KEGG   ORTHOLOGY: K05098
Entry
K05098                      KO                                     

Symbol
KDR, VEGFR2, CD309
Name
kinase insert domain protein receptor [EC:2.7.10.1]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04370  VEGF signaling pathway
map04510  Focal adhesion
map05205  Proteoglycans in cancer
map05418  Fluid shear stress and atherosclerosis
Disease
H01482  Infantile hemangioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04014 Ras signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04015 Rap1 signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04370 VEGF signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04020 Calcium signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
   04151 PI3K-Akt signaling pathway
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  VEGFR family [OT]
   K05098  KDR, VEGFR2, CD309; kinase insert domain protein receptor
CD molecules [BR:ko04090]
 Proteins
  K05098  CD309, KDR; kinase insert domain receptor (a type III receptor tyrosine kinase)
Genes
HSA: 3791(KDR)
PTR: 461315(KDR)
PPS: 100986594(KDR)
GGO: 101127110(KDR)
PON: 100462446(KDR)
NLE: 100604569(KDR)
MCC: 698293(KDR)
MCF: 102136227(KDR)
CSAB: 103235670(KDR)
CATY: 105591984(KDR)
PANU: 101021364(KDR)
RRO: 104662002(KDR)
RBB: 108531591(KDR)
TFN: 117085601(KDR)
PTEH: 111526494(KDR)
CJC: 100407045(KDR)
SBQ: 101036336(KDR)
MMUR: 105867839(KDR)
MMU: 16542(Kdr)
MCAL: 110294607(Kdr)
MPAH: 110330463(Kdr)
RNO: 25589(Kdr)
MCOC: 116071284(Kdr)
MUN: 110556944(Kdr)
CGE: 100756294(Kdr)
PLEU: 114683507(Kdr)
NGI: 103734390(Kdr)
HGL: 101726029(Kdr)
CPOC: 100726761(Kdr)
CCAN: 109698964(Kdr)
OCU: 100008607(KDR)
OPI: 101525767(KDR)
TUP: 102489981(KDR)
CFA: 482154(KDR)
VVP: 112923722(KDR)
VLG: 121473247(KDR)
AML: 100484938(KDR)
UMR: 103672740(KDR)
UAH: 113262503(KDR)
ORO: 101371459(KDR)
ELK: 111149192
MPUF: 101676197(KDR)
EJU: 114206757(KDR)
MLX: 118010519(KDR)
FCA: 101090260(KDR)
PYU: 121035518(KDR)
PBG: 122478869(KDR)
PTG: 102955197(KDR)
PPAD: 109278955(KDR)
AJU: 106983987(KDR)
HHV: 120243048(KDR)
BTA: 407170(KDR)
BOM: 102288007(KDR)
BIU: 109560478(KDR)
BBUB: 102412057(KDR)
CHX: 100860836(KDR)
OAS: 443087(KDR)
ODA: 120862130(KDR)
CCAD: 122428068(KDR)
SSC: 397311(KDR)
CFR: 102520881(KDR)
CBAI: 105077731(KDR)
CDK: 105091598(KDR)
BACU: 102999852(KDR)
LVE: 103087802(KDR)
OOR: 101290288(KDR)
DLE: 111169643(KDR)
PCAD: 102986785(KDR)
PSIU: 116754436(KDR)
ECB: 100033959(KDR)
EPZ: 103554974(KDR)
EAI: 106836923(KDR)
MYB: 102256532(KDR)
MYD: 102760801(KDR)
MMYO: 118668891(KDR)
MNA: 107532764(KDR)
PKL: 118706596(KDR)
HAI: 109381812(KDR)
DRO: 112316796(KDR)
SHON: 118978574(KDR)
AJM: 119044890(KDR)
PDIC: 114492293(KDR)
MMF: 118639624(KDR)
RFQ: 117022432(KDR)
PALE: 102896638(KDR)
PGIG: 120588082(KDR)
RAY: 107520899(KDR)
MJV: 108400781(KDR)
TOD: 119261390(KDR)
LAV: 100656232(KDR)
TMU: 101348626
MDO: 100017311(KDR)
GAS: 123252924(KDR)
SHR: 100929091(KDR)
PCW: 110200147(KDR)
OAA: 100075389(KDR)
GGA: 395323(KDR)
PCOC: 116225918(KDR)
CJO: 107313758(KDR)
NMEL: 110398187(KDR)
APLA: 101797579(KDR)
ACYG: 106030825(KDR)
TGU: 100231879(KDR)
LSR: 110470474(KDR)
SCAN: 103825225(KDR)
PMOA: 120497438(KDR)
OTC: 121334972(KDR)
PRUF: 121356907(KDR)
GFR: 102042381(KDR)
FAB: 101821250(KDR)
PHI: 102113293(KDR)
PMAJ: 107202958(KDR)
CCAE: 111928018(KDR)
CCW: 104690864(KDR)
ETL: 114058319(KDR)
FPG: 101920584(KDR)
FCH: 102059103(KDR)
CLV: 102095316(KDR)
EGZ: 104129460(KDR)
NNI: 104020821(KDR)
ACUN: 113479117(KDR)
PADL: 103926348(KDR)
AAM: 106490175
AROW: 112974609(KDR)
NPD: 112942612(KDR)
DNE: 112979497(KDR)
ASN: 102384502(KDR)
AMJ: 102567818(KDR)
CPOO: 109322249(KDR)
GGN: 109303986(KDR)
PSS: 102451309(KDR)
CMY: 102936088(KDR)
CPIC: 101936813(KDR)
TST: 117877988(KDR)
CABI: 116826031(KDR)
SUND: 121931586(KDR)
PGUT: 117662069(KDR)
VKO: 123017072(KDR)
ZVI: 118083754(KDR)
XLA: 108698463 108706593(kdr.S)
XTR: 100487501(kdr)
DRE: 554230(kdr)
SGH: 107601907(kdr)
IPU: 108258084(kdr)
PHYP: 113546829(kdr)
AMEX: 103022603(kdr)
EEE: 113586383(kdr)
TRU: 101073989(kdr)
LCO: 104919091(kdr)
NCC: 104947077(kdr)
CGOB: 115007113(kdr)
ELY: 117254002(kdr)
PLEP: 121940403(kdr)
SLUC: 116058785(kdr)
ECRA: 117950140(kdr)
PFLV: 114561463(kdr)
GAT: 120824144(kdr)
PPUG: 119216901(kdr)
MSAM: 119901062(kdr)
CUD: 121512496(kdr)
MZE: 101472847(kdr)
ONL: 100692052(kdr)
OAU: 116331100(kdr)
OLA: 101162439(kdr)
OML: 112136996(kdr)
XMA: 102225837(kdr)
XCO: 114151198(kdr)
XHE: 116726174(kdr)
PRET: 103463836(kdr)
GAF: 122838442(kdr)
CVG: 107091574(kdr)
CTUL: 119780621(kdr)
NFU: 107393390(kdr)
KMR: 108243429(kdr)
ALIM: 106534849(kdr)
AOCE: 111569594(kdr)
CSEM: 103376704(kdr)
POV: 109625885(kdr)
SSEN: 122781150(kdr)
HHIP: 117759682(kdr)
LCF: 108879132(kdr)
SDU: 111226355(kdr)
SLAL: 111644356(kdr)
XGL: 120790993(kdr)
HCQ: 109532106(kdr)
BPEC: 110154739(kdr)
MALB: 109962035(kdr)
SASA: 106584120(kdr)
OTW: 112249135(kdr)
OMY: 110521673(kdr)
SALP: 111972318
SNH: 120052584(kdr)
ELS: 105011839(kdr)
SFM: 108922800(kdr)
PKI: 111850117(kdr)
AANG: 118225803(kdr)
LOC: 102682636(kdr)
LCM: 102362684(KDR)
CMK: 103178168(kdr)
RTP: 109928943(kdr)
VPS: 122629567
NVI: 100123205
HMG: 100214305
 » show all
Reference
PMID:1656371
  Authors
Terman BI, Carrion ME, Kovacs E, Rasmussen BA, Eddy RL, Shows TB
  Title
Identification of a new endothelial cell growth factor receptor tyrosine kinase.
  Journal
Oncogene 6:1677-83 (1991)
  Sequence
[hsa:3791]
Reference
  Authors
Stuttfeld E, Ballmer-Hofer K
  Title
Structure and function of VEGF receptors.
  Journal
IUBMB Life 61:915-22 (2009)
DOI:10.1002/iub.234

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