KEGG   ORTHOLOGY: K05460
Entry
K05460                      KO                                     
Symbol
HGF
Name
hepatocyte growth factor
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04151  PI3K-Akt signaling pathway
map04510  Focal adhesion
map05144  Malaria
map05200  Pathways in cancer
map05205  Proteoglycans in cancer
map05208  Chemical carcinogenesis - reactive oxygen species
map05211  Renal cell carcinoma
map05218  Melanoma
map05223  Non-small cell lung cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00605  Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K05460  HGF; hepatocyte growth factor
   04014 Ras signaling pathway
    K05460  HGF; hepatocyte growth factor
   04015 Rap1 signaling pathway
    K05460  HGF; hepatocyte growth factor
   04020 Calcium signaling pathway
    K05460  HGF; hepatocyte growth factor
   04151 PI3K-Akt signaling pathway
    K05460  HGF; hepatocyte growth factor
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05460  HGF; hepatocyte growth factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05460  HGF; hepatocyte growth factor
   05205 Proteoglycans in cancer
    K05460  HGF; hepatocyte growth factor
   05208 Chemical carcinogenesis - reactive oxygen species
    K05460  HGF; hepatocyte growth factor
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K05460  HGF; hepatocyte growth factor
   05226 Gastric cancer
    K05460  HGF; hepatocyte growth factor
   05218 Melanoma
    K05460  HGF; hepatocyte growth factor
   05211 Renal cell carcinoma
    K05460  HGF; hepatocyte growth factor
   05223 Non-small cell lung cancer
    K05460  HGF; hepatocyte growth factor
  09174 Infectious disease: parasitic
   05144 Malaria
    K05460  HGF; hepatocyte growth factor
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K05460  HGF; hepatocyte growth factor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and growth factors
    K05460  HGF; hepatocyte growth factor
   00536 Glycosaminoglycan binding proteins
    K05460  HGF; hepatocyte growth factor
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05460  HGF; hepatocyte growth factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Growth factors/receptors
   K05460  HGF; hepatocyte growth factor
Other DBs
GO: 0005171
Genes
HSA: 3082(HGF)
PTR: 463503(HGF)
PPS: 100983117(HGF)
GGO: 101127877(HGF)
PON: 100462115(HGF)
NLE: 100586296(HGF)
MCC: 708316(HGF)
MCF: 102133907(HGF)
CSAB: 103226643(HGF)
CATY: 105583213(HGF)
PANU: 101018541(HGF)
TGE: 112620515(HGF)
RRO: 104681576(HGF)
RBB: 108536940(HGF)
TFN: 117072632(HGF)
PTEH: 111552446(HGF)
CJC: 100385966(HGF)
SBQ: 101045517(HGF)
CSYR: 103249922(HGF)
MMUR: 105879346(HGF)
LCAT: 123647201(HGF)
OGA: 100963467(HGF)
MMU: 15234(Hgf)
MCAL: 110294216(Hgf)
MPAH: 110316234(Hgf)
RNO: 24446(Hgf)
MCOC: 116097489(Hgf)
MUN: 110565312(Hgf)
CGE: 100764472(Hgf)
MAUA: 101829822(Hgf)
PLEU: 114687327(Hgf)
AAMP: 119803884(Hgf)
NGI: 103730723(Hgf)
HGL: 101707056(Hgf)
CPOC: 100730730(Hgf)
DORD: 105992969(Hgf)
DSP: 122111940(Hgf)
NCAR: 124991665
OCU: 100316908(HGF)
OPI: 101536351(HGF)
TUP: 102483689(HGF)
CFA: 403441(HGF)
CLUD: 112661349(HGF)
VVP: 112925397(HGF)
VLG: 121471954(HGF)
AML: 100463560(HGF)
UMR: 103658669(HGF)
UAH: 113259246(HGF)
UAR: 123789349(HGF)
ELK: 111155271
LLV: 125081138
MPUF: 101677610(HGF)
ORO: 101373766(HGF)
EJU: 114221299(HGF)
ZCA: 113911759(HGF)
MLX: 118020685(HGF)
FCA: 493705(HGF)
PYU: 121028796(HGF)
PBG: 122487823(HGF)
PTG: 102952318(HGF)
PPAD: 109268152(HGF)
AJU: 106975661(HGF)
HHV: 120221164 120245413(HGF)
BTA: 282879(HGF)
BOM: 102267837(HGF)
BIU: 109557878(HGF)
BBUB: 102406209(HGF)
CHX: 102183288(HGF)
OAS: 443075(HGF)
ODA: 120878117(HGF)
CCAD: 122438250(HGF)
SSC: 100525120(HGF)
CFR: 102515749(HGF)
CBAI: 105062379(HGF)
CDK: 105100369(HGF)
VPC: 102532383(HGF)
BACU: 102997605
LVE: 103079072(HGF)
OOR: 101273491(HGF)
DLE: 111164604(HGF)
PCAD: 102992196(HGF)
PSIU: 116759711(HGF)
ECB: 100049848(HGF)
EPZ: 103563173(HGF)
EAI: 106840178(HGF)
MYB: 102259449(HGF)
MYD: 102765945(HGF)
MMYO: 118666274(HGF)
MLF: 102441297(HGF)
MNA: 107527167(HGF)
PKL: 118714360(HGF)
HAI: 109392334(HGF)
DRO: 112301961(HGF)
SHON: 119000987(HGF)
AJM: 119044937(HGF)
PDIC: 114507737(HGF)
PHAS: 123811490(HGF)
MMF: 118620202(HGF)
RFQ: 117012542(HGF)
PALE: 102884470(HGF)
PGIG: 120591565(HGF)
PVP: 105295521(HGF)
RAY: 107501285(HGF)
MJV: 108399212(HGF)
TOD: 119244822(HGF)
SARA: 101546946(HGF)
LAV: 100665493(HGF)
TMU: 101344799
DNM: 101445147(HGF)
MDO: 100016122(HGF)
GAS: 123249991(HGF)
SHR: 100915696(HGF)
PCW: 110206952(HGF)
OAA: 100074892(HGF)
GGA: 395941(HGF)
PCOC: 116228074(HGF)
MGP: 100542153(HGF)
CJO: 107321440(HGF)
NMEL: 110392449(HGF)
APLA: 101793664(HGF)
ACYG: 106035566(HGF)
AFUL: 116497145(HGF)
TGU: 100218784(HGF)
LSR: 110469773(HGF)
SCAN: 103813737(HGF)
PMOA: 120509314(HGF)
OTC: 121336301(HGF)
PRUF: 121357407(HGF)
GFR: 102042539(HGF)
FAB: 101810717(HGF)
PHI: 102106058(HGF)
PMAJ: 107205229(HGF)
CCAE: 111923284 111923285(HGF)
CCW: 104686934(HGF)
CBRC: 103612073(HGF)
ETL: 114058724(HGF)
ZAB: 102069950(HGF)
FPG: 101917184(HGF)
FCH: 102052167(HGF)
CLV: 102084988(HGF)
EGZ: 104132389(HGF)
NNI: 104010752(HGF)
PLET: 104618081
PCRI: 104032357
ACUN: 113491250(HGF)
TALA: 104359062(HGF)
PADL: 103920599(HGF)
ACHC: 115341991(HGF)
HALD: 104320775(HGF)
CCRI: 104155142(HGF)
CSTI: 104552859
EHS: 104508841(HGF)
CMAC: 104480767(HGF)
FGA: 104083389(HGF)
GSTE: 104250295(HGF)
LDI: 104349387(HGF)
MNB: 103773603(HGF)
OHA: 104337639(HGF)
AAM: 106485602(HGF)
AROW: 112967578(HGF)
NPD: 112958373(HGF)
DNE: 112980299(HGF)
ASN: 102385607(HGF)
AMJ: 102564574(HGF)
CPOO: 109315770(HGF)
GGN: 109292183(HGF)
PSS: 102451409(HGF)
CMY: 102929769(HGF)
CPIC: 101946945(HGF)
TST: 117874925(HGF)
CABI: 116836199(HGF)
MRV: 120394336(HGF)
ACS: 100566618(hgf)
PVT: 110077194(HGF)
SUND: 121930396(HGF)
PBI: 103063662
PMUR: 107297173
TSR: 106554702
PGUT: 117675803
VKO: 123020075(HGF)
PMUA: 114605154(HGF)
ZVI: 118091334(HGF)
GJA: 107110492(HGF)
STOW: 125435141(HGF)
XLA: 108711206(hgf.L) 108713062(hgf.S)
XTR: 100495840(hgf)
NPR: 108792728(HGF)
RTEM: 120931733(HGF)
BBUF: 120983011(HGF)
BGAR: 122927846(HGF)
DRE: 100334116 493781(hgfa)
PPRM: 120462047 120476523(hgfa)
MAMB: 125245538(hgfa) 125254287
PHYP: 113534821(hgf)
SMEO: 124396193
TFD: 113652610
LCO: 104918123(hgf) 104918795
NCC: 104952156(hgf) 104958230
CGOB: 115009747(hgf) 115028611
ELY: 117249132(hgfa) 117261655
EFO: 125883075(hgfa) 125887218
PLEP: 121950574 121961520(hgfa)
SLUC: 116045660 116060187(hgfa)
ECRA: 117938959(hgfa) 117948721
ESP: 116673226 116694689(hgf)
PPUG: 119196459 119210907(hgfa)
MSAM: 119893453 119918297(hgfa)
CUD: 121505193(hgfa) 121515535
ALAT: 119025110 119032739(hgfa)
MZE: 101470516(hgf) 101486965
ONL: 100704765(hgf) 100704875
OAU: 116318304 116335108(hgfa)
OLA: 101156453 101167035(hgf)
XMA: 102226489(hgf) 102232629
XCO: 114136644(hgf) 114161125
XHE: 116711743(hgf) 116736982
PRET: 103459222 103466001(hgf)
PFOR: 103133768(hgf) 103146203
PLAI: 106944865 106964833(hgf)
PMEI: 106904919(hgf) 106915078
GAF: 122826592(hgfa) 122835771
CTUL: 119773623 119789721(hgfa)
GMU: 124857843 124882706(hgfa)
NFU: 107385652 107388871(hgf)
KMR: 108229905 108235047(hgfa)
ALIM: 106514764 106520334(hgf)
AOCE: 111563989 111564882(hgf)
MCEP: 124999725(hgfa) 125015538
CSEM: 103380100(hgf) 103382777
POV: 109624365(hgf) 109632742
SSEN: 122765767(hgfa) 122776532
HHIP: 117757219(hgfa) 117762738
HSP: 118101930(hgfa) 118110071
SDU: 111224573 111228480(hgf)
SLAL: 111653388(hgf) 111671911
XGL: 120793382 120801084(hgfa)
HCQ: 109523797 109526843(hgf)
MALB: 109959804 109967266(hgf)
BSPL: 114857737 114862956(hgfa)
SFM: 108921145(hgf) 108936428
PKI: 111833314 111846155(hgf)
LOC: 102698086(hgf)
LCM: 102354206(HGF)
CMK: 103177006
RTP: 109921451(hgf)
BBEL: 109468725
PMAX: 117340434
 » show all
Reference
PMID:2528952
  Authors
Miyazawa K, Tsubouchi H, Naka D, Takahashi K, Okigaki M, Arakaki N, Nakayama H, Hirono S, Sakiyama O, Takahashi K, et al.
  Title
Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.
  Journal
Biochem Biophys Res Commun 163:967-73 (1989)
DOI:10.1016/0006-291X(89)92316-4
  Sequence
[hsa:3082]

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