KEGG   ORTHOLOGY: K07515
Entry
K07515                      KO                                     

Symbol
HADHA
Name
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Pathway
map00062  Fatty acid elongation
map00071  Fatty acid degradation
map00280  Valine, leucine and isoleucine degradation
map00310  Lysine degradation
map00380  Tryptophan metabolism
map00410  beta-Alanine metabolism
map00627  Aminobenzoate degradation
map00640  Propanoate metabolism
map00650  Butanoate metabolism
map00930  Caprolactam degradation
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Disease
H00489  LCHAD deficiency
H00525  Disorders of mitochondrial fatty-acid oxidation
H01352  Mitochondrial trifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00650 Butanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00930 Caprolactam degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.211  long-chain-3-hydroxyacyl-CoA dehydrogenase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Other DBs
RN: R01778 R02685 R03026 R03045 R04137 R04170 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04743 R04744 R04745 R04746 R04748 R04749 R05595 R06942
GO: 0004300 0016509
Genes
HSA: 3030(HADHA)
PTR: 459079(HADHA)
PPS: 100973698 100978217(HADHA)
GGO: 101143053(HADHA)
PON: 100172963(HADHA)
NLE: 100593214 100593233(HADHA)
MCC: 695975(HADHA)
MCF: 102142372(HADHA)
CSAB: 103220642(HADHA)
CATY: 105578503(HADHA)
PANU: 101014815(HADHA)
RRO: 104677892(HADHA)
RBB: 108532679(HADHA)
TFN: 117062602(HADHA)
PTEH: 111554430(HADHA)
CJC: 100390439(HADHA)
SBQ: 101047074(HADHA)
MMUR: 105884363(HADHA)
MMU: 97212(Hadha)
MCAL: 110294690(Hadha)
MPAH: 110324206(Hadha)
RNO: 170670(Hadha)
MCOC: 116080906(Hadha)
MUN: 110547680(Hadha)
CGE: 100757947(Hadha)
PLEU: 114696488(Hadha)
NGI: 103735655(Hadha)
HGL: 101724137(Hadha)
CCAN: 109685831(Hadha)
OCU: 100355022(HADHA)
TUP: 102471941(HADHA) 102478660
CFA: 100856745(HADHA)
VVP: 112908532(HADHA)
VLG: 121490718(HADHA)
AML: 100469654(HADHA)
UMR: 103671672(HADHA)
UAH: 113270772(HADHA)
ORO: 101364854(HADHA)
ELK: 111154088
MPUF: 101690570(HADHA)
EJU: 114205821(HADHA)
MLX: 118007670(HADHA)
FCA: 101084701(HADHA)
PYU: 121044215(HADHA)
PBG: 122497372(HADHA)
PTG: 102966470(HADHA)
PPAD: 109267284(HADHA)
AJU: 106967830(HADHA)
HHV: 120235789(HADHA)
BTA: 281810(HADHA)
BOM: 102287426(HADHA)
BIU: 109566315(HADHA)
BBUB: 102398211(HADHA)
CHX: 102189046(HADHA)
OAS: 100192316(HADHA)
ODA: 120851587(HADHA)
CCAD: 122441976(HADHA)
SSC: 397012(HADHA)
CFR: 102516648(HADHA)
CBAI: 105063860(HADHA)
CDK: 105098509(HADHA)
BACU: 103001885(HADHA)
LVE: 103086620(HADHA)
OOR: 101286957(HADHA)
DLE: 111174988(HADHA)
PCAD: 102996843(HADHA)
ECB: 100071381(HADHA)
EPZ: 103546462(HADHA)
EAI: 106840921(HADHA)
MYB: 102263028(HADHA)
MYD: 102751724(HADHA)
MMYO: 118669207(HADHA)
MNA: 107534200(HADHA)
HAI: 109383051(HADHA)
DRO: 112297764(HADHA)
SHON: 119001366(HADHA)
AJM: 119050402(HADHA)
MMF: 118630828(HADHA)
PALE: 102889313(HADHA)
PGIG: 120621876(HADHA)
RAY: 107498535(HADHA)
MJV: 108392159(HADHA)
TOD: 119259491(HADHA)
LAV: 100675857(HADHA)
TMU: 101353485
MDO: 100030776(HADHA)
SHR: 100928252(HADHA)
PCW: 110206510(HADHA)
OAA: 100077524(HADHA)
GGA: 395929(HADHA)
PCOC: 116230687(HADHA)
MGP: 100548080(HADHA)
CJO: 107312378(HADHA)
NMEL: 110397114(HADHA)
ACYG: 106048383(HADHA)
LSR: 110478445(HADHA)
SCAN: 103824695(HADHA)
PMOA: 120502645(HADHA)
GFR: 102032411(HADHA)
FAB: 101815112(HADHA)
PHI: 102103703(HADHA)
PMAJ: 107198787(HADHA)
CCAE: 111927468(HADHA)
CCW: 104683133(HADHA)
ETL: 114071979(HADHA)
FPG: 101918262(HADHA)
FCH: 102045684(HADHA)
CLV: 102093055(HADHA)
EGZ: 104130955(HADHA)
NNI: 104014780(HADHA)
ACUN: 113478819(HADHA)
PADL: 103923913(HADHA)
AAM: 106499621(HADHA)
AROW: 112972947(HADHA)
NPD: 112956290(HADHA)
DNE: 112989866(HADHA)
ASN: 102387874(HADHA)
AMJ: 102559143(HADHA)
CPOO: 109311569(HADHA)
GGN: 109300077(HADHA)
PSS: 102461507(HADHA)
CMY: 102938765(HADHA)
CPIC: 101942783(HADHA)
TST: 117875458(HADHA)
CABI: 116823900(HADHA)
ACS: 100553746(hadha)
PVT: 110090547(HADHA)
PBI: 103053277(HADHA)
PMUR: 107291031(HADHA) 107300505
TSR: 106541761(HADHA)
PGUT: 117667656(HADHA)
PMUA: 114594987(HADHA)
ZVI: 118082904(HADHA)
GJA: 107113769(HADHA)
XLA: 108717268(hadha.L) 444044(hadha.S)
XTR: 394832(hadha)
NPR: 108803249(HADHA)
DRE: 553401(hadhaa) 793834(hadhab)
IPU: 100304971 108257474(hadha)
TRU: 101073662(hadha)
LCO: 104929997(hadha)
NCC: 104942173(hadha)
CGOB: 115027323(hadha)
ELY: 117267492(hadhab) 117271127(hadhaa)
PLEP: 121953563(hadhab) 121955566(hadhaa)
SLUC: 116057562(hadhab) 116066337(hadhaa)
ECRA: 117935938(hadhab)
GAT: 120833269(hadhab)
MSAM: 119910484(hadhab)
CUD: 121521089(hadhaa) 121526460(hadhab)
OAU: 116310316(hadhab) 116311176(hadhaa)
OLA: 101155646(hadha)
OML: 112146401(hadhab)
XMA: 102229661(hadha)
XCO: 114133804(hadha)
XHE: 116708744(hadha)
PRET: 103458382(hadha)
CVG: 107095825(hadha)
NFU: 107392010(hadha)
KMR: 108239107(hadhab)
ALIM: 106529789(hadha)
CSEM: 103380450(hadha)
POV: 109636387(hadha)
LCF: 108874899(hadha)
SDU: 111225708(hadha)
SLAL: 111673117(hadha)
XGL: 120795237(hadhab)
MALB: 109964597(hadha)
SASA: 106603767 106611334(ECHA)
OMY: 110497612(hadhab) 110505842
ELS: 105026863(hadha)
PKI: 111851531(hadha) 111857967
AANG: 118230436(hadhaa)
LOC: 102683906(hadha)
ARUT: 117402708
LCM: 102350823(HADHA)
CMK: 103183149(hadha)
RTP: 109910714(hadha)
BFO: 118404846
BBEL: 109480946
CIN: 100181980
SCLV: 120334615
SPU: 585357
APLC: 110978691
SKO: 100369576(HADHA)
DME: Dmel_CG4389(Mtpalpha)
DER: 6541344
DSE: 6611826
DSI: Dsimw501_GD22351(Dsim_GD22351)
DAN: 6504621
DSR: 110176800
DPE: 6589537
DMN: 108161786
DWI: 6641563
DGR: 6561593
DAZ: 108610802
DNV: 108649592
DHE: 111603880
DVI: 6634031
CCAT: 101457240
MDE: 101889137
LCQ: 111679665
ACOZ: 120955422
AARA: 120899980
AAG: 5572923
CPII: 120413536
AME: 410325
ACER: 107995032
BIM: 100741897
BBIF: 117206238
BTER: 100642892
CCAL: 108623987
OBB: 114875921
MGEN: 117229783
NMEA: 116435158
CGIG: 122404552
SOC: 105201374
MPHA: 105837947
AEC: 105152057
ACEP: 105621618
PBAR: 105434016
VEM: 105567443
HST: 105189285
DQU: 106748121
CFO: 105254374
FEX: 115242387
LHU: 105673815
PGC: 109863893
OBO: 105279823
PCF: 106784609
NVI: 100121740
CSOL: 105361087
MDL: 103579736
CCIN: 107272281
TCA: 662336
ATD: 109603223
AGB: 108909349
LDC: 111505103
NVL: 108558831
APLN: 108743158
PPYR: 116170876
OTU: 111424721
BMOR: 692820
BMAN: 114248364
MSEX: 115449399
BANY: 112051091
PMAC: 106719824
PPOT: 106099818
PXU: 106118328
PRAP: 110999633
ZCE: 119839977
HAW: 110371935
TNL: 113493488
PXY: 105387328
API: 100165657
DNX: 107168916
AGS: 114130103
RMD: 113555782
BTAB: 109036133
DCI: 103508490
CLEC: 106670657
HHAL: 106692538
NLU: 111051734
ZNE: 110827146
CSEC: 111865385
FCD: 110854334
DMK: 116935944
PVM: 113805029
HAME: 121879971
EAF: 111710504
DSV: 119465929
RSAN: 119372045
VDE: 111250076
VJA: 111259811
TUT: 107359547
DPTE: 113799485
CSCU: 111616495
CEL: CELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
CBR: CBG12562
BMY: BM_BM2467(Bm2467)
PCAN: 112574360
BGT: 106057657
GAE: 121374973
CRG: 105342066
OBI: 106883270
LAK: 106173898
EPA: 110254396
ATEN: 116304116
ADF: 107334024
AMIL: 114957985
PDAM: 113673361
SPIS: 111326946
DGT: 114535097
HMG: 100197152(hadha)
AQU: 100631983
FCY: FRACYDRAFT_183437(ECH_HADH2)
SPAR: SPRG_06557
 » show all
Reference
PMID:8135828
  Authors
Kamijo T, Aoyama T, Komiyama A, Hashimoto T
  Title
Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein.
  Journal
Biochem Biophys Res Commun 199:818-25 (1994)
DOI:10.1006/bbrc.1994.1302
  Sequence
[hsa:3030]

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