KEGG   ORTHOLOGY: K07425
Entry
K07425                      KO                                     
Symbol
CYP4A
Name
long-chain fatty acid omega-monooxygenase [EC:1.14.14.80]
Pathway
map00071  Fatty acid degradation
map00590  Arachidonic acid metabolism
map00830  Retinol metabolism
map01100  Metabolic pathways
map03320  PPAR signaling pathway
map04270  Vascular smooth muscle contraction
map04750  Inflammatory mediator regulation of TRP channels
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
   00590 Arachidonic acid metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.80  long-chain fatty acid omega-monooxygenase
     K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP4 family
   K07425  CYP4A; long-chain fatty acid omega-monooxygenase
Other DBs
RN: R01348 R07041 R07046 R07050 R08390
GO: 0052869
Genes
CJC: 100387637 100409032
SBQ: 101042627 101050377
MMU: 100040843(Cyp4a32) 13117(Cyp4a10) 13118(Cyp4a12b) 13119(Cyp4a14) 230639(Cyp4a29) 277753(Cyp4a12a) 435802(Cyp4a30b) 666168(Cyp4a31)
MCAL: 110288135 110292084 110293093 110293094 110293391 110293392
MPAH: 110315778 110322859 110322974 110323152 110323837
RNO: 24306(Cyp4a2) 266674(Cyp4a8) 298423(Cyp4a3) 50549(Cyp4a1)
MCOC: 116095748 116095749
MUN: 110539795 110539797 110541278 110550763
CGE: 100767149 100767636 100767921 100768211 100768783
MAUA: 101823194 101832451 101832714 101844652 121132790
NGI: 103740657
OCU: 100328576(CYP4A5) 100328944(CYP4A7) 100328946(CYP4A6) 100341018
GVR: 103595377
CFA: 475366(CYP4A38) 610385(CYP4A11)
VLG: 121481291
AML: 100470061
UMR: 103670742
UAH: 113249623
ORO: 101381707
NSU: 110578763
LWW: 102736045
BTA: 511890(CYP4A11) 516085(CYP4A22) 784417
SSC: 100522145 110255311 403326(CYP4A24)
CFR: 102523990
CBAI: 105065866
CDK: 105092933
VPC: 102540610
MYD: 102774956
MLF: 102442952
DRO: 112314476
AJM: 119054461
MMF: 118626316
RFQ: 117026835
RAY: 107514040
MJV: 108404957
DNM: 101422541
MDO: 100023663
 » show all
Reference
PMID:2766932 (CYP4A1)
  Authors
Kimura S, Hanioka N, Matsunaga E, Gonzalez FJ
  Title
The rat clofibrate-inducible CYP4A gene subfamily. I. Complete intron and exon sequence of the CYP4A1 and CYP4A2 genes, unique exon organization, and identification of a conserved 19-bp upstream element.
  Journal
DNA 8:503-16 (1989)
DOI:10.1089/dna.1.1989.8.503
  Sequence
[rno:50549]
Reference
PMID:2340280 (CYP4A5)
  Authors
Johnson EF, Walker DL, Griffin KJ, Clark JE, Okita RT, Muerhoff AS, Masters BS
  Title
Cloning and expression of three rabbit kidney cDNAs encoding lauric acid omega-hydroxylases.
  Journal
Biochemistry 29:873-9 (1990)
DOI:10.1021/bi00456a004
  Sequence
[ocu:100328576]
Reference
PMID:3410047 (CYP4A10)
  Authors
Earnshaw D, Dale JW, Goldfarb PS, Gibson GG
  Title
Differential splicing in the 3' non-coding region of rat cytochrome P-452 (P450 IVA1) mRNA.
  Journal
FEBS Lett 236:357-61 (1988)
DOI:10.1016/0014-5793(88)80055-3
  Sequence
[rno:50549]
Reference
PMID:9271096 (CYP4A14)
  Authors
Heng YM, Kuo CS, Jones PS, Savory R, Schulz RM, Tomlinson SR, Gray TJ, Bell DR
  Title
A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans.
  Journal
Biochem J 325 ( Pt 3):741-9 (1997)
DOI:10.1042/bj3250741
  Sequence
[mmu:13119]
Reference
PMID:11931657 (CYP4A24)
  Authors
Lundell K
  Title
Cloning and expression of two novel pig liver and kidney fatty acid hydroxylases [cytochrome P450 (CYP)4A24 and CYP4A25].
  Journal
Biochem J 363:297-303 (2002)
DOI:10.1042/0264-6021:3630297
  Sequence
[ssc:403326]

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