KEGG   ORTHOLOGY: K04374
Entry
K04374                      KO                                     
Symbol
ATF4, CREB2
Name
cyclic AMP-dependent transcription factor ATF-4
Pathway
map04010  MAPK signaling pathway
map04022  cGMP-PKG signaling pathway
map04137  Mitophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04212  Longevity regulating pathway - worm
map04214  Apoptosis - fly
map04261  Adrenergic signaling in cardiomyocytes
map04668  TNF signaling pathway
map04720  Long-term potentiation
map04722  Neurotrophin signaling pathway
map04725  Cholinergic synapse
map04728  Dopaminergic synapse
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04918  Thyroid hormone synthesis
map04922  Glucagon signaling pathway
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04932  Non-alcoholic fatty liver disease
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05034  Alcoholism
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05166  Human T-cell leukemia virus 1 infection
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05215  Prostate cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04668 TNF signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04022 cGMP-PKG signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04151 PI3K-Akt signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09143 Cell growth and death
   04210 Apoptosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04214 Apoptosis - fly
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04922 Glucagon signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04912 GnRH signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04915 Estrogen signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04926 Relaxin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04935 Growth hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04918 Thyroid hormone synthesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04928 Parathyroid hormone synthesis, secretion and action
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04925 Aldosterone synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04927 Cortisol synthesis and secretion
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09156 Nervous system
   04725 Cholinergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04728 Dopaminergic synapse
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04720 Long-term potentiation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04722 Neurotrophin signaling pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09149 Aging
   04211 Longevity regulating pathway
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04212 Longevity regulating pathway - worm
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05203 Viral carcinogenesis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09162 Cancer: specific types
   05215 Prostate cancer
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05161 Hepatitis B
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05163 Human cytomegalovirus infection
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05012 Parkinson disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05014 Amyotrophic lateral sclerosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05020 Prion disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05022 Pathways of neurodegeneration - multiple diseases
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09165 Substance dependence
   05030 Cocaine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05031 Amphetamine addiction
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   05034 Alcoholism
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
   04934 Cushing syndrome
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, CRE-BP/ATF
    K04374  ATF4, CREB2; cyclic AMP-dependent transcription factor ATF-4
Other DBs
GO: 0035497
Genes
HSA: 468(ATF4)
PTR: 744513(ATF4)
PPS: 100980724 100988487(ATF4)
GGO: 101139584(ATF4)
PON: 100431578 100462459(ATF4)
NLE: 100588160(ATF4)
MCC: 703965(ATF4)
MCF: 102117938(ATF4)
CSAB: 103223345(ATF4)
CATY: 105572871(ATF4)
PANU: 101013627(ATF4)
TGE: 112632664(ATF4)
RRO: 104682563(ATF4)
RBB: 108520463(ATF4)
TFN: 117096463(ATF4)
PTEH: 111548140 111548991(ATF4)
CJC: 100392193(ATF4)
SBQ: 101034435(ATF4)
CSYR: 103267309(ATF4)
MMUR: 105858535(ATF4)
LCAT: 123640339(ATF4)
OGA: 100940993(ATF4)
MMU: 11911(Atf4)
MCAL: 110310868(Atf4)
MPAH: 110334651(Atf4)
RNO: 79255(Atf4)
MCOC: 116076129(Atf4)
CGE: 100689386(Atf4)
MAUA: 101834246(Atf4)
PLEU: 114687991 114694285(Atf4)
MORG: 121461039(Atf4)
AAMP: 119822546(Atf4)
NGI: 103748563(Atf4)
HGL: 101724287(Atf4)
CPOC: 100732296(Atf4)
CCAN: 109693025(Atf4)
DORD: 105992070(Atf4)
DSP: 122123666(Atf4)
NCAR: 124984025
OCU: 100339383(ATF4)
OPI: 101521567(ATF4)
TUP: 102478154(ATF4)
CFA: 474503(ATF4)
CLUD: 112667576(ATF4)
VVP: 112934037(ATF4)
VLG: 121492052(ATF4)
AML: 100476284(ATF4)
UMR: 103676372(ATF4)
UAH: 113241758(ATF4)
UAR: 123780649(ATF4)
ELK: 111157635
LLV: 125106338
MPUF: 101680524(ATF4) 101694124
ORO: 101368122(ATF4)
EJU: 114218458(ATF4)
ZCA: 113921771(ATF4)
MLX: 117998657(ATF4)
FCA: 101084297(ATF4)
PYU: 121040318(ATF4)
PBG: 122472782(ATF4)
PTG: 102950077(ATF4)
PPAD: 109265586(ATF4)
AJU: 106979942(ATF4)
HHV: 120235229(ATF4)
BTA: 509107(ATF4)
BOM: 102267423(ATF4)
BIU: 109559832(ATF4)
BBUB: 102393344(ATF4) 112580290
CHX: 102185072(ATF4)
OAS: 100216465(ATF4)
ODA: 120857618(ATF4)
CCAD: 122423084(ATF4) 122444829
SSC: 100144302(ATF4)
CFR: 102508076(ATF4)
CBAI: 105073101(ATF4)
CDK: 105091928(ATF4)
VPC: 102531881(ATF4)
BACU: 103017770(ATF4)
LVE: 103083306(ATF4)
OOR: 101283438(ATF4)
DLE: 111186212(ATF4)
PCAD: 102984157(ATF4)
PSIU: 116761029(ATF4)
ECB: 100070334(ATF4)
EPZ: 103565289(ATF4)
EAI: 106842437(ATF4)
MYB: 102238786(ATF4)
MYD: 102763654(ATF4)
MMYO: 118649462(ATF4) 118666845
MLF: 102429560(ATF4)
MNA: 107531265(ATF4)
PKL: 118728295(ATF4)
HAI: 109392248(ATF4)
DRO: 112321682(ATF4)
SHON: 119002317(ATF4)
AJM: 119045974 119060217(ATF4)
PDIC: 114512782(ATF4)
PHAS: 123816126(ATF4)
MMF: 118623538(ATF4)
RFQ: 117028134(ATF4)
PALE: 102896553(ATF4)
PGIG: 120602997(ATF4)
PVP: 105298070(ATF4)
RAY: 107500816(ATF4)
MJV: 108397369(ATF4)
TOD: 119247241(ATF4)
SARA: 101539159(ATF4)
LAV: 100662521(ATF4)
TMU: 101345357
DNM: 101410879 101410933(ATF4)
MDO: 100012224(ATF4)
GAS: 123250763(ATF4)
SHR: 100913697(ATF4)
PCW: 110205802(ATF4)
OAA: 100089902(ATF4)
GGA: 395693(ATF4)
PCOC: 116233367(ATF4)
MGP: 100550984(ATF4)
CJO: 107312723(ATF4)
NMEL: 110392532(ATF4)
APLA: 101800475(ATF4)
ACYG: 106035925(ATF4)
AFUL: 116501070(ATF4)
TGU: 100190733(ATF4)
LSR: 110483790(ATF4)
SCAN: 103813275(ATF4)
PMOA: 120510126(ATF4)
OTC: 121342294(ATF4)
PRUF: 121361103(ATF4)
GFR: 102036875(ATF4)
FAB: 101814204(ATF4)
PHI: 102100681(ATF4)
PMAJ: 107204914(ATF4)
CCAE: 111934860(ATF4)
CCW: 104696333(ATF4)
CBRC: 103618102(ATF4)
ETL: 114055356(ATF4)
ZAB: 102067373(ATF4)
FPG: 101921834(ATF4)
FCH: 102049324(ATF4)
CLV: 102093872(ATF4)
EGZ: 104134330(ATF4)
NNI: 104021625(ATF4)
PLET: 104619915(ATF4)
PCRI: 104026495(ATF4)
ACUN: 113491317(ATF4)
TALA: 104367768(ATF4)
PADL: 103915003(ATF4)
ACHC: 115352336(ATF4)
HALD: 104312095(ATF4)
CCRI: 104167940(ATF4)
CSTI: 104560066(ATF4)
EHS: 104504854(ATF4)
CMAC: 104478786(ATF4)
FGA: 104081561(ATF4)
GSTE: 104252585(ATF4)
LDI: 104352989(ATF4)
MNB: 103776203(ATF4)
OHA: 104329819(ATF4)
AAM: 106488703(ATF4)
AROW: 112965719(ATF4)
NPD: 112946444(ATF4)
DNE: 112984152(ATF4)
ASN: 102369745(ATF4)
AMJ: 102564186(ATF4)
CPOO: 109316697(ATF4)
GGN: 109295982(ATF4)
PSS: 102449551(ATF4)
CMY: 102941988(ATF4)
CPIC: 101952513(ATF4)
TST: 117880204(ATF4)
CABI: 116824554(ATF4)
MRV: 120377804(ATF4)
ACS: 100565177(atf4)
PVT: 110088080(ATF4)
SUND: 121918233 121931934(ATF4)
PBI: 103055721(ATF4)
PMUR: 107288132(ATF4)
TSR: 106550401(ATF4)
PGUT: 117655911(ATF4)
VKO: 123036185(ATF4)
PMUA: 114605162(ATF4)
ZVI: 118090901(ATF4)
GJA: 107117129(ATF4)
STOW: 125434792(ATF4)
XLA: 398804(atf4.L) 734165(atf4.S)
XTR: 448005(atf4)
BBUF: 120978575(ATF4)
BGAR: 122943840(ATF4)
DRE: 406514(atf4a) 556410(atf4b)
PPRM: 120467966(atf4a) 120489995(atf4b)
MAMB: 125273291(atf4b) 125274434(atf4a)
IPU: 108273192(atf4a)
PHYP: 113538304(atf4)
SMEO: 124392712(atf4a)
TFD: 113634495(atf4a)
AMEX: 103027942(atf4)
EEE: 113579485(atf4)
TRU: 101070714(atf4) 101075957
NCC: 104958969 104967853(atf4)
CGOB: 115012736(atf4)
ELY: 117255624(atf4a) 117269048(atf4b)
EFO: 125879105(atf4b) 125885541(atf4a)
PLEP: 121942202(atf4a) 121957242(atf4b)
SLUC: 116042704(atf4a) 116065263(atf4b)
ECRA: 117952445(atf4a)
GAT: 120824619(atf4a) 120828216(atf4b)
PPUG: 119217987(atf4a) 119220723(atf4b)
MSAM: 119885408(atf4b) 119898630(atf4a)
CUD: 121503840(atf4b) 121508535(atf4a)
ALAT: 119008151(atf4a) 119014316(atf4b)
MZE: 101464981(atf4) 101475680
ONL: 100706109 100711796(atf4)
OAU: 116312590(atf4a) 116327828(atf4b)
OLA: 101168714(atf4-2) 101172388(atf4)
OML: 112137117(atf4a) 112146289(atf4b)
GAF: 122822234(atf4b) 122830317(atf4a)
CVG: 107087200(atf4) 107090074
CTUL: 119771569(atf4b) 119796308(atf4a)
GMU: 124863824 124869150(atf4a)
KMR: 108231541(atf4a) 108236059(atf4b)
ALIM: 106522498(atf4) 106534845
NWH: 119422100(atf4b) 119422427(atf4a)
MCEP: 124998068(atf4b) 125003859(atf4a)
SSEN: 122771101(atf4a) 122785474(atf4b)
HHIP: 117759410(atf4a) 117766567(atf4b)
HSP: 118116537(atf4a) 118124024(atf4b)
XGL: 120800522(atf4a) 120804743(atf4b)
HCQ: 109511289(atf4) 109520247
BSPL: 114858846(atf4a) 114860234(atf4b)
OTW: 112225885 112240072(atf4a) 112258481(atf4b)
OGO: 124000524(atf4b) 124002737(atf4a)
SNH: 120032473(atf4a) 120034366 120034522(atf4b)
CCLU: 121550432(atf4b) 121555875(atf4a) 121569728
ELS: 105008440(atf4) 105029665
SFM: 108930667(atf4)
AANG: 118217257(atf4b) 118220191(atf4a)
LOC: 102686890(atf4) 102690285
LCM: 102365086(ATF4)
RTP: 109919490
BFO: 118428974
BBEL: 109484052
CIN: 778545(atf4/5)
SCLV: 120332842
SPU: 586579
APLC: 110980911
SKO: 100376413
DME: Dmel_CG8669(crc)
DER: 6548901
DSI: Dsimw501_GD24316(Dsim_GD24316)
DPO: 6902604
DPE: 6596600
DMN: 108163164
DWI: 6646727
DGR: 6566734
DAZ: 108610991
DNV: 108658875
DHE: 111594286
CCAT: 101452757
BOD: 106623439
MDE: 101900076
SCAC: 106091381
LCQ: 111689832
LSQ: 119604332
ACOZ: 120959921
AARA: 120905189
AAG: 5576642
CPII: 120427768
CNS: 116340469
BCOO: 119075668
AME: 410226
ACER: 108001217
ALAB: 122710352
BIM: 100743669
BBIF: 117205230
BVK: 117243648
BVAN: 117162812
BTER: 100651688
BPYO: 122571833
CCAL: 108622952
OBB: 114874933
MGEN: 117220162
NMEA: 116431894
CGIG: 122403079
SOC: 105196269
MPHA: 105837964
AEC: 105150924
ACEP: 105624047
PBAR: 105427649
VEM: 105557230
HST: 105183921
DQU: 106740699
CFO: 105254686
FEX: 115233306
LHU: 105676463
PGC: 109855311
OBO: 105286490
PCF: 106789497
PFUC: 122524598
VPS: 122628239
NVI: 100122826
CSOL: 105362052
TPRE: 106659039
MDL: 103572891
CGLO: 123274647
FAS: 105272732
DAM: 107043167
AGIF: 122853124
CCIN: 107265644
TCA: 658480(ATF4)
DPA: 109541967
SOY: 115877808
CSET: 123320993
AGB: 108909348
LDC: 111503062
NVL: 108565295
APLN: 108743374
PPYR: 116179953
OTU: 111417404
BMOR: 692594(Atf)
BMAN: 114249574
MSEX: 115451201
BANY: 112051663
PMAC: 106711673
PPOT: 106104652
PXU: 106121235
PRAP: 111003028
ZCE: 119828359
HAW: 110370227
TNL: 113496582
SLIU: 111358736
OFU: 114365142
API: 100161513
DNX: 107161833
AGS: 114122290
RMD: 113551242
BTAB: 109033366
CLEC: 106663140
HHAL: 106679557
NLU: 111055672
FOC: 113207661
ZNE: 110834497
CSEC: 111867610
FCD: 110848208
DMK: 116923156
PVM: 113817207
PJA: 122255887
HAZT: 108681845
EAF: 111703235
LSM: 121118935
DSV: 119453228
RSAN: 119399950
RMP: 119180296
CSCU: 111613017
PTEP: 107437627
SDM: 118183614
CEL: CELE_T04C10.4(atf-4)
CBR: CBG_07594(Cbr-atf-5) CBG_25702
BMY: BM_BM6228(Bma-zip-3)
PCAN: 112557459
BGT: 106056861
GAE: 121378299
HRF: 124110830
HRJ: 124291710
MYI: 110465611
MMER: 123564103
OBI: 106880212
OSN: 115213971
NVE: 116611673
EPA: 110239948
ATEN: 116307396
AMIL: 114953195
PDAM: 113670326
SPIS: 111330254
DGT: 114529187
XEN: 124448676
HMG: 100197237
AQU: 100634724
DOSA: Os01t0211800-01(Os01g0211800)
MUS: 103997104
 » show all
Reference
  Authors
Ameri K, Harris AL
  Title
Activating transcription factor 4.
  Journal
Int J Biochem Cell Biol 40:14-21 (2008)
DOI:10.1016/j.biocel.2007.01.020
Reference
PMID:1534408
  Authors
Karpinski BA, Morle GD, Huggenvik J, Uhler MD, Leiden JM
  Title
Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.
  Journal
Proc Natl Acad Sci U S A 89:4820-4 (1992)
DOI:10.1073/pnas.89.11.4820
  Sequence
[hsa:468]
Reference
  Authors
Sayer JA, Otto EA, O'Toole JF, Nurnberg G, Kennedy MA, Becker C, Hennies HC, Helou J, Attanasio M, Fausett BV, Utsch B, Khanna H, Liu Y, Drummond I, Kawakami I, Kusakabe T, Tsuda M, Ma L, Lee H, Larson RG, Allen SJ, Wilkinson CJ, Nigg EA, Shou C, Lillo C, Williams DS, Hoppe B, Kemper MJ, Neuhaus T, Parisi MA, Glass IA, Petry M, Kispert A, Gloy J, Ganner A, Walz G, Zhu X, Goldman D, Nurnberg P, Swaroop A, Leroux MR, Hildebrandt F
  Title
The centrosomal protein nephrocystin-6 is mutated in Joubert syndrome and activates transcription factor ATF4.
  Journal
Nat Genet 38:674-81 (2006)
DOI:10.1038/ng1786
  Sequence
[hsa:468]

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