KEGG   ORTHOLOGY: K04427
Entry
K04427                      KO                                     

Symbol
MAP3K7, TAK1
Name
mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
Pathway
map04010  MAPK signaling pathway
map04013  MAPK signaling pathway - fly
map04064  NF-kappa B signaling pathway
map04140  Autophagy - animal
map04152  AMPK signaling pathway
map04214  Apoptosis - fly
map04310  Wnt signaling pathway
map04380  Osteoclast differentiation
map04520  Adherens junction
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map04657  IL-17 signaling pathway
map04660  T cell receptor signaling pathway
map04668  TNF signaling pathway
map04936  Alcoholic liver disease
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05135  Yersinia infection
map05140  Leishmaniasis
map05145  Toxoplasmosis
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H02226  Cardiospondylocarpofacial syndrome
H02227  Frontometaphyseal dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04013 MAPK signaling pathway - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04310 Wnt signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04064 NF-kappa B signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04668 TNF signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04152 AMPK signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09143 Cell growth and death
   04214 Apoptosis - fly
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04620 Toll-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04624 Toll and Imd signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04621 NOD-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04622 RIG-I-like receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04660 T cell receptor signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   04657 IL-17 signaling pathway
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05161 Hepatitis B
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05171 Coronavirus disease - COVID-19
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05162 Measles
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05168 Herpes simplex virus 1 infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05169 Epstein-Barr virus infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05132 Salmonella infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05131 Shigellosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05135 Yersinia infection
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05140 Leishmaniasis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
   05418 Fluid shear stress and atherosclerosis
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  MLK family
   K04427  MAP3K7, TAK1; mitogen-activated protein kinase kinase kinase 7
Other DBs
GO: 0004709
Genes
HSA: 6885(MAP3K7)
PTR: 462888(MAP3K7)
PPS: 100974026(MAP3K7)
GGO: 101144707(MAP3K7)
PON: 100171454(MAP3K7)
NLE: 100596471(MAP3K7)
MCC: 703101(MAP3K7)
MCF: 102140498(MAP3K7)
CSAB: 103240115(MAP3K7)
CATY: 105589048(MAP3K7)
PANU: 101013055(MAP3K7)
RRO: 104657888(MAP3K7)
RBB: 108539499(MAP3K7)
TFN: 117097099(MAP3K7)
PTEH: 111538092(MAP3K7)
CJC: 100403175(MAP3K7)
SBQ: 101045636(MAP3K7)
MMUR: 105863624(MAP3K7)
MMU: 26409(Map3k7)
MCAL: 110292293(Map3k7)
MPAH: 110338656(Map3k7)
RNO: 313121(Map3k7)
MCOC: 116088003(Map3k7)
CGE: 100774341(Map3k7)
PLEU: 114695419(Map3k7)
NGI: 103739547(Map3k7)
HGL: 101718269(Map3k7)
CCAN: 109698497(Map3k7)
OCU: 100343571(MAP3K7)
TUP: 102477331(MAP3K7)
CFA: 102156745(MAP3K7)
VVP: 112923157(MAP3K7)
VLG: 121496257(MAP3K7)
AML: 100466506(MAP3K7)
UMR: 103660092(MAP3K7)
UAH: 113264818(MAP3K7)
ORO: 101376824(MAP3K7)
ELK: 111158801
MPUF: 101682439(MAP3K7)
EJU: 114213021(MAP3K7)
MLX: 118001330(MAP3K7)
FCA: 101095899(MAP3K7)
PTG: 102963341(MAP3K7)
PPAD: 109263420(MAP3K7)
AJU: 106983077(MAP3K7)
HHV: 120231881(MAP3K7)
BTA: 529146(MAP3K7)
BOM: 102264816(MAP3K7)
BIU: 109563902(MAP3K7)
BBUB: 102415113(MAP3K7)
CHX: 102172719(MAP3K7)
OAS: 101108056(MAP3K7)
ODA: 120862713(MAP3K7)
SSC: 100135663(MAP3K7)
CFR: 102519538(MAP3K7)
CBAI: 105064109(MAP3K7)
CDK: 105095522(MAP3K7)
BACU: 103019299(MAP3K7)
LVE: 103075340(MAP3K7)
OOR: 101283961(MAP3K7)
DLE: 111163761(MAP3K7)
PCAD: 102995727(MAP3K7)
ECB: 100065841(MAP3K7)
EPZ: 103548805(MAP3K7)
EAI: 106847421(MAP3K7)
MYB: 102254118(MAP3K7)
MYD: 102763957(MAP3K7)
MMYO: 118659996(MAP3K7)
MNA: 107533446(MAP3K7)
HAI: 109389465(MAP3K7)
DRO: 112296959(MAP3K7)
SHON: 118982270(MAP3K7)
AJM: 119041421
MMF: 118621083(MAP3K7)
PALE: 102882452(MAP3K7)
PGIG: 120595002(MAP3K7)
RAY: 107508648(MAP3K7)
MJV: 108399127(MAP3K7)
TOD: 119252700(MAP3K7)
LAV: 100667170(MAP3K7)
TMU: 101346094
MDO: 100019975(MAP3K7)
SHR: 100920997(MAP3K7)
PCW: 110192034(MAP3K7)
OAA: 100076229(MAP3K7)
GGA: 421808(MAP3K7)
PCOC: 116240737(MAP3K7)
MGP: 100539749(MAP3K7)
CJO: 107311964(MAP3K7)
NMEL: 110395624(MAP3K7)
ACYG: 106035399(MAP3K7)
TGU: 100221443(MAP3K7)
LSR: 110478595(MAP3K7)
SCAN: 103819102(MAP3K7)
PMOA: 120512386(MAP3K7)
GFR: 102039929(MAP3K7)
FAB: 101814532(MAP3K7)
PHI: 102107403(MAP3K7)
PMAJ: 107201717(MAP3K7)
CCAE: 111925720(MAP3K7)
CCW: 104692210(MAP3K7)
ETL: 114057792(MAP3K7)
FPG: 101917746(MAP3K7)
FCH: 102058816(MAP3K7)
EGZ: 104135405(MAP3K7)
NNI: 104021941(MAP3K7)
ACUN: 113478050(MAP3K7)
PADL: 103913621(MAP3K7)
AAM: 106489690(MAP3K7)
ASN: 102386999(MAP3K7)
AMJ: 102569201(MAP3K7)
CPOO: 109311869(MAP3K7)
GGN: 109299677(MAP3K7)
CMY: 102936052(MAP3K7)
CPIC: 101931315(MAP3K7)
TST: 117875099(MAP3K7)
CABI: 116820302(MAP3K7)
ACS: 100554725(map3k7)
PVT: 110074609(MAP3K7)
PBI: 103067633(MAP3K7)
PMUR: 107301663 107302815(MAP3K7)
TSR: 106549515(MAP3K7)
PGUT: 117660774(MAP3K7)
PMUA: 114593961(MAP3K7)
ZVI: 118082247(MAP3K7)
GJA: 107114874(MAP3K7)
XLA: 379399(map3k7.S) 399459(map3k7.L)
XTR: 100101764(map3k7)
NPR: 108800110(MAP3K7)
DRE: 553788(map3k7)
CCAR: 109064262
IPU: 108256841(map3k7)
PHYP: 113529033(map3k7)
AMEX: 103039333(map3k7)
EEE: 113579878(map3k7)
TRU: 101063524(map3k7)
LCO: 104924081(map3k7) 104928162
CGOB: 115028876(map3k7)
ELY: 117267585 117270756(map3k7)
PLEP: 121953646 121955268(map3k7)
SLUC: 116040316(map3k7) 116065811
ECRA: 117935477 117961374(map3k7)
PFLV: 114547321 114573089(map3k7)
GAT: 120808062(map3k7) 120833079
MSAM: 119908660(map3k7) 119911008
CUD: 121520896(map3k7) 121526674
MZE: 101475992 101484924(map3k7)
ONL: 100689877(map3k7) 100699877
OAU: 116321722(map3k7) 116330303
OLA: 101164271(map3k7) 105356874
OML: 112154196 112158233(map3k7)
XMA: 102226534(map3k7) 102232287
XCO: 114133938 114158518(map3k7)
XHE: 116709106 116733629(map3k7)
PRET: 103457977(map3k7) 103458953
CTUL: 119779178 119786113(map3k7)
NFU: 107395980(map3k7)
KMR: 108245043 108251536(map3k7)
ALIM: 106519963 106535535(map3k7)
AOCE: 111566069(map3k7)
CSEM: 103380691(map3k7)
POV: 109628158 109632517(map3k7)
LCF: 108897885 108899288(map3k7)
SDU: 111226008 111238781(map3k7)
SLAL: 111645547 111661524(map3k7)
XGL: 120788739(map3k7) 120795051
HCQ: 109529256
BPEC: 110154967 110171242(map3k7)
MALB: 109959709 109967378(map3k7)
ELS: 105015746 105017873(map3k7)
SFM: 108929345(map3k7)
PKI: 111843005(map3k7)
AANG: 118208640 118230511(map3k7)
LOC: 102693991(map3k7)
PSPA: 121315455 121317588(map3k7)
ARUT: 117402843 117411069(map3k7)
LCM: 102358159(MAP3K7)
CMK: 103178276(map3k7)
RTP: 109927672(map3k7)
BFO: 118423204
BBEL: 109488053
CIN: 778771(tak1/mapkkk7)
SPU: 590951
APLC: 110983312
SKO: 100313751
DME: Dmel_CG18492(Tak1) Dmel_CG31421(Takl1) Dmel_CG4803(Takl2)
DSI: Dsimw501_GD15532(Dsim_Tak1) Dsimw501_GD18431(Dsim_GD18431) Dsimw501_GD20035(Dsim_GD20035)
DYA: Dyak_GE15342(Dyak_Tak1)
DVI: 6632056
CCAT: 101452422
MDE: 101898114
LCQ: 111684006
ACOZ: 120951365
AARA: 120908898
AAG: 5568685
AME: 413809
ACER: 108001395
BIM: 100746656
BBIF: 117215926
BTER: 100631093
OBB: 114873005
MGEN: 117224228
NMEA: 116426528
CGIG: 122398691
SOC: 105207936
MPHA: 105838917
AEC: 105150983
ACEP: 105619960
PBAR: 105427629
VEM: 105570275
HST: 105187438
DQU: 106752216
CFO: 105256050
FEX: 115245292
LHU: 105676340
PGC: 109853437
OBO: 105284644
PCF: 106793886
NVI: 100120628
CSOL: 105366930
MDL: 103579917
CCIN: 107267944
TCA: 656961(Tak1)
DPA: 109538196
ATD: 109608402
AGB: 108903524
LDC: 111506663
NVL: 108560912
APLN: 108742378
PPYR: 116161311
OTU: 111426480
BMOR: 101744000
BMAN: 114242540
MSEX: 115440218
BANY: 112045234
PMAC: 106721022
PPOT: 106110870
PXU: 106126784
PRAP: 110998182
ZCE: 119840187
HAW: 110382235
PXY: 105380044
API: 100159713
DNX: 107169096
AGS: 114123134
RMD: 113553054
DCI: 103517530
CLEC: 106666550
HHAL: 106679784
NLU: 111053447
ZNE: 110836178
CSEC: 111862208
FCD: 110853786
DMK: 116931562
PVM: 113820640
HAME: 121879194
HAZT: 108681249
EAF: 111715843
DSV: 119461765
RSAN: 119395590
VDE: 111246648
VJA: 111265870
TUT: 107362121
DPTE: 113799863
CSCU: 111632919
PTEP: 107450902
SDM: 118197492
CEL: CELE_F52F12.3(mom-4) CELE_Y105C5A.24(Y105C5A.24)
CBR: CBG03852(Cbr-mom-4)
PCAN: 112566950
BGT: 106060407
GAE: 121370565
CRG: 105332318
MYI: 110455078
OBI: 106880926
LAK: 106163922
NVE: 5519317
EPA: 110249937
ATEN: 116302330
ADF: 107335569
AMIL: 114961241
PDAM: 113665935
DGT: 114526269
VAR: 108340739
VUN: 114175685
CAM: 101505952
LANG: 109331017
APRO: F751_0620
 » show all
Reference
PMID:9079627
  Authors
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K, Nishida E
  Title
TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase.
  Journal
J Biol Chem 272:8141-4 (1997)
DOI:10.1074/jbc.272.13.8141
  Sequence
[hsa:6885]
Reference
PMID:9480845
  Authors
Sakurai H, Shigemori N, Hasegawa K, Sugita T
  Title
TGF-beta-activated kinase 1 stimulates NF-kappa B activation by an NF-kappa B-inducing kinase-independent mechanism.
  Journal
Biochem Biophys Res Commun 243:545-9 (1998)
DOI:10.1006/bbrc.1998.8124
  Sequence
[hsa:6885]

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