KEGG   ORTHOLOGY: K05068
Entry
K05068                      KO                                     
Symbol
IL2RA, CD25
Name
interleukin 2 receptor alpha
Pathway
map04060  Cytokine-cytokine receptor interaction
map04061  Viral protein interaction with cytokine and cytokine receptor
map04144  Endocytosis
map04151  PI3K-Akt signaling pathway
map04630  JAK-STAT signaling pathway
map04640  Hematopoietic cell lineage
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map05162  Measles
map05166  Human T-cell leukemia virus 1 infection
map05200  Pathways in cancer
Disease
H00408  Type 1 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04151 PI3K-Akt signaling pathway
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04061 Viral protein interaction with cytokine and cytokine receptor
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04658 Th1 and Th2 cell differentiation
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04659 Th17 cell differentiation
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   05162 Measles
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04050 Cytokine receptors
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
   04090 CD molecules
    K05068  IL2RA, CD25; interleukin 2 receptor alpha
Cytokine receptors [BR:ko04050]
 Interleukin receptor families
  IL2 receptor family
   K05068  IL2RA, CD25; interleukin 2 receptor alpha
CD molecules [BR:ko04090]
 Proteins
  K05068  CD25, IL2RA; interleukin 2 receptor, alpha
Other DBs
GO: 0004911
Genes
HSA: 3559(IL2RA)
PTR: 450884(IL2RA)
PPS: 100974407(IL2RA)
GGO: 101126210(IL2RA)
PON: 100440118(IL2RA)
NLE: 100582107(IL2RA)
MCC: 574300(IL2RA)
MCF: 102123605(IL2RA)
CSAB: 103237839(IL2RA)
CATY: 105597428(IL2RA)
PANU: 101004576(IL2RA)
TGE: 112631620(IL2RA)
RRO: 104664846(IL2RA)
RBB: 108529907(IL2RA)
TFN: 117082099(IL2RA)
PTEH: 111554868(IL2RA)
CJC: 100412016(IL2RA)
SBQ: 101036589(IL2RA)
CSYR: 103272187(IL2RA)
MMUR: 105858205(IL2RA)
OGA: 100967179(IL2RA)
MMU: 16184(Il2ra)
MCAL: 110289347(Il2ra)
MPAH: 110334116(Il2ra)
RNO: 25704(Il2ra)
MCOC: 116082367(Il2ra)
MUN: 110556899(Il2ra)
CGE: 100764797(Il2ra)
PLEU: 114708790(Il2ra)
NGI: 103727306(Il2ra)
HGL: 101696651(Il2ra)
CPOC: 100715332(Il2ra)
CCAN: 109690611(Il2ra)
DORD: 105980358(Il2ra)
DSP: 122113142(Il2ra)
OPI: 101526738(IL2RA)
TUP: 102503225(IL2RA)
CFA: 403870(IL2RA)
VVP: 112933655(IL2RA)
VLG: 121496900(IL2RA)
AML: 100466247(IL2RA)
UMR: 103676245(IL2RA)
UAH: 113241140(IL2RA)
UAR: 123802327(IL2RA)
ELK: 111158621
MPUF: 101683684(IL2RA)
ORO: 101378506(IL2RA)
EJU: 114217727(IL2RA)
ZCA: 113922120(IL2RA)
MLX: 118021614(IL2RA)
FCA: 493953(IL2RA)
PYU: 121014860(IL2RA)
PBG: 122472215(IL2RA)
PPAD: 109273771(IL2RA)
AJU: 106982335(IL2RA)
HHV: 120237209(IL2RA)
BTA: 281861(IL2RA)
BOM: 102274858(IL2RA)
BIU: 109567961(IL2RA)
BBUB: 102405003(IL2RA)
CHX: 102170059(IL2RA)
OAS: 443435(IL2RA)
ODA: 120869146(IL2RA)
CCAD: 122448159(IL2RA)
SSC: 396814(IL2RA)
CFR: 102520401(IL2RA)
CBAI: 105074697(IL2RA)
CDK: 105091372(IL2RA)
BACU: 102999308(IL2RA)
LVE: 103090256(IL2RA)
OOR: 101275717(IL2RA)
DLE: 111177977(IL2RA)
PCAD: 102974550(IL2RA)
PSIU: 116748786(IL2RA)
ECB: 100070292(IL2RA)
EPZ: 103548896(IL2RA)
EAI: 106833795(IL2RA)
MYB: 102249529(IL2RA)
MYD: 102769642(IL2RA)
MMYO: 118672311(IL2RA)
MLF: 102427118(IL2RA)
MNA: 107542420(IL2RA)
PKL: 118732022(IL2RA)
HAI: 109383783(IL2RA)
DRO: 112321040(IL2RA)
SHON: 119000807(IL2RA)
AJM: 119048017(IL2RA)
PDIC: 114491940(IL2RA)
PHAS: 123831329(IL2RA)
MMF: 118632297(IL2RA)
RFQ: 117019205(IL2RA)
PALE: 102891511(IL2RA)
PGIG: 120609005(IL2RA)
PVP: 105307737(IL2RA)
RAY: 107505982(IL2RA)
MJV: 108384839(IL2RA)
TOD: 119244171(IL2RA)
SARA: 101546623(IL2RA)
LAV: 100655361(IL2RA)
TMU: 101342095
DNM: 101410814(IL2RA)
MDO: 103093188(IL2RA)
GAS: 123250369(IL2RA)
SHR: 105750698(IL2RA)
PCW: 110198993(IL2RA)
OAA: 103165385(IL2RA)
GGA: 395294(IL2RA)
PCOC: 116239606
MGP: 100547769
CJO: 107315066
NMEL: 110392238(IL15RA)
APLA: 101789606
ACYG: 106038749(IL2RA)
AFUL: 116502392
TGU: 100222957
LSR: 110470954
SCAN: 103822517
PMOA: 120512514
OTC: 121340574
PRUF: 121356392
FAB: 101805774
PHI: 102109566
PMAJ: 107204108
CCAE: 111923146
CCW: 104694531
ETL: 114067844(IL15RA)
ZAB: 102065915
FPG: 101919123
FCH: 102049741
CLV: 102090507
EGZ: 104134819
NNI: 104010490
ACUN: 113475946(IL15RA)
TALA: 104363711
PADL: 103920842
ACHC: 115342260
AAM: 106487990
AROW: 112978085
NPD: 112958573
DNE: 112994748
ASN: 102369874
AMJ: 106737583(IL2RA)
CPOO: 109315828
GGN: 109292241
PSS: 102451419
CMY: 102937403(IL2RA)
CPIC: 101934224(IL2RA)
TST: 117867397(IL2RA)
CABI: 116823520(IL2RA)
ACS: 103278808(il2ra)
PVT: 110088980
SUND: 121931967
PMUR: 107294425(IL15RA)
PMUA: 114604914(IL2RA)
GJA: 107120141
LCM: 106704263
 » show all
Reference
PMID:6090949
  Authors
Nikaido T, Shimizu A, Ishida N, Sabe H, Teshigawara K, Maeda M, Uchiyama T, Yodoi J, Honjo T
  Title
Molecular cloning of cDNA encoding human interleukin-2 receptor.
  Journal
Nature 311:631-5 (1984)
DOI:10.1038/311631a0
  Sequence
[hsa:3559]
Reference
PMID:8476561
  Authors
Minami Y, Kono T, Miyazaki T, Taniguchi T
  Title
The IL-2 receptor complex: its structure, function, and target genes.
  Journal
Annu Rev Immunol 11:245-68 (1993)
DOI:10.1146/annurev.iy.11.040193.001333
Reference
  Authors
Knevel R, de Rooy DP, Zhernakova A, Grondal G, Krabben A, Steinsson K, Wijmenga C, Cavet G, Toes RE, Huizinga TW, Gregersen PK, van der Helm-van Mil AH
  Title
Association of variants in IL2RA with progression of joint destruction in rheumatoid arthritis.
  Journal
Arthritis Rheum 65:1684-93 (2013)
DOI:10.1002/art.37938
  Sequence
[hsa:3559]

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