TGU: 100151697(RAP1A)
LSR: 110475399(RAP1A)
SCAN: 103823268(RAP1A)
PMOA: 120495847(RAP1A)
GFR: 102036447(RAP1A)
FAB: 101806584(RAP1A)
PHI: 102112636(RAP1A)
PMAJ: 107214847(RAP1A)
CCAE: 111939824(RAP1A)
CCW: 104692321(RAP1A)
ETL: 114063112(RAP1A)
FPG: 101924077(RAP1A)
FCH: 102052801(RAP1A)
CLV: 102089030(RAP1A)
EGZ: 104126794(RAP1A)
NNI: 104010315(RAP1A)
ACUN: 113488776(RAP1A)
PADL: 103923560(RAP1A)
AAM: 106485263(RAP1A)
ASN: 102385556(RAP1A)
AMJ: 102571106(RAP1A)
CPOO: 109317882(RAP1A)
GGN: 109295298(RAP1A)
PSS: 102461781(RAP1A)
CMY: 102948045(RAP1A)
CPIC: 101952443(RAP1A)
TST: 117877457(RAP1A)
ACS: 100556443(rap1a)
PVT: 110072354(RAP1A)
PBI: 103065471(RAP1A)
PMUR: 107292543(RAP1A)
TSR: 106550518
PGUT: 117663826(RAP1A)
PMUA: 114599364(RAP1A)
ZVI: 118089490(RAP1A)
GJA: 107112269(RAP1A)
XLA: 414290(rap1a.S) 779127(rap1a.L)
XTR: 100124947(rap1a)
NPR: 108789680(RAP1A)
DRE: 406714(rap1ab) 415242(rap1aa)
IPU: 108255244(rap1b) 108265690(rap1a)
PHYP: 113526347(rap1a) 113538035
AMEX: 103022868 103047011(rap1a)
EEE: 113572077(rap1a) 113586523
NCC: 104961557
SLUC: 116043610(rap1aa) 116051393
OAU: 116317168(rap1aa) 116320713
XHE: 116710773(rap1a) 116712138
CTUL: 119794231 119799404(rap1aa)
CSEM: 103385603 103386699(rap1a)
SASA: 106566052(RAP1A) 106567206(RAP1B) 106572472(RAP1B) 106582744(RAP1B)
ELS: 105022336(rap1b) 105023688(rap1a)
SFM: 108928254(rap1a) 108930477
PKI: 111839862 111851087(rap1a)
AANG: 118208143(rap1aa) 118211443
LOC: 102690385(rap1a)
LCM: 102354992(RAP1A)
CMK: 103182425(rap1a)
RTP: 109939006(rap1b)
CIN: 445785(rap1b)
APLC: 110982135
DME: Dmel_CG1956(Rap1)
DER: 6546030
DSE: 6610415
DSI: Dsimw501_GD13432(Dsim_R)
DAN: 6507581
DSR: 110177618
DPE: 6595862
DMN: 108152172
DWI: 6645841
DGR: 6558342
DAZ: 108612588
DNV: 115564307
DHE: 111596946
DVI: 6622391
CCAT: 101458137
MDE: 101892158
ACOZ: 120953277
AARA: 120898453
AAG: 5571900
CPII: 120414326
AME: 413246
ACER: 107997692
BIM: 100747441
BBIF: 117216689
BTER: 100642405
CCAL: 108628416
OBB: 114877648
MGEN: 117221961
NMEA: 116432702
CGIG: 122396542
SOC: 105197651
MPHA: 105834702
AEC: 105152361
ACEP: 105626421
PBAR: 105431454
VEM: 105562403
HST: 105187881
DQU: 106748251
CFO: 105257324
FEX: 115241964
LHU: 105667796
PGC: 109860604
OBO: 105286800
PCF: 106786548
NVI: 100117170
CSOL: 105362693
MDL: 103568558
CCIN: 107269836
TCA: 658243
DPA: 109533808
ATD: 109602368
AGB: 108907483
NVL: 108560620
APLN: 108741848
PPYR: 116166698
OTU: 111425166
BMOR: 692519(Ras3)
BMAN: 114253491
BANY: 112054584
PMAC: 106712843
PPOT: 106106288
PXU: 106122542
PRAP: 111000490
HAW: 110375343
TNL: 113497012
PXY: 105387719
API: 100166893
DNX: 107165088
AGS: 114120531
RMD: 113556321
BTAB: 109038859
DCI: 103510908
CLEC: 106666901
HHAL: 106680081
NLU: 120354428
ZNE: 110835691
CSEC: 111864108
DMK: 116925683
HAME: 121854587
HAZT: 108680208
RSAN: 119407116
VJA: 111268922
TUT: 107362689
DPTE: 113795806
PTEP: 107449408
SDM: 118190860
CEL: CELE_C27B7.8(rap-1)
BMY: BM_BM2428(Bma-rap-1)
PCAN: 112572369
OBI: 106872353
PDAM: 113665889
SPIS: 111340737
DGT: 114521782
TASA: A1Q1_04105
DDI: DDB_G0272857(rapB)
DPP: DICPUDRAFT_26434(rapB)
DFA: DFA_02753
EHI: EHI_004860(203.t00010) EHI_049030 EHI_058090(179.t00009) EHI_101260(5.t00090)
 » show all
Reference
PMID:2642744
  Authors
Kitayama H, Sugimoto Y, Matsuzaki T, Ikawa Y, Noda M
  Title
A ras-related gene with transformation suppressor activity.
  Journal
Cell 56:77-84 (1989)
DOI:10.1016/0092-8674(89)90985-9
  Sequence
[hsa:5906]

KEGG   ORTHOLOGY: K07836
Entry
K07836                      KO                                     

Symbol
RAP1B
Name
Ras-related protein Rap-1B
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04510  Focal adhesion
map04611  Platelet activation
map04670  Leukocyte transendothelial migration
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04934  Cushing syndrome
map04972  Pancreatic secretion
map05211  Renal cell carcinoma
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04014 Ras signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04015 Rap1 signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
   04024 cAMP signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07836  RAP1B; Ras-related protein Rap-1B
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07836  RAP1B; Ras-related protein Rap-1B
   04670 Leukocyte transendothelial migration
    K07836  RAP1B; Ras-related protein Rap-1B
   04062 Chemokine signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
  09154 Digestive system
   04972 Pancreatic secretion
    K07836  RAP1B; Ras-related protein Rap-1B
  09156 Nervous system
   04720 Long-term potentiation
    K07836  RAP1B; Ras-related protein Rap-1B
   04722 Neurotrophin signaling pathway
    K07836  RAP1B; Ras-related protein Rap-1B
 09160 Human Diseases
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K07836  RAP1B; Ras-related protein Rap-1B
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07836  RAP1B; Ras-related protein Rap-1B
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K07836  RAP1B; Ras-related protein Rap-1B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07836  RAP1B; Ras-related protein Rap-1B
   04031 GTP-binding proteins
    K07836  RAP1B; Ras-related protein Rap-1B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of other body fluids (saliva and urine)
   K07836  RAP1B; Ras-related protein Rap-1B
  Exosomal proteins of colorectal cancer cells
   K07836  RAP1B; Ras-related protein Rap-1B
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Ras Family
   Rap [OT]
    K07836  RAP1B; Ras-related protein Rap-1B
Genes
HSA: 5908(RAP1B)
PTR: 452065(RAP1B)
PPS: 100995578(RAP1B)
GGO: 101125880(RAP1B)
PON: 100171907(RAP1B)
NLE: 100593411(RAP1B)
MCC: 693750 718171(RAP1B)
MCF: 102133022(RAP1B)
CSAB: 103215555 103238680(RAP1B)
CATY: 105600503(RAP1B)
PANU: 101013495(RAP1B)
RRO: 104658672(RAP1B)
RBB: 108532250(RAP1B)
TFN: 117089777(RAP1B) 117098609
PTEH: 111528626(RAP1B) 111532119
CJC: 100411763 100413220(RAP1B)
SBQ: 101036065(RAP1B)
MMUR: 105880992(RAP1B)
MMU: 215449(Rap1b)
MCAL: 110303320(Rap1b)
MPAH: 110326460(Rap1b)
RNO: 171337(Rap1b)
MCOC: 116075736(Rap1b)
MUN: 110562243(Rap1b)
CGE: 100769542(Rap1b)
PLEU: 114693311(Rap1b)
NGI: 103745076(Rap1b)
HGL: 101714409 101726671(Rap1b)
CCAN: 109699305
OCU: 100339891(RAP1B)
TUP: 102472381(RAP1B)
CFA: 608981(RAP1B)
VVP: 112922290(RAP1B)
VLG: 121476667 121491095(RAP1B)
AML: 100480240(RAP1B)
UMR: 103656863(RAP1B) 103659828
UAH: 113256300(RAP1B)
ORO: 101383971(RAP1B)
ELK: 111141969
MPUF: 101691404(RAP1B)
EJU: 114214898(RAP1B)
MLX: 118008596(RAP1B)
FCA: 101095993(RAP1B)
PTG: 102965011(RAP1B)
PPAD: 109259557 109270479(RAP1B)
AJU: 106966345(RAP1B)
HHV: 120240794(RAP1B)
BTA: 327708(RAP1B) 789148
BIU: 109559248(RAP1B)
BBUB: 102400135(RAP1B)
CHX: 102174543(RAP1B)
OAS: 101106317(RAP1B) 114113232
ODA: 120857713(RAP1B)
SSC: 100152555(RAP1B)
CFR: 102524037(RAP1B)
CBAI: 105081341(RAP1B)
CDK: 105101089(RAP1B)
BACU: 103018737 103019004(RAP1B)
LVE: 103083426(RAP1B) 103088976
OOR: 101284281(RAP1B)
DLE: 111173766(RAP1B)
PCAD: 102980344(RAP1B)
ECB: 100052025(RAP1B)
EPZ: 103558687(RAP1B)
EAI: 106843586(RAP1B)
MYB: 102254910(RAP1B)
MYD: 102772411(RAP1B)
MMYO: 118651809(RAP1B)
MNA: 107526932(RAP1B)
HAI: 109381707(RAP1B)
DRO: 112318977(RAP1B)
SHON: 118989371(RAP1B)
AJM: 119036470 119042914(RAP1B)
MMF: 118624733(RAP1B)
PALE: 102883778(RAP1B)
PGIG: 120605040(RAP1B)
RAY: 107512678(RAP1B)
MJV: 108407356
TOD: 119247531(RAP1B)
LAV: 100665185(RAP1B)
TMU: 101348129
MDO: 100014092(RAP1B)
SHR: 100920135(RAP1B)
PCW: 110211041(RAP1B)
OAA: 100079331(RAP1B)
GGA: 417840(RAP1B)
PCOC: 116226600(RAP1B)
MGP: 100543810(RAP1B)
CJO: 107310547(RAP1B)
NMEL: 110392786(RAP1B)
APLA: 101789925(RAP1B)
ACYG: 106046993(RAP1B)
TGU: 100223739(RAP1B)
LSR: 110477997(RAP1B)
SCAN: 103813454(RAP1B)
PMOA: 120499794(RAP1B)
GFR: 102042554(RAP1B)
FAB: 101812484(RAP1B)
PHI: 102099438(RAP1B)
PMAJ: 107204636(RAP1B)
CCAE: 111932715(RAP1B)
CCW: 104698372(RAP1B)
ETL: 114062143(RAP1B)
FPG: 101924298(RAP1B)
FCH: 102047995(RAP1B)
CLV: 102083646(RAP1B)
EGZ: 104132908(RAP1B)
NNI: 104011007(RAP1B)
ACUN: 113487398(RAP1B)
PADL: 103919959(RAP1B)
AAM: 106488632(RAP1B)
ASN: 102382819(RAP1B)
AMJ: 102561548(RAP1B)
CPOO: 109315520(RAP1B)
GGN: 109295712(RAP1B)
PSS: 102444055(RAP1B)
CMY: 102947916(RAP1B)
CPIC: 101935007(RAP1B)
TST: 117877671(RAP1B)
CABI: 116834442(RAP1B)
ACS: 100553457(rap1b)
PVT: 110075099(RAP1B)
PBI: 103064511(RAP1B)
PMUR: 107284411(RAP1B)
TSR: 106545246(RAP1B)
PGUT: 117655710(RAP1B)
PMUA: 114605252(RAP1B)
ZVI: 118090625(RAP1B)
GJA: 107105721(RAP1B)
XLA: 108713157 379883(rap1b.L)
XTR: 493557(rap1b)
NPR: 108804561(RAP1B)
DRE: 321107(rap1b)
SRX: 107725524 107732995(rap1b)
SGH: 107553881(rap1b)
CCAR: 109067672 109072174(rap1b)
IPU: 100528315(rap1b)
PHYP: 113532015(rap1b)
AMEX: 103035254(rap1b)
EEE: 113572528(rap1b)
TRU: 101070080
LCO: 104935802(rap1b)
ELY: 117249012
SLUC: 116047935
PFLV: 114549955
MSAM: 119895189
CUD: 121505291
MZE: 101471329
ONL: 100707998(rap1b)
OAU: 116318207
OLA: 101172864
OML: 112155385
XMA: 102223832
XCO: 114161580
XHE: 116736693(rap1b)
PRET: 103459326(rap1b)
CVG: 107089072(rap1b)
CTUL: 119796580
NFU: 107387503(rap1b)
AOCE: 111586839
CSEM: 103382506
LCF: 108901386(rap1b)
SDU: 111225046(rap1b)
SLAL: 111661323
XGL: 120803527
HCQ: 109532657(rap1b)
BPEC: 110161898(rap1b)
MALB: 109974612
SASA: 106576640 106593497(RAP1B)
SNH: 120050139
ELS: 105017798(rap1b)
SFM: 108920959 108936546(rap1b)
PKI: 111844324 111851234(rap1b)
LOC: 102697231(rap1b)
LCM: 102354357(RAP1B)
CMK: 103186117(rap1b)
RTP: 109924294
BBEL: 109463518
CIN: 100182890
SCLV: 120339668
SKO: 102804872
HAME: 121872443
PTEP: 107455620
SDM: 118179282
TSP: Tsp_02666
GAE: 121383738
CRG: 105347969
MYI: 110443111
PMAX: 117331920
ATEN: 116301360
AQU: 105313915
SCE: YGR152C(RSR1)
ERC: Ecym_1407
KMX: KLMA_60196(RSR1)
NCS: NCAS_0A01890(NCAS0A01890)
NDI: NDAI_0D03820(NDAI0D03820)
TPF: TPHA_0K01820(TPHA0K01820)
TBL: TBLA_0B00370(TBLA0B00370)
TDL: TDEL_0F02770(TDEL0F02770)
KAF: KAFR_0F03670(KAFR0F03670)
CAL: CAALFM_CR02140WA(RSR1)
CDU: CD36_27060(RSR1)
SLB: AWJ20_3825(RSR1)
BNN: FOA43_004055(RSR1)
BBRX: BRETT_002898(RSR1)
SMP: SMAC_09077(putative krev1)
MGR: MGG_02727
TRE: TRIREDRAFT_76880(rsr1)
MAW: MAC_00973
MAJ: MAA_10959
CMT: CCM_00788
BFU: BCIN_08g02920(Bcrsr1)
MBE: MBM_09336
ANG: ANI_1_524064(An07g04240)
ABE: ARB_00736
TVE: TRV_08011
PTE: PTT_20340
DDI: DDB_G0291237(rapA)
DPP: DICPUDRAFT_59134(rapA)
DFA: DFA_03257 DFA_12095(rapA)
 » show all
Reference
  Authors
Zwartkruis FJ, Bos JL
  Title
Ras and Rap1: two highly related small GTPases with distinct function.
  Journal
Exp Cell Res 253:157-65 (1999)
DOI:10.1006/excr.1999.4695
Reference
PMID:3137530
  Authors
Pizon V, Lerosey I, Chardin P, Tavitian A
  Title
Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B).
  Journal
Nucleic Acids Res 16:7719 (1988)
DOI:10.1093/nar/16.15.7719
  Sequence
[hsa:5908]

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