KEGG   ORTHOLOGY: K06054
Entry
K06054                      KO                                     
Symbol
HES1
Name
hairy and enhancer of split 1
Pathway
map03460  Fanconi anemia pathway
map04330  Notch signaling pathway
map04950  Maturity onset diabetes of the young
map05165  Human papillomavirus infection
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03460 Fanconi anemia pathway
    K06054  HES1; hairy and enhancer of split 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04330 Notch signaling pathway
    K06054  HES1; hairy and enhancer of split 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06054  HES1; hairy and enhancer of split 1
  09162 Cancer: specific types
   05224 Breast cancer
    K06054  HES1; hairy and enhancer of split 1
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K06054  HES1; hairy and enhancer of split 1
   05165 Human papillomavirus infection
    K06054  HES1; hairy and enhancer of split 1
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    K06054  HES1; hairy and enhancer of split 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K06054  HES1; hairy and enhancer of split 1
   03400 DNA repair and recombination proteins
    K06054  HES1; hairy and enhancer of split 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Hairy, Hairy/E(SPL)
    K06054  HES1; hairy and enhancer of split 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   FA (Fanconi anemia) pathway
    FA core complex binding factors
     K06054  HES1; hairy and enhancer of split 1
Genes
HSA: 3280(HES1)
PTR: 460942(HES1)
PPS: 100975593(HES1)
GGO: 101137927(HES1)
PON: 100455979(HES1)
NLE: 100603131(HES1)
MCC: 707140(HES1)
MCF: 102146862(HES1)
CSAB: 103241935(HES1)
CATY: 105575172(HES1)
PANU: 101006374(HES1)
TGE: 112619267(HES1)
RRO: 104669884(HES1)
RBB: 108530502(HES1)
TFN: 117084404(HES1)
PTEH: 111544302(HES1)
CJC: 100398058(HES1)
SBQ: 101047984(HES1)
CSYR: 103254216(HES1)
MMUR: 105879778(HES1)
OGA: 100948316(HES1)
MMU: 15205(Hes1)
MCAL: 110311640(Hes1)
MPAH: 110329664(Hes1)
RNO: 29577(Hes1)
MCOC: 116085780(Hes1)
MUN: 110552510(Hes1)
CGE: 100752756(Hes1)
PLEU: 114707351(Hes1)
NGI: 103738854(Hes1)
HGL: 101697897(Hes1)
CPOC: 100734567(Hes1)
CCAN: 109697826(Hes1)
DORD: 105987927(Hes1)
DSP: 122097551(Hes1)
OCU: 100358704(HES1)
OPI: 101517364(HES1)
TUP: 102495758(HES1)
CFA: 119865321(HES1)
VVP: 112925420(HES1)
VLG: 121479130(HES1)
AML: 100481439(HES1)
UMR: 103676171(HES1)
UAH: 113253430(HES1)
UAR: 123802085(HES1)
ELK: 111155108
LLV: 125102272
MPUF: 101691000(HES1)
ORO: 101385029(HES1)
EJU: 114207151(HES1)
ZCA: 113917247(HES1)
MLX: 118000498(HES1)
FCA: 101091223(HES1)
PYU: 121024515(HES1)
PBG: 122491598(HES1)
PTG: 102955935(HES1)
AJU: 106976345(HES1)
HHV: 120230662(HES1)
BTA: 539547(HES1)
BOM: 102264508(HES1)
BIU: 109556511(HES1)
BBUB: 102389836(HES1)
CHX: 102177474(HES1)
OAS: 101106560(HES1)
ODA: 120883528(HES1)
CCAD: 122444707(HES1)
SSC: 100499567(HES1)
CFR: 102503828(HES1)
CBAI: 105072364(HES1)
CDK: 105101259(HES1)
VPC: 102529913(HES1)
BACU: 103018658(HES1)
LVE: 103079775(HES1)
OOR: 101288687(HES1)
DLE: 111172508(HES1)
PCAD: 102975703(HES1)
PSIU: 116753605(HES1)
ECB: 100069015(HES1)
EPZ: 103560632(HES1)
EAI: 106832571(HES1)
MYB: 102247384(HES1)
MYD: 102755556(HES1)
MMYO: 118676420(HES1)
MLF: 102417036(HES1)
MNA: 107527413(HES1)
PKL: 118723388(HES1)
HAI: 109387269(HES1)
DRO: 112301010(HES1)
SHON: 118982930(HES1)
AJM: 119055258(HES1)
PDIC: 114490866(HES1)
PHAS: 123827079(HES1)
MMF: 118617337(HES1)
RFQ: 117031731(HES1)
PALE: 102890128(HES1)
PGIG: 120592866(HES1)
PVP: 105306395(HES1)
RAY: 107505922(HES1)
MJV: 108399743(HES1)
TOD: 119256797(HES1)
SARA: 101555081(HES1)
LAV: 100660397(HES1)
TMU: 101350794
DNM: 101447133(HES1)
MDO: 100011897(HES1) 100027474(HES4)
GAS: 123240915(HES4) 123255631
SHR: 111720114(HES1) 116422873(HES4)
PCW: 110193151(HES1) 110201244(HES4)
OAA: 100081083(HES1) 114812014(HES4)
GGA: 395128(HES4) 769039(HES1)
PCOC: 116230855(HES1) 116242587(HES4)
MGP: 100543952(HES4) 104912623(HES1)
CJO: 107318289(HES1) 107323568(HES4)
NMEL: 110398279(HES1) 110408746(HES4)
APLA: 101792654(HES4) 113844479(HES1)
AFUL: 116492614(HES1) 116497606(HES4)
TGU: 115498005(HES4)
LSR: 110473882(HES1) 110474387(HES4)
SCAN: 103815635(HES1)
PMOA: 120508630(HES1) 120511041(HES4)
OTC: 121341122(HES1) 121343959(HES4)
PRUF: 121356387 121357940(HES1)
GFR: 102033320(HES1)
FAB: 101816382(HES1) 101817621(HES4)
PHI: 102100435(HES1) 102101553(HES4)
PMAJ: 107208546(HES1) 107213594(HES4)
CCAE: 111945279(HES1)
CCW: 104693506(HES1) 120411123(HES4)
ETL: 114057575(HES1)
ZAB: 102061051(HES1)
FPG: 101912686(HES1) 101916136(HES4)
FCH: 102046674(HES1)
CLV: 102095829 102097253(HES4)
EGZ: 104127092(HES1) 104133390
NNI: 104009063 104015733(HES1)
ACUN: 113483351(HES1)
TALA: 116960134(HES1) 116965271(HES4)
PADL: 103925390(HES1)
ACHC: 115343355(HES4) 115347670(HES1)
AROW: 112962138(HES1) 112970085(HES4)
NPD: 112947451(HES1) 112957403(HES4)
DNE: 112981670(HES1) 112983470
ASN: 102386735(HES4)
AMJ: 106737359(HES1) 109280377 109284733(HES4)
CPOO: 109314436(HES4) 109319397
GGN: 109293721(HES4) 109304204
PSS: 102458752 102463824(HES4)
CMY: 102940045(HES1) 102942708(HES4)
CPIC: 101931539(HES1) 101940738(HES4)
TST: 117883312(HES1)
CABI: 116823523(HES1) 116824581(HES4)
MRV: 120371420(HES1) 120387630(HES4)
ACS: 100558110(hes1) 100558625(hes4)
PVT: 110073268(HES4) 110087091(HES1) 110088260
SUND: 121926016 121937338(HES4)
PMUR: 107291701(HES1) 107298929
TSR: 106557301(HES1)
PGUT: 117659026(HES4) 117669834(HES1)
VKO: 123031091(HES4)
PMUA: 114602496(HES4)
ZVI: 118087861(HES4) 118093676(HES1)
GJA: 107108767(HES1) 107110838(HES4)
STOW: 125437673(HES1) 125446041(HES4)
XLA: 379073(hes1.S) 397813(hes1.L) 398258(hes4.L) 398579(hes4.S)
XTR: 394465(hes4) 496617(hes1)
BBUF: 120997119(HES4) 120997959(HES1)
BGAR: 122926756(HES4) 122935114(HES1)
DRE: 140613(her9) 30288(her6)
PPRM: 120460059(her6) 120463831(her9)
MAMB: 125260462(her9) 125273691(her6)
IPU: 108272284(her6) 108275484(her9)
PHYP: 113525290 113530698(hes4) 113545814(hes1)
SMEO: 124387554(her6)
TFD: 113640716(her6) 113658083(her9)
EEE: 113570439(hes1) 113580143(hes4) 113587163
TRU: 101065156(hes1) 101065161 101070803(hes4)
LCO: 104920985 104923504(hes1) 104927063(hes4)
CGOB: 115006996(hes1) 115010930(hes4) 115022696
ELY: 117253593(her6) 117257863(her9) 117272331
SLUC: 116041041(her9) 116048845 116055469(her6)
ECRA: 117948123(her9) 117950939(her6) 117953826
PFLV: 114558906(hes4) 114561351(hes1) 114565517
GAT: 120816251 120824322(her6) 120829800(her9)
PPUG: 119209764 119217016(her6) 119223649(her9)
MSAM: 119900599(her6) 119902301 119919332(her9)
CUD: 121512349(her6) 121517596(her9) 121520463
MZE: 101470131(hes4) 101479362(hes1) 101482682
ONL: 100700093(hes4) 100703124 100709099(hes1)
OAU: 116309718(her9) 116328076 116334666(her6)
OLA: 100049440 100049441(hes4) 100049484(hes1)
OML: 112144436 112150879(her6) 112159512(her9)
XMA: 102220497(hes1) 102221827 102224196(hes4)
XCO: 114145951 114148399(hes4) 114151610(hes1)
XHE: 116721605 116726054(hes4) 116726480(hes1)
PRET: 103463479(hes1) 103467205(hes4) 103479094
PFOR: 103130554(hes1) 103149504 103155586(hes4)
PLAI: 106949469(hes4) 106953914(hes1) 106956385
PMEI: 106917123(hes4) 106929872 106932654(hes1)
GAF: 122834316(her9) 122838720(her6) 122840584
CTUL: 119777015 119794239(her6) 119797089(her9)
GMU: 124870353 124871816(her9) 124874094(her6)
NFU: 107384489 107390761(hes4) 107392731(hes1)
KMR: 108234279(her6) 108236735(her9) 108248536
ALIM: 106510988(hes1) 106522663(hes4)
NWH: 119407765(her6) 119415039 119417031(her9)
CSEM: 103385044(hes4) 103393710(hes1) 103396119
SSEN: 122776704(her9) 122777240 122780419(her6)
HHIP: 117760491(her6) 117764920(her9) 117778185
SDU: 111219112(hes4) 111228838 111239034(hes1)
SLAL: 111651410(hes1) 111661285 111670596(hes4)
XGL: 120791319(her6) 120799161 120803357(her9)
HCQ: 109511838(hes4) 109519150(hes1) 109520474
BPEC: 110153389 110160167(hes1) 110164673(hes4)
SASA: 106567371(HES1) 106568808(HES1) 106572133(HES1) 106574089 106599183 106613513(HES1)
ELS: 105011317(hes1) 105013779(hes4) 105030365
LOC: 102692315(hes4) 102697906(hes1)
CMK: 103173662 103187419(her9)
RTP: 109923078(hes1) 109927433
CIN: 778582(e(spl)/hairy-c) 778963(e(spl)/hairy-a)
SKO: 100303558(hes1)
SCAC: 106086185
CGLO: 123270389
TCA: 664077
DPA: 109543608
CSET: 123313492
AGB: 108904909
NVL: 108567683
APLN: 108740782
PPYR: 116172309
API: 100159053
DNX: 107162838
RMD: 113560980
BTAB: 109040189
CLEC: 106671959
CSEC: 111875290
PCLA: 123753004
HAZT: 108665347
VDE: 111253162
VJA: 111269929
CSCU: 111641260
PTEP: 107449847
TSP: Tsp_06034
PCAN: 112557550
OSN: 115232188
 » show all
Reference
PMID:8020957
  Authors
Feder JN, Li L, Jan LY, Jan YN
  Title
Genomic cloning and chromosomal localization of HRY, the human homolog to the Drosophila segmentation gene, hairy.
  Journal
Genomics 20:56-61 (1994)
DOI:10.1006/geno.1994.1126
  Sequence
[hsa:3280]
Reference
  Authors
Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Levesque G, Carreau M
  Title
HES1 is a novel interactor of the Fanconi anemia core complex.
  Journal
Blood 112:2062-70 (2008)
DOI:10.1182/blood-2008-04-152710

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