KEGG   ORTHOLOGY: K08009
Entry
K08009                      KO                                     

Symbol
CYBA, P22PHOX
Name
cytochrome b-245, alpha polypeptide
Pathway
map04145  Phagosome
map04380  Osteoclast differentiation
map04613  Neutrophil extracellular trap formation
map04621  NOD-like receptor signaling pathway
map04670  Leukocyte transendothelial migration
map05020  Prion disease
map05140  Leishmaniasis
map05208  Chemical carcinogenesis - reactive oxygen species
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00098  Chronic granulomatous disease
H01167  Granulibacter infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   04621 NOD-like receptor signaling pathway
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   04670 Leukocyte transendothelial migration
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09164 Neurodegenerative disease
   05020 Prion disease
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   05418 Fluid shear stress and atherosclerosis
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
   05415 Diabetic cardiomyopathy
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
Membrane trafficking [BR:ko04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    K08009  CYBA, P22PHOX; cytochrome b-245, alpha polypeptide
Other DBs
TC: 5.B.1.1.1
Genes
HSA: 1535(CYBA)
PTR: 468068(CYBA)
PPS: 100986914
GGO: 101141497
PON: 100456737
NLE: 100595279
MCC: 696748
MCF: 102143777
CSAB: 103233451
CATY: 105589952
PANU: 101005729
RRO: 104655986
RBB: 108520444
TFN: 117088204
PTEH: 111553835
CJC: 100414967(CYBA)
SBQ: 101045425
MMUR: 105855896
MMU: 13057(Cyba)
MCAL: 110300473
MPAH: 110337603
RNO: 79129(Cyba)
MCOC: 116070330
MUN: 110545249
CGE: 100766833
PLEU: 114700968
NGI: 103740013
HGL: 101717043
CCAN: 109692739
OCU: 100008800(CYBA)
TUP: 102471991
CFA: 489664(CYBA)
VVP: 112924621
VLG: 121500490
AML: 100482979
UMR: 103673846
UAH: 113252151
ORO: 101364731
ELK: 111152928
MPUF: 101672987
EJU: 114200838
MLX: 118023475
FCA: 101091745
PYU: 121009924
PBG: 122494596
PPAD: 109245544
AJU: 113604395
HHV: 120228254
BTA: 281111(CYBA)
BOM: 102270937
BIU: 109572735
BBUB: 102413072
CHX: 102188617
OAS: 101106452
ODA: 120872959
CCAD: 122420817
SSC: 397507(CYBA)
CFR: 102509853
CBAI: 105079445
CDK: 105104683
BACU: 102999052
LVE: 103090543
OOR: 101274948
DLE: 111179403
PCAD: 102973615
ECB: 100049843(CYBA)
EAI: 106828257
MYB: 102242122
MYD: 102760442
MMYO: 118674356
MNA: 107525738
HAI: 109389148
DRO: 112300849
SHON: 118982972
AJM: 119047041
MMF: 118638681
PALE: 102885155
PGIG: 120622893
RAY: 107502360
MJV: 108385610
TOD: 119250341
LAV: 100666572
TMU: 101355438
MDO: 100026086
SHR: 100932491
PCW: 110210311
OAA: 100084242
GGA: 100859840(CYBA)
PCOC: 116243722
MGP: 100544408
CJO: 107319525
NMEL: 110404326
TGU: 100230391
LSR: 110468832
SCAN: 103816882
PMOA: 120496262
GFR: 102036039
FAB: 101819099
PHI: 102100453
PMAJ: 107210059
CCAE: 111934735
CCW: 120410609
ETL: 114060625
FPG: 101915504
CLV: 102091746
NNI: 104023645
AAM: 106491416
AROW: 112978482
NPD: 112949947
DNE: 112989086
ASN: 102385608
AMJ: 102558462
CPOO: 109310371
PSS: 102449370
CMY: 102946998
CPIC: 101937351
TST: 117886699
CABI: 116815693
ACS: 100555174
PVT: 110076319
PBI: 103052761
PMUR: 107283532
TSR: 106549747
PGUT: 117671018
PMUA: 114602128
ZVI: 118087855
GJA: 107119316
XLA: 108704084(cyba.S) 446853(cyba.L)
XTR: 549234(cyba)
NPR: 108802186
DRE: 393551(cyba)
CAUA: 113118541
IPU: 108264585
PHYP: 113526918
AMEX: 103041742
EEE: 113570890
TRU: 445889(p22phox)
LCO: 104927415
NCC: 104964892
CGOB: 115023803
ELY: 117251251
PLEP: 121942736
SLUC: 116060568
ECRA: 117943171
PFLV: 114556629
GAT: 120810816
MSAM: 119891034
CUD: 121508021
MZE: 101470167
ONL: 100705310
OAU: 116335780
OLA: 101170577
OML: 112160324
XMA: 102219145
XCO: 114142753
XHE: 116718461
PRET: 103462573
CVG: 107084165
CTUL: 119797562
NFU: 107381322
KMR: 108250930
ALIM: 106513204
AOCE: 111577161
CSEM: 103379180
POV: 109636777
LCF: 108877826
SDU: 111222344
SLAL: 111646239
XGL: 120791656
HCQ: 109525911
BPEC: 110175258
MALB: 109965069
OMY: 100301566(p22-phox)
ELS: 105015958
SFM: 108940834
PKI: 111861200
AANG: 118215395
LOC: 102687462
PSPA: 121296377
ARUT: 117424066
LCM: 102353925
CMK: 103175997
RTP: 109937056
BFO: 118417857
BBEL: 109465002
CIN: 100182370
SCLV: 120338639
SPU: 100889590
APLC: 110975693
SKO: 102806390
PTEP: 107455428
SDM: 118186981
PCAN: 112576562
BGT: 106074408
GAE: 121388754
MYI: 110449899
PMAX: 117337139
OBI: 106870690
LAK: 106157842
NVE: 5508056
EPA: 110245830
ATEN: 116297406
ADF: 107348189
AMIL: 114954170
PDAM: 113675015
SPIS: 111340161
DGT: 114517092
HMG: 100213059
AQU: 100637130
DDI: DDB_G0267460(cybA)
DFA: DFA_07591(cybA)
 » show all
Reference
  Authors
Miyano K, Sumimoto H
  Title
Role of the small GTPase Rac in p22phox-dependent NADPH oxidases.
  Journal
Biochimie 89:1133-44 (2007)
DOI:10.1016/j.biochi.2007.05.003
Reference
PMID:3368442
  Authors
Parkos CA, Dinauer MC, Walker LE, Allen RA, Jesaitis AJ, Orkin SH
  Title
Primary structure and unique expression of the 22-kilodalton light chain of human neutrophil cytochrome b.
  Journal
Proc Natl Acad Sci U S A 85:3319-23 (1988)
DOI:10.1073/pnas.85.10.3319
  Sequence
[hsa:1535]

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