KEGG   ORTHOLOGY: K05697
Entry
K05697                      KO                                     

Symbol
PTPN6, SHP-1
Name
tyrosine-protein phosphatase non-receptor type 6 [EC:3.1.3.48]
Pathway
map04520  Adherens junction
map04630  JAK-STAT signaling pathway
map04650  Natural killer cell mediated cytotoxicity
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map05130  Pathogenic Escherichia coli infection
map05140  Leishmaniasis
map05205  Proteoglycans in cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04660 T cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   04662 B cell receptor signaling pathway
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Protein phosphatases and associated proteins [BR:ko01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K05697  PTPN6, SHP-1; tyrosine-protein phosphatase non-receptor type 6
Other DBs
GO: 0005001
Genes
HSA: 5777(PTPN6)
PTR: 748032(PTPN6)
PPS: 100990286(PTPN6)
GGO: 101137792(PTPN6)
PON: 100448471(PTPN6)
NLE: 100599057(PTPN6)
MCC: 714374(PTPN6)
MCF: 102133910(PTPN6)
CSAB: 103218491(PTPN6)
CATY: 105583047(PTPN6)
PANU: 100999491(PTPN6)
RRO: 104680085(PTPN6)
RBB: 108542024(PTPN6)
TFN: 117090601(PTPN6)
PTEH: 111555969(PTPN6)
CJC: 100410231(PTPN6)
SBQ: 101032306(PTPN6)
MMUR: 105868990(PTPN6)
MMU: 15170(Ptpn6)
MCAL: 110295792(Ptpn6)
MPAH: 110314992(Ptpn6)
RNO: 116689(Ptpn6)
MCOC: 116099571(Ptpn6)
MUN: 110548584(Ptpn6)
CGE: 100758996(Ptpn6)
PLEU: 114708811(Ptpn6)
NGI: 103727492(Ptpn6)
HGL: 101725029(Ptpn6)
CCAN: 109682813(Ptpn6)
OCU: 100348648(PTPN6)
TUP: 102488290(PTPN6)
CFA: 486717(PTPN6)
VVP: 112917324(PTPN6)
VLG: 121479639(PTPN6)
AML: 100473539(PTPN6)
UMR: 103656221(PTPN6)
UAH: 113257950(PTPN6)
ORO: 101374850(PTPN6)
ELK: 111159680
MPUF: 101677714(PTPN6)
EJU: 114222497(PTPN6)
MLX: 118025717(PTPN6)
FCA: 101087073(PTPN6)
PYU: 121021913(PTPN6)
PTG: 102951517(PTPN6)
PPAD: 109276095(PTPN6)
AJU: 106965341(PTPN6)
HHV: 120220450(PTPN6)
BTA: 512312(PTPN6)
BOM: 102283821(PTPN6)
BIU: 109558908(PTPN6)
BBUB: 102390574(PTPN6)
CHX: 102190308(PTPN6)
OAS: 101108643(PTPN6)
ODA: 120858748(PTPN6)
CCAD: 122423792(PTPN6)
SSC: 100171389(PTPN6)
CFR: 102513195(PTPN6)
CBAI: 105075198
CDK: 105098192(PTPN6)
BACU: 103005216(PTPN6)
LVE: 103086882(PTPN6)
OOR: 101289268(PTPN6)
DLE: 111176702(PTPN6)
PCAD: 102989908(PTPN6)
ECB: 100052882(PTPN6)
EPZ: 103547027(PTPN6)
EAI: 106847314(PTPN6)
MYB: 102256821(PTPN6)
MYD: 102755999(PTPN6)
MMYO: 118649839(PTPN6)
MNA: 107544062(PTPN6)
HAI: 109373664(PTPN6)
DRO: 112321823(PTPN6)
SHON: 119002403(PTPN6)
AJM: 119065712(PTPN6)
MMF: 118623590(PTPN6)
PALE: 102895931(PTPN6)
PGIG: 120611673(PTPN6)
RAY: 107519829(PTPN6)
MJV: 108384835(PTPN6)
TOD: 119247764(PTPN6)
LAV: 100676986(PTPN6)
TMU: 101358096
MDO: 100016514(PTPN6)
SHR: 100916661(PTPN6)
PCW: 110213796(PTPN6)
OAA: 100089663(PTPN6)
GGA: 427947(PTPN6)
PCOC: 116240006(PTPN6)
MGP: 100541130(PTPN6)
CJO: 107318608(PTPN6)
NMEL: 110398321(PTPN6)
APLA: 101791271(PTPN6)
ACYG: 106047839(PTPN6)
TGU: 100222135(PTPN6)
LSR: 110480841(PTPN6)
SCAN: 103827163(PTPN6)
PMOA: 120506447(PTPN6)
GFR: 102042677(PTPN6)
FAB: 101809704(PTPN6)
PHI: 102110203(PTPN6)
PMAJ: 107208334(PTPN6)
CCAE: 111938183(PTPN6)
CCW: 104687132(PTPN6)
ETL: 114058137(PTPN6)
FPG: 101914570(PTPN6)
FCH: 102049222(PTPN6)
CLV: 102092597(PTPN6)
EGZ: 104126541(PTPN6)
NNI: 104009493(PTPN6)
ACUN: 113477279(PTPN6)
PADL: 103920898(PTPN6)
AAM: 106497267
NPD: 112960153(PTPN6)
ASN: 102374529(PTPN6)
AMJ: 106737112(PTPN6)
CPOO: 109319380(PTPN6)
GGN: 109304343(PTPN6)
PSS: 102450493(PTPN6)
CMY: 102932473(PTPN6)
CPIC: 101943173(PTPN6)
TST: 117885696(PTPN6)
CABI: 116821041(PTPN6)
ACS: 100560131 100568003(ptpn6)
PVT: 110084628(PTPN6)
PBI: 103066339(PTPN6)
PMUR: 107285777(PTPN6)
TSR: 106552603(PTPN6)
PGUT: 117661828(PTPN6)
PMUA: 114587712(PTPN6)
ZVI: 118097466(PTPN6)
GJA: 107116796(PTPN6)
XLA: 100380954(ptpn6.L) 108696044 108697335(ptpn6.S)
XTR: 100144699(ptpn6) 100486059
NPR: 108784384(PTPN6)
DRE: 335573(ptpn6)
SGH: 107552793 107587794(ptpn6)
IPU: 108263538(PTPN6)
PHYP: 113525151
AMEX: 103022912(ptpn6)
EEE: 113574797
TRU: 101073366(ptpn6)
LCO: 104932546(ptpn6)
NCC: 104967151
CGOB: 115021685(ptpn6)
ELY: 117265764(ptpn6)
PLEP: 121945251(ptpn6)
SLUC: 116049713(ptpn6)
ECRA: 117946221(ptpn6)
PFLV: 114557481(ptpn6)
GAT: 120810824(ptpn6)
MSAM: 119897428(ptpn6)
CUD: 121512963(ptpn6)
MZE: 101478586(ptpn6)
ONL: 100707029(ptpn6)
OAU: 116323764(ptpn6)
OLA: 101174216(ptpn6)
OML: 112143660(ptpn6)
XMA: 102235723(ptpn6)
XCO: 114142163(ptpn6)
XHE: 116717758(ptpn6)
PRET: 103477996(ptpn6)
CVG: 107082167(ptpn6)
CTUL: 119783058(ptpn6)
NFU: 107379459(ptpn6)
KMR: 108235407(ptpn6)
ALIM: 106529151(ptpn6)
AOCE: 111585704(ptpn6)
CSEM: 103387950(ptpn6)
POV: 109633267(ptpn6)
LCF: 108880748(ptpn6)
SDU: 111230057(ptpn6)
SLAL: 111669899(ptpn6)
XGL: 120784084(ptpn6)
HCQ: 109515280(ptpn6)
BPEC: 110163058(ptpn6)
MALB: 109966237(ptpn6)
SASA: 100195421(ptn6) 106576571(PTN6)
OTW: 112226113
ELS: 105029958(ptpn6)
SFM: 108925851(ptpn6)
PKI: 111835379(ptpn6)
AANG: 118231462(ptpn6)
LOC: 102689026(ptpn6)
ARUT: 117425781(ptpn6)
LCM: 102352106
 » show all
Reference
  Authors
Keilhack H, Muller M, Bohmer SA, Frank C, Weidner KM, Birchmeier W, Ligensa T, Berndt A, Kosmehl H, Gunther B, Muller T, Birchmeier C, Bohmer FD
  Title
Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1.
  Journal
J Cell Biol 152:325-34 (2001)
DOI:10.1083/jcb.152.2.325
  Sequence
[hsa:5777]
Reference
PMID:1732748
  Authors
Yi TL, Cleveland JL, Ihle JN
  Title
Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
  Journal
Mol Cell Biol 12:836-46 (1992)
DOI:10.1128/MCB.12.2.836
  Sequence
[hsa:5777]

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