KEGG   ORTHOLOGY: K06642
Entry
K06642                      KO                                     

Name
PRKDC
Definition
DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
Pathway
ko03450  Non-homologous end-joining
ko04110  Cell cycle
Disease
H00092  T-B-Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03450 Non-homologous end-joining
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
   03400 DNA repair and recombination proteins
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other termination factors
    K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   NHEJ (non-homologous end-joining)
    DNA-PK complex
     K06642  PRKDC; DNA-dependent protein kinase catalytic subunit
Other DBs
GO: 0004677
Genes
HSA: 5591(PRKDC)
PTR: 464165(PRKDC)
PPS: 100981342(PRKDC)
GGO: 101128261(PRKDC)
PON: 100460398(PRKDC)
NLE: 100586225(PRKDC)
MCC: 708029(PRKDC)
MCF: 102119406(PRKDC)
CSAB: 103236758(PRKDC)
CATY: 105592465(PRKDC)
RRO: 104657634(PRKDC)
RBB: 108535350(PRKDC)
TFN: 117079536(PRKDC)
CJC: 100399020(PRKDC)
SBQ: 101053589(PRKDC)
MMUR: 105885240(PRKDC)
MMU: 19090(Prkdc)
MCAL: 110311468(Prkdc)
MPAH: 110330004(Prkdc)
RNO: 360748(Prkdc)
MCOC: 116085621(Prkdc)
MUN: 110561334(Prkdc)
CGE: 100770748(Prkdc)
PLEU: 114709460(Prkdc)
HGL: 101722248(Prkdc)
CCAN: 109688672(Prkdc)
OCU: 100125348(PRKDC)
TUP: 102497296(PRKDC)
CFA: 474176(PRKDC)
VVP: 112929152(PRKDC)
VLG: 121498879(PRKDC)
AML: 100472045(PRKDC)
UMR: 103677407(PRKDC)
UAH: 113268119(PRKDC)
ORO: 101380166(PRKDC)
ELK: 111155445
MPUF: 101687340(PRKDC)
EJU: 114220887(PRKDC)
FCA: 101088389(PRKDC)
PTG: 102960352(PRKDC)
PPAD: 109254736(PRKDC)
AJU: 106982122(PRKDC)
HHV: 120225456(PRKDC)
BTA: 512740(PRKDC)
BOM: 102285992(PRKDC)
BIU: 109568449(PRKDC)
BBUB: 102402820(PRKDC)
CHX: 102171625(PRKDC)
OAS: 101111377(PRKDC)
ODA: 120878553(PRKDC)
SSC: 100156379(PRKDC)
CFR: 102519846(PRKDC)
CDK: 105095924(PRKDC)
BACU: 103019606(PRKDC)
LVE: 103090600(PRKDC)
OOR: 101286290(PRKDC)
DLE: 111165833(PRKDC)
PCAD: 102996579(PRKDC)
ECB: 791233(PRKDC)
EPZ: 103567979(PRKDC)
EAI: 106848336(PRKDC)
MYD: 102770810(PRKDC)
MMYO: 118671010(PRKDC)
MNA: 107526457(PRKDC)
HAI: 109392680(PRKDC)
DRO: 112320750(PRKDC)
SHON: 118979346(PRKDC)
AJM: 119049347(PRKDC)
MMF: 118631854(PRKDC)
PALE: 102895801(PRKDC)
RAY: 107503009(PRKDC) 107505079
MJV: 108402211(PRKDC)
LAV: 100667300(PRKDC)
TMU: 101346733
MDO: 100030684(PRKDC)
SHR: 100915132(PRKDC)
PCW: 110212506(PRKDC)
OAA: 100084470(PRKDC)
GGA: 395376(PRKDC)
PCOC: 116242252(PRKDC)
MGP: 100546550(PRKDC)
CJO: 107310139(PRKDC)
NMEL: 110394403(PRKDC)
APLA: 101804792(PRKDC)
ACYG: 106038417(PRKDC)
TGU: 100224961(PRKDC)
LSR: 110473763(PRKDC)
SCAN: 103827354(PRKDC)
PMOA: 120499298(PRKDC)
GFR: 102042450(PRKDC)
FAB: 101819416(PRKDC)
PHI: 102108488(PRKDC)
PMAJ: 107200430(PRKDC)
CCAE: 111924874(PRKDC)
CCW: 104690434(PRKDC)
ETL: 114060600(PRKDC)
FPG: 101914535(PRKDC)
FCH: 102045681(PRKDC)
CLV: 102099053(PRKDC)
EGZ: 104126877 104127679(PRKDC)
NNI: 104019798(PRKDC)
ACUN: 113476127(PRKDC)
PADL: 103923190(PRKDC)
AAM: 106494392(PRKDC)
ASN: 102387673(PRKDC)
AMJ: 102575311(PRKDC)
CPOO: 109314867(PRKDC)
GGN: 109298708(PRKDC)
PSS: 102454928(PRKDC)
CMY: 102937565(PRKDC)
CPIC: 101936824(PRKDC)
TST: 117873465(PRKDC)
CABI: 116836465(PRKDC)
ACS: 100562493(prkdc)
PVT: 110077653(PRKDC)
PMUR: 107287153(PRKDC)
TSR: 106554042(PRKDC)
PGUT: 117672768(PRKDC)
PMUA: 114600632(PRKDC)
ZVI: 118089778(PRKDC)
GJA: 107122359(PRKDC)
XLA: 373602(prkdc.L)
XTR: 100488663(prkdc)
NPR: 108792226(PRKDC)
DRE: 562283(prkdc)
SANH: 107659432 107684509(prkdc)
SGH: 107591017(prkdc)
CAUA: 113106164(prkdc)
IPU: 108268160(prkdc)
PHYP: 113540485(prkdc)
AMEX: 103028565(prkdc)
EEE: 113583195(prkdc)
TRU: 101073073(prkdc)
LCO: 104928964(prkdc)
NCC: 104943222(prkdc)
ELY: 117264763(prkdc)
PLEP: 121960509(prkdc)
SLUC: 116055758(prkdc)
GAT: 120811646(prkdc)
MSAM: 119907076(prkdc)
MZE: 101484851(prkdc)
ONL: 100706243(prkdc)
OAU: 116335764(prkdc)
OLA: 101171206(prkdc)
OML: 112151428(prkdc)
XMA: 102221760(prkdc)
XCO: 114137103(prkdc)
XHE: 116711736(prkdc)
PRET: 103482327(prkdc)
CVG: 107084919(prkdc)
NFU: 107382641(prkdc)
KMR: 108235234(prkdc)
AOCE: 111574562(prkdc)
CSEM: 103377075(prkdc)
POV: 109629764(prkdc)
LCF: 108898307(prkdc)
SDU: 111228243(prkdc)
SLAL: 111648260(prkdc)
XGL: 120789644(prkdc)
HCQ: 109507813(prkdc)
BPEC: 110165311(prkdc)
MALB: 109952212(prkdc)
SASA: 106579558(prkdc)
OMY: 110535300(prkdc)
SALP: 111972800(prkdc)
ELS: 105019560(prkdc)
PKI: 111854631(prkdc)
LOC: 102698219(prkdc)
PSPA: 121314412(prkdc)
ARUT: 117435350(prkdc)
LCM: 102352949(PRKDC)
CMK: 103175370(prkdc)
RTP: 109915842
BFO: 118428664
SCLV: 120340358
APLC: 110990343
ACOZ: 120949564
AARA: 120904816
AAG: 5570160
AALB: 109414486
CPII: 120420930
AME: 552548
BIM: 100744526
BTER: 100644482
CCAL: 108624143
MGEN: 117220698
NMEA: 116431320
SOC: 105207712
MPHA: 105838146
AEC: 105148426
ACEP: 105619089
PBAR: 105433388
VEM: 105570421
HST: 105182659
DQU: 106744107
CFO: 105258805
FEX: 115242884
LHU: 105673241
PGC: 109854737
OBO: 105280397
PCF: 106785244
MDL: 103572309
TCA: 659348
DPA: 109546518
AGB: 108909059
NVL: 108562010
APLN: 108743426
PPYR: 116166624
OTU: 111424255
PPOT: 106107610
API: 100570557
DNX: 107168171
AGS: 114121157
BTAB: 109043096
CLEC: 106666628
NLU: 111058704
ZNE: 110836224
CSEC: 111873877
FCD: 110843047
PVM: 113805347
EAF: 111698553
RSAN: 119398985
CSCU: 111624779
TSP: Tsp_00850
PCAN: 112562170
BGT: 106074827
GAE: 121379650
CRG: 105317076
MYI: 110461426
PMAX: 117335443
OBI: 106874950
EGL: EGR_06214
NVE: 5505605
ATEN: 116309119
PDAM: 113673640
SPIS: 111320216
DGT: 114536016
HMG: 100210864(prkdc)
AQU: 100633457
PPP: 112286712
DDI: DDB_G0281167(dnapkcs)
DFA: DFA_11411(dnapkcs)
SPAR: SPRG_12566
 » show all
Reference
  Authors
Soubeyrand S, Pope L, Pakuts B, Hache RJ
  Title
Threonines 2638/2647 in DNA-PK are essential for cellular resistance to ionizing radiation.
  Journal
Cancer Res 63:1198-201 (2003)
  Sequence
[hsa:5591]

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