KEGG   ORTHOLOGY: K04433
Entry
K04433                      KO                                     
Symbol
MAP2K6, MKK6
Name
mitogen-activated protein kinase kinase 6 [EC:2.7.12.2]
Pathway
map04010  MAPK signaling pathway
map04015  Rap1 signaling pathway
map04212  Longevity regulating pathway - worm
map04218  Cellular senescence
map04380  Osteoclast differentiation
map04620  Toll-like receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04668  TNF signaling pathway
map04750  Inflammatory mediator regulation of TRP channels
map04912  GnRH signaling pathway
map04935  Growth hormone synthesis, secretion and action
map04936  Alcoholic liver disease
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05132  Salmonella infection
map05135  Yersinia infection
map05145  Toxoplasmosis
map05161  Hepatitis B
map05163  Human cytomegalovirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04015 Rap1 signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04668 TNF signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04664 Fc epsilon RI signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   04935 Growth hormone synthesis, secretion and action
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09149 Aging
   04212 Longevity regulating pathway - worm
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05161 Hepatitis B
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05163 Human cytomegalovirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05169 Epstein-Barr virus infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05135 Yersinia infection
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05022 Pathways of neurodegeneration - multiple diseases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
   05418 Fluid shear stress and atherosclerosis
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: STE group
  STE7 family
   K04433  MAP2K6, MKK6; mitogen-activated protein kinase kinase 6
Other DBs
GO: 0004708
Genes
HSA: 5608(MAP2K6)
PTR: 468310(MAP2K6)
PPS: 100972424(MAP2K6)
GGO: 101142374(MAP2K6)
PON: 100448382(MAP2K6)
NLE: 100591256(MAP2K6)
MCC: 693914(MAP2K6)
MCF: 101925060(MAP2K6)
CSAB: 103243132(MAP2K6)
CATY: 105577799(MAP2K6)
PANU: 101001515(MAP2K6)
TGE: 112609390(MAP2K6)
RRO: 104654038(MAP2K6)
RBB: 108523215(MAP2K6)
TFN: 117066601(MAP2K6)
PTEH: 111542478(MAP2K6)
CJC: 100397389(MAP2K6)
SBQ: 101030219(MAP2K6)
CSYR: 103254297
MMUR: 105861678(MAP2K6)
LCAT: 123650624(MAP2K6)
OGA: 100962457(MAP2K6)
MMU: 26399(Map2k6)
MCAL: 110304684(Map2k6)
MPAH: 110331335(Map2k6)
RNO: 114495(Map2k6)
MCOC: 116079135(Map2k6)
CGE: 100771767
MAUA: 101833237(Map2k6)
PLEU: 114690458(Map2k6)
MORG: 121436314(Map2k6)
AAMP: 119812035(Map2k6)
NGI: 103742218(Map2k6)
HGL: 101703028(Map2k6)
CPOC: 100731419(Map2k6)
CCAN: 109698990(Map2k6)
DORD: 106002705(Map2k6)
DSP: 122128383(Map2k6)
NCAR: 124981341
OCU: 100355230(MAP2K6)
OPI: 101519949(MAP2K6)
TUP: 102482054(MAP2K6)
CFA: 480454(MAP2K6)
VVP: 112920749(MAP2K6)
VLG: 121473314(MAP2K6)
AML: 100469111(MAP2K6)
UMR: 103665687(MAP2K6)
UAH: 113265227(MAP2K6)
UAR: 123803240(MAP2K6)
ELK: 111158041
LLV: 125087142
MPUF: 101670597(MAP2K6)
ORO: 101382167(MAP2K6)
EJU: 114216197(MAP2K6)
ZCA: 113908216(MAP2K6)
MLX: 118024329(MAP2K6)
FCA: 101089813(MAP2K6)
PYU: 121015350(MAP2K6)
PBG: 122485830(MAP2K6)
PTG: 102966485(MAP2K6)
PPAD: 109277026(MAP2K6)
AJU: 106988444(MAP2K6)
HHV: 120230246(MAP2K6)
BTA: 286883(MAP2K6)
BOM: 102272962(MAP2K6)
BIU: 109573853(MAP2K6)
BBUB: 102403288(MAP2K6)
CHX: 102169516(MAP2K6)
OAS: 101115047(MAP2K6)
ODA: 120866612(MAP2K6)
CCAD: 122429019(MAP2K6)
SSC: 100625946(MAP2K6)
CFR: 102519784(MAP2K6)
CBAI: 105063918(MAP2K6)
CDK: 105085694(MAP2K6)
VPC: 102545165(MAP2K6)
BACU: 103012537(MAP2K6)
LVE: 103081641
OOR: 101280413(MAP2K6)
DLE: 111182897(MAP2K6)
PCAD: 102982175(MAP2K6)
PSIU: 116746300(MAP2K6)
ECB: 100053056(MAP2K6)
EPZ: 103564566(MAP2K6)
EAI: 106830236(MAP2K6)
MYB: 102246913(MAP2K6)
MYD: 102759247(MAP2K6)
MMYO: 118672023(MAP2K6)
MLF: 102426303(MAP2K6)
MNA: 107528394(MAP2K6)
PKL: 118702109(MAP2K6)
HAI: 109371344(MAP2K6)
DRO: 112316519(MAP2K6)
SHON: 119003578(MAP2K6)
AJM: 119036284(MAP2K6)
PDIC: 114503069(MAP2K6)
PHAS: 123817154(MAP2K6)
MMF: 118634140(MAP2K6)
RFQ: 117013904(MAP2K6)
PALE: 102888822(MAP2K6)
PGIG: 120600014(MAP2K6)
PVP: 105298936(MAP2K6)
RAY: 107510279(MAP2K6)
MJV: 108405137(MAP2K6)
TOD: 119231622(MAP2K6)
SARA: 101542881(MAP2K6)
LAV: 100662511(MAP2K6)
TMU: 101344286
DNM: 101431376(MAP2K6)
MDO: 100029049(MAP2K6)
GAS: 123246222(MAP2K6)
PCW: 110219359(MAP2K6)
OAA: 100078394(MAP2K6)
GGA: 417445(MAP2K6)
PCOC: 116232481(MAP2K6)
MGP: 100545287(MAP2K6)
CJO: 107322198(MAP2K6)
NMEL: 110407251(MAP2K6)
ACYG: 106034753(MAP2K6)
AFUL: 116496466(MAP2K6)
TGU: 100226231(MAP2K6)
LSR: 110473926(MAP2K6)
SCAN: 103819965(MAP2K6)
PMOA: 120505376(MAP2K6)
OTC: 121338227(MAP2K6)
PRUF: 121363365(MAP2K6)
GFR: 102039445(MAP2K6)
FAB: 101819388(MAP2K6)
PHI: 102105268(MAP2K6)
PMAJ: 107212284(MAP2K6)
CCAE: 111937452(MAP2K6)
CCW: 104696025(MAP2K6)
ETL: 114060693(MAP2K6)
ZAB: 102067681(MAP2K6)
FPG: 101913671(MAP2K6)
FCH: 102053088(MAP2K6)
CLV: 102086996(MAP2K6)
EGZ: 104132828(MAP2K6)
NNI: 104014353(MAP2K6)
PLET: 104623176
ACUN: 113486793(MAP2K6)
TALA: 104367888(MAP2K6)
PADL: 103916640(MAP2K6)
ACHC: 115341693(MAP2K6)
AAM: 106490233(MAP2K6)
AROW: 112966967(MAP2K6)
NPD: 112953655(MAP2K6)
DNE: 112982537(MAP2K6)
ASN: 102373782(MAP2K6)
AMJ: 106736984(MAP2K6)
CPOO: 109314938(MAP2K6)
GGN: 109296704(MAP2K6)
PSS: 102461243(MAP2K6)
CMY: 102942953(MAP2K6)
CPIC: 101935028(MAP2K6)
TST: 117887377(MAP2K6)
CABI: 116834835(MAP2K6)
MRV: 120383171(MAP2K6)
ACS: 100567963(map2k6)
PVT: 110077815(MAP2K6)
SUND: 121921526(MAP2K6)
PBI: 103058491
PMUR: 107282569(MAP2K6)
TSR: 106543486
PGUT: 117662946(MAP2K6)
PMUA: 114588447(MAP2K6)
ZVI: 118079658(MAP2K6)
GJA: 107122462(MAP2K6)
STOW: 125428190(MAP2K6)
XLA: 379638(map2k6.L) 399150(map2k3)
XTR: 448132(map2k6)
RTEM: 120919063(MAP2K6)
BBUF: 121004730(MAP2K6)
BGAR: 122940256(MAP2K6)
DRE: 65239(map2k6)
SANH: 107684112
PPRM: 120474717(map2k6)
MAMB: 125255310(map2k6)
IPU: 108274084(map2k6)
PHYP: 113527237
SMEO: 124388598(map2k6)
TFD: 113651614(map2k6)
AMEX: 111191499
EEE: 113585643
NCC: 104944235(map2k6) 104948325
ELY: 117247143(map2k6) 117268766
PLEP: 121957025 121958775(map2k6)
SLUC: 116059565 116061169(map2k6)
ECRA: 117936952(map2k6) 117958358
GAT: 120819366(map2k6) 120828362
PPUG: 119213268(map2k6) 119220864
MSAM: 119890456 119915650(map2k6)
CUD: 121503317 121528906(map2k6)
ALAT: 119010027(map2k6) 119014532
OAU: 116325201 116328614(map2k6)
OML: 112146636 112154201(map2k6)
GAF: 122821663 122823765(map2k6)
CTUL: 119775958(map2k6) 119778260
NWH: 119421012 119424210(map2k6)
HHIP: 117752994(map2k6) 117766311
HSP: 118100279(map2k6) 118123527
XGL: 120794111(map2k6) 120805077
BSPL: 114846339(map2k6) 114860381
SFM: 108922496 108924851(map2k6)
PKI: 111848425(map2k6) 111859759
AANG: 118217112(map2k6)
LOC: 102692628(map2k6)
LCM: 102362389(MAP2K6)
CMK: 103175734
RTP: 109935499
BFO: 118428978
BBEL: 109485302
CIN: 778902(mapkk3/6)
SPU: 585817
APLC: 110980301
SKO: 102800622
PPOI: 119095498
DSV: 119453535
RSAN: 119399643
RMP: 119180279
VDE: 111252498
TUT: 107370390
CEL: CELE_R03G5.2(sek-1)
CBR: CBG_16802(Cbr-sek-1)
GAE: 121378396
CRG: 105325568
MYI: 110465116
PMAX: 117338058
MMER: 123564997
OBI: 106875020
EPA: 110248902
ATEN: 116288722
AMIL: 114959468
PDAM: 113671527
SPIS: 111324764
XEN: 124448246
HMG: 100209591
AQU: 100633628
 » show all
Reference
PMID:8622669
  Authors
Raingeaud J, Whitmarsh AJ, Barrett T, Derijard B, Davis RJ
  Title
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway.
  Journal
Mol Cell Biol 16:1247-55 (1996)
DOI:10.1128/MCB.16.3.1247
  Sequence
[hsa:5608]

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