KEGG   ORTHOLOGY: K08726
Entry
K08726                      KO                                     

Symbol
EPHX2
Name
soluble epoxide hydrolase / lipid-phosphate phosphatase [EC:3.3.2.10 3.1.3.76]
Pathway
map00590  Arachidonic acid metabolism
map00625  Chloroalkane and chloroalkene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
map04146  Peroxisome
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
  09111 Xenobiotics biodegradation and metabolism
   00625 Chloroalkane and chloroalkene degradation
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
   05208 Chemical carcinogenesis - reactive oxygen species
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
   01002 Peptidases and inhibitors
    K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.76  lipid-phosphate phosphatase
     K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.10  soluble epoxide hydrolase
     K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
Protein phosphatases and associated proteins [BR:ko01009]
 HAD phosphatases
  Other HAD phosphatases
   K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S33
   K08726  EPHX2; soluble epoxide hydrolase / lipid-phosphate phosphatase
Other DBs
RN: R05842 R07108 R07109 R07110 R07111
GO: 0004301 0042577
Genes
HSA: 2053(EPHX2)
PTR: 464074(EPHX2)
PPS: 100990932(EPHX2)
GGO: 101136750(EPHX2)
PON: 100172736(EPHX2)
NLE: 100585861(EPHX2)
MCC: 712926(EPHX2)
MCF: 102134633(EPHX2)
CSAB: 103215526(EPHX2)
CATY: 105579174(EPHX2)
PANU: 101025043(EPHX2)
RRO: 104673945(EPHX2)
RBB: 108537568(EPHX2)
TFN: 117093881(EPHX2)
PTEH: 111545735(EPHX2)
CJC: 100402999(EPHX2)
SBQ: 101033420(EPHX2)
MMUR: 105877163(EPHX2)
MMU: 13850(Ephx2)
MCAL: 110309184(Ephx2)
MPAH: 110325104(Ephx2)
RNO: 65030(Ephx2)
MCOC: 116084507(Ephx2)
MUN: 110559220(Ephx2)
CGE: 100757328(Ephx2)
PLEU: 114707310(Ephx2)
NGI: 103730002(Ephx2)
HGL: 101715352(Ephx2)
CCAN: 109683973
OCU: 100350230(EPHX2)
OPI: 101526632(EPHX2)
TUP: 102480725(EPHX2)
CFA: 477373(EPHX2)
VVP: 112926786(EPHX2)
VLG: 121496796(EPHX2)
AML: 100483572(EPHX2)
UMR: 103675990(EPHX2)
UAH: 113269956(EPHX2)
ORO: 101373863(EPHX2)
ELK: 111152645
MPUF: 101689697(EPHX2)
EJU: 114217531(EPHX2)
MLX: 118022112(EPHX2)
FCA: 101092355(EPHX2)
PYU: 121022524(EPHX2)
PBG: 122473878(EPHX2)
PTG: 102957184(EPHX2)
PPAD: 109262341(EPHX2)
AJU: 106973110(EPHX2)
HHV: 120220308(EPHX2)
BTA: 511716(EPHX2)
BOM: 102267808(EPHX2)
BIU: 109563159(EPHX2)
BBUB: 102411270(EPHX2)
CHX: 102185835(EPHX2)
OAS: 101106654(EPHX2)
CCAD: 122431866(EPHX2)
SSC: 414425(EPHX2)
CFR: 102517269(EPHX2)
CBAI: 105063866(EPHX2)
CDK: 105102229(EPHX2)
BACU: 103015729(EPHX2)
LVE: 103082628(EPHX2)
OOR: 101282222(EPHX2)
DLE: 111185405(EPHX2)
PCAD: 102997018(EPHX2)
ECB: 100060414(EPHX2)
EPZ: 103550424(EPHX2)
EAI: 106832514(EPHX2)
MYB: 102255588(EPHX2)
MYD: 102755564(EPHX2)
MMYO: 118659062(EPHX2)
MNA: 107538569(EPHX2)
HAI: 109379561(EPHX2)
DRO: 112312409(EPHX2)
SHON: 118984357(EPHX2)
AJM: 119044629
PALE: 102886924(EPHX2)
PGIG: 120613418(EPHX2)
RAY: 107507539(EPHX2)
MJV: 108394328(EPHX2)
TOD: 119258012(EPHX2)
LAV: 100658579(EPHX2)
TMU: 101343713
MDO: 100030580(EPHX2)
PCW: 110206532(EPHX2)
OAA: 100093187(EPHX2)
GGA: 421999(EPHX2)
PCOC: 116235639(EPHX2)
MGP: 100550075(EPHX2)
CJO: 107312419(EPHX2)
NMEL: 110396327(EPHX2)
APLA: 101802271(EPHX2)
TGU: 115494601(EPHX2)
LSR: 110477399(EPHX2)
SCAN: 103825122(EPHX2)
OTC: 121344673(EPHX2)
FAB: 101820851(EPHX2)
PHI: 102113903(EPHX2)
CCAE: 111927478(EPHX2)
FPG: 101922601(EPHX2)
FCH: 102047869(EPHX2)
CLV: 102084991(EPHX2)
EGZ: 104132029(EPHX2)
NNI: 104014768(EPHX2)
ACUN: 113478826(EPHX2)
AAM: 106486373(EPHX2)
AROW: 112966641(EPHX2)
NPD: 112949124(EPHX2)
DNE: 112993182(EPHX2)
ASN: 102382847(EPHX2)
AMJ: 102558789(EPHX2)
CPOO: 109311562(EPHX2)
PSS: 102463793(EPHX2)
CMY: 102944771(EPHX2)
CPIC: 101948727(EPHX2)
ACS: 100564154(ephx2)
PVT: 110089501(EPHX2)
PBI: 103065207
PMUR: 107296270
TSR: 106551030(EPHX2)
PGUT: 117667686(EPHX2)
PMUA: 114594946(EPHX2)
ZVI: 118082948(EPHX2)
GJA: 107118053(EPHX2)
XLA: 447032(ephx2.L)
XTR: 448759(ephx2)
NPR: 108798538(EPHX2)
DRE: 494099(ephx2)
SRX: 107717245(ephx2) 107733988
SGH: 107552031 107594076(ephx2)
CCAR: 109107424
IPU: 108270338(ephx2)
PHYP: 113538653(ephx2)
AMEX: 103037948(ephx2)
EEE: 113572683(ephx2)
TRU: 101078765(ephx2)
LCO: 104928568(ephx2)
NCC: 104958265(ephx2)
ELY: 117250024(ephx2)
PLEP: 121939287(ephx2)
SLUC: 116041392
ECRA: 117939678(ephx2)
PFLV: 114571310(ephx2)
GAT: 120818346(ephx2)
PPUG: 119220354(ephx2)
CUD: 121506165(ephx2)
MZE: 101483599(ephx2)
ONL: 100705182(ephx2)
OAU: 116325329(ephx2)
OLA: 101157276(ephx2)
OML: 112156764(ephx2)
XMA: 102235090(ephx2)
XCO: 114140564(ephx2)
XHE: 116715605(ephx2)
PRET: 103456621(ephx2)
CVG: 107096825(ephx2)
CTUL: 119794676(ephx2)
NFU: 107384625(ephx2)
KMR: 108246829(ephx2)
ALIM: 106527033(ephx2)
AOCE: 111573235(ephx2)
LCF: 108873166(ephx2)
SDU: 111234755(ephx2)
SLAL: 111672419(ephx2)
XGL: 120798362(ephx2)
MALB: 109955803(ephx2)
SASA: 106604359(HYES) 106611412(HYES)
OMY: 110498218(ephx2) 110504256
SALP: 112071651(ephx2)
SNH: 120023101(ephx2)
ELS: 105028738(ephx2)
AANG: 118209863(ephx2)
LOC: 102697721(ephx2)
PSPA: 121317357(ephx2)
ARUT: 117411030(ephx2)
BFO: 118420112
BBEL: 109472833
CIN: 113474027
SPU: 590472(EH1) 752510(eh2)
SKO: 100367532
NVE: 5521988
EPA: 110251610
ATEN: 116301187
PDAM: 113686980
SPIS: 111334437
DZI: 111302718
ADU: 107492180
PXB: 103939771
CMAX: 111482470
HAN: 110941524
CCAV: 112528667
BDI: 100841009
TDC: 119283936
SBI: 8071538
NCR: NCU02924
NTE: NEUTE1DRAFT119163(NEUTE1DRAFT_119163)
SSCK: SPSK_04392
MAW: MAC_03724
ANG: ANI_1_1944014(An01g14420)
PNO: SNOG_12792 SNOG_13782(SNOG_13781) SNOG_14994
ABP: AGABI1DRAFT110229(AGABI1DRAFT_110229) AGABI1DRAFT38499(AGABI1DRAFT_38499) AGABI1DRAFT70817(AGABI1DRAFT_70817)
ABV: AGABI2DRAFT184905(AGABI2DRAFT_184905) AGABI2DRAFT189875(AGABI2DRAFT_189875) AGABI2DRAFT78715(AGABI2DRAFT_78715)
 » show all
Reference
  Authors
Newman JW, Morisseau C, Harris TR, Hammock BD
  Title
The soluble epoxide hydrolase encoded by EPXH2 is a bifunctional enzyme with novel lipid phosphate phosphatase activity.
  Journal
Proc Natl Acad Sci U S A 100:1558-63 (2003)
DOI:10.1073/pnas.0437724100
  Sequence
[hsa:2053]
Reference
PMID:8342951
  Authors
Beetham JK, Tian T, Hammock BD
  Title
cDNA cloning and expression of a soluble epoxide hydrolase from human liver.
  Journal
Arch Biochem Biophys 305:197-201 (1993)
DOI:10.1006/abbi.1993.1411
  Sequence
[hsa:2053]

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