KEGG   ORTHOLOGY: K04448
Entry
K04448                      KO                                     

Symbol
JUN
Name
transcription factor AP-1
Pathway
map01522  Endocrine resistance
map04010  MAPK signaling pathway
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04024  cAMP signaling pathway
map04137  Mitophagy - animal
map04210  Apoptosis
map04214  Apoptosis - fly
map04310  Wnt signaling pathway
map04380  Osteoclast differentiation
map04510  Focal adhesion
map04530  Tight junction
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04624  Toll and Imd signaling pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04912  GnRH signaling pathway
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05161  Hepatitis B
map05162  Measles
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05210  Colorectal cancer
map05211  Renal cell carcinoma
map05224  Breast cancer
map05231  Choline metabolism in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05323  Rheumatoid arthritis
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04448  JUN; transcription factor AP-1
   04013 MAPK signaling pathway - fly
    K04448  JUN; transcription factor AP-1
   04012 ErbB signaling pathway
    K04448  JUN; transcription factor AP-1
   04310 Wnt signaling pathway
    K04448  JUN; transcription factor AP-1
   04668 TNF signaling pathway
    K04448  JUN; transcription factor AP-1
   04024 cAMP signaling pathway
    K04448  JUN; transcription factor AP-1
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04448  JUN; transcription factor AP-1
  09143 Cell growth and death
   04210 Apoptosis
    K04448  JUN; transcription factor AP-1
   04214 Apoptosis - fly
    K04448  JUN; transcription factor AP-1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K04448  JUN; transcription factor AP-1
   04530 Tight junction
    K04448  JUN; transcription factor AP-1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04624 Toll and Imd signaling pathway
    K04448  JUN; transcription factor AP-1
   04621 NOD-like receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04625 C-type lectin receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04660 T cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
   04658 Th1 and Th2 cell differentiation
    K04448  JUN; transcription factor AP-1
   04659 Th17 cell differentiation
    K04448  JUN; transcription factor AP-1
   04657 IL-17 signaling pathway
    K04448  JUN; transcription factor AP-1
   04662 B cell receptor signaling pathway
    K04448  JUN; transcription factor AP-1
  09152 Endocrine system
   04912 GnRH signaling pathway
    K04448  JUN; transcription factor AP-1
   04915 Estrogen signaling pathway
    K04448  JUN; transcription factor AP-1
   04921 Oxytocin signaling pathway
    K04448  JUN; transcription factor AP-1
   04926 Relaxin signaling pathway
    K04448  JUN; transcription factor AP-1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04448  JUN; transcription factor AP-1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04448  JUN; transcription factor AP-1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04448  JUN; transcription factor AP-1
   05207 Chemical carcinogenesis - receptor activation
    K04448  JUN; transcription factor AP-1
   05208 Chemical carcinogenesis - reactive oxygen species
    K04448  JUN; transcription factor AP-1
   05203 Viral carcinogenesis
    K04448  JUN; transcription factor AP-1
   05231 Choline metabolism in cancer
    K04448  JUN; transcription factor AP-1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04448  JUN; transcription factor AP-1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04448  JUN; transcription factor AP-1
   05211 Renal cell carcinoma
    K04448  JUN; transcription factor AP-1
   05224 Breast cancer
    K04448  JUN; transcription factor AP-1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04448  JUN; transcription factor AP-1
   05170 Human immunodeficiency virus 1 infection
    K04448  JUN; transcription factor AP-1
   05161 Hepatitis B
    K04448  JUN; transcription factor AP-1
   05171 Coronavirus disease - COVID-19
    K04448  JUN; transcription factor AP-1
   05162 Measles
    K04448  JUN; transcription factor AP-1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04448  JUN; transcription factor AP-1
   05169 Epstein-Barr virus infection
    K04448  JUN; transcription factor AP-1
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04448  JUN; transcription factor AP-1
   05130 Pathogenic Escherichia coli infection
    K04448  JUN; transcription factor AP-1
   05132 Salmonella infection
    K04448  JUN; transcription factor AP-1
   05131 Shigellosis
    K04448  JUN; transcription factor AP-1
   05135 Yersinia infection
    K04448  JUN; transcription factor AP-1
   05133 Pertussis
    K04448  JUN; transcription factor AP-1
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K04448  JUN; transcription factor AP-1
   05142 Chagas disease
    K04448  JUN; transcription factor AP-1
  09163 Immune disease
   05323 Rheumatoid arthritis
    K04448  JUN; transcription factor AP-1
   05321 Inflammatory bowel disease
    K04448  JUN; transcription factor AP-1
  09165 Substance dependence
   05030 Cocaine addiction
    K04448  JUN; transcription factor AP-1
   05031 Amphetamine addiction
    K04448  JUN; transcription factor AP-1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04448  JUN; transcription factor AP-1
   05418 Fluid shear stress and atherosclerosis
    K04448  JUN; transcription factor AP-1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04448  JUN; transcription factor AP-1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04448  JUN; transcription factor AP-1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04448  JUN; transcription factor AP-1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04448  JUN; transcription factor AP-1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   AP-1(-like) components, Jun
    K04448  JUN; transcription factor AP-1
Genes
HSA: 3725(JUN)
PTR: 456893(JUN)
PPS: 100980908(JUN)
GGO: 101145729(JUN)
PON: 100450292(JUN)
NLE: 100586501(JUN)
MCC: 716452(JUN)
MCF: 102126446(JUN)
CSAB: 103224726(JUN)
CATY: 105595973(JUN)
PANU: 101010894(JUN)
RRO: 104664278(JUN)
RBB: 108532921(JUN)
TFN: 117091985(JUN)
PTEH: 111523160(JUN)
CJC: 100400411(JUN)
SBQ: 101043809(JUN)
MMUR: 105882585(JUN)
MMU: 16476(Jun)
MCAL: 110292423(Jun)
MPAH: 110323252(Jun)
RNO: 24516(Jun)
MCOC: 116096245(Jun)
CGE: 113834001
PLEU: 114693768(Jun)
NGI: 103737138(Jun)
HGL: 101722197(Jun)
CCAN: 109700777(Jun)
OCU: 100008856(JUN) 100338341(EIF5A)
TUP: 102496870(JUN)
CFA: 609429(JUN)
VVP: 112926091(JUN)
VLG: 121500205(JUN)
AML: 100483834(JUN)
UMR: 103670861(JUN)
UAH: 113254611(JUN)
ORO: 101368207(JUN)
ELK: 111143174
MPUF: 101680348(JUN)
EJU: 114212152(JUN)
MLX: 118019356(JUN)
FCA: 101097261(JUN)
PYU: 121027214(JUN)
PBG: 122480569(JUN)
PTG: 102958666(JUN)
PPAD: 109266785(JUN)
AJU: 106974986(JUN)
HHV: 120236252(JUN)
BTA: 280831(JUN)
BOM: 102267895(JUN)
BIU: 109556235(JUN)
BBUB: 102405224(JUN)
CHX: 102185423(JUN)
OAS: 443219(JUN)
ODA: 120857086(JUN)
CCAD: 122436906(JUN)
SSC: 396913(JUN)
CFR: 102516943(JUN)
CBAI: 105071674(JUN)
CDK: 105092850(JUN)
LVE: 103071861(JUN)
OOR: 101288913(JUN)
DLE: 111175871(JUN)
PCAD: 102975458(JUN)
ECB: 100067469(JUN)
EAI: 106833477(JUN)
MYB: 102260808(JUN)
MYD: 102752693(JUN) 107183844(JUNB)
MMYO: 118676104(JUN)
MNA: 107536966(JUN)
HAI: 109371251(JUN) 109371257
DRO: 112314642(JUN)
SHON: 118984936(JUN)
AJM: 119051654(JUN)
MMF: 118627223(JUN)
PALE: 102896121(JUN)
PGIG: 120621837(JUN)
RAY: 107518352(JUN)
MJV: 108386817(JUN)
TOD: 119235421(JUN)
LAV: 100670432(JUN)
TMU: 101361653
MDO: 100018774(JUN)
SHR: 116423739(JUN)
PCW: 110212948(JUN)
GGA: 424673(JUN)
PCOC: 116235320(JUN)
MGP: 100548501(JUN)
CJO: 107317693(JUN)
NMEL: 110402812(JUN)
APLA: 101796626(JUN)
ACYG: 106032923(JUN)
TGU: 100229914(JUN)
LSR: 110476957(JUN)
SCAN: 103815057(JUN)
PMOA: 120503126(JUN)
GFR: 102039078(JUN)
FAB: 101816255(JUN)
PHI: 102112236(JUN)
PMAJ: 107208073(JUN)
CCAE: 111932998(JUN)
CCW: 104695158(JUN)
ETL: 114055179(JUN)
FPG: 101918818(JUN)
FCH: 102050406(JUN)
CLV: 102092209(JUN)
EGZ: 104123944(JUN)
NNI: 104009262(JUN)
ACUN: 113482645(JUN)
PADL: 103913320(JUN)
AAM: 106494500(JUN)
AROW: 112967663(JUN)
NPD: 112943557(JUN)
DNE: 112986058(JUN)
ASN: 102374896(JUN)
AMJ: 102566064(JUN)
CPOO: 109307535(JUN)
GGN: 109286591(JUN)
PSS: 102455008(JUN)
CMY: 102937264(JUN)
CPIC: 101930786(JUN)
TST: 117881919(JUN)
CABI: 116838113(JUN)
ACS: 100567718(jun)
PVT: 110077124(JUN)
PBI: 103057921(JUN)
PMUR: 107302456(JUN)
TSR: 106545185(JUN)
PGUT: 117664293(JUN)
PMUA: 114598927(JUN)
ZVI: 118089100(JUN)
GJA: 107111867(JUN)
XLA: 108700666 379050(jun.S) 399400(jun.L)
XTR: 100493911(jun)
NPR: 108788164(JUN)
DRE: 335916(jun)
IPU: 108258130(jun) 108260086 108267848(JUN)
AMEX: 103021920 103026868(jun)
TRU: 101064806(jun) 101077059
ELY: 117253294(jun) 117269419(june) 117271897
PLEP: 121951914 121960294(june) 121963101(jun)
SLUC: 116041404(june) 116045703 116058852(jun)
ECRA: 117949980(jun) 117953876 117959572(june)
GAT: 120815715 120824340(jun) 120831506(june)
MSAM: 119901002(jun) 119902398 119915034(june)
CUD: 121512795(jun) 121520730 121524721(june)
OAU: 116314808 116331225(jun) 116334108(june)
OML: 112144196(june) 112147409 112150898(jun)
XMA: 102230050(jun) 102234665
XCO: 114145916(jun) 114151264
PRET: 103463760 103478989(jun)
CVG: 107083648(jun) 107095895
CTUL: 119772327 119778327(june) 119799267(jun)
NFU: 107384375(jun) 107396464
KMR: 108230559(jun) 108238338
ALIM: 106521291(jun) 106534447
AOCE: 111577530 111587627(jun)
CSEM: 103376719(jun) 103398819
POV: 109625845 109643961(jun)
LCF: 108879142 108883834(jun)
SDU: 111228982(jun) 111231968
XGL: 120791293(jun) 120799405
BPEC: 110154702(jun) 110173458
MALB: 109952420 109970646(jun)
AANG: 118226519(jun)
LOC: 102689161 102693762(jun)
LCM: 102350279(JUN) 102358101
CMK: 103185297(jun)
BFO: 118431712
BBEL: 109475262
CIN: 778972(jun)
SCLV: 120347297
APLC: 110977802
SKO: 100313553
DME: Dmel_CG2275(Jra)
DER: 6541513
DSE: 6608460
DSI: Dsimw501_GD15385(Dsim_GD15385)
DAN: 6494876
DSR: 110178000
DPE: 6592569
DMN: 108160413
DWI: 6640122
DGR: 6560997
DAZ: 108617394
DNV: 108654006
DVI: 6626359
CCAT: 101461665
MDE: 101896731
LCQ: 111688738
ACOZ: 120953126
AARA: 120897200
AAG: 5578266
AALB: 109408179
CPII: 120418815
AME: 726289
ACER: 107997545
BIM: 100750048
BBIF: 117207147
BTER: 100645950
CCAL: 108627361
OBB: 114875381
MGEN: 117217542
NMEA: 116429394
CGIG: 122396769
SOC: 105200133
MPHA: 105830524
AEC: 105155106
ACEP: 105621323
PBAR: 105428867
VEM: 105565543
HST: 105190515
DQU: 106744297
CFO: 105253340
FEX: 115236485
LHU: 105671646
PGC: 109856529
OBO: 105277703
NVI: 100123087
CSOL: 105368040
MDL: 103568136
CCIN: 107273385
TCA: 663937(Jra)
DPA: 109542182
ATD: 109593897
AGB: 111691268
NVL: 108557779
OTU: 111426302
BMOR: 101736835
BMAN: 114249964
MSEX: 115452083
BANY: 112047037
PMAC: 106715838
PPOT: 106102499
PXU: 106114386
PRAP: 110996297
ZCE: 119832097
HAW: 110381290
TNL: 113505301
PXY: 105388607
DNX: 107166782
AGS: 114122336
RMD: 113557503
BTAB: 109035563
DCI: 103519231
ZNE: 110827968
CSEC: 111864826
FCD: 110859845
DMK: 116916511
PVM: 113800779
HAME: 121879991
EAF: 111700297
VDE: 111243751
VJA: 111265619
TUT: 107364868
DPTE: 113799532
BMY: BM_BM5997(Bma-jun-1)
PCAN: 112574619
BGT: 106064986
CRG: 105341654
PMAX: 117325996
OBI: 106868153
LAK: 106165046
HMG: 100204820(jun) 105851038
AQU: 100640297
 » show all
Reference
  Authors
Liu J, Han Q, Peng T, Peng M, Wei B, Li D, Wang X, Yu S, Yang J, Cao S, Huang K, Hutchins AP, Liu H, Kuang J, Zhou Z, Chen J, Wu H, Guo L, Chen Y, Chen Y, Li X, Wu H, Liao B, He W, Song H, Yao H, Pan G, Chen J, Pei D
  Title
The oncogene c-Jun impedes somatic cell reprogramming.
  Journal
Nat Cell Biol 17:856-67 (2015)
DOI:10.1038/ncb3193
Reference
PMID:3194415
  Authors
Hattori K, Angel P, Le Beau MM, Karin M
  Title
Structure and chromosomal localization of the functional intronless human JUN protooncogene.
  Journal
Proc Natl Acad Sci U S A 85:9148-52 (1988)
DOI:10.1073/pnas.85.23.9148
  Sequence
[hsa:3725]

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