KEGG   ORTHOLOGY: K05632
Entry
K05632                      KO                                     

Name
ITCH, AIP4
Definition
E3 ubiquitin-protein ligase Itchy [EC:2.3.2.26]
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04668  TNF signaling pathway
ko04932  Non-alcoholic fatty liver disease
Disease
H01232  Syndromic multisystem autoimmune disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
   04121 Ubiquitin system
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.26  HECT-type E3 ubiquitin transferase
     K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  HECT type E3
   K05632  ITCH, AIP4; E3 ubiquitin-protein ligase Itchy
Genes
HSA: 83737(ITCH)
PTR: 458191(ITCH)
PPS: 100975428(ITCH)
GGO: 101129438(ITCH)
PON: 100442751(ITCH)
NLE: 100599625(ITCH)
MCC: 707640(ITCH)
MCF: 101925768(ITCH)
CSAB: 103248756(ITCH)
RRO: 104680506(ITCH)
RBB: 108533724(ITCH)
CJC: 100400273(ITCH)
SBQ: 101050449(ITCH)
MMU: 16396(Itch)
MCAL: 110309477(Itch)
MPAH: 110317579(Itch)
RNO: 311567(Itch)
MUN: 110550572(Itch)
CGE: 100751263(Itch)
HGL: 101711522(Itch)
CCAN: 109685893(Itch) 109695579
OCU: 100356696(ITCH)
TUP: 102490973(ITCH)
CFA: 477199(ITCH)
VVP: 112928234(ITCH)
AML: 100480824(ITCH)
UMR: 103669818(ITCH)
UAH: 113258514(ITCH)
ORO: 101370748(ITCH)
ELK: 111141415
FCA: 101086133(ITCH)
PTG: 102963505(ITCH)
PPAD: 109272538(ITCH)
AJU: 106989132(ITCH)
BTA: 508431(ITCH)
BOM: 102266581(ITCH)
BIU: 109567383(ITCH)
BBUB: 102390921(ITCH)
CHX: 102191813(ITCH)
OAS: 101118041(ITCH)
CFR: 102524299(ITCH)
CDK: 105084946(ITCH)
BACU: 103003555(ITCH)
LVE: 103090259(ITCH)
OOR: 101278816(ITCH)
DLE: 111184253(ITCH)
PCAD: 102982983(ITCH)
ECB: 100069340(ITCH)
EPZ: 103553776(ITCH)
EAI: 106824941(ITCH)
MYB: 102245579(ITCH)
MYD: 102766823(ITCH)
MNA: 107537192(ITCH)
HAI: 109389600(ITCH)
DRO: 112304130(ITCH)
PALE: 102897965(ITCH)
RAY: 107519483(ITCH)
MJV: 108391264(ITCH)
LAV: 100665515(ITCH)
TMU: 101356519
MDO: 100032356(ITCH)
SHR: 100926872(ITCH)
PCW: 110216682(ITCH)
OAA: 100089108(ITCH)
GGA: 419145(ITCH)
MGP: 100541785(ITCH)
CJO: 107322843(ITCH)
NMEL: 110408063(ITCH)
APLA: 101795643(ITCH)
ACYG: 106045424(ITCH)
TGU: 100232505(ITCH)
LSR: 110479210(ITCH)
SCAN: 103818584(ITCH)
GFR: 102043996(ITCH)
FAB: 101813986(ITCH)
PHI: 102099918(ITCH)
PMAJ: 107213310(ITCH)
CCAE: 111938382(ITCH)
CCW: 104683779(ITCH)
ETL: 114070955(ITCH)
FPG: 101923443(ITCH)
FCH: 102049631(ITCH)
CLV: 102095059(ITCH)
EGZ: 104124972(ITCH)
NNI: 104019915(ITCH)
ACUN: 113487429(ITCH)
PADL: 103912391(ITCH)
AAM: 106486232(ITCH)
ASN: 102377307(ITCH)
AMJ: 102571523(ITCH)
PSS: 102444318(ITCH)
CMY: 102942150(ITCH)
CPIC: 101949925(ITCH)
ACS: 100567001(itch)
PVT: 110085919(ITCH)
PBI: 103052699
PMUR: 107288388(ITCH)
TSR: 106538618(ITCH)
PMUA: 114599512(ITCH)
GJA: 107112263(ITCH)
XTR: 780194(itch)
NPR: 108786814(ITCH)
DRE: 100330031(itchb) 100331274(itcha)
XCO: 114134640(itch) 114135506
PRET: 103464828 103467052(itch)
NFU: 107385376(itch) 107391319
KMR: 108231686(itcha) 108233117(itchb)
ALIM: 106517648(itch) 106522383
AOCE: 111574438 111576049(itch)
CSEM: 103384749(itch) 103386711
BPEC: 110158088 110173739(itch)
SFM: 108918588 108939341(itch)
PKI: 111842301(itch) 111856426
LCM: 102365782(ITCH)
CMK: 103188616(itch)
RTP: 109914922
HMG: 100204448
 » show all
Reference
  Authors
Marchese A, Raiborg C, Santini F, Keen JH, Stenmark H, Benovic JL
  Title
The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4.
  Journal
Dev Cell 5:709-22 (2003)
DOI:10.1016/S1534-5807(03)00321-6
  Sequence
[hsa:83737]
Reference
  Authors
Zhang P, Wang C, Gao K, Wang D, Mao J, An J, Xu C, Wu D, Yu H, Liu JO, Yu L
  Title
The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation.
  Journal
J Biol Chem 285:8869-79 (2010)
DOI:10.1074/jbc.M109.063321
  Sequence
[hsa:83737]

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