KEGG   ORTHOLOGY: K04393
Entry
K04393                      KO                                     

Symbol
CDC42
Name
cell division control protein 42
Pathway
map04010  MAPK signaling pathway
map04011  MAPK signaling pathway - yeast
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04062  Chemokine signaling pathway
map04144  Endocytosis
map04360  Axon guidance
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04520  Adherens junction
map04530  Tight junction
map04660  T cell receptor signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04722  Neurotrophin signaling pathway
map04810  Regulation of actin cytoskeleton
map04912  GnRH signaling pathway
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map05100  Bacterial invasion of epithelial cells
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05205  Proteoglycans in cancer
map05211  Renal cell carcinoma
map05212  Pancreatic cancer
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04393  CDC42; cell division control protein 42
   04011 MAPK signaling pathway - yeast
    K04393  CDC42; cell division control protein 42
   04014 Ras signaling pathway
    K04393  CDC42; cell division control protein 42
   04015 Rap1 signaling pathway
    K04393  CDC42; cell division control protein 42
   04370 VEGF signaling pathway
    K04393  CDC42; cell division control protein 42
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K04393  CDC42; cell division control protein 42
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04393  CDC42; cell division control protein 42
   04520 Adherens junction
    K04393  CDC42; cell division control protein 42
   04530 Tight junction
    K04393  CDC42; cell division control protein 42
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04393  CDC42; cell division control protein 42
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K04393  CDC42; cell division control protein 42
   04666 Fc gamma R-mediated phagocytosis
    K04393  CDC42; cell division control protein 42
   04670 Leukocyte transendothelial migration
    K04393  CDC42; cell division control protein 42
   04062 Chemokine signaling pathway
    K04393  CDC42; cell division control protein 42
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04393  CDC42; cell division control protein 42
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04393  CDC42; cell division control protein 42
  09158 Development and regeneration
   04360 Axon guidance
    K04393  CDC42; cell division control protein 42
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04393  CDC42; cell division control protein 42
   05205 Proteoglycans in cancer
    K04393  CDC42; cell division control protein 42
   05203 Viral carcinogenesis
    K04393  CDC42; cell division control protein 42
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04393  CDC42; cell division control protein 42
   05211 Renal cell carcinoma
    K04393  CDC42; cell division control protein 42
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K04393  CDC42; cell division control protein 42
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04393  CDC42; cell division control protein 42
   05130 Pathogenic Escherichia coli infection
    K04393  CDC42; cell division control protein 42
   05132 Salmonella infection
    K04393  CDC42; cell division control protein 42
   05131 Shigellosis
    K04393  CDC42; cell division control protein 42
   05135 Yersinia infection
    K04393  CDC42; cell division control protein 42
   05100 Bacterial invasion of epithelial cells
    K04393  CDC42; cell division control protein 42
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04393  CDC42; cell division control protein 42
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04393  CDC42; cell division control protein 42
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04393  CDC42; cell division control protein 42
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04393  CDC42; cell division control protein 42
   03036 Chromosome and associated proteins
    K04393  CDC42; cell division control protein 42
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04393  CDC42; cell division control protein 42
   04031 GTP-binding proteins
    K04393  CDC42; cell division control protein 42
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rho GTPases
    K04393  CDC42; cell division control protein 42
 Endocytosis
  Lipid raft mediated endocytosis
   GRAF1-dependent endocytosis
    K04393  CDC42; cell division control protein 42
  Macropinocytosis
   Ras GTPases
    K04393  CDC42; cell division control protein 42
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04393  CDC42; cell division control protein 42
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of microglial cells
   K04393  CDC42; cell division control protein 42
  Exosomal proteins of breast milk
   K04393  CDC42; cell division control protein 42
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K04393  CDC42; cell division control protein 42
Other DBs
COG: COG1100
Genes
HSA: 998(CDC42)
PTR: 456609(CDC42)
PPS: 100990246(CDC42) 100993131
GGO: 101124029(CDC42)
PON: 100438199(CDC42)
NLE: 100605245(CDC42)
MCC: 707637(CDC42)
MCF: 101925934(CDC42)
CSAB: 103225423(CDC42)
CATY: 105571986 105595026(CDC42)
PANU: 101004833(CDC42)
RRO: 104663221(CDC42)
RBB: 108538451(CDC42)
TFN: 117063724 117093160(CDC42)
PTEH: 111547718(CDC42)
CJC: 100404291(CDC42)
SBQ: 101050895(CDC42)
MMUR: 105873610(CDC42)
MMU: 12540(Cdc42)
MCAL: 110292517(Cdc42)
MPAH: 110322847(Cdc42)
RNO: 64465(Cdc42)
MCOC: 116096877(Cdc42)
MUN: 110545010(Cdc42)
CGE: 100765433(Cdc42)
NGI: 103746394(Cdc42)
HGL: 101701374(Cdc42) 101711269
CPOC: 100717195(Cdc42)
CCAN: 109694921(Cdc42)
OCU: 100008965(CDC42)
OPI: 101532470(CDC42) 101535581
TUP: 102488344(CDC42)
CFA: 119863888(CDC42) 119866928
VVP: 112929847(CDC42)
AML: 100465076(CDC42)
UMR: 103666578(CDC42)
UAH: 113268543(CDC42)
ORO: 101364638(CDC42)
ELK: 111154823
MPUF: 101687739(CDC42)
EJU: 114199036(CDC42) 114224473
FCA: 101094772(CDC42)
PYU: 121017794 121022813(CDC42)
PBG: 122480065(CDC42) 122480120
PTG: 102973021(CDC42)
PPAD: 109274276(CDC42)
AJU: 106977652(CDC42)
HHV: 120231260(CDC42) 120233626
BTA: 532712(CDC42)
BOM: 102266310(CDC42)
BIU: 109574100(CDC42)
BBUB: 102403472(CDC42)
CHX: 102188638(CDC42)
OAS: 101102792(CDC42) 114108599
ODA: 120855017(CDC42)
CCAD: 122426807(CDC42)
SSC: 780428(CDC42)
CFR: 102514486(CDC42)
CBAI: 105070875(CDC42)
CDK: 105088868(CDC42)
BACU: 103008817(CDC42)
LVE: 103088294(CDC42)
OOR: 101270289(CDC42)
DLE: 111163214(CDC42) 111175094
PCAD: 102975958(CDC42)
PSIU: 116752435(CDC42)
ECB: 100058188(CDC42)
EPZ: 103558482(CDC42)
EAI: 106840004(CDC42)
MYB: 102239987 102257260(CDC42)
MYD: 102758165(CDC42)
MMYO: 118675144(CDC42)
MLF: 102439024(CDC42)
MNA: 107538414(CDC42) 107540891
PKL: 118722445(CDC42)
HAI: 109396744(CDC42)
DRO: 112299195(CDC42)
SHON: 118977719(CDC42)
AJM: 119042192(CDC42)
PDIC: 114496144(CDC42) 114507316
MMF: 118626070(CDC42) 118638912
RFQ: 117026985(CDC42)
PALE: 102889114(CDC42)
PGIG: 120596202(CDC42)
RAY: 107513058(CDC42)
MJV: 108391531(CDC42)
TOD: 119237218(CDC42)
LAV: 100664103(CDC42)
TMU: 101361943
MDO: 100009767 100023099(CDC42)
SHR: 100918370(CDC42)
PCW: 110206033(CDC42)
OAA: 100086186(CDC42)
GGA: 395917(CDC42)
PCOC: 116238350(CDC42)
MGP: 100546318(CDC42)
CJO: 107323393(CDC42)
NMEL: 110408527(CDC42)
ACYG: 106049156(CDC42)
TGU: 100227983(CDC42)
LSR: 110472241(CDC42)
SCAN: 103824159(CDC42)
PMOA: 120498994(CDC42)
OTC: 121333079(CDC42)
PRUF: 121365792(CDC42)
GFR: 102036055(CDC42)
FAB: 101806194(CDC42)
PHI: 102106254(CDC42)
PMAJ: 107213677(CDC42)
CCAE: 111938571(CDC42)
CCW: 104697540(CDC42)
ETL: 114066848(CDC42)
FPG: 101914879(CDC42)
FCH: 102055425(CDC42)
CLV: 102098077(CDC42)
EGZ: 104131862(CDC42)
NNI: 104011199(CDC42)
ACUN: 113487836(CDC42)
PADL: 103925407(CDC42)
AAM: 106498596(CDC42)
AROW: 112966852(CDC42)
NPD: 112957357(CDC42)
DNE: 112988465(CDC42)
ASN: 102385507(CDC42)
AMJ: 102558748(CDC42)
CPOO: 109314291(CDC42)
GGN: 109293877(CDC42)
PSS: 102447391(CDC42)
CMY: 102931327(CDC42)
CPIC: 101940859(CDC42)
TST: 117867802(CDC42)
CABI: 116817598(CDC42)
MRV: 120387901(CDC42)
ACS: 103282300(cdc42) 107983928
PVT: 110086811(CDC42)
SUND: 121924210 121936654(CDC42)
PBI: 103053939(CDC42)
PMUR: 107290017(CDC42)
TSR: 106554373
PGUT: 117659748(CDC42)
VKO: 123030987(CDC42)
PMUA: 114602591(CDC42)
ZVI: 118086883(CDC42)
GJA: 107116700(CDC42)
XLA: 108697660(cdc42.S) 379055(cdc42.L)
XTR: 493389(cdc42)
NPR: 108797397(CDC42)
DRE: 336839(cdc42) 556226(cdc42l2) 793158(cdc42l)
PLEP: 121945302(cdc42l) 121946633 121952675(cdc42) 121957557
SLUC: 116043633 116046410 116049717(cdc42l) 116055515(cdc42)
ECRA: 117943341(cdc42) 117946299(cdc42l) 117947828 117957009
PPUG: 119197284(cdc42l) 119219038 119221854 119229710(cdc42)
GAF: 122830998(cdc42l) 122834160(cdc42) 122839609 122843911
SSEN: 122762620 122767996(cdc42) 122775048(cdc42l) 122776876
XGL: 120784131(cdc42l) 120786424 120803711 120807080(cdc42)
SASA: 106565619(CDC42) 106567263(cdc42) 106569986(CDC42) 106572399(CDC42) 106576553(CDC42) 106583122(CDC42) 106588426 106605852
AANG: 118208351 118210904(cdc42) 118232949(cdc42l) 118234664
LOC: 102683416(cdc42) 102698253
LCM: 102358869(CDC42)
CMK: 103181348(cdc42)
RTP: 109936137(cdc42)
CIN: 445701(cdc42) 445704
SPU: 584477
DME: Dmel_CG12530(Cdc42)
DER: 6550501
DSE: 6615043
DSI: Dsimw501_GD17456(Dsim_GD17456)
DAN: 6503130
DSR: 110180142
DPE: 6600764
DMN: 108164643
DWI: 6652889
DGR: 6564863
DAZ: 108619514
DNV: 115564295
DHE: 111593412
DVI: 6634824
CCAT: 101463272
BOD: 106619097
AGA: AgaP_AGAP002440(CDC42_ANOGA) AgaP_AGAP006279
ACOZ: 120950023
AARA: 120895944
AAG: 5570780
BVK: 117230940
MDL: 103575682
CGLO: 123268190
FAS: 105273302
DAM: 107042820
AGIF: 122856883
DPA: 109542387
AGB: 108916043
LDC: 111509612
NVL: 108560692
APLN: 108733720
BMOR: 101742319
BMAN: 114252509
MSEX: 115444866
BANY: 112048222
PMAC: 106717056
PPOT: 106110268
PXU: 106126386
PRAP: 110996319
ZCE: 119835426
HAW: 110373859
TNL: 113495620
API: 100145828(Cdc42)
DNX: 107164525
AGS: 114126895
RMD: 113552383
DCI: 103508197
CLEC: 106670837
HHAL: 106692613
NLU: 111046558
ZNE: 110836944
CSEC: 111871870
FCD: 110852274
DMK: 116915469
PVM: 113805842
HAME: 121872665
EAF: 111710996
DSV: 119446850
RSAN: 119389307
RMP: 119184613
VDE: 111252314
VJA: 111267313
TUT: 107364892
DPTE: 113794067
PTEP: 107437746
CEL: CELE_R07G3.1(cdc-42) CELE_Y32F6B.3(crp-1)
CBR: CBG_09601(Cbr-crp-1) CBG_13013(Cbr-cdc-42)
BMY: BM_BM5286(Bma-cdc-42)
OSN: 115224447
EGL: EGR_00052
NVE: 5508990
EPA: 110254357
ATEN: 116303859
ADF: 107344029
HMG: 100204156
SCE: YLR229C(CDC42)
ERC: Ecym_4146
KMX: KLMA_50127(CDC42)
NCS: NCAS_0B02880(NCAS0B02880)
NDI: NDAI_0C04820(NDAI0C04820)
TPF: TPHA_0C02190(TPHA0C02190)
TBL: TBLA_0H00690(TBLA0H00690) TBLA_0H03330(TBLA0H03330)
TDL: TDEL_0F05450(TDEL0F05450)
KAF: KAFR_0B06320(KAFR0B06320)
PIC: PICST_35277(CDC42)
CAL: CAALFM_C108450CA(CDC42)
SLB: AWJ20_1676(CDC42)
BNN: FOA43_003400(CDC42)
BBRX: BRETT_004250(CDC42)
NCR: NCU06454(cdc42)
NTE: NEUTE1DRAFT81132(NEUTE1DRAFT_81132)
SMP: SMAC_02216(putative cdc42)
MGR: MGG_00466
SSCK: SPSK_01924
TRE: TRIREDRAFT_50335(cdc42)
MAW: MAC_05067
MAJ: MAA_03565
CMT: CCM_00979
MBE: MBM_04474
ANI: AN7487.2
ANG: ANI_1_1958024(An02g14200)
ABE: ARB_03852
TVE: TRV_01751
PTE: PTT_09197
ZTR: MYCGRDRAFT_99553(MgCdc42)
SPO: SPAC110.03(cdc42)
TASA: A1Q1_00917
ABP: AGABI1DRAFT82759(AGABI1DRAFT_82759)
ABV: AGABI2DRAFT134270(AGABI2DRAFT_134270)
MGL: MGL_0548
MRT: MRET_4344
MSYM: MSY001_3465(RHO1.4)
 » show all
Reference
  Authors
Gao XD, Sperber LM, Kane SA, Tong Z, Tong AH, Boone C, Bi E
  Title
Sequential and distinct roles of the cadherin domain-containing protein Axl2p in cell polarization in yeast cell cycle.
  Journal
Mol Biol Cell 18:2542-60 (2007)
DOI:10.1091/mbc.E06-09-0822
  Sequence
[sce:YLR229C]
Reference
PMID:2122236
  Authors
Munemitsu S, Innis MA, Clark R, McCormick F, Ullrich A, Polakis P
  Title
Molecular cloning and expression of a G25K cDNA, the human homolog of the yeast cell cycle gene CDC42.
  Journal
Mol Cell Biol 10:5977-82 (1990)
DOI:10.1128/MCB.10.11.5977
  Sequence
[hsa:998]

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