KEGG   ORTHOLOGY: K05850
Entry
K05850                      KO                                     

Symbol
ATP2B
Name
P-type Ca2+ transporter type 2B [EC:7.2.2.10]
Pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04925  Aldosterone synthesis and secretion
map04961  Endocrine and other factor-regulated calcium reabsorption
map04970  Salivary secretion
map04972  Pancreatic secretion
map04978  Mineral absorption
Disease
H01603  Primary aldosteronism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K05850  ATP2B; P-type Ca2+ transporter type 2B
   04024 cAMP signaling pathway
    K05850  ATP2B; P-type Ca2+ transporter type 2B
   04022 cGMP-PKG signaling pathway
    K05850  ATP2B; P-type Ca2+ transporter type 2B
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K05850  ATP2B; P-type Ca2+ transporter type 2B
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K05850  ATP2B; P-type Ca2+ transporter type 2B
  09154 Digestive system
   04970 Salivary secretion
    K05850  ATP2B; P-type Ca2+ transporter type 2B
   04972 Pancreatic secretion
    K05850  ATP2B; P-type Ca2+ transporter type 2B
   04978 Mineral absorption
    K05850  ATP2B; P-type Ca2+ transporter type 2B
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    K05850  ATP2B; P-type Ca2+ transporter type 2B
Enzymes [BR:ko01000]
 7. Translocases
  7.2  Catalysing the translocation of inorganic cations
   7.2.2  Linked to the hydrolysis of a nucleoside triphosphate
    7.2.2.10  P-type Ca2+ transporter
     K05850  ATP2B; P-type Ca2+ transporter type 2B
Other DBs
GO: 0005388
TC: 3.A.3.2
Genes
HSA: 490(ATP2B1) 491(ATP2B2) 492(ATP2B3) 493(ATP2B4)
PTR: 452116(ATP2B1) 457646(ATP2B4) 460168(ATP2B2) 465918(ATP2B3)
PPS: 100973331(ATP2B1) 100978284(ATP2B3) 100982359(ATP2B2) 100988724(ATP2B4)
GGO: 101125769(ATP2B2) 101129497(ATP2B1) 101146683(ATP2B4) 101151836(ATP2B3)
PON: 100172812(ATP2B1) 100438617(ATP2B3) 100446010(ATP2B4) 100450436(ATP2B2)
NLE: 100579834(ATP2B2) 100584463(ATP2B3) 100591048(ATP2B1) 100603540(ATP2B4)
MCC: 574317(ATP2B4) 695803(ATP2B3) 701149(ATP2B2) 709102(ATP2B1)
MCF: 101866192(ATP2B1) 101866950(ATP2B2) 102116890(ATP2B3) 102144572(ATP2B4)
CSAB: 103228005(ATP2B2) 103230273(ATP2B4) 103232787(ATP2B3) 103238835(ATP2B1)
CATY: 105574405(ATP2B3) 105575889(ATP2B4) 105585782(ATP2B2) 105596823(ATP2B1) 105598747
PANU: 101008158(ATP2B3) 101013979(ATP2B1) 101021808(ATP2B2) 101022739(ATP2B4)
RRO: 104653804(ATP2B4) 104661187(ATP2B3) 104662549(ATP2B1) 104673281(ATP2B2)
RBB: 108512290(ATP2B2) 108515001(ATP2B4) 108527219(ATP2B1) 108535088(ATP2B3)
TFN: 117075419(ATP2B4) 117078477(ATP2B3) 117083249(ATP2B2) 117089644(ATP2B1)
PTEH: 111522746(ATP2B4) 111535861(ATP2B3) 111546925(ATP2B2) 111548994(ATP2B1)
CJC: 100403194(ATP2B3) 100404341(ATP2B2) 100407701(ATP2B1) 100410901(ATP2B4)
SBQ: 101028696(ATP2B3) 101032189(ATP2B2) 101033947(ATP2B4) 101049275(ATP2B1)
MMUR: 105865371(ATP2B1) 105867325(ATP2B3) 105868229(ATP2B4) 105882651(ATP2B2)
MMU: 11941(Atp2b2) 320707(Atp2b3) 381290(Atp2b4) 67972(Atp2b1)
MCAL: 110286561(Atp2b3) 110295976(Atp2b2) 110299202(Atp2b4) 110302903(Atp2b1)
MPAH: 110313330(Atp2b3) 110315948(Atp2b2) 110321647(Atp2b4) 110326860(Atp2b1)
RNO: 24215(Atp2b2) 29598(Atp2b1) 29599(Atp2b3) 29600(Atp2b4)
MCOC: 116075957(Atp2b1) 116085949(Atp2b3) 116099379(Atp2b4) 116099413(Atp2b2)
MUN: 110546737(Atp2b4) 110548952(Atp2b2) 110552126(Atp2b1) 110560453(Atp2b3)
CGE: 100753233(Atp2b3) 100759670(Atp2b2) 100764066(Atp2b1) 100764868(Atp2b4)
PLEU: 114689622(Atp2b2) 114698097(Atp2b4) 114701199(Atp2b1) 114702318 114706243(Atp2b3)
NGI: 103726423(Atp2b1) 103731188(Atp2b3) 103731865(Atp2b4) 103751438(Atp2b2)
HGL: 101699650(Atp2b4) 101707619(Atp2b2) 101713508(Atp2b3) 101725886(Atp2b1)
CCAN: 109681646 109688961(Atp2b2) 109689491(Atp2b1) 109694277(Atp2b4)
TUP: 102469597(ATP2B1) 102479023(ATP2B3) 102479920(ATP2B4) 102496553(ATP2B2)
CFA: 403480(ATP2B1) 403731(ATP2B4) 476535(ATP2B2) 492238(ATP2B3)
VVP: 112911488(ATP2B3) 112914411(ATP2B4) 112914901(ATP2B1) 112933678
VLG: 121481086(ATP2B1) 121483442(ATP2B3) 121494659(ATP2B2) 121501357(ATP2B4)
AML: 100465354(ATP2B1) 100472949(ATP2B2) 100476768(ATP2B3) 100484762(ATP2B4)
UMR: 103657738(ATP2B4) 103660077(ATP2B1) 103669556(ATP2B2) 103679703(ATP2B3)
UAH: 113242516(ATP2B4) 113247848(ATP2B3) 113256184(ATP2B1) 113257169(ATP2B2)
ORO: 101368088(ATP2B2) 101374723(ATP2B3) 101376015(ATP2B1) 101377158(ATP2B4)
MPUF: 101683196(ATP2B2) 101686157(ATP2B1) 101688195(ATP2B4) 101692722(ATP2B3)
EJU: 114201591(ATP2B3) 114207817(ATP2B2) 114210949(ATP2B1) 114222012(ATP2B4)
MLX: 117998905(ATP2B1) 118005092(ATP2B2) 118014170(ATP2B4) 118014964(ATP2B3)
FCA: 101087822(ATP2B2) 101098392(ATP2B1) 101101451(ATP2B3) 101101538(ATP2B4)
PTG: 102950685(ATP2B1) 102958377(ATP2B4) 102962589(ATP2B2) 102965264(ATP2B3)
PPAD: 109254361(ATP2B2) 109256714(ATP2B4) 109259867(ATP2B3) 109265308(ATP2B1)
AJU: 106970793(ATP2B4) 106972378(ATP2B2) 106976608(ATP2B1) 106978648(ATP2B3)
HHV: 120221711(ATP2B3) 120228891(ATP2B4) 120231315(ATP2B2) 120237072(ATP2B1)
BTA: 282146(ATP2B4) 282641(ATP2B1) 504353(ATP2B3) 613800(ATP2B2)
BOM: 102269433(ATP2B3) 102270847(ATP2B4) 102276558(ATP2B2) 102281006(ATP2B1)
BIU: 109555546(ATP2B3) 109558967(ATP2B1) 109570406(ATP2B4) 109576121(ATP2B2)
BBUB: 102390342(ATP2B3) 102394074(ATP2B1) 102395917(ATP2B4) 102406795(ATP2B2)
CHX: 102168898(ATP2B3) 102174093(ATP2B1) 102176524 102187815(ATP2B2)
OAS: 101101873(ATP2B3) 101104306(ATP2B4) 101111268(ATP2B1) 101121046(ATP2B2)
ODA: 120858399(ATP2B1) 120868133(ATP2B2) 120881802(ATP2B3)
SSC: 100520061(ATP2B3) 100623420(ATP2B4) 100625418(ATP2B2) 397636(ATP2B1)
CFR: 102511780(ATP2B4) 102511904(ATP2B2) 102514915(ATP2B1) 102519924(ATP2B3)
CBAI: 105067005(ATP2B1) 105067459(ATP2B2) 105074573(ATP2B4) 105076090(ATP2B3)
CDK: 105093111(ATP2B2) 105094859(ATP2B1) 105103904(ATP2B3) 105104496(ATP2B4)
BACU: 102998829(ATP2B1) 103005751(ATP2B4) 103008697(ATP2B2) 103018602(ATP2B3)
LVE: 103070670(ATP2B2) 103078806(ATP2B1) 103085203(ATP2B4) 103088376(ATP2B3)
OOR: 101273845(ATP2B3) 101274437(ATP2B2) 101279530(ATP2B1) 101286148(ATP2B4)
DLE: 111163607(ATP2B1) 111168980(ATP2B2) 111170588(ATP2B3) 111184798(ATP2B4)
PCAD: 102974975(ATP2B4) 102989311(ATP2B3) 102993901(ATP2B1) 112062816
ECB: 100034081(ATP2B2) 100049920(ATP2B4) 100051636(ATP2B1) 100057711(ATP2B3)
EPZ: 103547847(ATP2B1) 103560346(ATP2B4) 103561469(ATP2B2)
EAI: 106824024(ATP2B4) 106826650(ATP2B3) 106835630(ATP2B2) 106845648(ATP2B1)
MYB: 102239691(ATP2B3) 102254169 102257503(ATP2B1) 102259346(ATP2B4) 102259512(ATP2B2)
MYD: 102758321(ATP2B1) 102764572(ATP2B4) 102766714(ATP2B2) 102767971(ATP2B3)
MMYO: 118650773(ATP2B1) 118654086(ATP2B3) 118668061(ATP2B2) 118672983(ATP2B4)
MNA: 107534770(ATP2B2) 107538560(ATP2B4) 107538818(ATP2B3) 107538895(ATP2B1)
HAI: 109386487(ATP2B4) 109387285(ATP2B2) 109392787(ATP2B1) 109394331(ATP2B3)
DRO: 112296275(ATP2B3) 112301133(ATP2B2) 112314689(ATP2B1) 112317852(ATP2B4)
SHON: 118993327(ATP2B2) 118996031(ATP2B3) 118999918(ATP2B1) 119001707(ATP2B4)
AJM: 119038334(ATP2B2) 119053230(ATP2B1) 119053360(ATP2B3) 119055061(ATP2B4)
MMF: 118623540(ATP2B1) 118633330(ATP2B2) 118635789(ATP2B3) 118637529(ATP2B4)
PALE: 102878692(ATP2B4) 102883154(ATP2B3) 102885387(ATP2B1) 102889420(ATP2B2)
PGIG: 120605880(ATP2B3) 120607278(ATP2B1) 120617985(ATP2B4)
RAY: 107498349(ATP2B2) 107504061(ATP2B3) 107508151(ATP2B4) 107520906(ATP2B1)
MJV: 108383479(ATP2B3) 108398426(ATP2B1) 108408139(ATP2B2) 108409522(ATP2B4)
TOD: 119234364(ATP2B4) 119245811(ATP2B3) 119247443(ATP2B1) 119255512(ATP2B2)
LAV: 100655542(ATP2B2) 100656297(ATP2B4) 100656362(ATP2B3) 100656553(ATP2B1)
MDO: 100011221(ATP2B1) 100014855(ATP2B3) 100016381(ATP2B4) 100024542(ATP2B2) 100033060
SHR: 100914244(ATP2B3) 100921801(ATP2B1) 100922398(ATP2B4) 100926374(ATP2B2) 100930479
PCW: 110196403 110201535(ATP2B3) 110203727 110204871(ATP2B2) 110213232(ATP2B1) 110219533(ATP2B4)
OAA: 100074008(ATP2B1) 100074053(ATP2B2) 100077867 100078819(ATP2B3) 100089144(ATP2B4)
GGA: 374244(ATP2B1) 415958(ATP2B2) 419934(ATP2B4)
PCOC: 116226697(ATP2B1) 116236974 116239155(ATP2B2)
MGP: 100540186(ATP2B2) 100542569(ATP2B1) 100549255
CJO: 107311305(ATP2B1) 107319666(ATP2B2) 107324889
NMEL: 110388176 110395170(ATP2B1) 110404987(ATP2B2)
APLA: 101798634(ATP2B2) 101803323(ATP2B1)
ACYG: 106036919(ATP2B1) 106040076(ATP2B2) 106045871(ATP2B4)
TGU: 100219974(ATP2B1) 100222645(ATP2B4) 100223109(ATP2B2) 115491935
LSR: 110469363(ATP2B1) 110470658(ATP2B2) 110474982(ATP2B4)
SCAN: 103813406(ATP2B1) 103816942(ATP2B2) 103824510(ATP2B4)
PMOA: 120498367(ATP2B2) 120499108(ATP2B4) 120499769(ATP2B1) 120505131
GFR: 102034786(ATP2B1) 102036839(ATP2B2) 102041326(ATP2B4)
FAB: 101811123(ATP2B1) 101818557 101818810 101819826(ATP2B2)
PHI: 102100080(ATP2B4) 102105769(ATP2B2) 102106911(ATP2B3) 102111921(ATP2B1)
PMAJ: 107204416(ATP2B1) 107210272(ATP2B2) 107214898(ATP2B4)
CCAE: 111933482(ATP2B1) 111935222(ATP2B2) 111939756(ATP2B4)
CCW: 104692364(ATP2B4) 104695754(ATP2B2) 104698433(ATP2B1)
ETL: 114063220(ATP2B1) 114065532(ATP2B2) 114067502(ATP2B4)
FPG: 101914389(ATP2B4) 101915075(ATP2B2) 101922673(ATP2B1)
FCH: 102046062(ATP2B4) 102053029(ATP2B2) 102057091(ATP2B1)
CLV: 102089881(ATP2B2) 102091043(ATP2B4) 102094917(ATP2B1)
EGZ: 104124319(ATP2B2) 104125788(ATP2B4) 104134507(ATP2B1)
NNI: 104011641(ATP2B1) 104013141(ATP2B4) 104022940(ATP2B2)
ACUN: 113484930(ATP2B2) 113487622(ATP2B1) 113488811(ATP2B4)
PADL: 103914646(ATP2B1) 103919807(ATP2B4) 103921328
AAM: 106482157 106486662(ATP2B2) 106488634(ATP2B1) 106492320
ASN: 102371752 102374086 102377303(ATP2B4) 102386773(ATP2B1)
AMJ: 102564127(ATP2B1) 102566828(ATP2B4) 102574612(ATP2B3) 106736870
CPOO: 109311415(ATP2B2) 109316875(ATP2B1) 109317759(ATP2B4)
GGN: 109289162(ATP2B2) 109295407(ATP2B4) 109295785(ATP2B1)
PSS: 102446396(ATP2B4) 102448489(ATP2B2) 102462235(ATP2B1)
CMY: 102935232(ATP2B1) 102937017 102938116(ATP2B4) 102942507(ATP2B2)
CPIC: 101932175(ATP2B1) 101940571(ATP2B3) 101951740(ATP2B4) 101952257(ATP2B2)
TST: 117875818(ATP2B4) 117878394(ATP2B1) 117880090(ATP2B2)
CABI: 116821211(ATP2B2) 116827918(ATP2B4) 116830754 116833533
ACS: 100551522(atp2b3) 100555058(atp2b2) 100558540(atp2b4) 100563814 100564194(atp2b1)
PVT: 110069872(ATP2B1) 110078651(ATP2B3) 110080770(ATP2B4) 110085967(ATP2B2) 110087603
PBI: 103049230(ATP2B4) 103059504(ATP2B1) 103061711(ATP2B3) 103065790
PMUR: 107283119(ATP2B1) 107286722(ATP2B3) 107288091 107302472 107302988(ATP2B4)
PGUT: 117655515(ATP2B1) 117663917(ATP2B4) 117675498(ATP2B3) 117677866(ATP2B2) 117678014
PMUA: 114587358(ATP2B3) 114591625(ATP2B2) 114597179 114599279(ATP2B4) 114605901(ATP2B1)
ZVI: 118075200(ATP2B3) 118080658(ATP2B2) 118088146(ATP2B4) 118090657(ATP2B1) 118095662 118096559
XLA: 108699986(atp2b3.S) 108704804(atp2b3.L) 108709452 108713181(atp2b1.S) 108715812(atp2b4.S) 446855(atp2b4.L)
XTR: 100125191(atp2b3) 100127567(atp2b1) 100487776(atp2b2) 100488346
NPR: 108787233(ATP2B1) 108798381(ATP2B3) 108804864
DRE: 378746(atp2b1a) 436745(atp2b3a) 557430(atp2b2) 558525(atp2b3b) 561190(atp2b1b)
IPU: 108254915(atp2b4) 108255227(atp2b2) 108265719 108268426 108275496(atp2b3) 108279880(atp2b1)
PHYP: 113529376 113530469(atp2b3) 113531947 113534929 113537795(atp2b2) 113539687(atp2b4)
AMEX: 103021579(atp2b1) 103022925 103024646(atp2b3) 103025027(atp2b2) 103040534(atp2b4) 103045095
LCO: 104923708(atp2b1) 104927822 104929905(atp2b2) 104936163(atp2b3)
ELY: 117249502(atp2b1a) 117256551 117256931(atp2b2) 117258909(atp2b3b) 117262414
PLEP: 121946783(atp2b3b) 121949963 121957572(atp2b2) 121960036 121961517(atp2b1a) 121962888
SLUC: 116036252 116047816 116048394 116051337(atp2b2) 116058071(atp2b3b) 116059962(atp2b1a)
ECRA: 117938677(atp2b1a) 117941866 117942658 117943028(atp2b2) 117947173(atp2b3b) 117948830
GAT: 120809894 120818098(atp2b1a) 120828981(atp2b3b) 120834865 120835188(atp2b2)
MSAM: 119885928(atp2b2) 119886904 119893441 119905765(atp2b3b) 119918194(atp2b1a)
CUD: 121505350(atp2b1a) 121505643 121505800(atp2b2) 121515159 121517918(atp2b3b)
MZE: 101464682(atp2b2) 101473100 101479313(atp2b1) 101484596(atp2b3) 101484996
OAU: 116309837(atp2b1a) 116310544(atp2b3b) 116311056 116313645(atp2b2) 116315061 116317495
OLA: 101156400(atp2b2) 101161727(atp2b3) 101166674(atp2b1) 101172706 101173614
OML: 112139202 112145568(atp2b2) 112145680 112158805(atp2b1a) 112159035(atp2b3b)
XMA: 102218973(atp2b3) 102222415 102231044(atp2b2) 102236786 102237036(atp2b1)
XHE: 116709418 116710278 116711109(atp2b2) 116720760(atp2b3) 116737112(atp2b1)
PRET: 103459249(atp2b1) 103464285 103464436(atp2b2) 103465674 103466947(atp2b3)
KMR: 108231596(atp2b2) 108235083(atp2b1a) 108249176(atp2b3b) 108250956
XGL: 120783271 120783338(atp2b2) 120793341 120798068(atp2b1a) 120803716(atp2b3b)
HCQ: 109510289 109522514(atp2b2) 109522916 109523764(atp2b1) 109528585(atp2b3)
MALB: 109956438 109959925(atp2b1) 109962904(atp2b2) 109966397 109969960(atp2b3)
SFM: 108918468(atp2b3) 108925547 108929803(atp2b2) 108931538(atp2b1) 108938219(atp2b4) 108939261
AANG: 118207724 118211054(atp2b4) 118211203(atp2b2) 118219149 118231146(atp2b1a)
LOC: 102687968(atp2b1) 102689464(atp2b2) 102689917(atp2b4) 102696101(atp2b3)
LCM: 102345954(ATP2B3) 102346479 102353242(ATP2B1) 102359098(ATP2B2)
CMK: 103179842(atp2b1) 103182465(atp2b4) 103188792
BFO: 118416622
BBEL: 109470003
CIN: 100180580
SCLV: 120340151
SPU: 580345(PMCA)
APLC: 110973723
SKO: 100374040(ATP2B3)
DME: Dmel_CG42314(PMCA)
DER: 6555816
DSE: 6619454
DSI: Dsimw501_GD24384(Dsim_GD24384)
DAN: 6504364
DSR: 110185466
DPE: 6601994
DMN: 108164401
DWI: 6650888
DGR: 6570451
DAZ: 108617913
DNV: 108655405
DHE: 111593718
DVI: 6636242
CCAT: 101455930
LCQ: 111679385
ACOZ: 120954918
AARA: 120900070
AAG: 5566699
AALB: 109425852
CPII: 120423878
AME: 551261
ACER: 107992595
BIM: 100741341
BBIF: 117214247
BTER: 100645179
CCAL: 108630174
OBB: 114872172
MGEN: 117227017
NMEA: 116425727
CGIG: 122401035
SOC: 105196571
MPHA: 105831941
AEC: 105150082
ACEP: 105621441
PBAR: 105428976
VEM: 105565560
HST: 105183123
DQU: 106748481
CFO: 105254317
FEX: 115237065
LHU: 105671653
PGC: 109857545
OBO: 105277680
PCF: 106787065
NVI: 100121013
CSOL: 105368860
MDL: 103568828
CCIN: 107269990
TCA: 656486
DPA: 109533790
ATD: 109594709
AGB: 108912412
NVL: 108566359
PPYR: 116165478
OTU: 111425623
BMOR: 101744319
BMAN: 114253608
MSEX: 115456009
BANY: 112058339
PMAC: 106716828
PPOT: 106111345
PXU: 106123111
PRAP: 110999589
ZCE: 119837710
HAW: 110373901
TNL: 113498289
PXY: 105381280
DNX: 107167341
AGS: 114125413
RMD: 113555684
CLEC: 106671441
HHAL: 106682096
NLU: 111043351
ZNE: 110840041
CSEC: 111863401
EAF: 111705625
DSV: 119460722
RSAN: 119396471
RMP: 119174659
VDE: 111246891
VJA: 111258900
CSCU: 111612430
SDM: 118194695
CEL: CELE_R05C11.3(mca-2) CELE_W09C2.3(mca-1) CELE_Y67D8C.10(mca-3)
CBR: CBG03371 CBG20066(Cbr-mca-1) CBG22506
BMY: BM_BM14792(Bma-mca-3) BM_BM5210(Bma-mca-2)
PCAN: 112572782
BGT: 106051462
GAE: 121368252
CRG: 105337328
MYI: 110443351
PMAX: 117330606
OBI: 106883701
DGT: 114521342
HMG: 100201160(atp2b3) 100204114 100206247(atp2b3) 100209323(atp2b3)
AQU: 100639471
MNG: MNEG_9638
APRO: F751_1720
EHI: EHI_016480(80.t00032) EHI_030830(195.t00001)
PTI: PHATRDRAFT_54778(ATPse2-2B)
 » show all
Reference
PMID:8386431
  Authors
Kumar R, Haugen JD, Penniston JT
  Title
Molecular cloning of a plasma membrane calcium pump from human osteoblasts.
  Journal
J Bone Miner Res 8:505-13 (1993)
DOI:10.1002/jbmr.5650080415
  Sequence
[hsa:490]
Reference
PMID:1427863
  Authors
Brandt P, Ibrahim E, Bruns GA, Neve RL
  Title
Determination of the nucleotide sequence and chromosomal localization of the ATP2B2 gene encoding human Ca(2+)-pumping ATPase isoform PMCA2.
  Journal
Genomics 14:484-7 (1992)
DOI:10.1016/S0888-7543(05)80246-0
  Sequence
[hsa:491]

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