KEGG   ORTHOLOGY: K06498
Entry
K06498                      KO                                     

Symbol
FCGR1A, CD64
Name
high affinity immunoglobulin gamma Fc receptor I
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map04613  Neutrophil extracellular trap formation
map04640  Hematopoietic cell lineage
map04666  Fc gamma R-mediated phagocytosis
map05140  Leishmaniasis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05202  Transcriptional misregulation in cancer
map05221  Acute myeloid leukemia
map05322  Systemic lupus erythematosus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
   04613 Neutrophil extracellular trap formation
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
   04666 Fc gamma R-mediated phagocytosis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
   05152 Tuberculosis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06498  FCGR1A, CD64; high affinity immunoglobulin gamma Fc receptor I
CD molecules [BR:ko04090]
 Proteins
  K06498  CD64, FCGR1A; Fc fragment of IgG, high affinity Ia, receptor for (CD64)
Other DBs
GO: 0019770
Genes
HSA: 2209(FCGR1A)
PTR: 457259
PPS: 100984157
GGO: 101151244
PON: 100431914
NLE: 100591598(FCGR1A)
MCC: 714664(FCGR1A)
MCF: 102147198(FCGR1A)
CSAB: 103247163
CATY: 105592899
PANU: 101003793(FCGR1A)
RRO: 104670100
RBB: 108538696
TFN: 117075485(FCGR1A)
PTEH: 111543589(FCGR1A)
CJC: 100393738(FCGR1A)
SBQ: 101027415
MMUR: 105865511
MMU: 14129(Fcgr1)
MCAL: 110291166
MPAH: 110320097
RNO: 295279(Fcgr1a)
MCOC: 116094184(Fcgr1a)
MUN: 110543586
CGE: 100774550(Fcgr1a)
PLEU: 114682367
NGI: 103742641(Fcgr1a)
HGL: 101725560
CCAN: 109677124
OCU: 100358696
TUP: 102492164(FCGR1A)
CFA: 403462(FCGR1A)
VVP: 112907678(FCGR1A)
VLG: 121491076(FCGR1A)
AML: 100471819(FCGR1A)
UMR: 103667577(FCGR1A)
UAH: 113246145
ORO: 101381082
ELK: 111162063
MPUF: 101672891
EJU: 114197301(FCGR1A)
FCA: 101087936
PYU: 121021100(FCGR1A)
PTG: 102955538
PPAD: 109257074
AJU: 106982107
HHV: 120241244(FCGR1A)
BTA: 282227(FCGR1A)
BOM: 102280754
BIU: 109555819
BBUB: 102410120
CHX: 102173987
OAS: 100192431(FCGR1A)
ODA: 120855951(FCGR1A)
CCAD: 122433929(FCGR1A)
SSC: 613130(FCGR1A)
CFR: 102521148(FCGR1A)
CBAI: 105071776
CDK: 105103159
EPZ: 103540002
EAI: 106848287
MYB: 102249630
MYD: 102764315
MMYO: 118673015(FCGR1A)
MNA: 107545392
HAI: 109378026
DRO: 112314050
SHON: 118982019(FCGR1A)
AJM: 119064971(FCGR1A)
MMF: 118637846(FCGR1A)
PALE: 102889680(FCGR1A)
PGIG: 120585164(FCGR1A)
RAY: 107504605(FCGR1A)
MJV: 108409964
TOD: 119235968(FCGR1A)
LAV: 100654406(FCGR1B) 100654974(FCGR1A)
TMU: 101342556
MDO: 103093099(FCRL6)
OAA: 100093395
PMOA: 120504147
XLA: 108699133
NPR: 108802144
CCAR: 109113072
PHYP: 113543113
AMEX: 103021574
TRU: 101062846(fcer1a)
NCC: 104954275(fcer1a)
CGOB: 115018213
ELY: 117259307
PLEP: 121943037
SLUC: 116050848
ECRA: 117942248
PFLV: 114552665
GAT: 120824579
CUD: 121525981
OLA: 101158714
OML: 112149588
XMA: 102220103
XCO: 114133593
XHE: 116708297
CTUL: 119797342
KMR: 108240830
ALIM: 106519409
POV: 109630247
SDU: 111239819(fcer1a)
SLAL: 111654383
XGL: 120791524
HCQ: 109518428
BPEC: 110163648
SASA: 106580961(FCGR1) 106612904(FCGR1) 106614022
ELS: 105027167
SFM: 108922389
LOC: 102696605
 » show all
Reference
PMID:2974947
  Authors
Allen JM, Seed B
  Title
Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI).
  Journal
Nucleic Acids Res 16:11824 (1988)
DOI:10.1093/nar/16.24.11824
  Sequence
[hsa:2209]
Reference
  Authors
Fossati G, Bucknall RC, Edwards SW
  Title
Fcgamma receptors in autoimmune diseases.
  Journal
Eur J Clin Invest 31:821-31 (2001)
DOI:10.1046/j.1365-2362.2001.00881.x

KEGG   ORTHOLOGY: K06472
Entry
K06472                      KO                                     

Symbol
FCGR2A, CD32
Name
low affinity immunoglobulin gamma Fc receptor II-a
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map04611  Platelet activation
map04613  Neutrophil extracellular trap formation
map04666  Fc gamma R-mediated phagocytosis
map05130  Pathogenic Escherichia coli infection
map05135  Yersinia infection
map05140  Leishmaniasis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05171  Coronavirus disease - COVID-19
map05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H01360  Allergic rhinitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   04613 Neutrophil extracellular trap formation
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   04666 Fc gamma R-mediated phagocytosis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05135 Yersinia infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05150 Staphylococcus aureus infection
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
   05152 Tuberculosis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06472  FCGR2A, CD32; low affinity immunoglobulin gamma Fc receptor II-a
CD molecules [BR:ko04090]
 Proteins
  K06472  CD32a, FCGR2A; Fc fragment of IgG, low affinity IIa, receptor for (CD32)
Other DBs
GO: 0019770
Genes
HSA: 2212(FCGR2A)
PTR: 107973075 450194(FCGR2A)
PPS: 100991644(FCGR2A)
GGO: 101130688(FCGR2A)
PON: 100455333(FCGR2A)
NLE: 101176530(FCGR2A)
MCC: 719996(FCGR2A)
MCF: 102143568(FCGR2A)
CSAB: 103223676(FCGR2A)
CATY: 105589239(FCGR2A)
PANU: 101009922(FCGR2A)
RRO: 104669518(FCGR2A)
RBB: 108542586(FCGR2A)
TFN: 117074579(FCGR2A)
PTEH: 111525036(FCGR2A)
CJC: 100387574(FCGR2A)
SBQ: 101040113(FCGR2A)
MMUR: 105873561(FCGR2A)
MCAL: 110288995
MPAH: 110321588
RNO: 498276
MCOC: 116103299(Fcgr2a)
MUN: 110554429(Fcgr2a)
CGE: 103161891
PLEU: 119086087(Fcgr2a)
NGI: 103746769(Fcgr2a)
HGL: 101700630(Fcgr2a)
CCAN: 109693506(Fcgr2a)
OCU: 100338413(FCGR2A)
BOM: 102274112
BIU: 109578180
OAS: 101106730
PCAD: 112062432
EPZ: 103540857 103540858(FCGR2A)
EAI: 106831113 106831115(FCGR2A)
MYB: 102263991
MMYO: 118673376
SHON: 118979127
AJM: 119052436
MMF: 118637096
PALE: 102879478
RAY: 107502475
LAV: 104846329(FCGR2A)
TMU: 101350744
SANH: 107686749
CAUA: 113096681
TRU: 101072820
GAT: 120823128
OLA: 105356322
XMA: 111611255
KMR: 112449806
SDU: 111239865
XGL: 120797466
BPEC: 110172767
SASA: 106571983
ELS: 109615278
ARUT: 117965893
 » show all
Reference
PMID:2824655
  Authors
Stuart SG, Trounstine ML, Vaux DJ, Koch T, Martens CL, Mellman I, Moore KW
  Title
Isolation and expression of cDNA clones encoding a human receptor for IgG (Fc gamma RII).
  Journal
J Exp Med 166:1668-84 (1987)
DOI:10.1084/jem.166.6.1668
  Sequence
[hsa:2212]
Reference
  Authors
Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, Sun PD
  Title
Structural recognition and functional activation of FcgammaR by innate pentraxins.
  Journal
Nature 456:989-92 (2008)
DOI:10.1038/nature07468

KEGG   ORTHOLOGY: K16824
Entry
K16824                      KO                                     

Symbol
FCGR2C, CD32
Name
low affinity immunoglobulin gamma Fc receptor II-c
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map05140  Leishmaniasis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
Disease
H01240  Immune thrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
 09150 Organismal Systems
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
   05152 Tuberculosis
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K16824  FCGR2C, CD32; low affinity immunoglobulin gamma Fc receptor II-c
CD molecules [BR:ko04090]
 Proteins
  K16824  CD32c, FCGR2C; Fc fragment of IgG, low affinity IIc, receptor for (CD32)
Other DBs
GO: 0019770
Genes
HSA: 9103(FCGR2C)
PTR: 748765
MMU: 14131(Fcgr3)
BTA: 782652(FCGR2A)
CCAD: 122430223
CBAI: 105068024
Reference
PMID:2531080
  Authors
Stuart SG, Simister NE, Clarkson SB, Kacinski BM, Shapiro M, Mellman I
  Title
Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.
  Journal
EMBO J 8:3657-66 (1989)
DOI:10.1002/j.1460-2075.1989.tb08540.x
  Sequence
[hsa:9103]

KEGG   ORTHOLOGY: K06463
Entry
K06463                      KO                                     

Symbol
FCGR3, CD16
Name
low affinity immunoglobulin gamma Fc receptor III
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04666  Fc gamma R-mediated phagocytosis
map05140  Leishmaniasis
map05150  Staphylococcus aureus infection
map05152  Tuberculosis
map05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00090  NK cell defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   04666 Fc gamma R-mediated phagocytosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
   00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Fc receptors
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
CD molecules [BR:ko04090]
 Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc receptor III
Other DBs
GO: 0019770
Genes
HSA: 2214(FCGR3A) 2215(FCGR3B)
PTR: 457457 745350
GGO: 101129837 101143892
PON: 100453994
NLE: 101176357
MCC: 720006(FCGR3)
MCF: 102140945(FCGR3)
CSAB: 103223675
CATY: 105589237
PANU: 100126738(FCGR3A)
RRO: 104671953
RBB: 108542585
TFN: 117074580
PTEH: 111525035
CJC: 100387926
SBQ: 101040447
MMUR: 105873562
MMU: 246256(Fcgr4)
MCAL: 110299183
MPAH: 110322271
RNO: 116591(Fcgr2a) 304966(Fcgr3a)
MCOC: 116103308
MUN: 110554430
CGE: 103161892
PLEU: 114689891
NGI: 103746771
HGL: 101701607
CCAN: 109693505
TUP: 102499391(FCGR3B)
CFA: 478984
VVP: 112914295
VLG: 121501273
AML: 100481923
UMR: 103658250
UAH: 113268656
ORO: 101363133
ELK: 111151151
MPUF: 101680253
EJU: 114210408
MLX: 118014023(FCGR3A)
FCA: 493677(FCGR3A)
PYU: 121020853
PTG: 102959153
PPAD: 109276673(FCGR3A)
AJU: 106986773
HHV: 120241040(FCGR3A)
BTA: 281766(FCGR3A)
BOM: 102273538
BIU: 109578151
BBUB: 102410092
CHX: 102185698
OAS: 100192433(FCGR3A)
CCAD: 122430259
SSC: 397684(FCGR3B)
CFR: 102516303
CBAI: 105068022
CDK: 105105185
BACU: 103008795
LVE: 103068717
OOR: 101270000
DLE: 111170413
PCAD: 102990877(FCGR3A)
ECB: 100051526
EPZ: 103540860(FCGR3A)
MYB: 102247789(FCGR3B)
MYD: 102754425(FCGR3A)
MMYO: 118673542
MNA: 107535119
HAI: 109392302
DRO: 112297203
SHON: 118979169
AJM: 119052423
MMF: 118637098(FCGR3A)
PALE: 102893884
PGIG: 120584194
RAY: 107502476
TOD: 119240091
LAV: 104846346
MDO: 100015157
SHR: 100924138(FCGR3B)
PCW: 110209910
XTR: 116406731
MSAM: 119884101
OAU: 120439321
XMA: 111611195
XCO: 114156970
KMR: 112450140
AOCE: 111567090
POV: 109646743
ELS: 105009337
RTP: 109932873
 » show all
Reference
PMID:2526846
  Authors
Ravetch JV, Perussia B
  Title
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
  Journal
J Exp Med 170:481-97 (1989)
DOI:10.1084/jem.170.2.481
  Sequence
[hsa:2214 2215]
Reference
  Authors
Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
  Title
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.
  Journal
PLoS One 10:e0121788 (2015)
DOI:10.1371/journal.pone.0121788

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